In this paper, we introduce a new class of p-valent analytic functions defined by using a linear operator Lαk . For functions in this class Hαk （p,λ;h） we estimate the coefficients. Furthermore, some subordinatio...In this paper, we introduce a new class of p-valent analytic functions defined by using a linear operator Lαk . For functions in this class Hαk （p,λ;h） we estimate the coefficients. Furthermore, some subordination properties related to the operator Lαk are also derived.展开更多
Congenital analbuminemia is a rare autosomic recessive inherited disorder characterized by low plasma albumin and hypercholesterolemia, which may increase cardiovascular risk. Patients are essentially asymptomatic, ap...Congenital analbuminemia is a rare autosomic recessive inherited disorder characterized by low plasma albumin and hypercholesterolemia, which may increase cardiovascular risk. Patients are essentially asymptomatic, apart from ease of fatigue, minimal ankle oedema and hypotension. There is no accepted strategy for safely treating both hypercholesterolemia and analbuminemia in order to eventually decrease the atherosclerotic risk. We report a case of congenital analbuminemia(1.0 g/dL) in a 38-year-old male with hypercholesterolemia(range: 406-475 mg/dL) and severe arterial dysfunction [no brachial artery flow-mediated dilation(FMD)]. Long-term, cholesterol-lowering treatment with atorvastatin was associated with the appearance of peripheral edema. Twomonths of infusion with albumin improved FMD(7%) and reduced serum cholesterol(273 mg/dL), supporting the hypothesis of a compensatory role of hypercholesterolemia. Statin treatment, together with periodical albumin infusions, may contribute to the safe reduction of cardiovascular risk.展开更多
This paper introduces a dynamic facilitating mechan is m for the integration of process planning and scheduling in a batch-manufacturi ng environment. This integration is essential for the optimum use of production re...This paper introduces a dynamic facilitating mechan is m for the integration of process planning and scheduling in a batch-manufacturi ng environment. This integration is essential for the optimum use of production resources and generation of realistic process plans that can be readily executed with little or no modification. In this paper, integration is modeled in two le vels, viz., process planning and scheduling, which are linked by an intelligent facilitator. The process planning module employs an optimization approach in whi ch the entire plan solution space is first generated and a search algorithm is t hen used to find the optimal plan. Based on the result of scheduling module an u nsatisfactory performance parameter is fed back to the facilitator, which then i dentifies a particular job and issues a change to its process plan solution spac e to obtain a satisfactory schedule.展开更多
AIM:To study the possible actions and mechanisms of peroxisome proliferator-activated receptorγ(PPARγ) ,a ligand-activated transcription factor,in pancreatic carcinogenesis,especially in angiogenesis. METHODS:Expres...AIM:To study the possible actions and mechanisms of peroxisome proliferator-activated receptorγ(PPARγ) ,a ligand-activated transcription factor,in pancreatic carcinogenesis,especially in angiogenesis. METHODS:Expressions of PPARγand retinoid acid receptor(RXRα) were examined by reverse-transcription polymerase chain reaction(RT-PCR) with immunocytochemical staining.Pancreatic carcinoma cells,PANC-1,were treated either with 9-cis-RA,a ligand of RXRα,or with 15-deoxy-Δ 12,14 prostaglandin J2(15d-PGJ2) ,a ligand of PPARγ,or both.Antiproliferative effect was evaluated by cell viability using methyltetrazolium(MTT) assay.A pancreatic carcinoma xenograft tumor model of nude mice was established by inoculating PANC-1 cells subcutaneously.Rosiglitazone,a specific ligand of PPARγ,was administered via water drinking in experimental group of nude mice.After 75 d,all mice were sacrificed.Expression of proliferating cell nuclear antigen(PCNA) in tumor tissue was examined with immunohistochemical staining.Expression of vascular endothelial growth factor(VEGF) mRNA in PANC-1 cells,which were treated with 15d-PGJ2 or 9-cis-RA at various concentrations or different duration,was detected by semi-quantitative RT-PCR.Effects of Rosiglitazone on changes of microvascular density(MVD) and VEGF expression were investigated in xenograft tumor tissue.Neovasculature was detected with immunohistochemistry staining labeled with anti-Ⅳcollagen antibody,and indicated by MVD. RESULTS:RT-PCR and immunocytochemical staining showed that PPARγand RXRαwere expressed in PANC-1 cells at both transcription level and translation level.MTT assay demonstrated that 15d-PGJ2,9-cis-RA and their combination inhibited the growth of PANC-1 cells in a dose-dependent manner.9-cis-RA had a combined inhibiting action with 15d-PGJ2 on the growth of pancreatic carcinoma.In vivo studies revealed that Rosiglitazone significantly suppressed the growth of