Using observation and reanalysis data throughout 1961-1990, the East Asian surface air temperature, precipitation and sea level pressure climatology as simulated by seven fully coupled atmosphere-ocean models, namely ...Using observation and reanalysis data throughout 1961-1990, the East Asian surface air temperature, precipitation and sea level pressure climatology as simulated by seven fully coupled atmosphere-ocean models, namely CCSR/NIES, CGCM2, CSIRO-Mk2, ECHAM4/OPYC3, GFDL-R30, HadCM3, and NCAR-PCM, are systematically evaluated in this study. It is indicated that the above models can successfully reproduce the annual and seasonal surface air temperature and precipitation climatology in East Asia, with relatively good performance for boreal autumn and annual mean. The models' ability to simulate surface air temperature is more reliable than precipitation. In addition, the models can dependably capture the geographical distribution pattern of annual, boreal winter, spring and autumn sea level pressure in East Asia. In contrast, relatively large simulation errors are displayed when simulated boreal summer sea level pressure is compared with reanalysis data in East Asia. It is revealed that the simulation errors for surface air temperature, precipitation and sea level pressure are generally large over and around the Tibetan Plateau. No individual model is best in every aspect. As a whole, the ECHAM4/OPYC3 and HadCM3 performances are much better, whereas the CGCM2 is relatively poorer in East Asia. Additionally, the seven-model ensemble mean usually shows a relatively high reliability.展开更多
This study examines cloud radiative forcing (CRF) in the Asian monsoon region (0° 50°N, 60° 150°E) simulated by Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report (AR4...This study examines cloud radiative forcing (CRF) in the Asian monsoon region (0° 50°N, 60° 150°E) simulated by Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report (AR4) AMIP models. During boreal winter, no model realistically reproduces the larger long-wave cloud radiative forcing (LWCF) over the Tibet Plateau (TP) and only a couple of models reasonably capture the larger short-wave CRF (SWCF) to the east of the TP. During boreal summer, there are larger biases for central location and intensity of simulated CRF in active convective regions. The CRF biases are closely related to the rainfall biases in the models. Quantitative analysis further indicates that the correlation between simulated CRF and observations are not high, and that the biases and diversity in SWCF are larger than that in LWCF. The annual cycle of simulated CRF over East Asia (0°-50°N, 100°-145°E) is also examined. Though many models capture the basic annual cycle in tropics, strong LWCF and SWCF to the east of the TP beginning in early spring are underestimated by most models. As a whole, GFDL-CM2.1, MPI-ECHAM5, UKMO-HadGAM1, and MIROC3.2 (medres) perform well for CRF simulation in the Asian monsoon region, and the multi-model ensemble (MME) has improved results over the individual simulations. It is suggested that strengthening the physical parameterizations involved over the TP, and improving cumulus convection processes and model experiment design are crucial to CRF simulation in the Asian monsoon region.展开更多
Based on a 200 year simulation and reanalysis data (1980–1996), the general characteristics of East Asian monsoon (EAM) were analyzed in the first part of the paper. It is clear from this re-search that the South Asi...Based on a 200 year simulation and reanalysis data (1980–1996), the general characteristics of East Asian monsoon (EAM) were analyzed in the first part of the paper. It is clear from this re-search that the South Asian monsoon (SAM) defined by Webster and Yang (1992) is geographically and dynamically different from the East Asian monsoon (EAM). The region of the monsoon defined by Webster and Yang (1992) is located in the tropical region of Asia (40–110°E, 10–20°N), including the Indian monsoon and the Southeast Asian monsoon, while the EAM de-fined in this paper is located in the subtropical region of East Asia (110–125°E, 20–40°N). The components and the seasonal variations of the SAM and EAM are different and they characterize the tropical and subtropical Asian monsoon systems respectively. A suitable index (EAMI) for East Asian monsoon was then defined to describe the strength of EAM in this paper. In the second part of the paper, the interannual variability of EAM and its relationship with sea surface temperature (SST) in the 200 year simulation were studied by using the composite method, wavelet transformation, and the moving correlation coefficient method. The summer EAMI is negatively correlated with ENSO (El Nino and Southern Oscillation) cycle represented by the NINO3 sea surface temperature anomaly (SSTA) in the preceding April and January, while the winter EAM is closely correlated with the succeeding spring SST over the Pacific in the coupled model. The general differences of EAM between El Nino and La Nina cases were studied in the model through composite analysis. It was also revealed that the dominating time scales of EAM variability may change in the long-term variation and the strength may also change. The anoma-lous winter EAM may have some correlation with the succeeding summer EAM, but this relation-ship may disappear sometimes in the long-term climate variation. Such time-dependence was found in the relationship between EAM and SST in the long-term climate simulation as well. Key words East Asian monsoon - Interannual variability - Coupled climate model The author wishes to thank Profs. Wu G.X., Zhang X.H., and Dr. Yu Y.Q. for providing the coupled model re-sults. Dr. Yu also kindly provided assistance in using the model output. This work was supported jointly by the Na-tional Natural Science Foundation of China key project ’ The analysis on the seasonal-to-interannual variation of the general circulation’ under contract 49735160 and Chinese Academy of Sciences key project ’ The Interannual Va-riability and Predictability of East Asian Monsoon’.展开更多
In this paper, the global and regional features of the seasonal variation of general circulation, and especially the Asian monsoon simulated by the Institute of Atmospheric Physics Two-level AGCM coupled with a sophis...In this paper, the global and regional features of the seasonal variation of general circulation, and especially the Asian monsoon simulated by the Institute of Atmospheric Physics Two-level AGCM coupled with a sophisticated land-surface model (IAP94-GCM) are presented and compared with the observation. The comparison is made by using the equilibrium multiyear seasonal cycle climate from a 100-year integration. In the integration sea surface temperature (SST) and sea ice are taken from the observed climatological data (with seasonal variation) because our purpose is to see the improvement of simulation due to the coupling with an advanced land surface model. Overall, the IAP94-GCM provides a reasonably realistic simulation of the interseasonal and intraseasonal climatology of the Asian monsoon and yields an important information that sheds light on the thermal underpinning and the thermodynamics of the seasonal and even multiscale variabilities associated with the Asian summer monsoon.展开更多
The performance of a regional air-sea coupled model, comprising the Regional Integrated Environment Model System (RIEMS) and the Princeton Ocean Model (POM), in simulating the seasonal and intraseasonal variations...The performance of a regional air-sea coupled model, comprising the Regional Integrated Environment Model System (RIEMS) and the Princeton Ocean Model (POM), in simulating the seasonal and intraseasonal variations of East Asian summer monsoon (EASM) rainfall was investigated. Through comparisons of the model results among the coupled model, the uncoupled RIEMS, and observations, the impact of air-sea coupling on simulating the EASM was also evaluated. Results showed that the regional air sea coupled climate model performed better in simulating the spatial pattern of the precipitation climatology and produced more realistic variations of the EASM rainfall in terms of its amplitude and principal EOF modes. The coupled model also showed greater skill than the uncoupled RIEMS in reproducing the principal features of climatological intraseasonal oscillation (CISO) of EASM rainfall, including its dominant period, intensity, and northward propagation. Further analysis indicated that the improvements in the simulation of the EASM rainfall climatology and its seasonal variation in the coupled model were due to better simulation of the western North Pacific Subtropical High, while the improvements of CISO simulation were owing to the realistic phase relationship between the intraseasonal convection and the underlying SST resulting from the air-sea coupling.展开更多
