由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3000余张患者图片,约合中...由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3000余张患者图片,约合中文170万字。此书分为Overview、Diagnosis of Uveitis、Treatment of Uveitis.Uveitisentities,Scleritis and Episcleritis四大部分,详细介绍了葡萄膜炎类疾病的疾病谱,常见类型的临床特征、进展和致盲规律,疾病诊疗的思想、原则、策略,并使用大量精美图片展现了常见葡萄膜炎类型的表现谱,即从发病到疾病后期,从最细微的异常到最严重的改变,从罕见的表现到典型的特征,展示出葡萄膜炎的全貌和细节,既可使临床医师快速掌握疾病要点,又不至于遗漏细微之处。这也是中国眼科医师首次向国际介绍葡萄膜炎诊疗的中国标准、方案和经验。展开更多
The development of epigenetic maps, such as the ENCODE project in humans, provides resources for gene regulation studies and a reference for research of disease-related regulatory elements. However,epigenetic informat...The development of epigenetic maps, such as the ENCODE project in humans, provides resources for gene regulation studies and a reference for research of disease-related regulatory elements. However,epigenetic information, such as a bird-specific chromatin accessibility atlas, is currently lacking for the thousands of bird species currently described.The major genomic difference between birds and mammals is their shorter introns and intergenic distances, which seriously hinders the use of humans and mice as a reference for studying the function of important regulatory regions in birds. In this study, using chicken as a model bird species, we systematically compiled a chicken chromatin accessibility atlas using 53 Assay of Transposase Accessible Chromatin sequencing(ATAC-seq)samples across 11 tissues. An average of 50 ?796open chromatin regions were identified per sample,cumulatively accounting for 20.36% of the chicken genome. Tissue specificity was largely reflected by differences in intergenic and intronic peaks, with specific functional regulation achieved by two mechanisms: recruitment of several sequence-specific transcription factors and direct regulation of adjacent functional genes. By integrating data from genome-wide association studies, our results suggest that chicken body weight is driven by different regulatory variants active in growth-relevant tissues. We propose CAB39L(active in the duodenum), RCBTB1(muscle and liver), and novel long non-coding RNA ENSGALG00000053256(bone) as candidate genes regulating chicken body weight. Overall, this study demonstrates the value of epigenetic data in fine-mapping functional variants and provides a compendium of resources for further research on the epigenetics and evolution of birds and mammals.展开更多
The development of orogenic belts structures in the Southern-Central Tunisian Atlas is influenced by the evolution of tectonic activities during different phases,which are also closely linked to the formation of gravi...The development of orogenic belts structures in the Southern-Central Tunisian Atlas is influenced by the evolution of tectonic activities during different phases,which are also closely linked to the formation of gravitational collapse structure.The typical example is that of the northern flank of the Jebel Orbata particularly the Ben Zannouch fold.It is an asymmetrical anticline interpreted by the model of“Fault Propagation Folds”.The development of the Ben Zannouch structures is resulted from landslides,scree falls and inverted layers plunging to the south.The direction of resulted gravitational structure is parallel to the main thrust direction of the Bou Omrane anticline.The thrust activity of Bou Omrane fault is associated to the important paleo-slope facing south and plastic lithology(incompetent marl layers)of outcropped series,facilitates the development of the Ben Zannouch Flap structure.The definition of gravitational collapse structures for the first time in Tunisia particularly in the northern flank of the Jebel Orbata is controlled by many principal structural conditions:fragmentation of the landslide surfaces,rheology and topography.Other regional factors can be distinguished in the Southern-Central Tunisian Atlas as the seismic activity of the pre-existing Gafsa fault reactivated during compressive phases and the weather conditions during the postglacial period.展开更多
2022年10月,林金杏、陈秋生、胡建华撰写的英文专著Color Atlas of Zebrafish Histology and Cytology由Springer Singapore出版(https://link.springer.com/book/10.1007/978-981-16-9852-1)。本书共分15章,包含700余幅原创性图片,总页...2022年10月,林金杏、陈秋生、胡建华撰写的英文专著Color Atlas of Zebrafish Histology and Cytology由Springer Singapore出版(https://link.springer.com/book/10.1007/978-981-16-9852-1)。本书共分15章,包含700余幅原创性图片,总页码304页,首先展示斑马鱼全鱼横切和纵切的组织学全貌,然后详细系统地解读斑马鱼体内消化、呼吸、泌尿、生殖、免疫、内分泌、心血管、神经、感觉、表皮、肌肉和骨骼等组织器官的微细结构,并对斑马鱼主要器官进行3D重构,以直观展现其立体形态。展开更多
