Dyspnea(or breathlessness) is a symptom describing a perceived experience of breathing discomfort. Children's awareness of dyspnea is variable and there is only a poor correlation between the objective respiratory...Dyspnea(or breathlessness) is a symptom describing a perceived experience of breathing discomfort. Children's awareness of dyspnea is variable and there is only a poor correlation between the objective respiratory distress measurements and the subjectively awareness of dyspnea. Those who do not perceive dyspnea may not be motivated to comply with their daily prophylactic treatment. Since dyspnea is the main symptom of asthma, and disease management is based largely on the description of symptoms between clinic visits, unreliable symptom report may mislead decision-making for longterm treatment of asthma. Thus, therapeutic decisions should not be taken solely on patients' perception and description of dyspnea.展开更多
Asthma is the most common chronic disease among children, and its incidences are often imminent among elementary schoolchildren. This study aimed to examine the prevalence of asthma symptoms in Golestan schoolchildren...Asthma is the most common chronic disease among children, and its incidences are often imminent among elementary schoolchildren. This study aimed to examine the prevalence of asthma symptoms in Golestan schoolchildren aged 6-7 and 13-14 years in Northeast Iran. The prevalence rate was compared according to age group （aged 6-7 years vs. aged 13-14 years） and gender （male vs. female）. In this cross-sectional study, 1706 Iranian schoolchildren aged 6-7 and 13-14 years in Golestan Province were enrolled. Participants completed questionnaires between February and July 2014. Asthma symptoms were assessed using the questionnaire of the International Study of Asthma and Allergies in Childhood protocol in Persian. The logistic regression model was used to estimate the odds ratios （ORs） and 95% confidence intervals （CIs） of the asthma symptoms for each of the gender and age groups. The prevalence rates of ＂current asthma＂ symptoms and ＂asthma ever＂ in all the children were estimated as 9.5%and 7.5%, respectively. The prevalence of asthma （＂asthma ever＂ and ＂wheezing in the past 12 months＂） in junior high schoolchildren （aged 13-14 years） is higher than that in elementary schoolchildren （aged 6-7 years） （P 〈 0.05）. The prevalence of the severity of wheezing in girls is lower than that in boys （OR = 1.7, 95%CI = 1.06-2.96, P = 0.02）. Asthma is still a major public health problem. This study shows that the prevalence of the asthma symptoms in boys is lower than that in girls in both age groups, and the severity of asthma in girls is higher than that in boys aged 13-14 years.展开更多
Accumulating evidence suggests that a disruption of early brain development,in which insulin-like growth factor-2(IGF-2)has a crucial role,may underlie the pathophysiology of schizophrenia.Our previous study has shown...Accumulating evidence suggests that a disruption of early brain development,in which insulin-like growth factor-2(IGF-2)has a crucial role,may underlie the pathophysiology of schizophrenia.Our previous study has shown that decreased serum IGF-2 was correlated with the severity of psychopathology in patients with schizophrenia.Here we conducted a prospective observation trial to investigate the effects of atypical antipsychotics on serum IGF-2 level and its relationship with clinical improvements in schizophrenia patients.Thirty-one schizophrenia patients with acute exacerbation and 30 healthy individuals were recruited in this study.Psychiatric symptoms were assessed using the Positive and Negative Syndrome Scale(PANSS)and serum IGF-2 levels were determined using ELISA.We found that schizophrenia patients with acute exacerbation had lower serum IGF-2 levels than control individuals at baseline(P<0.05).After 2 months of atypical antipsychotic treatment,a significant improvement in each PANSS subscore and total score was observed in patients(all P<0.01),and the serum IGF-2 levels of patients were significantly increased compared with those at baseline(203.13±64.62 vs.426.99±124.26 ng/mL;t=−5.044,P<0.001).Correlation analysis revealed that the changes of serum IGF-2 levels in patients were significantly correlated with the improvements of negative symptoms(r=−0.522,P=0.006).Collectively,our findings demonstrated changes of serum IGF-2 response to improvements of negative symptoms in schizophrenia patients treated with atypical antipsychotics,suggesting that serum IGF-2 might be a treatment biomarker for schizophrenia.展开更多
BACKGROUND The first case of pneumonia subsequently attributed to severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) occurred in Wuhan,Hubei Province on December 8,2019.The symptoms included fever,coughing,...BACKGROUND The first case of pneumonia subsequently attributed to severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) occurred in Wuhan,Hubei Province on December 8,2019.The symptoms included fever,coughing,and breathing difficulties.A few patients with this infection may only have atypical symptoms,which could lead to a misdiagnosis and subsequently further facilitate the spread of the virus.CASE SUMMARY A 74-year-old female patient complained of severe diarrhea.She did not have fever,coughing,or breathing difficulties.A physical examination revealed no obvious positive signs.The patient had been hypertensive for more than 10 years.Her blood pressture was well controlled.On January 9,2020,the patient’s son visited a colleague who was later confirmed positive for SARS-CoV-2 and his first close contact with our patient was on January 17.The patient was first diagnosed with gastrointestinal dysfunction.However,considering her indirect contact with a SARS-CoV-2-infected individual,we suggested that an atypical pneumonia virus infection should be ruled out.A computed tomography scan was performed on January 26,and showed ground-glass nodules scattered along the two lungs,suggestive of viral pneumonia.Given the clinical characteristics,epidemiological history,and examination,the patient was diagnosed with corona virus disease-2019 (COVID-19).CONCLUSION Our patient had atypical symptoms of COVID-19.Careful acquisition of an epidemiological history is necessary to make a correct diagnosis and strategize a treatment plan.展开更多
文摘Dyspnea(or breathlessness) is a symptom describing a perceived experience of breathing discomfort. Children's awareness of dyspnea is variable and there is only a poor correlation between the objective respiratory distress measurements and the subjectively awareness of dyspnea. Those who do not perceive dyspnea may not be motivated to comply with their daily prophylactic treatment. Since dyspnea is the main symptom of asthma, and disease management is based largely on the description of symptoms between clinic visits, unreliable symptom report may mislead decision-making for longterm treatment of asthma. Thus, therapeutic decisions should not be taken solely on patients' perception and description of dyspnea.