The interannual variation of the East Asian upper-tropospheric westerly jet (EAJ) significantly affects East Asian climate in summer. Identifying its performance in model prediction may provide us another viewpoint,...The interannual variation of the East Asian upper-tropospheric westerly jet (EAJ) significantly affects East Asian climate in summer. Identifying its performance in model prediction may provide us another viewpoint, from the perspective of uppertropospheric circulation, to understand the predictability of summer climate anomalies in East Asia. This study presents a comprehensive assessment of year-to-year variability of the EAJ based on retrospective seasonal forecasts, initiated from 1 May, in the five state-of-the-art coupled models from ENSEMBLES during 1960-2005. It is found that the coupled models show certain capability in describing the interannual meridional displacement of the EAJ, which reflects the models' performance in the first leading empirical orthogonal function (EOF) mode. This capability is mainly shown over the region south of the EAJ axis. Additionally, the models generally capture well the main features of atmospheric circulation and SST anomalies related to the interannual meridional displacement of the EAJ. Further analysis suggests that the predicted warm SST anomalies in the concurrent summer over the tropical eastern Pacific and northern Indian Ocean are the two main sources of the potential prediction skill of the southward shift of the EAJ. In contrast, the models are powerless in describing the variation over the region north of the EAJ axis, associated with the meridional displacement, and interannual intensity change of the EAJ, the second leading EOF mode, meaning it still remains a challenge to better predict the EAJ and, subsequently, summer climate in East Asia, using current coupled models.展开更多
A WRF-Chem model including a comprehensive gas-phase nitrogen chemistry module was used to simulate a severe dust event appearing in the eastern China on 19-25 March, 2002. The modeling result well reproduced PM10 con...A WRF-Chem model including a comprehensive gas-phase nitrogen chemistry module was used to simulate a severe dust event appearing in the eastern China on 19-25 March, 2002. The modeling result well reproduced PM10 concentrations in various distances from the dust sources and the transport pathway of the dust strom. The results showed that both the concentrations and the dry deposition fluxes of PM10 increased over the China seas during the dust event following the passage of a cold front system. The maximum fluxes of PM10 in the Yellow Sea and the East China Sea during the dust event were 5.5 and 8.4 times of those before the event, respectively. However, the temporal variations of the dry deposition fluxes of particulate inorganic nitrogen differed over the Yellow Sea from those over the East China Sea. Nitrate and ammonium in the whole northern China rapidly decreased because of the intrusion of dust-loaded air on 19 March. The dust plume arrived in the Yellow Sea on 20 March, decreasing the particulate inorganic nitrogen in mass concentration accordingly. The minimum dry deposition fluxes of nitrate and ammonium in the Yellow Sea were about 3/5 and 1/6 of those before the dust arrival, respectively. In contrast, when the dust plume crossed over the Yangtze Delta area, it became abundant in nitrate and ammonium and increased the concentrations and dry deposition fluxes of particulate inorganic nitrogen over the East China Sea, where the maximum dry deposition fluxes of nitrate and ammonium increased approximately by 4.1 and 2.6 times of those prior to the dust arrival.展开更多
The reproducibility and future changes of the onset of the Asian summer monsoon were analyzed based on the simulations and projections under the Representative Concentration Pathways (RCP) scenario in which anthropo...The reproducibility and future changes of the onset of the Asian summer monsoon were analyzed based on the simulations and projections under the Representative Concentration Pathways (RCP) scenario in which anthropogenic emissions continue to rise throughout the 21 st century (i.e. RCP8.5) by all realizations from four Chinese models that participated in the Coupled Model Intercomparison Project Phase 5 (CMIP5). Delayed onset of the monsoon over the Arabian Sea was evident in all simulations for present-day climate, which was associated with a too weak simulation of the low-level Somali jet in May. A consistent advanced onset of the monsoon was found only over the Arabian Sea in the projections, where the advanced onset of the monsoon was accompanied by an increase of rainfall and an anomalous anticyclone over the northern Indian Ocean. In all the models except FGOALS-g2, the enhanced low-level Somali jet transported more water vapor to the Arabian Sea, whereas in FGOALS-g2 the enhanced rainfall was determined more by the increased wind convergence. Furthermore, and again in all models except FGOALS-g2, the equatorial SST warming, with maximum increase over the eastern Pacific, enhanced convection in the central West Pacific and reduced convection over the eastern Indian Ocean and Maritime Continent region, which drove the anomalous anticyclonic circulation over the western Indian Ocean. In contrast, in FGOALS-g2, there was minimal (near-zero) warming of projected SST in the central equatorial Pacific, with decreased convection in the central West Pacific and enhanced convection over the Maritime Continent. The broader-scale differences among the models across the Pacific were related to both the differences in the projected SST pattern and in the present-day simulations.展开更多
This study introduces a new global climate model--the Integrated Climate Model (ICM)--developed for the seasonal prediction of East Asian-western North Pacific (EA-WNP) climate by the Center for Monsoon System Res...This study introduces a new global climate model--the Integrated Climate Model (ICM)--developed for the seasonal prediction of East Asian-western North Pacific (EA-WNP) climate by the Center for Monsoon System Research at the Institute of Atmospheric Physics (CMSR, IAP), Chinese Academy of Sciences. ICM integrates ECHAM5 and NEMO2.3 as its atmospheric and oceanic components, respectively, using OASIS3 as the coupler. The simulation skill of ICM is evaluated here, including the simulated climatology, interannual variation, and the influence of E1 Nifio as one of the most important factors on EA-WNP climate. ICM successfully reproduces the distribution of sea surface temperature (SST) and precipitation without climate shift, the seasonal cycle of equatorial Pacific SST, and the precipitation and circulation of East Asian summer monsoon. The most prominent biases of ICM are the excessive cold tongue and unrealistic westward phase propagation of equatorial Pacific SST. The main interannual variation of the tropical Pacific SST and EA-WNP climate E1 Nifio and the East Asia-Pacific Pattern--are also well simulated in ICM, with realistic spatial pattern and period. The simulated E1 Nifio has significant impact on EA-WNP climate, as in other models. The assessment shows ICM should be a reliable model for the seasonal prediction of EA-WNP climate.展开更多
Asian aridity can be traced back to the early Cenozoic(e.g.,Guo et al.,2008;Licht et al.,2016;Li et al.,2018a).Previous modelling studies focus mainly on the monsoon climate during the early Cenozoic,and studies for t...Asian aridity can be traced back to the early Cenozoic(e.g.,Guo et al.,2008;Licht et al.,2016;Li et al.,2018a).Previous modelling studies focus mainly on the monsoon climate during the early Cenozoic,and studies for the Asian aridity are still limited(e.g.,Huber and Goldner,2012;Zhang et al.,2012;Li et al.,2018b).Here Asian aridity during the early Cenozoic is investigated through climate modelling by changing atmospheric CO2 concentration,orbital parameters,and topography.展开更多
