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The Impact of Seasonal Variation on Clinical Pregnancy and Live Birth Rates in Assisted Reproductive Technology: A Retrospective Cohort Study in Hainan
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作者 Jingjing Zhong Zhiyong Lu +10 位作者 Ning Ma Zhi Zhou Hui Lu Yejuan Li Jiajia Hu Bangbei Wan Jin Huang Anguo Wang Hailing Ruan Liqiang Zhaol Weiying Lu 《Journal of Clinical and Nursing Research》 2024年第8期243-250,共8页
Objective:To investigate the influence of season on live birth and clinical pregnancy rates,as well as assisted reproductive technology(ART)outcomes,in the Hainan region.Methods:Patients were categorized into four gro... Objective:To investigate the influence of season on live birth and clinical pregnancy rates,as well as assisted reproductive technology(ART)outcomes,in the Hainan region.Methods:Patients were categorized into four groups based on the dates of artificial insemination and transplantation:spring,summer,autumn,or winter.The main outcome measures were clinical pregnancy rates and live birth rates.Secondary outcomes included body mass index(BMI),oocyte number,two pronuclei(2PN)cleavage rate,total gonadotropin(Gn)dosage and days,age,2PN fertilization rate,sperm concentration,sperm PR rate,anti-Müllerian hormone(AMH),and endometrial thickness.Outpatient semen quality indicators included sperm PR rate,total sperm count,sperm concentration,and total sperm motility.Results:This retrospective cohort study analyzed 2,016 artificial insemination cycles and 1,783 ovarian retrieval cycles from January 2017 to October 2022,and assessed the semen quality of 6,651 outpatients from May 2017 to October 2022.In artificial insemination cycles,sperm PR rate and clinical pregnancy rate were highest in winter,with a statistically significant difference between groups(P<0.05).Clinical pregnancy rate was influenced by both age and sperm PR rate(P<0.05).In ovarian retrieval cycles,the winter group had significantly higher clinical pregnancy,2PN fertilization,and 2PN cleavage rates than the other groups.The autumn group had higher live birth rates,though not significantly different.Additionally,winter months showed higher total sperm concentration and total sperm number compared to other seasons.Conclusion:Seasonality affected clinical pregnancy and live birth rates in artificial insemination cycles but not in ovarian retrieval cycles in the Hainan region.These findings suggest that while there is no need to choose a specific season for ovarian retrieval cycles,artificial insemination in winter may be preferable for patients. 展开更多
关键词 ENDOCRINOLOGY assisted reproductive technology SEASONALITY Pregnancy rate Artificial insemination
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Benign ovarian cysts in reproductive-age women undergoing assisted reproductive technology treatment 被引量:2
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作者 Guy Rofe Ron Auslender Martha Dirnfeld 《Open Journal of Obstetrics and Gynecology》 2013年第7期17-22,共6页
The scope of this review is to focus on the management of benign ovarian cyst in the reproductive-age group of women undergoing ART. Ovarian cysts are a common occurrence in this patient population. The differential d... The scope of this review is to focus on the management of benign ovarian cyst in the reproductive-age group of women undergoing ART. Ovarian cysts are a common occurrence in this patient population. The differential diagnosis includes functional cysts, dermoid cysts, endometrioma. The appropriate evaluation includes medical history and physical examination, laboratory tests and imaging. The treatment options include conservative follow-up, medical treatment and surgery. This review will explore the differential diagnosis, appropriate work-up and treatment options to the various cyst types encountered. 展开更多
关键词 OVARIAN CYST assisted reproductive technology reproductive Age
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Assisted Reproductive Technology for HIV-1 Serodiscordant Couples: A Review of Current Controversies 被引量:1
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作者 Gary S.Nakhuda Mark V.Sauer 《Journal of Reproduction and Contraception》 CAS 2007年第1期41-48,共8页
