A highly efficient and enantioselective method for the asymmetric reductive amination ofβ-keto phosphine de-rivatives was disclosed,and the correspondingβ-amino phosphine oxides could be obtained in high yields(up t...A highly efficient and enantioselective method for the asymmetric reductive amination ofβ-keto phosphine de-rivatives was disclosed,and the correspondingβ-amino phosphine oxides could be obtained in high yields(up to 97%yield)and excellent enantioselectivities(up to 97%ee).Moreover,the reaction worked well on a gram scale,indicating that our protocol has potential applications in the synthesis of chiral ligands and organocatalysts.展开更多
基金the National Natural Science Foundation of China(No.21901107)Shenzhen Bay Laboratory(No.SZBL2019062801006)+5 种基金Shenzhen Science and Technology Innovation Committee(No.KQTD20150717103157174)Key-Area Research and Development Program of Guangdong Province(No.2020B010188001)Stable Support Plan Program of Shenzhen Science and Technology Innovation Committee(No.20200925161222002)Innovative Team of Universities in Guangdong Province(No.2020KCXTD016).G.Q.Chen gratefully acknowledges the National Natural Science Foundation of China(Nos.21901107 and 22171129)the Guangdong Basic and Applied Basic Research Foundation(No.2022B1515020055)the Shenzhen Science and Technology Innovation Committee(No.JCYJ20210324104202007)for financial support.B.Ma is indebted to the financial support from the National Natural Science Foundation of China(No.22001113)B.Ma is the National Natural Science Foundation of China(No.22001113).
文摘A highly efficient and enantioselective method for the asymmetric reductive amination ofβ-keto phosphine de-rivatives was disclosed,and the correspondingβ-amino phosphine oxides could be obtained in high yields(up to 97%yield)and excellent enantioselectivities(up to 97%ee).Moreover,the reaction worked well on a gram scale,indicating that our protocol has potential applications in the synthesis of chiral ligands and organocatalysts.
