Genome-wide association studies have found that rs17612742 increases the risk of large artery atherosclerotic stroke.The rs17612742 was located in the intron region of Endothelin receptor type A(NRA),which was cellula...Genome-wide association studies have found that rs17612742 increases the risk of large artery atherosclerotic stroke.The rs17612742 was located in the intron region of Endothelin receptor type A(NRA),which was cellular and gender-heterogeneous.Functional genomics studies of rs17612742 were carried out through some public databases,and it was found that rs17612742 was located in the chromatin open region and promoted the expression of NRA.Compared with the control group,EDNRA expression increased in middle cerebral artery occlusion exposed rodents.However,age heterogeneity of EDNRA expression under physiological and pathological conditions was not observed.In addition,we also discussed how to conduct further empirical studies to provide evidence that rs17612742 confers the risk of large artery atherosclerotic stroke by increasing the expression of NRA.展开更多
Ischemic stroke resulting from atherosclerosis(particularly in the carotid artery)is one of the major subtypes of stroke and has a high incidence of death.Disordered lipid homeostasis,lipid deposition,local macrophage...Ischemic stroke resulting from atherosclerosis(particularly in the carotid artery)is one of the major subtypes of stroke and has a high incidence of death.Disordered lipid homeostasis,lipid deposition,local macrophage infiltration,smooth muscle cell proliferation,and plaque rupture are the main pathological processes of atherosclerotic ischemic stroke.Hepatocytes,macrophages,endothelial cells and vascular smooth muscle cells are the main cell types participating in these processes.By inhibiting the expression of the target genes in these cells,microRNAs play a key role in regulating lipid disorders and atherosclerotic ischemic stroke.In this article,we listed the microRNAs implicated in the pathology of atherosclerotic ischemic stroke and aimed to explain their pro-or antiatherosclerotic roles.Our article provides an update on the potential diagnostic use of miRNAs for detecting growing plaques and impending clinical events.Finally,we provide a perspective on the therapeutic use of local microRNA delivery and discuss the challenges for this potential therapy.展开更多
文摘Genome-wide association studies have found that rs17612742 increases the risk of large artery atherosclerotic stroke.The rs17612742 was located in the intron region of Endothelin receptor type A(NRA),which was cellular and gender-heterogeneous.Functional genomics studies of rs17612742 were carried out through some public databases,and it was found that rs17612742 was located in the chromatin open region and promoted the expression of NRA.Compared with the control group,EDNRA expression increased in middle cerebral artery occlusion exposed rodents.However,age heterogeneity of EDNRA expression under physiological and pathological conditions was not observed.In addition,we also discussed how to conduct further empirical studies to provide evidence that rs17612742 confers the risk of large artery atherosclerotic stroke by increasing the expression of NRA.
文摘Ischemic stroke resulting from atherosclerosis(particularly in the carotid artery)is one of the major subtypes of stroke and has a high incidence of death.Disordered lipid homeostasis,lipid deposition,local macrophage infiltration,smooth muscle cell proliferation,and plaque rupture are the main pathological processes of atherosclerotic ischemic stroke.Hepatocytes,macrophages,endothelial cells and vascular smooth muscle cells are the main cell types participating in these processes.By inhibiting the expression of the target genes in these cells,microRNAs play a key role in regulating lipid disorders and atherosclerotic ischemic stroke.In this article,we listed the microRNAs implicated in the pathology of atherosclerotic ischemic stroke and aimed to explain their pro-or antiatherosclerotic roles.Our article provides an update on the potential diagnostic use of miRNAs for detecting growing plaques and impending clinical events.Finally,we provide a perspective on the therapeutic use of local microRNA delivery and discuss the challenges for this potential therapy.