Since 1992, assisted reproductive technology (ART) has been reported as a viable means of helping HIV-1 serodiscordant couples achieve pregnancy while theoretically reducing the risk for viral transmission. While th... Since 1992, assisted reproductive technology (ART) has been reported as a viable means of helping HIV-1 serodiscordant couples achieve pregnancy while theoretically reducing the risk for viral transmission. While the sum of the evidence suggests that ART is effective and safe, numerous controversies still exist, The follow- ing review addresses several of the important issues involved in the use of ART for HIV-serodiscordant couples, including patient selection, semen processing techniques, post-process HIV testing, the use of lUI vs IVF-ICSI. 展开更多
关键词 HIV serodiscordant assisted reproductive technology (ART) IVF ICSI
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Live birth rates of assisted reproductive technology treatment and spontaneous conception among subfertile couples in Singapore: A follow-up study
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作者 Ho Lee Mee de Souza Nurun Nisa +1 位作者 Lee Shaw Ni Yu Su Ling 《Asian pacific Journal of Reproduction》 2018年第5期206-213,共8页
Objective: To explore the potential predictors of a live birth (LB) outcome among subfertile couples of Asian ethnicity undergoing the first fertility treatment cycle;to assess the cumulative live birth rates after su... Objective: To explore the potential predictors of a live birth (LB) outcome among subfertile couples of Asian ethnicity undergoing the first fertility treatment cycle;to assess the cumulative live birth rates after successive cycles;and to determine the incidence rate of spontaneous conception (SC).Methods:Subfertile couples were grouped according to treatment modalities at the first fertility treatment cycle: intrauterine insemination (IUI),in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI) and no treatment, and were followed-up for duration up to seven years. Multivariable logistic regression analysis was used for statistical analyses. Results: Age of female subjects [35-38 years, odds ratio (OR): 0.39;≥39 years, OR: 0.14], uterine factor subfertility (OR: 5.24), and treatment modalities (ORs: IUI 0.25, IVF 2.33 and ICSI 1.91) significantly predicted a LB outcome (P<0.05). The cumulative live birth rates were 11.7% IUI, 41.5% IVF, 27.5% ICSI and 22.6% from frozen embryo transfer cycles. The cumulative SC rate was 24.6% in the non-treated group and 10.7% in the treated group. All LBs from IVF cycles were delivered by the second cycle and within four years, compared to SC delivery of within five years in the non-treated group and six years in the treated group. Conclusions:Age of female subject, uterine factor and modalities of treatment are significant predictors for LB outcome at the first cycle. Higher delivery rates could be achieved following fewer successive IVF cycles and within a shorter duration compared to SC. 展开更多
关键词 assisted reproductive technology SEMEN parameters SPERM hyaluronan-binding assay SPONTANEOUS CONCEPTION Subfertile Asian couples
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Embryo quality and chromosomal abnormality in embryos from couples undergoing assisted reproductive technology using preimplantation genetic screening
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作者 Mina Niusha Seyed Ali Rahmani +3 位作者 Leila Kohan Ladan Sadeghi Mohammad Nouri Hamid Reza Nejabati 《Asian pacific Journal of Reproduction》 2023年第1期16-22,共7页
Objective:To detect common chromosomal aneuploidy variations in embryos from couples undergoing assisted reproductive technology and preimplantation genetic screening and their possible associations with embryo qualit... Objective:To detect common chromosomal aneuploidy variations in embryos from couples undergoing assisted reproductive technology and preimplantation genetic screening and their possible associations with embryo quality.Methods:In this study,359 embryos from 62 couples were screened for chromosomes 13,21,18,X,and Y by fluorescence insitu hybridization.For biopsy of blastomere,a laser was used to remove a significantly smaller portion of the zona pellucida.One blastomere was gently biopsied by an aspiration pipette through the hole.After biopsy,the embryo was immediately returned to the embryo scope until transfer.Embryo integrity and blastocyst formation were assessed on day 5.Results:Totally,282 embryos from 62 couples were evaluated.The chromosomes were normal in 199(70.57%)embryos and abnormal in 83(29.43%)embryos.There was no significant association between the quality of embryos and numerical chromosomal abnormality(P=0.67).Conclusions:Embryo quality is not significantly correlated with its genetic status.Hence,the quality of embryos determined by morphological parameters is not an appropriate method for choosing embryos without these abnormalities. 展开更多