Seasonal prediction of Asian-Australian monsoon (A-AM) precipitation is one of the most important and challenging tasks in climate prediction. In this paper, we evaluate the performance of Grid Atmospheric Model of ...Seasonal prediction of Asian-Australian monsoon (A-AM) precipitation is one of the most important and challenging tasks in climate prediction. In this paper, we evaluate the performance of Grid Atmospheric Model of IAP LASG (GAMIL) on retrospective prediction of the A-AM interannual variation (IAV), and determine to what extent GAMIL can capture the two major observed modes of A-AM rainfall IAV for the period 1979-2003. The first mode is associated with the turnabout of warming (cooling) in the Nifio 3.4 region, whereas the second mode leads the warming/cooling by about one year, signaling precursory conditions for ENSO. We show that the GAMIL one-month lead prediction of the seasonal precipitation anomalies is primarily able to capture major features of the two observed leading modes of the IAV, with the first mode better predicted than the second. It also depicts the relationship between the first mode and ENSO rather well. On the other hand, the GAMIL has deficiencies in capturing the relationship between the second mode and ENSO. We conclude: (1) successful reproduction of the E1 Nifio-excited monsoon-ocean interaction and E1 Nifio forcing may be critical for the seasonal prediction of the A-AM rainfall IAV with the GAMIL; (2) more efforts are needed to improve the simulation not only in the Nifio 3.4 region but also in the joining area of Asia and the Indian-Pacific Ocean; (3) the selection of a one-tier system may improve the ultimate prediction of the A-AM rainfall IAV. These results offer some references for improvement of the GAMIL and associated seasonal prediction skill.展开更多
Recent work has shown the dominance of the Himalaya in supporting the Indian summer monsoon (ISM), perhaps by surface sensible heating along its southern slope and by mechanical blocking acting to separate moist tro...Recent work has shown the dominance of the Himalaya in supporting the Indian summer monsoon (ISM), perhaps by surface sensible heating along its southern slope and by mechanical blocking acting to separate moist tropical flow from drier midlatitnde air. Previous studies have also shown that Indian snmmer rainfall is largely unaffected in sensitivity experiments that remove only the Tibetan Plateau. However, given the large biases in simulating the monsoon in CMIP5 models, such results may be model dependent. This study investigates the impact of orographic forcing from the Tibetan Plateau, Himalaya and Iranian Plateau on the ISM and East Asian snmmer monsoon (EASM) in the UK Met Office's HadGEM3-GA6 and China's Institute of Atmospheric Physics FGOALS-FAMIL global climate models. The models chosen featnre oppositesigned biases in their simulation of the ISM rainfall and circulation climatology. The changes to ISM and EASM circulation across the sensitivity experiments are similar in both models and consistent with previous studies. However, considerable differences exist in the rainfall responses over India and China, and in the detailed aspects such as onset and retreat dates. In particular, the models show opposing changes in Indian monsoon rainfall when the Himalaya and Tibetan Plateau orography are removed. Our results show that a multi-model approach, as suggested in the forthcoming Global Monsoon Model Intercomparison Project (GMMIP) associated with CMIP6, is needed to clarify the impact of orographic forcing on the Asian monsoon and to fully understand the implications of model systematic error.展开更多
Objective This study was to investigate the HIV current situation in Liangshan prefecture, in order to predict prevalence and transmission trends. Methods Region-specific population, behavior, serosurveillence, and po...Objective This study was to investigate the HIV current situation in Liangshan prefecture, in order to predict prevalence and transmission trends. Methods Region-specific population, behavior, serosurveillence, and policy/program data (from 1995 to 2020) were gathered from various local and national organizations and applied to the Asian Epidemic Model (AEM) and used to derive estimates of future HIV prevalence, epidemic trends, and outcomes of intervention strategies. Results The AEM projections for 2020 included increased number of people living with HIV (PLHIV; to 136 617), increased HIV prevalence (2.51%), and 8037 deaths from acquired immunodeficiency syndrome (AIDS) in this region. However, the overall HIV incidence rate (per 10 000) was projected to decline from 27 in 2015 to 22 in 2020, largely due to a predicted decrease in HIV infection rate (per 10 000) from 658 in 2013 to 621 in 2020 among intravenous drug users. In contrast, the cases of HIV infection per i0 000 was projected to increase from 420 in 2010 to 503 in 2020 among men who have sex with men, and from 8 in 2010 to 15 in 2020 among the general population. The predominant risk factor for HIV transmission over the next decade in Liangshan was casual sex. Community-based outreach strategies to reduce injected drug use and casual sex, and to promote condom use, were predicted as effective interventions to decrease HIV transmission. Conclusion Implementation of a comprehensive public health program, with targeting to the region-specific at-risk populations, will help to mitigate HIV/AIDS spread in Liangshan.展开更多
As the first leading mode of upper-tropospheric circulation in observations, the meridional displacement of the East Asian westerly jet (EAJ) varies closely with the East Asian rainfall in summer. In this study, the i...As the first leading mode of upper-tropospheric circulation in observations, the meridional displacement of the East Asian westerly jet (EAJ) varies closely with the East Asian rainfall in summer. In this study, the interannual variation of the EAJ meridional displacement and its relationship with the East Asian summer rainfall are evaluated, using the historical simulations of CMIP5 (phase 5 of the Coupled Model Intercomparison Project). The models can generally reproduce the meridional displacement of the EAJ, which is mainly manifested as the first principal mode in most of the simulations. For the relationship between the meridional displacement of the EAJ and East Asian rainfall, almost all the models depict a weaker correlation than observations and exhibit considerably large spread across the models. It is found that the discrepancy in the interannual relationship is closely related to the simulation of the climate mean state, including the climatological location of the westerly jet in Eurasia and rainfall bias in South Asia and the western North Pacific. In addition, a close relationship between the simulation discrepancy and intensity of EAJ variability is also found: the models with a stronger intensity of the EAJ meridional displacement tend to reproduce a closer interannual relationship, and vice versa.展开更多
A global atmospheric general circulation model has been used to perform eleven idealized numerical experiments, i.e., TP10, TP10, .., TP100, corresponding to different percentages of the Tibetan Plateau altitude. The ...A global atmospheric general circulation model has been used to perform eleven idealized numerical experiments, i.e., TP10, TP10, .., TP100, corresponding to different percentages of the Tibetan Plateau altitude. The aim is to explore the sensitivity of East Asian climate to the uplift and expansion of the Tibetan Plateau under the reconstructed boundary conditions for the mid-Pliocene about 3 Ma ago. When the plateau is progressively uplifted, global annual surface temperature is gradually declined and statistically significant cooling signals emerge only in the Northern Hemisphere, especially over and around the Tibetan Plateau, with larger magnitudes over land than over the oceans. On the contrary, annual surface temperature rises notably over Central Asia and most parts of Africa, as well as over northeasternmost Eurasia in the experiments TP60 to TP100. Meanwhile, the plateau uplift also leads to annual precipitation augmentation over the Tibetan Plateau but a reduction in northern Asia, the Indian Peninsula, much of Central Asia, parts of western Asia and the southern portions of northeastern Europe. Additionally, it is found that an East Asian summer monsoon system similar to that of the present initially exists in the TP60 and is gradually intensified with the continued plateau uplift. At 850 hPa the plateau uplift induces an anomalous cyclonic circulation around the Tibetan Plateau in summertime and two anomalous westerly currents respectively located to the south and north of the Tibetan Plateau in wintertime. In the mid-troposphere, similarto-modern spatial pattern of summertime western North Pacific subtropical high is only exhibited in the experiments TP60 to TP100, and the East Asian trough is steadily deepened in response to the progressive uplift and expansion of the Tibetan Plateau.展开更多
