Analysis of the relationship between 24-hour sodium and blood pressure and the dietary status based on mobile phone APP in the high-risk population of hypertension in Haikou

Objective:To understand the dietary intake of high-risk population with hypertension in Haikou,and to analyze the relationship between dietary intake and blood pressure,especially the relationship between sodium intake and blood pressure,so as to provide a scientific basis for salt reduction.Methods:A multi-stage cluster sampling 2021 was used from July to December to collect 3-4 cscs from each of the four districts in Haikou.A total of 15 cscs were collected,295 permanent residents aged 55-74 were recruited from 15 community service centers,with 20 eligible subjects from each community.The subjects underwent general physical examination,laboratory tests,and a dietary survey using the self-developed Android phone APP“Nutrition Assistant”(registration number:2021SR1547832).SPSS 21.0 was used 2 for t test,x^(2) test and multiple Regression analysis.Result:In Haikou,69.4%of the subjects had energy intake above energy requirement,and 44.8%had fat intake above the acceptable range of macronutrients.There were only differences in energy,carbohydrate,vitamin B 6 and sodium intake(t=-2.174,-1.990,2.333,-5.442,P=0.031,0.048,0.021,<0.001,respectively).There were significant differences in BMI,family history of chronic diseases,systolic blood 2 pressure and diastolic blood pressure(f value or x^(2) value were 4.260,19.045,139.916,36.864,P value were 0.015,<0.001,<0.001,<0.001,respectively).Multiple Regression analysis analysis showed that 24h sodium excretion was significantly correlated with systolic and diastolic blood pressure(t=12.964,P<0.001),systolic and diastolic blood pressure increased by 0.135 mmhg and 0.068 mmhg,respectively.Conclusion:The dietary intake of the middle-aged and elderly people at high risk of hypertension in the Haikou community was unbalanced,and the intake of sodium salt was strongly correlated with blood pressure,it is necessary to continue to promote salt reduction as one of the key ways to prevent and control hypertension.

Sero-Prevalence of <i>H. pylori</i>Antibodies among Asymptomatic Rural Population in Bauchi State, Nigeria—A Preliminary Study

Helicobacter pylori infection is a major public health problem globally, with high prevalence in developing countries associated with poor sanitation, low standard of living, urban-rural disparity and increased gastrointestinal pathologies. This preliminary study determined the seroprevalence of H. pylori infection among asymptomatic rural population and association of sociodemographic variables on the result outcome. A total of 250 asymptomatic volunteered participants were screened for H. pylori antibodies, using rapid immunochromatographic strips. 44.8% (112/250) were seropositive, and showed increased prevalence with the age group, <15 years (8.0%), 18 - 39 years (23.5%) and 40 - 65 years (12.0%) with no significant difference. High prevalence among males, 88 (35.2) compared to 24 (9.6) females (p < 0.228). Significant association was observed with marital status, high prevalence among married participants 63 (25.0) followed by singles, 41 (16.4) (p < 0.010). Similarly, significant prevalence was observed among participants with non-formal education, 60 (24.0) followed by primary education, 21 (8.4) (p < 0.51). While non-salary earners accounted for 79 (31.6) (p < 0.244). The H. pylori seropositivity of 44.8% is relatively low in region with previous reports of high prevalence and predisposing risk factors. Further studies are needed to evaluate the effect of environmental and occupational risk factors for better epidemiological understanding of H. pylori infection and a template for intervention measures.

Detection of Asymptomatic Carotid Artery Stenosis in High-Risk Individuals of Stroke Using a Machine-Learning Algorithm

