Cardiovascular disease,predominantly coronary heart disease and stroke,leads to high morbidity and mortality not only in developed worlds but also in underdeveloped regions.The dominant pathologic foundation for cardi...Cardiovascular disease,predominantly coronary heart disease and stroke,leads to high morbidity and mortality not only in developed worlds but also in underdeveloped regions.The dominant pathologic foundation for cardiovascular disease is atherosclerosis and,as to coronary heart disease,coronary atherosclerosis and resulting lumen stenosis,even total occlusions.In translational research,several animals,such as mice,rabbits and pigs,have been used as disease models of human atherosclerosis and related cardiovascular disorders.However,coronary lesions are either naturally rare or hard to be fast induced in these models,hence,coronary heart disease induction mostly relies on surgical or pharmaceutical interventions with no or limited primary coronary lesions,thus unrepresentative of human coronary heart disease progression and pathology.In this review,we describe the progress of animal models of coronary heart disease following either spontaneous or diet-accelerated coronary lesions.展开更多
Coronary atherosclerotic heart disease had been regarded as the leading killer of human being.The atherosclerotic lesion would cause blood flow blockage or lumen stenosis of coronary arteries,thus resulting in myocard...Coronary atherosclerotic heart disease had been regarded as the leading killer of human being.The atherosclerotic lesion would cause blood flow blockage or lumen stenosis of coronary arteries,thus resulting in myocardial ischemic or sudden cardiac death.Though exact causes of coronary atherosclerosis heart disease is not known,the promising Apo C-Ⅲthat played a crucial role in metabolism of triglyceride-rich lipoproteins had been supposed to be one of the key factor of pathogenesis.In this review,we discuss roles of Apo C-Ⅲin the development of CAD and its insights being a new therapeutic target.展开更多
文摘Cardiovascular disease,predominantly coronary heart disease and stroke,leads to high morbidity and mortality not only in developed worlds but also in underdeveloped regions.The dominant pathologic foundation for cardiovascular disease is atherosclerosis and,as to coronary heart disease,coronary atherosclerosis and resulting lumen stenosis,even total occlusions.In translational research,several animals,such as mice,rabbits and pigs,have been used as disease models of human atherosclerosis and related cardiovascular disorders.However,coronary lesions are either naturally rare or hard to be fast induced in these models,hence,coronary heart disease induction mostly relies on surgical or pharmaceutical interventions with no or limited primary coronary lesions,thus unrepresentative of human coronary heart disease progression and pathology.In this review,we describe the progress of animal models of coronary heart disease following either spontaneous or diet-accelerated coronary lesions.
文摘Coronary atherosclerotic heart disease had been regarded as the leading killer of human being.The atherosclerotic lesion would cause blood flow blockage or lumen stenosis of coronary arteries,thus resulting in myocardial ischemic or sudden cardiac death.Though exact causes of coronary atherosclerosis heart disease is not known,the promising Apo C-Ⅲthat played a crucial role in metabolism of triglyceride-rich lipoproteins had been supposed to be one of the key factor of pathogenesis.In this review,we discuss roles of Apo C-Ⅲin the development of CAD and its insights being a new therapeutic target.