BACKGROUND Cellular senescence is a recognized barrier for progression of chronic liver diseases to hepatocellular carcinoma(HCC). The expression of a cluster of genes is altered in response to environmental factors d...BACKGROUND Cellular senescence is a recognized barrier for progression of chronic liver diseases to hepatocellular carcinoma(HCC). The expression of a cluster of genes is altered in response to environmental factors during senescence. However, it is questionable whether these genes could serve as biomarkers for HCC patients.AIM To develop a signature of senescence-associated genes(SAGs) that predicts patients' overall survival(OS) to improve prognosis prediction of HCC.METHODS SAGs were identified using two senescent cell models. Univariate COX regression analysis was performed to screen the candidate genes significantly associated with OS of HCC in a discovery cohort(GSE14520) for the least absolute shrinkage and selection operator modelling. Prognostic value of this seven-gene signature was evaluated using two independent cohorts retrieved from the GEO(GSE14520) and the Cancer Genome Atlas datasets, respectively.Time-dependent receiver operating characteristic(ROC) curve analysis was conducted to compare the predictive accuracy of the seven-SAG signature and serum α-fetoprotein(AFP).RESULTS A total of 42 SAGs were screened and seven of them, including KIF18 B, CEP55,CIT, MCM7, CDC45, EZH2, and MCM5, were used to construct a prognostic formula. All seven genes were significantly downregulated in senescent cells andupregulated in HCC tissues. Survival analysis indicated that our seven-SAG signature was strongly associated with OS, especially in Asian populations, both in discovery and validation cohorts. Moreover, time-dependent ROC curve analysis suggested the seven-gene signature had a better predictive accuracy than serum AFP in predicting HCC patients' 1-, 3-, and 5-year OS.CONCLUSION We developed a seven-SAG signature, which could predict OS of Asian HCC patients. This risk model provides new clinical evidence for the accurate diagnosis and targeted treatment of HCC.展开更多
The hydrologic changes and the impact of these changes constitute a fundamental global-warmingrelated concern. Faced with threats to human life and natural ecosystems, such as droughts, floods, and soil erosion, water...The hydrologic changes and the impact of these changes constitute a fundamental global-warmingrelated concern. Faced with threats to human life and natural ecosystems, such as droughts, floods, and soil erosion, water resource planners must increasingly make future risk assessments. Though hydrological predictions associated with the global climate change are already being performed, mainly through the use of GCMs, coarse spatial resolutions and uncertain physical processes limit the representation of terrestrial water/energy interactions and the variability in such systems as the Asian monsoon. Despite numerous studies, the regional responses of hydrologic changes resulting from climate change remains inconclusive. In this paper, an attempt at dynamical downsealing of future hydrologic projection under global climate change in Asia is addressed. The authors conducted present and future Asian regional climate simulations which were nested in the results of Atmospheric General Circulation Model (AGCM) experiments. The regional climate model could capture the general simulated features of the AGCM. Also, some regional phenomena such as orographic precipitation, which did not appear in the outcome of the AGCM simulation, were successfully produced. Under global warming, the increase of water vapor associated with the warmed air temperature was projected. It was projected to bring more abundant water vapor to the southern portions of India and the Bay of Bengal, and to enhance precipitation especially over the mountainous regions, the western part of India and the southern edge of the Tibetan Plateau. As a result of the changes in the synoptic flow patterns and precipitation under global warming, the increases of annual mean precipitation and surface runoff were projected in many regions of Asia. However, both the positive and negative changes of seasonal surface runoff were projected in some regions which will increase the flood risk and cause a mismatch between water demand and water availability in the agricultural season.展开更多
The East Asian summer monsoon (EASM) is a distinctive component of the Asian climate system and critically influences the economy and society of the region.To understand the ability of AGCMs in capturing the major f...The East Asian summer monsoon (EASM) is a distinctive component of the Asian climate system and critically influences the economy and society of the region.To understand the ability of AGCMs in capturing the major features of EASM,10 models that participated in Coupled Model Intercomparison Project/Atmospheric Model Intercomparison Project (CMIP5/AMIP),which used observational SST and sea ice to drive AGCMs during the period 1979-2008,were evaluated by comparing with observations and AMIP Ⅱ simulations.The results indicated that the multi-model ensemble (MME) of CMIP5/AMIP captures the main characteristics of precipitation and monsoon circulation,and shows the best skill in EASM simulation,better than the AMIP Ⅱ MME.As for the Meiyu/Changma/Baiyu rainbelt,the intensity of rainfall is underestimated in all the models.The biases are caused by a weak western Pacific subtropical high (WPSH) and accompanying eastward southwesterly winds in group Ⅰ models,and by a too strong and west-extended WPSH as well as westerly winds in group Ⅱ models.Considerable systematic errors exist in the simulated seasonal migration of rainfall,and the notable northward jumps and rainfall persistence remain a challenge for all the models.However,the CMIP5/AMIP MME is skillful in simulating the western North Pacific monsoon index (WNPMI).展开更多
By using a 9-level global atmospheric general circulation model developed at the Institute of Atmospheric Physics (IAP9L-AGCM) under the Chinese Academy of Sciences, the authors investigated the response of the East...By using a 9-level global atmospheric general circulation model developed at the Institute of Atmospheric Physics (IAP9L-AGCM) under the Chinese Academy of Sciences, the authors investigated the response of the East Asian monsoon climate to changes both in orbital forcing and the snow and glaciers over the Tibetan Plateau at the mid-Holocene, about 6000 calendar years before the present (6 kyr BP). With the Earth's orbital parameters appropriate for the mid-Holocene, the IAP9L-AGCM computed warmer and wetter conditions in boreal summer than for the present day. Under the precondition of continental snow and glacier cover existing over part of the Tibetan Plateau at the mid-Holocene, the authors examined the regional climate response to the Tibetan Plateau cooling. The simulations indicated that climate changes in South Asia and parts of central Asia as well as in East Asia are sensitive to the Tibetan Plateau cooling at the mid-Holocene, showing a significant decrease in precipitation in northern India, northern China and southern Mongolia and an increase in Southeast Asia during boreal summer. The latter seems to correspond to the weakening, southeastward shift of the Asian summer monsoon system resulting from reduced heat contrast between the Eurasian continent and the Pacific and Indian Oceans when a cooling over the Tibetan Plateau was imposed. The simulation results suggest that the snow and glacier environment over the Tibetan Plateau is an important factor for mid-Holocene climate change in the areas highly influenced by the Asian monsoon.展开更多
基金This research was jointly supported by the Chinese Academy of Sciences(CAS)under Grant No.KZCX3-SW-221by the National Natural Science Foundation of China under Grant No.40405015+1 种基金by the Chinese Ministry of Science and Technology under Grant No.2001BA611B(part 1)by the CAS“Hundred Talent Project"funding awarded to Gao Yongqi.