Objective Asymptomatic carotid stenosis(ACS)is closely associated to the incidence of severe cerebrovascular diseases.Early identifying the individuals with ACS and its associated risk factors could be beneficial for primary prevention of stroke.This study aimed to investigate a machine-learning algorithm for the detection of ACS among high-risk population of stroke based on the associated risk factors.Methods A novel model of machine learning was utilized to screen the associated predictors of ACS based on 30 potential risk factors.The algorithm of this model adopted a random forest pattern based on the training data and then was verified using the testing data.All of the original data were retrieved from the China National Stroke Screening and Prevention Project(CNSSPP),including demographic,clinical and laboratory characteristics.The individuals with high risk of stroke were enrolled and randomly divided into a training group and a testing group at a ratio of 4:1.The identification of carotid stenosis by carotid artery duplex scans was set as the golden standard.The receiver operating characteristic(ROC)curve and the area under the curve(AUC)was used to evaluate the efficacy of the model in detecting ACS.Results Of 2841 high risk individual of stroke enrolled,326(11.6%)were diagnosed as ACS by ultrasonography.The top five risk fectors contributing to ACS in this model were identified as family history of dyslipidemia,high level of lowdensity lipoprotein cholesterol(LDL-c),low level of high-density lipoprotein cholesterol(HDL-c),aging,and low body.

Living with liver disease in the era of COVID-19-the impact of the epidemic and the threat to high-risk populations

The cardinal symptoms of severe acute respiratory syndrome coronavirus 2 infection as the pandemic began in 2020 were cough,fever,and dyspnea,thus characterizing the virus as a predominantly pulmonary disease.While it is apparent that many patients presenting acutely to the hospital with coronavirus disease 2019(COVID-19)infection have complaints of respiratory symptoms,other vital organs and systems are also being affected.In fact,almost half of COVID-19 hospitalized patients were found to have evidence of some degree of liver injury.Incidence and severity of liver injury in patients with underlying liver disease were even greater.According to the Centers of Disease Control and Prevention,from August 1,2020 to May 31,2022 there have been a total of 4745738 COVID-19 hospital admissions.Considering the gravity of the COVID-19 pandemic and the incidence of liver injury in COVID-19 patients,it is imperative that we as clinicians understand the effects of the virus on the liver and conversely,the effect of underlying hepatobiliary conditions on the severity of the viral course itself.In this article,we review the spectrum of novel studies regarding COVID-19 induced liver injury,compiling data on the effects of the virus in various age and high-risk groups,especially those with preexisting liver disease,in order to obtain a comprehensive understanding of this disease process.We also provide an update of the impact of the new Omicron variant and the changing nature of COVID-19 pathogenesis.

Large Population Screening Identified the Main Risk Factors of Stroke in Shashi District of Jingzhou City

Objective: This paper aims to screen and analyze the current status of high-risk stroke patients in Shashi District of Jingzhou City and the exposure levels of related risk factors, and provides suggestions as the references for prevention and treatment of stroke. Methods: Using cluster sampling, on-site investigations were conducted on 1060 permanent residents aged 40 years and over at 3 townships and 2 communities in Shashi District of Jingzhou City from January 2018 to December 2018. Risk assessment of stroke is based on the stroke risk screening form. Statistical analysis was performed by using SPSS 22.0 software. Results: After making a stroke risk assessment, a total of 313 high-risk stroke patients were screened, and the detection rate was 29.53%. The exposure rate of risk factors from high to low was hypertension (70.93%), dyslipidemia (46.33%), less physical exercise (46.01%), diabetes (36.10%), overweight (33.55%), smoking (33.23%), family history of stroke (24.92%), atrial fibrillation or valvular heart disease (7.35%). There are statistically significant differences among all risk factors between the high-risk group and middle and low-risk groups (P Conclusion: The detection rate of high-risk stroke patients in Shashi District of Jingzhou City is high. Hypertension, dyslipidemia and less physical exercise are the main risk factors of stroke occurrence and recurrence in the region. The prevention and treatment of risk factors for stroke should be strengthened to control the incidence and recurrence rate of stroke.