关键词 assisted reproductive technology Preimplantation genetic screening ANEUPLOIDY Fluorescence insitu hybridization Chromosomal abnormalities Embryo quality BLASTOMERE BLASTOCYST
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Awareness and perception of assisted reproductive technology practice amongst women with infertility in Northern Nigeria
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作者 Adebiyi Gbadebo Adesiyun Nkeiruka Ameh +1 位作者 Solomon Avidime Abdulsalam Muazu 《Open Journal of Obstetrics and Gynecology》 2011年第3期144-148,共5页
Background: Involuntary infertility is a tragedy in most African setting. This is due to premium placed on fertility as a result of roles children fulfill in the family and the society. Aetiologic factors of infertili... Background: Involuntary infertility is a tragedy in most African setting. This is due to premium placed on fertility as a result of roles children fulfill in the family and the society. Aetiologic factors of infertility in sub-Saharan Africa are mostly infection related and they are mainly associated with poor treatment outcome to conventional non assisted conception technique. Objective: To evaluate the level of awareness and perception of assisted conception treatment among women attending fertility clinic. Methods: A descriptive cross-sectional study. Results: One hundred and ninety six women attending fertility clinic were interviewed. Mean age was 34.8year and mean duration of infertility of 4.1 years. Of the 196 infertile women interviewed, 150 (76.5%) have heard of Assisted Reproductive Technology treatment. Sources of information were mainly family relation (46%) and friends (28.7%). Knowledge on some of Assisted Reproductive Technology practices showed that 50.7% were aware that the treatment could fail, 36.8% knew it could be applied for male infertility treatment, 9.3% and 18.7% respectively are aware that donor oocyte and sperm could be used for treatment. Perception on babies conceived from assisted conception treatment revealed that 52% of patients interviewed could not comment if they are normal and natural babies. Majority of patients could not affirm if they will agree to the use of donor gamete or zygote for their treatment. Conclusion: Awareness of assisted conception treatment was high, however knowledge on specifics of treatment was low and perception on some of the practices was unfavorable. Sensitization of the public will help overcome some beliefs that may be at tangent to some practices of assisted conception. 展开更多
关键词 AWARENESS PERCEPTION INFERTILITY assisted reproductive technology
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Implementation and Evaluation of Infertility Reflection in Early Pregnancy after the Use of Assisted Reproductive Technology: A Feasibility Study
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作者 Takayo Sakiyama 《Open Journal of Nursing》 2021年第6期477-488,共12页
<strong>Background: </strong>This study aims to evaluate the infertility reflection in early pregnancy after assistive reproductive therapy (ART), including 1) process evaluation (the use and evaluation of... <strong>Background: </strong>This study aims to evaluate the infertility reflection in early pregnancy after assistive reproductive therapy (ART), including 1) process evaluation (the use and evaluation of infertility reflection) and 2) outcome evaluation (satisfaction of care needs, anticipatory anxiety towards the loss of a pregnancy or fetus, cognition of infertility experience, and depression and anxiety). <strong>Methods: </strong>This program evaluation study used a one-group pre-post-test design. The participants were 50 primiparas who had undergone ART at two fertility treatment facilities in a metropolitan area in Japan. For the infertility reflection, they conducted an online reflection. Data were collected three times: at the 5th week of pregnancy (Time 1), the 8th week of