文摘Using observation and reanalysis data throughout 1961-1990, the East Asian surface air temperature, precipitation and sea level pressure climatology as simulated by seven fully coupled atmosphere-ocean models, namely CCSR/NIES, CGCM2, CSIRO-Mk2, ECHAM4/OPYC3, GFDL-R30, HadCM3, and NCAR-PCM, are systematically evaluated in this study. It is indicated that the above models can successfully reproduce the annual and seasonal surface air temperature and precipitation climatology in East Asia, with relatively good performance for boreal autumn and annual mean. The models' ability to simulate surface air temperature is more reliable than precipitation. In addition, the models can dependably capture the geographical distribution pattern of annual, boreal winter, spring and autumn sea level pressure in East Asia. In contrast, relatively large simulation errors are displayed when simulated boreal summer sea level pressure is compared with reanalysis data in East Asia. It is revealed that the simulation errors for surface air temperature, precipitation and sea level pressure are generally large over and around the Tibetan Plateau. No individual model is best in every aspect. As a whole, the ECHAM4/OPYC3 and HadCM3 performances are much better, whereas the CGCM2 is relatively poorer in East Asia. Additionally, the seven-model ensemble mean usually shows a relatively high reliability.
基金supported by the CAS project under Grant No. KZCX2-YW-Q11-01the Major State Basic Research Development Program of China under Grant No. 2006CB403607the National Natural Science Foundation of China (Grant Nos.40523001, 40821092, 40875034)
文摘This study examines cloud radiative forcing (CRF) in the Asian monsoon region (0° 50°N, 60° 150°E) simulated by Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report (AR4) AMIP models. During boreal winter, no model realistically reproduces the larger long-wave cloud radiative forcing (LWCF) over the Tibet Plateau (TP) and only a couple of models reasonably capture the larger short-wave CRF (SWCF) to the east of the TP. During boreal summer, there are larger biases for central location and intensity of simulated CRF in active convective regions. The CRF biases are closely related to the rainfall biases in the models. Quantitative analysis further indicates that the correlation between simulated CRF and observations are not high, and that the biases and diversity in SWCF are larger than that in LWCF. The annual cycle of simulated CRF over East Asia (0°-50°N, 100°-145°E) is also examined. Though many models capture the basic annual cycle in tropics, strong LWCF and SWCF to the east of the TP beginning in early spring are underestimated by most models. As a whole, GFDL-CM2.1, MPI-ECHAM5, UKMO-HadGAM1, and MIROC3.2 (medres) perform well for CRF simulation in the Asian monsoon region, and the multi-model ensemble (MME) has improved results over the individual simulations. It is suggested that strengthening the physical parameterizations involved over the TP, and improving cumulus convection processes and model experiment design are crucial to CRF simulation in the Asian monsoon region.
文摘Based on a 200 year simulation and reanalysis data (1980–1996), the general characteristics of East Asian monsoon (EAM) were analyzed in the first part of the paper. It is clear from this re-search that the South Asian monsoon (SAM) defined by Webster and Yang (1992) is geographically and dynamically different from the East Asian monsoon (EAM). The region of the monsoon defined by Webster and Yang (1992) is located in the tropical region of Asia (40–110°E, 10–20°N), including the Indian monsoon and the Southeast Asian monsoon, while the EAM de-fined in this paper is located in the subtropical region of East Asia (110–125°E, 20–40°N). The components and the seasonal variations of the SAM and EAM are different and they characterize the tropical and subtropical Asian monsoon systems respectively. A suitable index (EAMI) for East Asian monsoon was then defined to describe the strength of EAM in this paper. In the second part of the paper, the interannual variability of EAM and its relationship with sea surface temperature (SST) in the 200 year simulation were studied by using the composite method, wavelet transformation, and the moving correlation coefficient method. The summer EAMI is negatively correlated with ENSO (El Nino and Southern Oscillation) cycle represented by the NINO3 sea surface temperature anomaly (SSTA) in the preceding April and January, while the winter EAM is closely correlated with the succeeding spring SST over the Pacific in the coupled model. The general differences of EAM between El Nino and La Nina cases were studied in the model through composite analysis. It was also revealed that the dominating time scales of EAM variability may change in the long-term variation and the strength may also change. The anoma-lous winter EAM may have some correlation with the succeeding summer EAM, but this relation-ship may disappear sometimes in the long-term climate variation. Such time-dependence was found in the relationship between EAM and SST in the long-term climate simulation as well. Key words East Asian monsoon - Interannual variability - Coupled climate model The author wishes to thank Profs. Wu G.X., Zhang X.H., and Dr. Yu Y.Q. for providing the coupled model re-sults. Dr. Yu also kindly provided assistance in using the model output. This work was supported jointly by the Na-tional Natural Science Foundation of China key project ’ The analysis on the seasonal-to-interannual variation of the general circulation’ under contract 49735160 and Chinese Academy of Sciences key project ’ The Interannual Va-riability and Predictability of East Asian Monsoon’.
文摘In this paper, the global and regional features of the seasonal variation of general circulation, and especially the Asian monsoon simulated by the Institute of Atmospheric Physics Two-level AGCM coupled with a sophisticated land-surface model (IAP94-GCM) are presented and compared with the observation. The comparison is made by using the equilibrium multiyear seasonal cycle climate from a 100-year integration. In the integration sea surface temperature (SST) and sea ice are taken from the observed climatological data (with seasonal variation) because our purpose is to see the improvement of simulation due to the coupling with an advanced land surface model. Overall, the IAP94-GCM provides a reasonably realistic simulation of the interseasonal and intraseasonal climatology of the Asian monsoon and yields an important information that sheds light on the thermal underpinning and the thermodynamics of the seasonal and even multiscale variabilities associated with the Asian summer monsoon.
基金the National Natural Science Foundation of China,the National Basic Research Program of China (973 Program)
文摘The performance of a regional air-sea coupled model, comprising the Regional Integrated Environment Model System (RIEMS) and the Princeton Ocean Model (POM), in simulating the seasonal and intraseasonal variations of East Asian summer monsoon (EASM) rainfall was investigated. Through comparisons of the model results among the coupled model, the uncoupled RIEMS, and observations, the impact of air-sea coupling on simulating the EASM was also evaluated. Results showed that the regional air sea coupled climate model performed better in simulating the spatial pattern of the precipitation climatology and produced more realistic variations of the EASM rainfall in terms of its amplitude and principal EOF modes. The coupled model also showed greater skill than the uncoupled RIEMS in reproducing the principal features of climatological intraseasonal oscillation (CISO) of EASM rainfall, including its dominant period, intensity, and northward propagation. Further analysis indicated that the improvements in the simulation of the EASM rainfall climatology and its seasonal variation in the coupled model were due to better simulation of the western North Pacific Subtropical High, while the improvements of CISO simulation were owing to the realistic phase relationship between the intraseasonal convection and the underlying SST resulting from the air-sea coupling.