不同诊断标准下的代谢综合征与无症状心血管损害的相关性研究

目的选取无心血管疾病史的上海北部社区老年人群为研究对象,探讨无症状心血管损害与4种不同诊断标准判定的代谢综合征(metabolic syndrome,MS)的关系。方法研究选择1958例无心血管疾病史的老年人群,年龄66.5-73.1岁。MS的定义依据以下标准:2005年美国国家胆固醇教育计划成人治疗专家组第三次会议(National Cholesterol Education Program Adult Treatment PanelⅢ,NCEPⅢ)、国际糖尿病联盟(International Diabetes Federation,IDF)、中华医学会糖尿病学分会(Chinese Diabetes Society,CDS)和中国成人血脂异常防治指南制定联合委员会(Chinese Joint Committee for Developing Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults,JCDCG)。无症状心血管损害指标包括测定左心室质量指数、二尖瓣峰值血流速度/舒张早期组织多普勒血流速度、颈股脉搏波传导速度、踝臂指数、动脉斑块和尿白蛋白/肌酐比值。二分类Logistic回归模型用于评价无症状心血管损害与4种不同诊断标准判定的MS之间的相关性。结果(1)NCEPⅢ(2005)、IDF、CDS和ICDCG诊断标准判别的MS患病率分别为46.4%,37.1%,21.6%和28.7%。(2)未校正的Logistic回归分析显示,4种不同诊断标准判定的MS均与左心室肥厚、左心室舒张功能不全、动脉硬化和微量白蛋白尿显著相关(均P<0.01)。(3)在校正了年龄、性别、吸烟和早发心血管疾病家族史后,左心室肥厚、左心室舒张功能不全、动脉硬化和微量白蛋白尿与4种不同诊断标准判定的MS的关联仍存在(均P<0.01)。结论在上海北部社区老年人群中,不同诊断标准判定的MS与无症状心血管损害均密切相关。

无症状人群中项韧带钙化发生率调查

目的:调查无症状人群中项韧带钙化发生率及影像学特点。方法:回顾性分析318名无症状志愿者临床和影像学资料,分析无症状人群中项韧带钙化发生率、形态分类及节段分布特点;根据有无项韧带钙化分为两组,分析两组间志愿者性别、年龄、体重指数(BMI)和下颈椎椎间参数之间差异,并基于Roussouly分型,比较各组间颈胸矢状位参数差异;最后分析项韧带钙化程度与上述因素之间相关性,找出影响项韧带钙化的危险因素。结果:318名无症状受试者中,项韧带钙化发生率为23.27%,项韧带钙化组男女性别比例、年龄、体重指数与无项韧带钙化组相比较,差异均有统计学意义(P<0.001)。按形态将项韧带钙化分类,其中局灶型钙化50.0%、连续型钙化27.0%、节段型钙化7.0%、混合型钙化9.0%、未分型钙化7.0%,而各节段项韧带钙化发生率为C2/31.4%,C3/49.5%,C4/555.4%,C5/663.5%,C6/718.9%。对比下颈椎椎间参数,项韧带钙化组角位移(angular displacement,AD)、水平位移(horizontal displacemen,HD)较对照组显著增大(P<0.001)。基于Roussouly分型下比较各组间颈胸矢状位参数,发现上颈椎前凸角(O-C2)、颈椎矢状轴(C2-C7 SVA)和T1倾斜角(TS)存在显著统计学差异(P<0.05)。经Pearson相关性分析显示,项韧带钙化程度与AD、O-C2和C2-C7 SVA呈中度相关性,与HD、TS呈高度相关性。经多元Logistic分析发现,HD是项韧带钙化最重要的危险因素,其次是O-C2,还有年龄因素和AD。结论:无症状人群中年龄大、体重指数高的男性群体中项韧带钙化发生率较高。项韧带钙化人群中颈胸矢状位参数:O-C2、C2-C7 SVA和TS增大;下颈椎椎间参数:角位移(AD)和水平位移(HD)增大,且这些参数与项韧带钙化程度存在相关性。

早期踝肱指数对下肢动脉硬化性疾病无症状高危人群的预测价值

目的探讨下肢动脉硬化性疾病无症状高危人群的危险因素及踝肱指数(ankle-brachial index,ABI)的预测价值。方法选取2020年1月至2022年12月成武县人民医院110例无下肢动脉硬化性疾病症状的高危人群为研究对象,均接受ABI测量,根据ABI将其分为异常组和正常组,对比两组基线资料,并分析影响下肢动脉硬化性疾病无症状高危人群的危险因素及ABI的预测价值。结果经ABI测量显示,ABI≤0.9共31例,占比28.18%。异常组年龄,有高血压史、糖尿病史、吸烟史占比,C反应蛋白及同型半胱高于正常组,总胆固醇及ABI低于正常组(P均<0.05)。年龄、高血压史、糖尿病史、吸烟史、同型半胱氨酸、ABI是下肢动脉硬化性疾病无症状高危人群的影响因素(P均<0.05)。年龄、同型半胱氨酸、ABI预测下肢动脉硬化性疾病无症状高危人群的曲线下面积(area under curve,AUC)分别为0.959、0.965、0.986,ABI预测的敏感度优于年龄和同型半胱氨酸预测(P均<0.05)。结论早期检测ABI对下肢动脉硬化性疾病无症状高危人群具有预测作用。