pregnancy as the final consultation at the clinic (Time 2), and the 16th week of pregnancy as the final point of early pregnancy (Time 3). <strong>Results: </strong>The data from 40 participants were analyzed. More than 80% of the users of the online reflection positively evaluated the appropriateness and usefulness of the methods and contents. Organized thoughts and feelings by reflection were shown as the reasons for the usefulness. The evaluation of the online reflection showed a relatively strong correlation with the Care Need Satisfaction Scale (CNSS) for both Time 2 and Time 3, but the online reflection did not show a significant correlation with the other outcome variables. There were no significant differences in outcome variables between users and non-users of online reflection between Time 2 and Time 3. <strong>Conclusions:</strong> Attempts at the reflection in early pregnancy require modified methods that do not have a negative impact and lead to the fulfillment of needs. 展开更多
关键词 Infertility Reflection Online Support Program assisted reproductive technology Early Pregnancy Program Evaluation
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Clinical study of different fertilization methods of assisted reproductive technology on neonatal birth defects
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作者 Bao-Guo Xie Yan-Lin Ma Yuan-Hua Huang 《Journal of Hainan Medical University》 2021年第22期23-26,共4页
Objective:To investigate the incidence of neonatal birth defects in assisted reproductive technology(ART)by in vitro fertilization(IVF)and intracytoplasmic sperm injection(ICSI).Methods:The clinical data of 4229 cases... Objective:To investigate the incidence of neonatal birth defects in assisted reproductive technology(ART)by in vitro fertilization(IVF)and intracytoplasmic sperm injection(ICSI).Methods:The clinical data of 4229 cases of singleton deliver by infertile patients under 35 years old who received IVF/ICSI-ET in our center were analyzed.According to different fertilization methods,they were divided into IVF group(2967 cases)and ICSI group(1262 cases).The general situation of birth,birth defects and the location of defects were compared between the two groups.Results:a total of 38 cases of neonatal birth defects were found,the incidence of birth defects was 0.89%,including 30 cases(1.01%)in IVF group and 8 cases(0.64%)in ICSI group.There was no significant difference in the incidence of birth defects between the two groups(P>0.05).There was also no significant difference in birth weight,gestational age and gender ratio between the two groups(P>0.05).Conclusion:Different fertilization methods in assisted reproductive technology do not increase the incidence of neonatal birth defects. 展开更多
关键词 assisted reproductive technology Birth defects In vitro fertilization Intracytoplasmic sperm injection
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Pregnancies Outcome after Assisted Reproductive Technology: A Multicenter Case Control Study in a Low Income Setting Douala, Cameroon
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作者 Tchente Nguefack Charlotte Bourdanne Tekouake Didier +7 位作者 T. Nana Njamen Nda Mefo’o Jean Pierre Ekono Michel Roger Essome Henri Tsingaing Kamgaing Jacques Gwet Bell Ernestine Sandjon Guy Halle Ekane Edie Gregory 《Open Journal of Obstetrics and Gynecology》 2021年第6期720-731,共12页
The objective was to assess the outcome of pregnancies after assisted reproductive technology (ART). It was a case-control study carried out in four health facilities in Douala-Cameroon, over a period of five years. T... The objective was to assess the outcome of pregnancies after assisted reproductive technology (ART). It was a case-control study carried out in four health facilities in Douala-Cameroon, over a period of five years. The cases were pregnant women who conceived through ART and the controls were those who conceived naturally. Cases and controls were matched for maternal age and parity (one case for two controls). A logistic regression analysis was used to compute Odds ratios. Statistical significance was set at 0.05. A total of 174 women who conceived through ART and 348 who conceived naturally were enrolled. Some independent factors associated with ART were: age over 45 years [aOR:</span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">7.55;</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">95%</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">CI</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">(1.55 - 36.76);p:</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">0.01], twin pregnancies [aOR:</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">16.55;</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">95%</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">CI (7.91 - 34.60);p < 0.01], Cervical cerclage [aOR:</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">3.04;</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">95% CI (1.23 - 7.50);p:</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">0.01], miscarriages [aOR:</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">11.73;</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">95%</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">CI (5.07 - 27.10);p:</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">0.01], elective cesarean section [aOR:</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">4.63;</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">95%</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">CI (2.27 - 9.45);p:</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">0.01] and low birth weight [aOR:</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">3.32;</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">95%</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">CI (1.90 - 5.82);p < 0.01]. Women who conceived by ART were older with higher rates of multiple pregnancy and complications. We recommend transfer of a single embryo. 展开更多
关键词 Pregnancy Outcome assisted reproductive technology Douala
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Support from Healthcare Professionals for Couples/Partners Undergoing Assisted Reproductive Technology in Japan: A Literature Review
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作者 Mikio Watanabe Naohiro Hohashi 《Open Journal of Nursing》 2023年第12期875-889,共15页
Background and Purpose: A growing number of couples/partners have been undergoing assisted reproductive technology (ART) in Japan. The purpose of this study was to clarify the support from healthcare professionals bas... Background and Purpose: A growing number of couples/partners have been undergoing assisted reproductive technology (ART) in Japan. The purpose of this study was to clarify the support from healthcare professionals based on the support vectors in the Family Care/Caring Theory proposed by Hohashi (2015) through a literature review. Methods: Using Ichushi-Web, we searched for original articles using the keywords “assisted reproductive technology”, “infertility”, “family”, “couple”, “nursing”, “care”, and “support”. Thirteen articles suitable for the purpose of this study were subjected to content analysis. Family support was encoded and grouped into subcategories and categories, and classified according to support vectors. Results: A total of 21 categories of support from healthcare professionals was extracted. Intervention for family internal environment included seven categories, such as “Nursing professionals stay close to females”. Intervention for family system unit included five categories, such as “Nursing professionals adjust couple/partner relationships”. Intervention for micro system only included “Nursing professionals provide opportunities for peer support to the couples/partners” and intervention for macro system only included “Nursing professionals encourage medical doctors to relate to females”. Intervention for family chrono environment included seven categories, such as “Healthcare professionals resolve female’s anxieties”. Conclusion: The support from healthcare professionals could be organized by the support vectors of Family Care/Caring Theory, but intervention for supra system (culture, religion, etc.) was lacking. Moreover, because most support was directed toward females or couples/partners, male-focused direct and/or indirect support are also needed. . 展开更多
关键词 assisted reproductive technology INFERTILITY Family Support Family Care/Caring Theory Literature Review
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The relationship between maternal body fat and pre-implantation embryonic weight: Implications for survival and long-term development in an assisted reproductive environment