pancreatic carcinoma as compared to control group(0.48±0.23 cm 3 vs 2.488±0.59 cm3,P<0.05) ,and the growth inhibition rate was 80.7%.Immunohistochemistry study showed that PCNA was down regulated in Rosiglitazone-treated group compared to the control group.15d-PGJ2,9-cis-RA and their combination inhibited the expression of VEGF mRNA in PANC-1 cells in a dose-and time-dependent manner. MVD was decreased more significantly in Rosiglitazonetreated mice(10.67±3.07) than in the control group(31.44±6.06)(P<0.01) .VEGF expression in xenograft tumor tissue was also markedly down-regulated in Rosiglitazone-treated mice. CONCLUSION:Activation of PPARγinhibits the growth of pancreatic carcinoma both in vitro and in vivo.Suppression of tumor angiogenesis by down-regulating the expression of VEGF may be one of the mechanisms by which PPARγactivation inhibits the growth of pancreatic carcinoma.展开更多
BNCT is finally becoming "a new option against cancer".The difficulties for its development progress of that firstly is to improve the performance of boron compounds,secondly,it is the requirements of quanti...BNCT is finally becoming "a new option against cancer".The difficulties for its development progress of that firstly is to improve the performance of boron compounds,secondly,it is the requirements of quantification and accuracy upon radiation dosimetry evaluation in clinical trials.Furthermore,that is long anticipation on hospital base neutron sources.It includes dedicated new NCT reactor,accelerator based neutron sources,and isotope source facilities.In addition to reactors,so far,the technology of other types of sources for clinical trials is not yet completely proven.The In-Hospital Neutron Irradiator specially designed for NCT,based on the MNSR successfully developed by China,can be installed inside or near the hospital and operated directly by doctors.The Irradiator has two neutron beams for respective treatment of the shallow and deep tumors.It is expected to initiate operation in the end of this year.It would provide a safe,low cost,and effective treatment tool for the NCT routine application in near future.展开更多
In this paper, we analyze a class of bounded radial operators on the weighted Bergman space A2α(Bn, d Vα), we get that these kinds of operators are diagonal with respect to the standard orthonomal basis. We also inv...In this paper, we analyze a class of bounded radial operators on the weighted Bergman space A2α(Bn, d Vα), we get that these kinds of operators are diagonal with respect to the standard orthonomal basis. We also investigate the connection between compactness of operators and the boundary behaviour of the corresponding Berezin transform. We further study a special class of radial operators, i.e., Toeplitz operators with a radial L1 symbol.展开更多
文摘In this paper, we introduce a new class of p-valent analytic functions defined by using a linear operator Lαk . For functions in this class Hαk （p,λ;h） we estimate the coefficients. Furthermore, some subordination properties related to the operator Lαk are also derived.
文摘Congenital analbuminemia is a rare autosomic recessive inherited disorder characterized by low plasma albumin and hypercholesterolemia, which may increase cardiovascular risk. Patients are essentially asymptomatic, apart from ease of fatigue, minimal ankle oedema and hypotension. There is no accepted strategy for safely treating both hypercholesterolemia and analbuminemia in order to eventually decrease the atherosclerotic risk. We report a case of congenital analbuminemia(1.0 g/dL) in a 38-year-old male with hypercholesterolemia(range: 406-475 mg/dL) and severe arterial dysfunction [no brachial artery flow-mediated dilation(FMD)]. Long-term, cholesterol-lowering treatment with atorvastatin was associated with the appearance of peripheral edema. Twomonths of infusion with albumin improved FMD(7%) and reduced serum cholesterol(273 mg/dL), supporting the hypothesis of a compensatory role of hypercholesterolemia. Statin treatment, together with periodical albumin infusions, may contribute to the safe reduction of cardiovascular risk.
文摘This paper introduces a dynamic facilitating mechan is m for the integration of process planning and scheduling in a batch-manufacturi ng environment. This integration is essential for the optimum use of production resources and generation of realistic process plans that can be readily executed with little or no modification. In this paper, integration is modeled in two le vels, viz., process planning and scheduling, which are linked by an intelligent facilitator. The process planning module employs an optimization approach in whi ch the entire plan solution space is first generated and a search algorithm is t hen used to find the optimal plan. Based on the result of scheduling module an u nsatisfactory performance parameter is fed back to the facilitator, which then i dentifies a particular job and issues a change to its process plan solution spac e to obtain a satisfactory schedule.