Development and validation of a prediction model for early screening of people at high risk for colorectal cancer

BACKGROUND Colorectal cancer(CRC)is a serious threat worldwide.Although early screening is suggested to be the most effective method to prevent and control CRC,the current situation of early screening for CRC is still not optimistic.In China,the incidence of CRC in the Yangtze River Delta region is increasing dramatically,but few studies have been conducted.Therefore,it is necessary to develop a simple and efficient early screening model for CRC.AIM To develop and validate an early-screening nomogram model to identify individuals at high risk of CRC.METHODS Data of 64448 participants obtained from Ningbo Hospital,China between 2014 and 2017 were retrospectively analyzed.The cohort comprised 64448 individuals,of which,530 were excluded due to missing or incorrect data.Of 63918,7607(11.9%)individuals were considered to be high risk for CRC,and 56311(88.1%)were not.The participants were randomly allocated to a training set(44743)or validation set(19175).The discriminatory ability,predictive accuracy,and clinical utility of the model were evaluated by constructing and analyzing receiver operating characteristic(ROC)curves and calibration curves and by decision curve analysis.Finally,the model was validated internally using a bootstrap resampling technique.RESULTS Seven variables,including demographic,lifestyle,and family history information,were examined.Multifactorial logistic regression analysis revealed that age[odds ratio(OR):1.03,95%confidence interval(CI):1.02-1.03,P<0.001],body mass index(BMI)(OR:1.07,95%CI:1.06-1.08,P<0.001),waist circumference(WC)(OR:1.03,95%CI:1.02-1.03 P<0.001),lifestyle(OR:0.45,95%CI:0.42-0.48,P<0.001),and family history(OR:4.28,95%CI:4.04-4.54,P<0.001)were the most significant predictors of high-risk CRC.Healthy lifestyle was a protective factor,whereas family history was the most significant risk factor.The area under the curve was 0.734(95%CI:0.723-0.745)for the final validation set ROC curve and 0.735(95%CI:0.728-0.742)for the training set ROC curve.The calibration curve demonstrated a high correlation between the CRC high-risk population predicted by the nomogram model and the actual CRC high-risk population.CONCLUSION The early-screening nomogram model for CRC prediction in high-risk populations developed in this study based on age,BMI,WC,lifestyle,and family history exhibited high accuracy.

从中国有症状和无症状人群中分离的芽囊原虫感染率和亚型分布的meta分析(英文)

目的:了解中国有症状人群和无症状人群芽囊原虫的流行情况及亚型分布。方法:采用Mesh主题词和自由词,包括“芽囊原虫“”人芽囊原虫“”芽囊原虫感染“”流行病学“”患病率“”发生情况“”亚型“”基因型“”中国”等在中英文数据库进行系统检索。采用Cochran's Q检验和Stata 14的I2指数进行异质性检验。结果:共纳入16项研究。芽囊原虫的分子检出率为10%(95%CI:0.07~0.12)。无症状人群芽囊原虫感染率14%(95%CI:0.08~0.19)高于有症状人群7%(95%CI:0.05~0.09)。芽囊原虫最常见的亚型为ST3,在无症状人群中感染率为7%(95%CI:0.04~0.09),在有症状人群中为3%(95%CI:0.02~0.04)。其次为ST1,在无症状人群中感染率为2%(95%CI:0.01~0.04),在有症状人群中感染率为2%(95%CI:0.01~0.03)。结论:芽囊原虫的致病性无亚型特异性,无症状人群的感染率高于有症状人群。

Rational Use of Computed Tomography for Individual Health Assessment in Asymptomatic Population： Chinese Experience