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作者 Julie Weathers Natalie Zimmerer +2 位作者 Lindsay Penrose Kory Graves-Evenson Samuel Prien 《Open Journal of Obstetrics and Gynecology》 2013年第5期1-5,共5页
There can be little argument that embryo quality is one of the most critical factors in the success of assisted reproductive techniques. Yet the current methods of grading embryos are subjective at best. While a numbe... There can be little argument that embryo quality is one of the most critical factors in the success of assisted reproductive techniques. Yet the current methods of grading embryos are subjective at best. While a number of different groups have described more qualitative means of assessing embryo quality, the current standard remains morphology. Morphology has proven a good standard, but it does not allow for the detection of chromosomal abnormalities nor can it assess the biochemical status of the embryo prior to transfer. This laboratory recently described a method to estimate embryo weight and suggested weight might be a good indicator of biochemical status. The objective of the present study was to determine the relationship between maternal body composition and embryo weight and determine the influence maternal chemistry had on embryo development. The data continue to suggest that maternal body composition, especially body fat, influences the chemical nature of the embryo and may play a critical role in long-term survival. 展开更多
关键词 EMBRYO WEIGHT Body Fat assisted reproductive Technologies Specific Gravity
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Assessment of Risk of Carrier Waves in the Assisted Reproductive Laboratory
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作者 Samuel D. Prien Jessica Smith +5 位作者 Christy Barron Joseph Martin Naghma Farooqi Alita Loveless Amy Van Gheem Lindsay L. Penrose 《Open Journal of Obstetrics and Gynecology》 2015年第10期535-541,共7页
Assisted reproductive technology (ART) laboratories represent the marriage of the most basic of biological activities with the most cutting edge technologies. While this association has worked well, the mixture of bio... Assisted reproductive technology (ART) laboratories represent the marriage of the most basic of biological activities with the most cutting edge technologies. While this association has worked well, the mixture of biology and technology can create risks to normal embryo development. Recently a significant amount of literature has explored the risks of manmade, electrically induced magnetic fields and carrier waves on reproduction, which some studies have suggested will lower functional gamete numbers in the males and potentially induce genetic issues in embryos. However, little is known about these phenomena within the ART laboratory, a laboratory filled with electronic equipment. The object of the present study was to explore the potential exposure of gametes and early stage embryos to two of the most prevalent fields and waves utilized in manmade technologies seen in the general environment, electromagnetic fields (EMF) and radio frequency waves (RF), and determine the effect varying levels of these energetic forces had on gamete function and embryo development. Results indicated that while extremely high concentrations of EMF (approximately 50-100X of laboratory background) caused negative outcomes in both gametes and embryos, levels consistent will the majority of lab equipment did not appear to impact growth, or function. Further, even extremely high RF appeared to have no impact cellular function. Results suggest few issues with EMF or RF on gamete and embryo function at normal laboratory levels for the relatively short exposure times seen in the ART laboratory. 展开更多
关键词 assisted reproductive Technologies Electromagnetic FIELDS Radio Frequency WAVES Embryos SPERM
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多囊卵巢综合征不孕患者的影响因素分析与ATR助孕结局的研究
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作者 杨晓丽 杨贵芳 +3 位作者 王云燕 韩蓓蓓 张慧芳 张烁 《山西中医学院学报》 2019年第3期196-198,共3页
目的:探讨多囊卵巢综合征(PCOS)不孕患者的影响因素以及分析ATR助孕后的妊娠率。方法:选取2017年1月-2018年12月太原市中心医院生殖中心收治的984例不孕患者作为研究对象,分为PCOS组与非PCOS组。收集患者的一般资料,采用卡方检验与Logis... 目的:探讨多囊卵巢综合征(PCOS)不孕患者的影响因素以及分析ATR助孕后的妊娠率。方法:选取2017年1月-2018年12月太原市中心医院生殖中心收治的984例不孕患者作为研究对象,分为PCOS组与非PCOS组。收集患者的一般资料,采用卡方检验与Logistic回归进行单因素、多因素分析。比较PCOS组与非PCOS组ATR助孕后的临床妊娠率。结果:单因素分析显示:PCOS组与非PCOS组在年龄、不孕年限、妊娠史差异无统计学意义(P>0.05),而在肥胖、有PCOS家族史、有妇科慢性炎症史、有甲状腺疾病史、有糖尿病/血糖高史差异有统计学意义(P<0.05)。Logistic回归多因素分析显示:调整其他因素后,肥胖、PCOS家族史、甲状腺疾病史为PCOS不孕患者的独立影响因素(P<0.05)。接受ATR助孕后PCOS组的妊娠率(20.25%)低于非PCOS组的妊娠率(42.00%)。结论:肥胖、PCOS家族史、甲状腺疾病史为PCOS致不孕的独立影响因素,且接受ATR助孕妊娠率低于其他因素不孕患者。 展开更多