基金supported by the National Natural Science Foundation of China(Grant Nos.41375086,41320104007 and 41305067)
文摘The interannual variation of the East Asian upper-tropospheric westerly jet (EAJ) significantly affects East Asian climate in summer. Identifying its performance in model prediction may provide us another viewpoint, from the perspective of uppertropospheric circulation, to understand the predictability of summer climate anomalies in East Asia. This study presents a comprehensive assessment of year-to-year variability of the EAJ based on retrospective seasonal forecasts, initiated from 1 May, in the five state-of-the-art coupled models from ENSEMBLES during 1960-2005. It is found that the coupled models show certain capability in describing the interannual meridional displacement of the EAJ, which reflects the models' performance in the first leading empirical orthogonal function (EOF) mode. This capability is mainly shown over the region south of the EAJ axis. Additionally, the models generally capture well the main features of atmospheric circulation and SST anomalies related to the interannual meridional displacement of the EAJ. Further analysis suggests that the predicted warm SST anomalies in the concurrent summer over the tropical eastern Pacific and northern Indian Ocean are the two main sources of the potential prediction skill of the southward shift of the EAJ. In contrast, the models are powerless in describing the variation over the region north of the EAJ axis, associated with the meridional displacement, and interannual intensity change of the EAJ, the second leading EOF mode, meaning it still remains a challenge to better predict the EAJ and, subsequently, summer climate in East Asia, using current coupled models.
基金supported by the National Science Foundation of China (No.40976063)International Cooperative Projects of MOST (No.2010DFA91350)
文摘A WRF-Chem model including a comprehensive gas-phase nitrogen chemistry module was used to simulate a severe dust event appearing in the eastern China on 19-25 March, 2002. The modeling result well reproduced PM10 concentrations in various distances from the dust sources and the transport pathway of the dust strom. The results showed that both the concentrations and the dry deposition fluxes of PM10 increased over the China seas during the dust event following the passage of a cold front system. The maximum fluxes of PM10 in the Yellow Sea and the East China Sea during the dust event were 5.5 and 8.4 times of those before the event, respectively. However, the temporal variations of the dry deposition fluxes of particulate inorganic nitrogen differed over the Yellow Sea from those over the East China Sea. Nitrate and ammonium in the whole northern China rapidly decreased because of the intrusion of dust-loaded air on 19 March. The dust plume arrived in the Yellow Sea on 20 March, decreasing the particulate inorganic nitrogen in mass concentration accordingly. The minimum dry deposition fluxes of nitrate and ammonium in the Yellow Sea were about 3/5 and 1/6 of those before the dust arrival, respectively. In contrast, when the dust plume crossed over the Yangtze Delta area, it became abundant in nitrate and ammonium and increased the concentrations and dry deposition fluxes of particulate inorganic nitrogen over the East China Sea, where the maximum dry deposition fluxes of nitrate and ammonium increased approximately by 4.1 and 2.6 times of those prior to the dust arrival.
基金jointly supported by the National Natural Science Foundation of China (Grant Nos. 41330423, 41205080, and 41023002)the Carbon Budget and Related Issues project of the Chinese Academy of Sciences (Grant No. XDA05110301)the Joint Center for Global Change Studies (Project No. 105019), Beijing, China
文摘The reproducibility and future changes of the onset of the Asian summer monsoon were analyzed based on the simulations and projections under the Representative Concentration Pathways (RCP) scenario in which anthropogenic emissions continue to rise throughout the 21 st century (i.e. RCP8.5) by all realizations from four Chinese models that participated in the Coupled Model Intercomparison Project Phase 5 (CMIP5). Delayed onset of the monsoon over the Arabian Sea was evident in all simulations for present-day climate, which was associated with a too weak simulation of the low-level Somali jet in May. A consistent advanced onset of the monsoon was found only over the Arabian Sea in the projections, where the advanced onset of the monsoon was accompanied by an increase of rainfall and an anomalous anticyclone over the northern Indian Ocean. In all the models except FGOALS-g2, the enhanced low-level Somali jet transported more water vapor to the Arabian Sea, whereas in FGOALS-g2 the enhanced rainfall was determined more by the increased wind convergence. Furthermore, and again in all models except FGOALS-g2, the equatorial SST warming, with maximum increase over the eastern Pacific, enhanced convection in the central West Pacific and reduced convection over the eastern Indian Ocean and Maritime Continent region, which drove the anomalous anticyclonic circulation over the western Indian Ocean. In contrast, in FGOALS-g2, there was minimal (near-zero) warming of projected SST in the central equatorial Pacific, with decreased convection in the central West Pacific and enhanced convection over the Maritime Continent. The broader-scale differences among the models across the Pacific were related to both the differences in the projected SST pattern and in the present-day simulations.
基金supported by the National Basic Research Program of China (Grant Nos.2012CB955604 and 2014CB953903)the National Natural Sciences Foundation of China (Grant No.41375112)
文摘This study introduces a new global climate model--the Integrated Climate Model (ICM)--developed for the seasonal prediction of East Asian-western North Pacific (EA-WNP) climate by the Center for Monsoon System Research at the Institute of Atmospheric Physics (CMSR, IAP), Chinese Academy of Sciences. ICM integrates ECHAM5 and NEMO2.3 as its atmospheric and oceanic components, respectively, using OASIS3 as the coupler. The simulation skill of ICM is evaluated here, including the simulated climatology, interannual variation, and the influence of E1 Nifio as one of the most important factors on EA-WNP climate. ICM successfully reproduces the distribution of sea surface temperature (SST) and precipitation without climate shift, the seasonal cycle of equatorial Pacific SST, and the precipitation and circulation of East Asian summer monsoon. The most prominent biases of ICM are the excessive cold tongue and unrealistic westward phase propagation of equatorial Pacific SST. The main interannual variation of the tropical Pacific SST and EA-WNP climate E1 Nifio and the East Asia-Pacific Pattern--are also well simulated in ICM, with realistic spatial pattern and period. The simulated E1 Nifio has significant impact on EA-WNP climate, as in other models. The assessment shows ICM should be a reliable model for the seasonal prediction of EA-WNP climate.
基金granted by the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDA20070103)the National Natural Science Foundation of China(Grant Nos.41775088 and 41625018).
文摘Asian aridity can be traced back to the early Cenozoic(e.g.,Guo et al.,2008;Licht et al.,2016;Li et al.,2018a).Previous modelling studies focus mainly on the monsoon climate during the early Cenozoic,and studies for the Asian aridity are still limited(e.g.,Huber and Goldner,2012;Zhang et al.,2012;Li et al.,2018b).Here Asian aridity during the early Cenozoic is investigated through climate modelling by changing atmospheric CO2 concentration,orbital parameters,and topography.
基金the support of the National Natural Science Foundation of China(Grant Nos.40523001 and 40605022)the Chinese Acadiemy of the International Partnership Creative Group entitled"Climate System Model Development and Application Studies".