由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3 000余张患者图片,约合...由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3 000余张患者图片,约合中文170万字。展开更多
由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3000余张患者图片,约合中...由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3000余张患者图片,约合中文l70万字。展开更多
由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3000余张患者图片,约合中...由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3000余张患者图片,约合中文l70万字。此书分为Overview、Diagnosis of Uveitis、Treatment of Uveitis.Uveitisentities,Scleritis and Episcleritis四大部分,详细介绍了葡萄膜炎类疾病的疾病谱,常见类型的临床特征、进展和致盲规律,疾病诊疗的思想、原则、策略。展开更多
由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3 000余张患者图片,约合...由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3 000余张患者图片,约合中文170万字。此书分为Overview、Diagnosis of Uveitis、Treatment of Uveitis. Uveitisentities,Scleritis and Episcleritis四大部分,详细介绍了葡萄膜炎类疾病的疾病谱,常见类型的临床特征、进展和致盲规律,疾病诊疗的思想、原则、策略,并使用大量精美图片展现了常见葡萄膜炎类型的表现谱,即从发病到疾病后期,从最细微的异常到最严重的改变,从罕见的表现到典型的特征,展示出葡萄膜炎的全貌和细节,既可使临床医师快速掌握疾病要点,又不至于遗漏细微之处。展开更多
由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3000余张患者图片,约合中...由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3000余张患者图片,约合中文l70万字。此书分为Overview、Diagnosis of Uveitis、Treatment of Uveitis.Uveitisentities,Scleritis and Episcleritis四大部分,详细介绍了葡萄膜炎类疾病的疾病谱,常见类型的临床特征、进展和致盲规律,疾病诊疗的思想、原则、策略,并使用大量精美图片展现了常见葡萄膜炎类型的表现谱,即从发病到疾病后期,从最细微的异常到最严重的改变,从罕见的表现到典型的特征,展示出葡萄膜炎的全貌和细节,既可使临床医师快速掌握疾病要点,又不至于遗漏细微之处。这也是中国眼科医师首次向国际介绍葡萄膜炎诊疗的中国标准、方案和经验。本书的主要阅读对象为眼科各级医师、硕士和博士研究生,对葡萄膜炎诊断治疗及研究具有指导价值,同时也可为免疫性疾病专业的医师提供参考和帮助。展开更多
由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3000余张患者图片,约合中...由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3000余张患者图片,约合中文l70万字。此书分为Overview、Diagnosis of Uveitis、Treatment of Uveitis.Uveitisentities,Scleritis and Episcleritis四大部分,详细介绍了葡萄膜炎类疾病的疾病谱,常见类型的临床特征、进展和致盲规律,疾病诊疗的思想、原则、策略,并使用大量精美图片展现了常见葡萄膜炎类型的表现谱,即从发病到疾病后期,从最细微的异常到最严重的改变,从罕见的表现到典型的特征,展示出葡萄膜炎的全貌和细节,既可使临床医师快速掌握疾病要点,又不至于遗漏细微之处。展开更多
文摘由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3000余张患者图片,约合中文170万字。此书分为Overview、Diagnosis of Uveitis、Treatment of Uveitis.Uveitisentities,Scleritis and Episcleritis四大部分,详细介绍了葡萄膜炎类疾病的疾病谱,常见类型的临床特征、进展和致盲规律,疾病诊疗的思想、原则、策略,并使用大量精美图片展现了常见葡萄膜炎类型的表现谱,即从发病到疾病后期,从最细微的异常到最严重的改变,从罕见的表现到典型的特征,展示出葡萄膜炎的全貌和细节,既可使临床医师快速掌握疾病要点,又不至于遗漏细微之处。这也是中国眼科医师首次向国际介绍葡萄膜炎诊疗的中国标准、方案和经验。
基金supported by the National Natural Science Foundation of China(U2002205,32272862)。
文摘The development of epigenetic maps, such as the ENCODE project in humans, provides resources for gene regulation studies and a reference for research of disease-related regulatory elements. However,epigenetic information, such as a bird-specific chromatin accessibility atlas, is currently lacking for the thousands of bird species currently described.The major genomic difference between birds and mammals is their shorter introns and intergenic distances, which seriously hinders the use of humans and mice as a reference for studying the function of important regulatory regions in birds. In this study, using chicken as a model bird species, we systematically compiled a chicken chromatin accessibility atlas using 53 Assay of Transposase Accessible Chromatin sequencing(ATAC-seq)samples across 11 tissues. An average of 50 ?796open chromatin regions were identified per sample,cumulatively accounting for 20.36% of the chicken genome. Tissue specificity was largely reflected by differences in intergenic and intronic peaks, with specific functional regulation achieved by two mechanisms: recruitment of several sequence-specific transcription factors and direct regulation of adjacent functional genes. By integrating data from genome-wide association studies, our results suggest that chicken body weight is driven by different regulatory variants active in growth-relevant tissues. We propose CAB39L(active in the duodenum), RCBTB1(muscle and liver), and novel long non-coding RNA ENSGALG00000053256(bone) as candidate genes regulating chicken body weight. Overall, this study demonstrates the value of epigenetic data in fine-mapping functional variants and provides a compendium of resources for further research on the epigenetics and evolution of birds and mammals.