关键词 多囊卵巢综合征 辅助生殖技术 不孕症
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The impact of male overweight on semen quality and outcome of assisted reproduction 被引量:9
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作者 Lise Thomsen Peter Humaidan +1 位作者 Leif Bungum Mona Bungum 《Asian Journal of Andrology》 SCIE CAS CSCD 2014年第5期749-754,I0010,共7页
It is well-documented that male overweight and obesity causes endocrine disorders that might diminish the male reproductive capacity; however, reports have been conflicting regarding the influence of male body mass in... It is well-documented that male overweight and obesity causes endocrine disorders that might diminish the male reproductive capacity; however, reports have been conflicting regarding the influence of male body mass index (BMI) on semen quality and the outcome of assisted reproductive technology (ART). The aim of this study was to investigate whether increased male BMI affects sperm quality and the outcome of assisted reproduction in couples with an overweight or obese man and a non-obese partner. Data was prospectively collected from 612 infertile couples undergoing ART at a Danish fertility center. Self-reported information on paternal height and weight were recorded and BMI was calculated. The men were divided into four BMI categories: underweight BMI 〈 20 kgm^-2, normal BMI 20-24.9 kg m^-2, overweight BMI 25-29.9 kgm^-2 and obese BMI 〉 30 kgm^-2. Conventional semen analysis was performed according to the World Health Organization guideline and sperm DNA integrity was analyzed by the Sperm Chromatin Structure Assay (SCSA). No statistically significant effect of male BMI was seen on conventional semen parameters (sperm concentration, total sperm count, seminal volume and motility) or on SCSA-results. Furthermore, the outcome of ART regarding fertilization rate, number of good quality embryos (GQE), implantation and pregnancy outcome was not influenced by the increasing male BMIo 展开更多
关键词 assisted reproductive technology body mass index male obesity sperm chromatin structure assay sperm quality
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Reproductive fluids,used for the in vitro production of pig embryos,result in healthy offspring and avoid aberrant placental expression of PEG3 and LUM 被引量:1
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作者 E.París-Oller S.Navarro-Serna +8 位作者 C.Soriano-Úbeda J.S.Lopes C.Matás S.Ruiz R.Latorre O.López-Albors R.Romar S.Cánovas P.Coy 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2021年第3期972-983,共12页
Background:In vitro embryo production(IVP)and embryo transfer(ET)are two very common assisted reproductive technologies(ART)in human and cattle.However,in pig,the combination of either procedures,or even their use sep... Background:In vitro embryo production(IVP)and embryo transfer(ET)are two very common assisted reproductive technologies(ART)in human and cattle.However,in pig,the combination of either procedures,or even their use separately,is still considered suboptimal due to the low efficiency of IVP plus the difficulty of performing ET in the long and contorted uterus of the sow.In addition,the potential impact of these two ART on the health of the offspring is unknown.We investigated here if the use of a modified IVP system,with natural reproductive fluids(RF)as supplements to the culture media,combined with a minimally invasive surgery to perform ET,affects the output of the own IVP system as well as the reproductive performance of the mother and placental molecular traits.Results:The blastocyst rates obtained by both in vitro systems,conventional(C-IVP)and modified(RF-IVP),were similar.Pregnancy and farrowing rates were also similar.However,when compared to in vivo control(artificial insemination,AI),litter sizes of both IVP groups were lower,while placental efficiency was higher in AI than in RF-IVP.Gene expression studies revealed aberrant expression levels for PEG3 and LUM in placental tissue for C-IVP group when compared to AI,but not for RF-IVP group.Conclusions:The use of reproductive fluids as additives for the culture media in pig IVP does not improve reproductive performance of recipient mothers but could mitigate the impact of artificial procedures in the offspring. 展开更多