INTRODUCTIONSince computed tomography （CT） was invented and used clinically or in research, it is currently widely used in the diagnosis, staging, assessment of disease response to treatment, with clearer image quality and shorter scanning time. There are many diseases which are not easily found at an early stage with noticeable symptoms,

Safety and immunogenicity of inactivated SARS-CoV-2 vaccine in high-risk occupational population:a randomized,parallel,controlled clinical trial

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting coronavirus disease 2019 (COVID-19) have a substantial burden on health-care systems around the world. This is a randomized parallel controlled trial for assessment of the immunogenicity and safety of an inactivated SARS-CoV-2 vaccine, aiming to determine an appropriate vaccination interval of the vaccine for high-risk occupational population.Methods: In an ongoing randomized, parallel, controlled phase IV trial between January and May 2021 in Taiyuan City, Shanxi Province, China, we randomly assigned the airport ground staff and public security officers aged 18 to 59 years to receive two doses of inactivated SARS-CoV-2 vaccine at 14 days, 21 days, or 28 days. The serum neutralizing antibody to live SARS-CoV-2 was performed at baseline and 28 days after immunization. Long-term data are being collected. The primary immunogenicity endpoints were neutralization antibody seroconversion and geometric mean titer (GMT) at 28 days after the second dose. Analysis of variance (ANOVA), chi-square, and logistic regression analysis were used for data analysis.Results: A total of 809 participants underwent randomization and received two doses of injections: 270, 270, 269 in the 0-14, 0-21, and 0-28 vaccination group, respectively. By day 28 after the second injection, SARS-CoV-2 neutralizing antibody of GMT was 98.4 (95%CI: 88.4-108.4) in the 0-14 group, which was significantly lower compared with 134.4 (95%CI: 123.1-145.7) in the 0-21 group (P < 0.001 vs 0-14 group) and 145.5 (95%CI: 131.3-159.6) in the 0-28 group (P < 0.001 vs 0-14 group), resulting in the seroconversion rates to neutralizing antibodies (GMT ≥ 16) of 100.0% for all three groups, respectively. The intention-to-treat (ITT) analysis yielded similar results. All reported adverse reactions were mild.Conclusions: Both a two-dose of inactivated SARS-CoV-2 vaccine at 0-21 days and 0-28 days regimens significantly improved SARS-CoV-2 neutralizing antibody level compared to the 0-14 days regimen in high-risk occupational population, with seroconversion rates of 100.0%.

载脂蛋白对无症状非糖尿病人群冠状动脉粥样硬化的预测价值

目的分析无症状非糖尿病人群载脂蛋白（Apo）水平及Apo B/Apo A1比值,研究其与冠状动脉粥样硬化发生的相关性及对冠状动脉病变的预测价值。方法回顾性分析2013年4月至2014年3月在中国人民解放军总医院行冠状动脉CT血管成像和血生化检查的无症状体检者401例,根据检查结果分为粥样硬化组（n=224）和对照组（n=177）,比较两组相关危险因素、脂质及Apo水平,找出预测冠状动脉粥样硬化的最佳血脂指标。结果粥样硬化组Apo B、Apo C2、Apo C3、Apo E水平及Apo B/ApoA1比值均显著高于对照组（P均〈0.01）,Apo A1、ApoA2及脂蛋白a水平两组间差异无统计学意义（P均〉0.05）。Logistic回归分析结果显示,年龄、男性、高血压病史、Apo C3（OR=1.572,95%CI1.200-2.061）及ApoB/Apo A1（OR=1.767,95%CI 1.335-2.338）是本研究人群冠状动脉粥样硬化的独立危险因素（P均〈0.01）。预测冠状动脉病变的受试者工作特征曲线分析结果显示,ApoB的曲线下面积最大,最佳截断点为1.005 g/L。结论 ApoC3与亚临床期冠状动脉粥样硬化关系密切,这一时期ApoA1降低并不明显,ApoB较其他脂类指标对无症状非糖尿病人群冠状动脉病变有很强的预测价值。