文摘AIM:To study the possible actions and mechanisms of peroxisome proliferator-activated receptorγ(PPARγ) ,a ligand-activated transcription factor,in pancreatic carcinogenesis,especially in angiogenesis. METHODS:Expressions of PPARγand retinoid acid receptor(RXRα) were examined by reverse-transcription polymerase chain reaction(RT-PCR) with immunocytochemical staining.Pancreatic carcinoma cells,PANC-1,were treated either with 9-cis-RA,a ligand of RXRα,or with 15-deoxy-Δ 12,14 prostaglandin J2(15d-PGJ2) ,a ligand of PPARγ,or both.Antiproliferative effect was evaluated by cell viability using methyltetrazolium(MTT) assay.A pancreatic carcinoma xenograft tumor model of nude mice was established by inoculating PANC-1 cells subcutaneously.Rosiglitazone,a specific ligand of PPARγ,was administered via water drinking in experimental group of nude mice.After 75 d,all mice were sacrificed.Expression of proliferating cell nuclear antigen(PCNA) in tumor tissue was examined with immunohistochemical staining.Expression of vascular endothelial growth factor(VEGF) mRNA in PANC-1 cells,which were treated with 15d-PGJ2 or 9-cis-RA at various concentrations or different duration,was detected by semi-quantitative RT-PCR.Effects of Rosiglitazone on changes of microvascular density(MVD) and VEGF expression were investigated in xenograft tumor tissue.Neovasculature was detected with immunohistochemistry staining labeled with anti-Ⅳcollagen antibody,and indicated by MVD. RESULTS:RT-PCR and immunocytochemical staining showed that PPARγand RXRαwere expressed in PANC-1 cells at both transcription level and translation level.MTT assay demonstrated that 15d-PGJ2,9-cis-RA and their combination inhibited the growth of PANC-1 cells in a dose-dependent manner.9-cis-RA had a combined inhibiting action with 15d-PGJ2 on the growth of pancreatic carcinoma.In vivo studies revealed that Rosiglitazone significantly suppressed the growth of pancreatic carcinoma as compared to control group(0.48±0.23 cm 3 vs 2.488±0.59 cm3,P<0.05) ,and the growth inhibition rate was 80.7%.Immunohistochemistry study showed that PCNA was down regulated in Rosiglitazone-treated group compared to the control group.15d-PGJ2,9-cis-RA and their combination inhibited the expression of VEGF mRNA in PANC-1 cells in a dose-and time-dependent manner. MVD was decreased more significantly in Rosiglitazonetreated mice(10.67±3.07) than in the control group(31.44±6.06)(P<0.01) .VEGF expression in xenograft tumor tissue was also markedly down-regulated in Rosiglitazone-treated mice. CONCLUSION:Activation of PPARγinhibits the growth of pancreatic carcinoma both in vitro and in vivo.Suppression of tumor angiogenesis by down-regulating the expression of VEGF may be one of the mechanisms by which PPARγactivation inhibits the growth of pancreatic carcinoma.
文摘BNCT is finally becoming "a new option against cancer".The difficulties for its development progress of that firstly is to improve the performance of boron compounds,secondly,it is the requirements of quantification and accuracy upon radiation dosimetry evaluation in clinical trials.Furthermore,that is long anticipation on hospital base neutron sources.It includes dedicated new NCT reactor,accelerator based neutron sources,and isotope source facilities.In addition to reactors,so far,the technology of other types of sources for clinical trials is not yet completely proven.The In-Hospital Neutron Irradiator specially designed for NCT,based on the MNSR successfully developed by China,can be installed inside or near the hospital and operated directly by doctors.The Irradiator has two neutron beams for respective treatment of the shallow and deep tumors.It is expected to initiate operation in the end of this year.It would provide a safe,low cost,and effective treatment tool for the NCT routine application in near future.
文摘In this paper, we analyze a class of bounded radial operators on the weighted Bergman space A2α(Bn, d Vα), we get that these kinds of operators are diagonal with respect to the standard orthonomal basis. We also investigate the connection between compactness of operators and the boundary behaviour of the corresponding Berezin transform. We further study a special class of radial operators, i.e., Toeplitz operators with a radial L1 symbol.