关键词 assisted reproductive technologies Embryo transfer In vitro embryo production PLACENTA reproductive fluids
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剖宫产子宫瘢痕缺损对采用辅助生殖技术孕妇妊娠结局的影响及对策 被引量:1
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作者 王玲 赵晨含 章勤 《浙江大学学报(医学版)》 CAS CSCD 北大核心 2024年第3期313-320,共8页
近二十年中国的剖宫产率持续上升,导致继发性不孕的剖宫产瘢痕缺损(CSD)患者增加,需要通过辅助生殖技术(ART)解决再生育问题。CSD可显著降低ART活产率、临床妊娠率和胚胎植入率,这与患者子宫内膜容受性下降、瘢痕局部发生腺肌病及子宫... 近二十年中国的剖宫产率持续上升,导致继发性不孕的剖宫产瘢痕缺损(CSD)患者增加,需要通过辅助生殖技术(ART)解决再生育问题。CSD可显著降低ART活产率、临床妊娠率和胚胎植入率,这与患者子宫内膜容受性下降、瘢痕局部发生腺肌病及子宫内膜异位症、宫腔微环境紊乱、ART操作难度及妊娠并发症增加有关。除了使用促性腺激素释放激素类似物可能改善妊娠结局,宫腔镜手术、腹腔镜手术和经阴道手术是治疗CSD的有效方法,可提高妊娠率。本文通过文献回顾,分析CSD对采用ART孕妇妊娠结局的影响及相应的治疗方法,以期为CSD患者管理及改善ART妊娠结局提供新思路。 展开更多
关键词 剖宫产 剖宫产瘢痕缺损 辅助生殖技术 妊娠结局 综述
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辅助生殖科护士岗位胜任力评价指标体系的构建研究
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作者 史莉 罗丽燕 +1 位作者 刘金莲 宋东红 《中华护理教育》 CSCD 2024年第11期1358-1363,共6页
目的构建辅助生殖科护士岗位胜任力评价指标体系。方法以岗位胜任力“冰山模型”为理论依据,通过文献回顾和半结构式访谈初步构建辅助生殖科护士岗位胜任力评价指标体系;通过德尔菲法对13个省市20名专家开展2轮函询,并结合层次分析法计... 目的构建辅助生殖科护士岗位胜任力评价指标体系。方法以岗位胜任力“冰山模型”为理论依据,通过文献回顾和半结构式访谈初步构建辅助生殖科护士岗位胜任力评价指标体系;通过德尔菲法对13个省市20名专家开展2轮函询,并结合层次分析法计算各级指标权重。结果2轮专家咨询的问卷回收率均为100%(20/20),专家权威系数分别为0.898、0.900,总指标的肯德尔和谐系数分别为0.318、0.346(均P<0.01)。构建的辅助生殖科护士岗位胜任力评价指标体系包括一级指标4项、二级指标15项、三级指标56项。结论本研究构建的辅助生殖科护士岗位胜任力评价指标体系科学、可靠、内容合理,可为辅助生殖科护士岗位培训、考核提供依据。 展开更多
关键词 德尔菲技术 护士 辅助生殖技术 岗位胜任力
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遗传性疾病患者生育权与子代权益的伦理冲突——1例外胚层发育不良申请辅助生殖技术助孕案例的伦理分析
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作者 奚慧琴 徐于睿 +1 位作者 谢雷 周艳茂 《中国医学伦理学》 北大核心 2024年第4期470-474,共5页
随着人类辅助生殖技术的进步,更多的遗传性疾病被发现并通过创新技术的使用拟降低遗传风险,不孕症夫妇的生育权得到更大程度的保护和满足。但对一些特殊遗传病例,子代权益需要被充分考虑。以1例“外胚层发育不良”申请实施人类辅助生殖... 随着人类辅助生殖技术的进步,更多的遗传性疾病被发现并通过创新技术的使用拟降低遗传风险,不孕症夫妇的生育权得到更大程度的保护和满足。但对一些特殊遗传病例,子代权益需要被充分考虑。以1例“外胚层发育不良”申请实施人类辅助生殖技术进行助孕的个案为基础进行伦理剖析,揭示在对遗传性疾病患者实施辅助生殖技术治疗中,由于患者生育权与子代权益保护存在矛盾、人类辅助生殖技术实施与阻断遗传风险之间存在矛盾,处理该类病例会面临伦理困境。通过文献回顾提出:在遗传性病例的诊疗及伦理判断过程中,应充分履行知情同意,基于关怀伦理基础,采用叙事医学方法形成医患共同决策,避免家长主义;同时提供充分的信息支持及完善伦理监督机制,以有效应对伦理困境。 展开更多
关键词 生育权 子代权益 医学伦理 人类辅助生殖技术
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辅助生殖技术治疗后不孕症患者心理状况变化及其影响因素分析
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作者 符春苗 李兆萍 +2 位作者 王韫琪 胡耀华 郑新莲 《中外医疗》 2024年第31期32-35,共4页
目的探讨行辅助生殖技术治疗后不孕症患者的心理状况变化及其影响因素。方法回顾性选取2023年4月—2024年2月海南省中医院进行辅助生殖技术治疗的136例不孕症患者为研究对象,按照治疗后是否妊娠进行分组,其中妊娠102例,未妊娠34例。通... 目的探讨行辅助生殖技术治疗后不孕症患者的心理状况变化及其影响因素。方法回顾性选取2023年4月—2024年2月海南省中医院进行辅助生殖技术治疗的136例不孕症患者为研究对象,按照治疗后是否妊娠进行分组,其中妊娠102例,未妊娠34例。通过问卷调查患者治疗前后的心理状态、应对方式和睡眠质量情况,分析影响患者心理状况的相关因素。结果不孕症患者均存在焦虑、抑郁等不良心理状态。观察组患者在不同时间段的简易应对方式量表(Simplified Coping Style Questionnaire,SCSQ)和睡眠质量自评量表(Self-rating Scale of Sleep,SRSS)评分对比,未妊娠患者SCSQ评分低于妊娠组,SRSS评分高于妊娠组,差异有统计学意义(P均<0.05)。结论行辅助生殖技术不孕症患者主要面临的心理压力因素包括生理、心理、环境和社会因素,患者主要存在心理焦虑、抑郁等情况。经过辅助生殖技术治疗后,患者心理状态能够得到一定改善。 展开更多
关键词 辅助生殖技术 不孕症 心理状况
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不同HPV感染亚型对不孕女性阴道微生态及辅助生殖助孕结局的影响
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作者 刘阳 徐珲 李萍 《中国妇幼健康研究》 2024年第11期69-75,共7页
目的探讨不同人乳头瘤病毒(HPV)感染亚型对不孕女性阴道微生态及辅助生殖(ART)助孕结局的影响。方法选取2020年1月至2022年3月期间于宝鸡市中心医院进行ART助孕的HPV阳性不孕女性190例,对所有患者均进行了HPV分型检查,根据患者感染HPV... 目的探讨不同人乳头瘤病毒(HPV)感染亚型对不孕女性阴道微生态及辅助生殖(ART)助孕结局的影响。方法选取2020年1月至2022年3月期间于宝鸡市中心医院进行ART助孕的HPV阳性不孕女性190例,对所有患者均进行了HPV分型检查,根据患者感染HPV的不同亚型将其分为高危组(151例)与低危组(39例),选取同期进行ART助孕的HPV阴性不孕女性纳入对照组(95例)。检查患者阴道微生态情况及阴道病原菌感染情况,记录患者ART助孕结局(获卵数、可移植胚胎数及优质胚胎数)和妊娠结局(临床妊娠率、活产分娩率及流产率),并对各组数据进行统计分析。结果高危组、低危组、对照组的H_(2)O_(2)阳性率比较差异无统计学意义(P>0.05);高危组、低危组、对照组的乳酸杆菌、唾液酸苷酶、白细胞酯酶的阳性率及阴道微生态失衡率比较差异均有统计学意义(χ^(2)值分别为7.604、9.086、6.825、8.502,P<0.05);高危组的乳酸杆菌、唾液酸苷酶、白细胞酯酶的阳性率及阴道微生态失衡率均明显高于对照组,经比较差异均有统计学意义(χ^(2)值分别为7.087、9.038、6.767、8.373,P<0.05)。高危组、低危组、对照组的外阴阴道假丝酵母菌病(VVC)、细菌性阴道病(BV)的感染率比较差异均无统计学意义(P>0.05),高危组、低危组、对照组的混合型阴道感染率比较差异有统计学意义(χ^(2)=15.258,P<0.05);高危组的混合型阴道感染率均明显高于低危组和对照组,经比较差异均有统计学意义(χ^(2)值分别为4.808、12.002,P<0.05)。高危组、低危组、对照组患者的获卵数、可移植胚胎数及优质胚胎数比较差异均无统计学意义(P>0.05)。高危组、低危组、对照组患者的临床妊娠率比较差异无统计学意义(P>0.05),三组的活产分娩率和流产率比较差异均有统计学意义(χ^(2)值分别为2.841、2.936,P<0.05);高危组的活产分娩率明显低于对照组,流产率明显高于对照组,经比较差异均有统计学意义(χ^(2)值分别为7.981、5.123,P<0.05)。结论不同HPV感染亚型对不孕患者阴道微生态情况、ART助孕结局、临床妊娠率及活产分娩率的影响较小,但高危HPV感染会增加不孕患者混合型阴道感染的风险。 展开更多
关键词 人乳头瘤病毒 亚型 不孕症 阴道微生态 辅助生殖 助孕结局
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