A new naphthoquinone compound named 7-hydroxyl-8-methoxyltrypethelone 3 together with two known compounds trypethelone 1 and trypethelone methyl ether 2 was isolated from cultured mycobiont of Astrothelium sp.The stru...A new naphthoquinone compound named 7-hydroxyl-8-methoxyltrypethelone 3 together with two known compounds trypethelone 1 and trypethelone methyl ether 2 was isolated from cultured mycobiont of Astrothelium sp.The structures were elucidated by 1D and 2D NMR spectroscopic analysis as well as comparison with those reported in literatures.Compound 1 displayed significant antibacterial activity against Bacillus subtilis（ATCC 6633）,and showed modest antibacterial activity against Staphylococcus aureus col（MRSA）（CGMCC 1.2465）,while compounds 2 and 3 showed modest antibacterial activity against Enterococcus faecalis 850E（CGMCC 1.2135） and S.aureus col（MRSA）（CGMCC 1.2465）.展开更多
基金supported by National Natural Science Foundation of China(No.302700005)the Ministry of Science and Technology of the People's Republic of China(MOST,No.2007Aa021405).
文摘A new naphthoquinone compound named 7-hydroxyl-8-methoxyltrypethelone 3 together with two known compounds trypethelone 1 and trypethelone methyl ether 2 was isolated from cultured mycobiont of Astrothelium sp.The structures were elucidated by 1D and 2D NMR spectroscopic analysis as well as comparison with those reported in literatures.Compound 1 displayed significant antibacterial activity against Bacillus subtilis（ATCC 6633）,and showed modest antibacterial activity against Staphylococcus aureus col（MRSA）（CGMCC 1.2465）,while compounds 2 and 3 showed modest antibacterial activity against Enterococcus faecalis 850E（CGMCC 1.2135） and S.aureus col（MRSA）（CGMCC 1.2465）.
