Sepsis and septic shock are common diagnoses for patients requiring intensive care unit admission and associated with high morbidity and mortality.In addition to aggressive fluid resuscitation and antibiotic therapy,s...Sepsis and septic shock are common diagnoses for patients requiring intensive care unit admission and associated with high morbidity and mortality.In addition to aggressive fluid resuscitation and antibiotic therapy,several other drugs have been tried as adjuvant therapies to reduce the inflammatory response and improve outcomes.Vitamin C has been shown to have several biological actions,including anti-inflammatory and immunomodulatory effects,which may prove beneficial in sepsis management.Initial trials showed improved patient outcomes when high dose vitamin C was used in combination with thiamine and hydrocortisone.These results,along with relative safety of high-dose(supra-physiological)vitamin C,encouraged physicians across the globe to add vitamin C as an adjuvant therapy in the management of sepsis.However,subsequent largescale randomised control trials could not replicate these results,leaving the world divided regarding the role of vitamin C in sepsis management.Here,we discuss the rationale,safety profile,and the current clinical evidence for the use of highdose vitamin C in the management of sepsis and septic shock.展开更多
Burn injury can be detrimental to the health of individuals,meanwhile victims lose proteins and micronutrients in wound exudates.Victims also experience extensive protein catabolism.These make them prone to malnutriti...Burn injury can be detrimental to the health of individuals,meanwhile victims lose proteins and micronutrients in wound exudates.Victims also experience extensive protein catabolism.These make them prone to malnutrition.Burn patients also suffer a lot of emotional trauma that reduce nutrient intake.The aim of this paper was to review primary evidence on the effect of antioxidant micronutrients on the recovery rate of burn patients.Electronic databases such as PubMed,BioMed,and Cochrane were systematically searched between January 1,2014,and January 30,2014.Keywords include vitamin A,vitamin C,vitamin E,ascorbic acid,zinc,copper,selenium,tocopherol,carotenoids,dietary intake,supplementation,wound healing,infection,recovery rate,and burn patients.The systematic search was done to retrieve all published data from 1990 to 2013.A total of 518 journal articles were obtained,and after the removal of duplicates,reviews,commentaries,and studies with non-human subjects,11 papers were accepted for review.The review considered only papers that were published,and there might be some unpublished data that may have been omitted.Generally,the wound healing time and infection rates were reduced by the administration of the antioxidant micronutrients.The review revealed that there was no such published work in developing countries and children were excluded from most studies.It was also stated clearly that there was no uniformity in burn management;hence,there is a need for more studies on burn management in various populations.展开更多
文摘Sepsis and septic shock are common diagnoses for patients requiring intensive care unit admission and associated with high morbidity and mortality.In addition to aggressive fluid resuscitation and antibiotic therapy,several other drugs have been tried as adjuvant therapies to reduce the inflammatory response and improve outcomes.Vitamin C has been shown to have several biological actions,including anti-inflammatory and immunomodulatory effects,which may prove beneficial in sepsis management.Initial trials showed improved patient outcomes when high dose vitamin C was used in combination with thiamine and hydrocortisone.These results,along with relative safety of high-dose(supra-physiological)vitamin C,encouraged physicians across the globe to add vitamin C as an adjuvant therapy in the management of sepsis.However,subsequent largescale randomised control trials could not replicate these results,leaving the world divided regarding the role of vitamin C in sepsis management.Here,we discuss the rationale,safety profile,and the current clinical evidence for the use of highdose vitamin C in the management of sepsis and septic shock.
文摘Burn injury can be detrimental to the health of individuals,meanwhile victims lose proteins and micronutrients in wound exudates.Victims also experience extensive protein catabolism.These make them prone to malnutrition.Burn patients also suffer a lot of emotional trauma that reduce nutrient intake.The aim of this paper was to review primary evidence on the effect of antioxidant micronutrients on the recovery rate of burn patients.Electronic databases such as PubMed,BioMed,and Cochrane were systematically searched between January 1,2014,and January 30,2014.Keywords include vitamin A,vitamin C,vitamin E,ascorbic acid,zinc,copper,selenium,tocopherol,carotenoids,dietary intake,supplementation,wound healing,infection,recovery rate,and burn patients.The systematic search was done to retrieve all published data from 1990 to 2013.A total of 518 journal articles were obtained,and after the removal of duplicates,reviews,commentaries,and studies with non-human subjects,11 papers were accepted for review.The review considered only papers that were published,and there might be some unpublished data that may have been omitted.Generally,the wound healing time and infection rates were reduced by the administration of the antioxidant micronutrients.The review revealed that there was no such published work in developing countries and children were excluded from most studies.It was also stated clearly that there was no uniformity in burn management;hence,there is a need for more studies on burn management in various populations.