文摘Seasonal prediction of Asian-Australian monsoon (A-AM) precipitation is one of the most important and challenging tasks in climate prediction. In this paper, we evaluate the performance of Grid Atmospheric Model of IAP LASG (GAMIL) on retrospective prediction of the A-AM interannual variation (IAV), and determine to what extent GAMIL can capture the two major observed modes of A-AM rainfall IAV for the period 1979-2003. The first mode is associated with the turnabout of warming (cooling) in the Nifio 3.4 region, whereas the second mode leads the warming/cooling by about one year, signaling precursory conditions for ENSO. We show that the GAMIL one-month lead prediction of the seasonal precipitation anomalies is primarily able to capture major features of the two observed leading modes of the IAV, with the first mode better predicted than the second. It also depicts the relationship between the first mode and ENSO rather well. On the other hand, the GAMIL has deficiencies in capturing the relationship between the second mode and ENSO. We conclude: (1) successful reproduction of the E1 Nifio-excited monsoon-ocean interaction and E1 Nifio forcing may be critical for the seasonal prediction of the A-AM rainfall IAV with the GAMIL; (2) more efforts are needed to improve the simulation not only in the Nifio 3.4 region but also in the joining area of Asia and the Indian-Pacific Ocean; (3) the selection of a one-tier system may improve the ultimate prediction of the A-AM rainfall IAV. These results offer some references for improvement of the GAMIL and associated seasonal prediction skill.
基金supported jointly by the UK-China Research and Innovation Partnership Fund through the Met Office Climate Science for Service Partnership(CSSP) Chinathe Major Research Plan of the National Natural Science Foundation of China(Grant Nos.91637312 and 91437219)
文摘Recent work has shown the dominance of the Himalaya in supporting the Indian summer monsoon (ISM), perhaps by surface sensible heating along its southern slope and by mechanical blocking acting to separate moist tropical flow from drier midlatitnde air. Previous studies have also shown that Indian snmmer rainfall is largely unaffected in sensitivity experiments that remove only the Tibetan Plateau. However, given the large biases in simulating the monsoon in CMIP5 models, such results may be model dependent. This study investigates the impact of orographic forcing from the Tibetan Plateau, Himalaya and Iranian Plateau on the ISM and East Asian snmmer monsoon (EASM) in the UK Met Office's HadGEM3-GA6 and China's Institute of Atmospheric Physics FGOALS-FAMIL global climate models. The models chosen featnre oppositesigned biases in their simulation of the ISM rainfall and circulation climatology. The changes to ISM and EASM circulation across the sensitivity experiments are similar in both models and consistent with previous studies. However, considerable differences exist in the rainfall responses over India and China, and in the detailed aspects such as onset and retreat dates. In particular, the models show opposing changes in Indian monsoon rainfall when the Himalaya and Tibetan Plateau orography are removed. Our results show that a multi-model approach, as suggested in the forthcoming Global Monsoon Model Intercomparison Project (GMMIP) associated with CMIP6, is needed to clarify the impact of orographic forcing on the Asian monsoon and to fully understand the implications of model systematic error.
基金funded by China-MSD HIV/AIDS Partnership Project(2012-83)Comprehensive Assessment for HIV/AIDS Control and Prevention in Sichuan Province Project(2006-2010)
文摘Objective This study was to investigate the HIV current situation in Liangshan prefecture, in order to predict prevalence and transmission trends. Methods Region-specific population, behavior, serosurveillence, and policy/program data (from 1995 to 2020) were gathered from various local and national organizations and applied to the Asian Epidemic Model (AEM) and used to derive estimates of future HIV prevalence, epidemic trends, and outcomes of intervention strategies. Results The AEM projections for 2020 included increased number of people living with HIV (PLHIV; to 136 617), increased HIV prevalence (2.51%), and 8037 deaths from acquired immunodeficiency syndrome (AIDS) in this region. However, the overall HIV incidence rate (per 10 000) was projected to decline from 27 in 2015 to 22 in 2020, largely due to a predicted decrease in HIV infection rate (per 10 000) from 658 in 2013 to 621 in 2020 among intravenous drug users. In contrast, the cases of HIV infection per i0 000 was projected to increase from 420 in 2010 to 503 in 2020 among men who have sex with men, and from 8 in 2010 to 15 in 2020 among the general population. The predominant risk factor for HIV transmission over the next decade in Liangshan was casual sex. Community-based outreach strategies to reduce injected drug use and casual sex, and to promote condom use, were predicted as effective interventions to decrease HIV transmission. Conclusion Implementation of a comprehensive public health program, with targeting to the region-specific at-risk populations, will help to mitigate HIV/AIDS spread in Liangshan.
基金supported by the National Key Research and Development Program of China (Grant No. 2018YFA0606501)the National Natural Science Foundation of China (Grant Nos. 41721004, U1502233 and 41775083)
文摘As the first leading mode of upper-tropospheric circulation in observations, the meridional displacement of the East Asian westerly jet (EAJ) varies closely with the East Asian rainfall in summer. In this study, the interannual variation of the EAJ meridional displacement and its relationship with the East Asian summer rainfall are evaluated, using the historical simulations of CMIP5 (phase 5 of the Coupled Model Intercomparison Project). The models can generally reproduce the meridional displacement of the EAJ, which is mainly manifested as the first principal mode in most of the simulations. For the relationship between the meridional displacement of the EAJ and East Asian rainfall, almost all the models depict a weaker correlation than observations and exhibit considerably large spread across the models. It is found that the discrepancy in the interannual relationship is closely related to the simulation of the climate mean state, including the climatological location of the westerly jet in Eurasia and rainfall bias in South Asia and the western North Pacific. In addition, a close relationship between the simulation discrepancy and intensity of EAJ variability is also found: the models with a stronger intensity of the EAJ meridional displacement tend to reproduce a closer interannual relationship, and vice versa.
基金the Chinese Academy of Sciences under Grant Nos. KZCX2-YW-205 and KZCX3-SW-229the National NaturalScience Foundation of China under Grant Nos. 40505017and 40775052.
文摘A global atmospheric general circulation model has been used to perform eleven idealized numerical experiments, i.e., TP10, TP10, .., TP100, corresponding to different percentages of the Tibetan Plateau altitude. The aim is to explore the sensitivity of East Asian climate to the uplift and expansion of the Tibetan Plateau under the reconstructed boundary conditions for the mid-Pliocene about 3 Ma ago. When the plateau is progressively uplifted, global annual surface temperature is gradually declined and statistically significant cooling signals emerge only in the Northern Hemisphere, especially over and around the Tibetan Plateau, with larger magnitudes over land than over the oceans. On the contrary, annual surface temperature rises notably over Central Asia and most parts of Africa, as well as over northeasternmost Eurasia in the experiments TP60 to TP100. Meanwhile, the plateau uplift also leads to annual precipitation augmentation over the Tibetan Plateau but a reduction in northern Asia, the Indian Peninsula, much of Central Asia, parts of western Asia and the southern portions of northeastern Europe. Additionally, it is found that an East Asian summer monsoon system similar to that of the present initially exists in the TP60 and is gradually intensified with the continued plateau uplift. At 850 hPa the plateau uplift induces an anomalous cyclonic circulation around the Tibetan Plateau in summertime and two anomalous westerly currents respectively located to the south and north of the Tibetan Plateau in wintertime. In the mid-troposphere, similarto-modern spatial pattern of summertime western North Pacific subtropical high is only exhibited in the experiments TP60 to TP100, and the East Asian trough is steadily deepened in response to the progressive uplift and expansion of the Tibetan Plateau.