基金supported by the Tunisian Ministry of Higher Education and Scientific Research,particularly Research Laboratory Geosystems,Goresources and Goenvironments LR21ES05 at the Faculty of Sciences Gabès。
文摘The development of orogenic belts structures in the Southern-Central Tunisian Atlas is influenced by the evolution of tectonic activities during different phases,which are also closely linked to the formation of gravitational collapse structure.The typical example is that of the northern flank of the Jebel Orbata particularly the Ben Zannouch fold.It is an asymmetrical anticline interpreted by the model of“Fault Propagation Folds”.The development of the Ben Zannouch structures is resulted from landslides,scree falls and inverted layers plunging to the south.The direction of resulted gravitational structure is parallel to the main thrust direction of the Bou Omrane anticline.The thrust activity of Bou Omrane fault is associated to the important paleo-slope facing south and plastic lithology(incompetent marl layers)of outcropped series,facilitates the development of the Ben Zannouch Flap structure.The definition of gravitational collapse structures for the first time in Tunisia particularly in the northern flank of the Jebel Orbata is controlled by many principal structural conditions:fragmentation of the landslide surfaces,rheology and topography.Other regional factors can be distinguished in the Southern-Central Tunisian Atlas as the seismic activity of the pre-existing Gafsa fault reactivated during compressive phases and the weather conditions during the postglacial period.
文摘2022年10月,林金杏、陈秋生、胡建华撰写的英文专著Color Atlas of Zebrafish Histology and Cytology由Springer Singapore出版(https://link.springer.com/book/10.1007/978-981-16-9852-1)。本书共分15章,包含700余幅原创性图片,总页码304页,首先展示斑马鱼全鱼横切和纵切的组织学全貌,然后详细系统地解读斑马鱼体内消化、呼吸、泌尿、生殖、免疫、内分泌、心血管、神经、感觉、表皮、肌肉和骨骼等组织器官的微细结构,并对斑马鱼主要器官进行3D重构,以直观展现其立体形态。
文摘由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3000余张患者图片,约合中文l70万字。此书分为Overview、Diagnosis of Uveitis、Treatment of Uveitis.Uveitisentities,Scleritis and Episcleritis四大部分,详细介绍了葡萄膜炎类疾病的疾病谱,常见类型的临床特征、进展和致盲规律,疾病诊疗的思想、原则、策略。
文摘由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3 000余张患者图片,约合中文170万字。此书分为Overview、Diagnosis of Uveitis、Treatment of Uveitis. Uveitisentities,Scleritis and Episcleritis四大部分,详细介绍了葡萄膜炎类疾病的疾病谱,常见类型的临床特征、进展和致盲规律,疾病诊疗的思想、原则、策略,并使用大量精美图片展现了常见葡萄膜炎类型的表现谱,即从发病到疾病后期,从最细微的异常到最严重的改变,从罕见的表现到典型的特征,展示出葡萄膜炎的全貌和细节,既可使临床医师快速掌握疾病要点,又不至于遗漏细微之处。
文摘由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3000余张患者图片,约合中文l70万字。此书分为Overview、Diagnosis of Uveitis、Treatment of Uveitis.Uveitisentities,Scleritis and Episcleritis四大部分,详细介绍了葡萄膜炎类疾病的疾病谱,常见类型的临床特征、进展和致盲规律,疾病诊疗的思想、原则、策略,并使用大量精美图片展现了常见葡萄膜炎类型的表现谱,即从发病到疾病后期,从最细微的异常到最严重的改变,从罕见的表现到典型的特征,展示出葡萄膜炎的全貌和细节,既可使临床医师快速掌握疾病要点,又不至于遗漏细微之处。这也是中国眼科医师首次向国际介绍葡萄膜炎诊疗的中国标准、方案和经验。本书的主要阅读对象为眼科各级医师、硕士和博士研究生,对葡萄膜炎诊断治疗及研究具有指导价值,同时也可为免疫性疾病专业的医师提供参考和帮助。
文摘由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3000余张患者图片,约合中文l70万字。此书分为Overview、Diagnosis of Uveitis、Treatment of Uveitis.Uveitisentities,Scleritis and Episcleritis四大部分,详细介绍了葡萄膜炎类疾病的疾病谱,常见类型的临床特征、进展和致盲规律,疾病诊疗的思想、原则、策略,并使用大量精美图片展现了常见葡萄膜炎类型的表现谱,即从发病到疾病后期,从最细微的异常到最严重的改变,从罕见的表现到典型的特征,展示出葡萄膜炎的全貌和细节,既可使临床医师快速掌握疾病要点,又不至于遗漏细微之处。
