SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the world.Asymptomatic transmission of SARS-CoV-2 is the Achilles’heel of COVID-19 public health control measures.Phylogenomic data...SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the world.Asymptomatic transmission of SARS-CoV-2 is the Achilles’heel of COVID-19 public health control measures.Phylogenomic data on SARS-CoV-2 could provide more direct information about asymptomatic transmission.In this study,using a novel MINERVA sequencing technology,we traced asymptomatic transmission of COVID-19 patients in Beijing,China.One hundred and seventy-eight close contacts were quarantined,and 14 COVID-19 patients were laboratory confirmed by RT-PCR.We provide direct phylogenomic evidence of asymptomatic transmission by constructing the median joining network in the cluster.These data could help us to determine whether the current symptom-based screening should cover asymptomatic persons.展开更多
基金This work was supported by the National Key Research and Development Project of China(2020YFC0840800)the National Natural Science Foundation of China(no.31801093).
文摘SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the world.Asymptomatic transmission of SARS-CoV-2 is the Achilles’heel of COVID-19 public health control measures.Phylogenomic data on SARS-CoV-2 could provide more direct information about asymptomatic transmission.In this study,using a novel MINERVA sequencing technology,we traced asymptomatic transmission of COVID-19 patients in Beijing,China.One hundred and seventy-eight close contacts were quarantined,and 14 COVID-19 patients were laboratory confirmed by RT-PCR.We provide direct phylogenomic evidence of asymptomatic transmission by constructing the median joining network in the cluster.These data could help us to determine whether the current symptom-based screening should cover asymptomatic persons.