广东籍献血人群HTLV感染状况调查

目的了解东南沿海省份的无症状献血人群人类嗜T淋巴细胞病毒(human T cell lymphotvopic virus,HTLV)的血清学流行状况。方法从符合卫生部健康标准并经血液常规检测合格的标本中,依据籍贯选择性收集2 500份血样,采用双抗原夹心的酶免吸附(EIA)方法进行HTLV-Ⅰ/Ⅱ抗体筛查。EIA初筛阳性结果经复检后,由蛋白印迹法(Western Blot,WB)进行确认试验。结果初筛获得EIA反应性样本5例,HTLV抗体阳性率为0.20%(5/2 500),均为广东籍。经蛋白印迹试验,仅1例OD值为3.00的EIA强反应者获确认为HTLV-Ⅰ型病毒感染,2例未获确认,2例为确认阴性。经追溯,确认HTLV-Ⅰ阳性者为无症状定期献血者,已有6次合格献血经历。结论尽管深圳献血人群HTLV流行率的总体水平较低,但多次献血的经历使经血传播HTLV的风险增大数倍。

无症状人群盆底表面肌电的研究及其临床意义

目的探讨无症状人群盆底表面肌电特征。方法采用多中心研究，南京市中医院、沈阳肛肠医院及湖州肛肠医院共招募无症状人群116例，按照性别、年龄进行分组。采用Glazer盆底表面肌电评估方案采集静息及收缩状态的波幅、变异系数、收缩反应时间及中值频率。结果男性在不同收缩阶段其收缩波幅均明显大于女性（P〈0．05）；随着年龄增加，快速收缩时收缩反应时间延长，持续收缩时收缩波幅下降、变异系数升高，耐久收缩时变异系数升高。结论初步获得了无症状人群盆底表面肌电值范围，说明了不同性别及年龄段之间有差异，为今后的研究提供了参考依据，具有一定的临床应用前景。

胶囊内镜在无症状人群体检中的应用价值

目的探讨胶囊内镜在无症状人群体检中的应用价值。方法回顾性分析2013年3月至2014年9月期间282例无症状体检者在爱康国宾体检中心采用胶囊内镜行消化道检查的临床资料,观察胶囊内镜检查的耐受性、安全性、消化道各段运行时间以及病变检出情况。结果 282例受检者中,276例(97.9%)顺利完成胶囊内镜检查,66.3%(183/276)发现消化道病变,57.6%(159/276)检出小肠病变,所检出小肠病变以淋巴管扩张、非特异性小肠炎(充血、糜烂、散在浅溃疡)、十二指肠炎、十二指肠糜烂、毛细血管扩张等多见。胶囊在胃内平均运行时间为(55.0±72.7)min,在小肠内平均运行时间为(243.6±102.6)min。检查过程中,受检者无不适感。受检者均于检查后72 h内排出胶囊。结论小肠病变在无症状人群中的检出率并不低,胶囊内镜作为一种无创、简便、安全、有效的消化道检查手段,应用于无症状人群的体检中,有助于小肠病变的早期检出,为小肠疾病的早期诊断、早期治疗提供有力依据。

4214名健康体检者幽门螺杆菌检验结果分析

目的探讨大连地区体检人群幽门螺杆菌尿素酶抗体阳性率及分布特点。方法用胶体金法对2013年9月至2015年9月期间在大连市第三人民医院做体检的4214名健康体检者的幽门螺杆菌尿素酶抗体进行检测,以性别和年龄进行分组,对其检验结果进行统计学分析。结果 4214名健康体检者幽门螺杆菌总阳性率为21.76%（917/4214）;其中男性和女性健康体检者阳性率分别为23.98%（480/2002）、19.76%（437/2212）,男性和女性健康体检者幽门螺杆菌阳性率比较,差异有统计学意义（P〈0.05）;再将这些体检者分为〈45岁、45-59岁、60-74岁和75-89岁4个组,幽门螺杆菌阳性率在4个年龄组分别为19.13%（447/2337）、24.77%（357/1441）、26.09%（102/391）和24.44%（11/45）,组间幽门螺杆菌尿素酶抗体阳性率差异具有统计学意义（P〈0.05）。结论大连地区体检人群幽门螺杆菌尿素酶抗体阳性率分布与性别和年龄有关。