文摘Asthma is the most common chronic disease among children, and its incidences are often imminent among elementary schoolchildren. This study aimed to examine the prevalence of asthma symptoms in Golestan schoolchildren aged 6-7 and 13-14 years in Northeast Iran. The prevalence rate was compared according to age group （aged 6-7 years vs. aged 13-14 years） and gender （male vs. female）. In this cross-sectional study, 1706 Iranian schoolchildren aged 6-7 and 13-14 years in Golestan Province were enrolled. Participants completed questionnaires between February and July 2014. Asthma symptoms were assessed using the questionnaire of the International Study of Asthma and Allergies in Childhood protocol in Persian. The logistic regression model was used to estimate the odds ratios （ORs） and 95% confidence intervals （CIs） of the asthma symptoms for each of the gender and age groups. The prevalence rates of ＂current asthma＂ symptoms and ＂asthma ever＂ in all the children were estimated as 9.5%and 7.5%, respectively. The prevalence of asthma （＂asthma ever＂ and ＂wheezing in the past 12 months＂） in junior high schoolchildren （aged 13-14 years） is higher than that in elementary schoolchildren （aged 6-7 years） （P 〈 0.05）. The prevalence of the severity of wheezing in girls is lower than that in boys （OR = 1.7, 95%CI = 1.06-2.96, P = 0.02）. Asthma is still a major public health problem. This study shows that the prevalence of the asthma symptoms in boys is lower than that in girls in both age groups, and the severity of asthma in girls is higher than that in boys aged 13-14 years.
基金This work was supported by grants from the National Natural Science Foundation of China(No.81760254)the Natural Science Foundation of Fujian Province of China(No.2019J01164)the Scientific Foundation of Quanzhou City for High Level Talents(No.2019C075R).
文摘Accumulating evidence suggests that a disruption of early brain development,in which insulin-like growth factor-2(IGF-2)has a crucial role,may underlie the pathophysiology of schizophrenia.Our previous study has shown that decreased serum IGF-2 was correlated with the severity of psychopathology in patients with schizophrenia.Here we conducted a prospective observation trial to investigate the effects of atypical antipsychotics on serum IGF-2 level and its relationship with clinical improvements in schizophrenia patients.Thirty-one schizophrenia patients with acute exacerbation and 30 healthy individuals were recruited in this study.Psychiatric symptoms were assessed using the Positive and Negative Syndrome Scale(PANSS)and serum IGF-2 levels were determined using ELISA.We found that schizophrenia patients with acute exacerbation had lower serum IGF-2 levels than control individuals at baseline(P<0.05).After 2 months of atypical antipsychotic treatment,a significant improvement in each PANSS subscore and total score was observed in patients(all P<0.01),and the serum IGF-2 levels of patients were significantly increased compared with those at baseline(203.13±64.62 vs.426.99±124.26 ng/mL;t=−5.044,P<0.001).Correlation analysis revealed that the changes of serum IGF-2 levels in patients were significantly correlated with the improvements of negative symptoms(r=−0.522,P=0.006).Collectively,our findings demonstrated changes of serum IGF-2 response to improvements of negative symptoms in schizophrenia patients treated with atypical antipsychotics,suggesting that serum IGF-2 might be a treatment biomarker for schizophrenia.
基金the National Natural Science Foundation of China,No.81801379Top-level Clinical Discipline Project of Shanghai Pudong District,No.PWYgf2018-02.
文摘BACKGROUND The first case of pneumonia subsequently attributed to severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) occurred in Wuhan,Hubei Province on December 8,2019.The symptoms included fever,coughing,and breathing difficulties.A few patients with this infection may only have atypical symptoms,which could lead to a misdiagnosis and subsequently further facilitate the spread of the virus.CASE SUMMARY A 74-year-old female patient complained of severe diarrhea.She did not have fever,coughing,or breathing difficulties.A physical examination revealed no obvious positive signs.The patient had been hypertensive for more than 10 years.Her blood pressture was well controlled.On January 9,2020,the patient’s son visited a colleague who was later confirmed positive for SARS-CoV-2 and his first close contact with our patient was on January 17.The patient was first diagnosed with gastrointestinal dysfunction.However,considering her indirect contact with a SARS-CoV-2-infected individual,we suggested that an atypical pneumonia virus infection should be ruled out.A computed tomography scan was performed on January 26,and showed ground-glass nodules scattered along the two lungs,suggestive of viral pneumonia.Given the clinical characteristics,epidemiological history,and examination,the patient was diagnosed with corona virus disease-2019 (COVID-19).CONCLUSION Our patient had atypical symptoms of COVID-19.Careful acquisition of an epidemiological history is necessary to make a correct diagnosis and strategize a treatment plan.