基金Supported by the National Natural Science Foundation of China,No.81773128 and No.81871998the Natural Science Basic Research Plan in Shaanxi Province of China,No.2018JM7013 and No.2017JM8039+1 种基金the Research Fund for Young Star of Science and Technology in Shaanxi Province,No.2018KJXX-022China Postdoctoral Science Foundation,No.2018M641000
文摘BACKGROUND Cellular senescence is a recognized barrier for progression of chronic liver diseases to hepatocellular carcinoma(HCC). The expression of a cluster of genes is altered in response to environmental factors during senescence. However, it is questionable whether these genes could serve as biomarkers for HCC patients.AIM To develop a signature of senescence-associated genes(SAGs) that predicts patients' overall survival(OS) to improve prognosis prediction of HCC.METHODS SAGs were identified using two senescent cell models. Univariate COX regression analysis was performed to screen the candidate genes significantly associated with OS of HCC in a discovery cohort(GSE14520) for the least absolute shrinkage and selection operator modelling. Prognostic value of this seven-gene signature was evaluated using two independent cohorts retrieved from the GEO(GSE14520) and the Cancer Genome Atlas datasets, respectively.Time-dependent receiver operating characteristic(ROC) curve analysis was conducted to compare the predictive accuracy of the seven-SAG signature and serum α-fetoprotein(AFP).RESULTS A total of 42 SAGs were screened and seven of them, including KIF18 B, CEP55,CIT, MCM7, CDC45, EZH2, and MCM5, were used to construct a prognostic formula. All seven genes were significantly downregulated in senescent cells andupregulated in HCC tissues. Survival analysis indicated that our seven-SAG signature was strongly associated with OS, especially in Asian populations, both in discovery and validation cohorts. Moreover, time-dependent ROC curve analysis suggested the seven-gene signature had a better predictive accuracy than serum AFP in predicting HCC patients' 1-, 3-, and 5-year OS.CONCLUSION We developed a seven-SAG signature, which could predict OS of Asian HCC patients. This risk model provides new clinical evidence for the accurate diagnosis and targeted treatment of HCC.
基金the Global Environment Research Fund of Japan's Ministry of the En- vironment (S-5-3)The data used in this study were acquired as part of the Tropical Rainfall Measuring Mission (TRMM)+1 种基金The algorithms were developed by the TRMM Science TeamThe data were processed by the TRMM Science Data and Information System (TSDIS) and the TRMM Offce.
文摘The hydrologic changes and the impact of these changes constitute a fundamental global-warmingrelated concern. Faced with threats to human life and natural ecosystems, such as droughts, floods, and soil erosion, water resource planners must increasingly make future risk assessments. Though hydrological predictions associated with the global climate change are already being performed, mainly through the use of GCMs, coarse spatial resolutions and uncertain physical processes limit the representation of terrestrial water/energy interactions and the variability in such systems as the Asian monsoon. Despite numerous studies, the regional responses of hydrologic changes resulting from climate change remains inconclusive. In this paper, an attempt at dynamical downsealing of future hydrologic projection under global climate change in Asia is addressed. The authors conducted present and future Asian regional climate simulations which were nested in the results of Atmospheric General Circulation Model (AGCM) experiments. The regional climate model could capture the general simulated features of the AGCM. Also, some regional phenomena such as orographic precipitation, which did not appear in the outcome of the AGCM simulation, were successfully produced. Under global warming, the increase of water vapor associated with the warmed air temperature was projected. It was projected to bring more abundant water vapor to the southern portions of India and the Bay of Bengal, and to enhance precipitation especially over the mountainous regions, the western part of India and the southern edge of the Tibetan Plateau. As a result of the changes in the synoptic flow patterns and precipitation under global warming, the increases of annual mean precipitation and surface runoff were projected in many regions of Asia. However, both the positive and negative changes of seasonal surface runoff were projected in some regions which will increase the flood risk and cause a mismatch between water demand and water availability in the agricultural season.
基金supported by the National High Technology Research and Development Program of China (Grant No. 2010AA012305)the General Project of the National Natural Science Foundation of China (Grant No. 41275108)+1 种基金the National Basic Research Program of China (Grant No. 2010CB950504)the Fundamental Research Funds for the Central Universities (Grant No. 2012YBXS27)
文摘The East Asian summer monsoon (EASM) is a distinctive component of the Asian climate system and critically influences the economy and society of the region.To understand the ability of AGCMs in capturing the major features of EASM,10 models that participated in Coupled Model Intercomparison Project/Atmospheric Model Intercomparison Project (CMIP5/AMIP),which used observational SST and sea ice to drive AGCMs during the period 1979-2008,were evaluated by comparing with observations and AMIP Ⅱ simulations.The results indicated that the multi-model ensemble (MME) of CMIP5/AMIP captures the main characteristics of precipitation and monsoon circulation,and shows the best skill in EASM simulation,better than the AMIP Ⅱ MME.As for the Meiyu/Changma/Baiyu rainbelt,the intensity of rainfall is underestimated in all the models.The biases are caused by a weak western Pacific subtropical high (WPSH) and accompanying eastward southwesterly winds in group Ⅰ models,and by a too strong and west-extended WPSH as well as westerly winds in group Ⅱ models.Considerable systematic errors exist in the simulated seasonal migration of rainfall,and the notable northward jumps and rainfall persistence remain a challenge for all the models.However,the CMIP5/AMIP MME is skillful in simulating the western North Pacific monsoon index (WNPMI).
基金This research was supported by the Na- tional Natural Science Foundation of China (NSFC) (Grant No. 40571169) the NSFC Innovation Team Project (Grant No. 40421101).
文摘By using a 9-level global atmospheric general circulation model developed at the Institute of Atmospheric Physics (IAP9L-AGCM) under the Chinese Academy of Sciences, the authors investigated the response of the East Asian monsoon climate to changes both in orbital forcing and the snow and glaciers over the Tibetan Plateau at the mid-Holocene, about 6000 calendar years before the present (6 kyr BP). With the Earth's orbital parameters appropriate for the mid-Holocene, the IAP9L-AGCM computed warmer and wetter conditions in boreal summer than for the present day. Under the precondition of continental snow and glacier cover existing over part of the Tibetan Plateau at the mid-Holocene, the authors examined the regional climate response to the Tibetan Plateau cooling. The simulations indicated that climate changes in South Asia and parts of central Asia as well as in East Asia are sensitive to the Tibetan Plateau cooling at the mid-Holocene, showing a significant decrease in precipitation in northern India, northern China and southern Mongolia and an increase in Southeast Asia during boreal summer. The latter seems to correspond to the weakening, southeastward shift of the Asian summer monsoon system resulting from reduced heat contrast between the Eurasian continent and the Pacific and Indian Oceans when a cooling over the Tibetan Plateau was imposed. The simulation results suggest that the snow and glacier environment over the Tibetan Plateau is an important factor for mid-Holocene climate change in the areas highly influenced by the Asian monsoon.