中老年体检人群无症状性颈动脉狭窄发病现状及危险因素研究

目的探讨中老年体检人群无症状性颈动脉狭窄(ACS)发病率及危险因素。方法选取2019年3月~2019年9月哈尔滨医科大学附属第一医院中老年体检人群1926例,均行颈动脉超声检查,记录ACS患病率,并收集研究对象的一般资料和临床资料,比较不同临床特征人群ACS患病率差异,多因素logistic回归分析ACS发生的危险因素。结果ACS678例(ACS组),未患ACS1248例(非ACS组),ACS患病率为35.20%;单因素结果显示,ACS组年龄、性别比例、体质指数、文化程度、吸烟、饮酒、体育锻炼、高血压、糖尿病、高脂血症、收缩压、血肌酐、尿酸、空腹血糖、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇与非ACS组比较,差异均有统计学意义(P<0.05),婚姻状况、舒张压、尿素氮等与非ACS组比较,差异无统计学意义(P>0.05);多因素logistic回归分析结果显示,年龄>65岁、男性、糖尿病、吸烟、高脂血症是中老年体检人群发生ACS的危险因素(P<0.01),体育锻炼是其保护因素(P<0.001)。结论中老年人群ACS患病率较高,年龄>65岁、男性、糖尿病、吸烟、高脂血症可增加ACS发生风险。提示对于老年男性人群应戒烟,对糖尿病、高脂血症等基础疾病早期干预、积极治疗,同时进行适量体育锻炼,有助于降低ACS发生率。

OMOM胶囊内镜在无症状人群体检中的应用

目的探讨OMOM胶囊内镜在无症状人群体检中应用价值。方法受检者为2005年8月-2010年3月到北京军区总医院消化内科进行胶囊内镜检查的无症状体检人群,受检者按就诊的时间顺序随机分为研究组(A组)、对照组(B组)、自身对照组(C组)。A组受检者按一定体位进行胶囊内镜检查,送服胶囊后立即依次平卧位3 min,左侧卧位3 min,右侧卧位3 min,半卧位3min,观察食管黏膜情况,再观察胃依次左侧卧位10 min,平卧位10 min,右侧卧位10 min,站立位10 min,随后可自由活动,直至胶囊内镜排出体外。B组受检者按常规要求进行胶囊内镜检查。C组受检者进行胶囊内镜检查后即安排胃镜和结肠镜检查。结果 A组和B组胶囊内镜食管运行平均时间和胃排空平均时间差异均有统计学意义(P<0.05);但A组和B组胶囊内镜排出平均时间差异无统计学意义(P>0.05)。A组和C组胶囊内镜食管运行平均时间和排出平均时间差异均有统计学意义(P<0.05);但A组和C组胶囊内镜胃排空平均时间差异无统计学意义(P>0.05)。90例A组受检者中检出消化道病变者28例,检出率31.11%;160例B组受检者中检出消化道病变者42例,检出率26.25%;110例C组受检者中检出消化道病变者43例,检出率39.09%。A组和B组食管病变检出率比较差异具有统计学意义(P<0.05)。结论胶囊内镜在特定体位下可以提高食管及胃病变检出率。胶囊内镜检查可以指导胃镜及结肠镜检查能更有效提高消化道疾病检出率,用于无症状人群体检无疑是一种安全、无创、无痛苦的消化道检查方法。

苏南地区无症状人群大肠息肉病理特点分析

目的 对苏南地区无症状人群大肠息肉的病理类型结构进行评价分析.方法 选取我院2013年1月~2015年12月进行健康体检并检出结肠息肉的无症状平均风险人群患者359例,根据年龄分为<45岁(青年),45~60岁(中年),>60岁(老年)三个组,对每个年龄组大肠息肉患者的病理类型进行统计学分析.结果 所有发现结肠息肉患者中,男性比例较高(69.4%);三个年龄段的息肉病理类型构成中,中年组(45~60岁)的腺瘤性息肉所占比例最高(68.8%),而青年组(<45岁)及老年组(>60岁)的腺瘤性息肉比例较低,其差异有统计学意义(P<0.05).结论 对于中年以上(>45岁)的人群,特别是男性人群,应提高结肠镜的检查率,对检出的结肠息肉尽可能早期干预治疗,对结肠癌的防治有重要意义.