Atractylodis Rhizoma,a traditional Chinese medicine with an extensive history of treating gastrointestinal disorders and other diseases,undergoes various processing methods in China to enhance its therapeutic efficacy...Atractylodis Rhizoma,a traditional Chinese medicine with an extensive history of treating gastrointestinal disorders and other diseases,undergoes various processing methods in China to enhance its therapeutic efficacy for specific conditions.However,a comprehensive report detailing the changes in chemical composition and pharmacological effects due to these processing methods is currently lacking.This article provides a systematic review of the commonly employed processing techniques for Atractylodis Rhizoma,including raw Atractylodis Rhizoma(SCZ),bran-fried Atractylodis Rhizoma(FCZ),deep-fried Atractylodis Rhizoma(JCZ),and rice water-processed Atractylodis Rhizoma(MCZ).It examines the alterations in chemical constituents and pharmacological activities resulting from these processes and elucidates the mechanisms of action of the primary components in the various processed forms of Atractylodis Rhizoma in the treatment of gastrointestinal diseases.展开更多
This paper summarizes the Epidemic Lung Preventive Mixture from three aspects of research status, development trends and prospects, so as to deepen the understanding of Epidemic Lung Preventive Mixture and provide a m...This paper summarizes the Epidemic Lung Preventive Mixture from three aspects of research status, development trends and prospects, so as to deepen the understanding of Epidemic Lung Preventive Mixture and provide a more detailed theoretical basis for its further clinical research and development.展开更多
OBJECTIVE:To investigate the antagonistic effect of the extract of Baizhu(Rhizoma Atractylodis Macrocephalae)(RAM)on the intestinal absorption of brucine and strychnine in Strychnos nux-vomica(NUX)and propose the mech...OBJECTIVE:To investigate the antagonistic effect of the extract of Baizhu(Rhizoma Atractylodis Macrocephalae)(RAM)on the intestinal absorption of brucine and strychnine in Strychnos nux-vomica(NUX)and propose the mechanism of these effects.METHODS:The apparent permeability value(Papp)and absorption rate constant(Ka)were chosen as indices.The everted intestinal sac model and in situ single-pass intestinal perfusion model were used to study the effects of the RAM extract on the absorption of brucine and strychnine.To confirm the results,the brucine and strychnine concentrations in hepatic portal venous blood were determined.Western blotting was used to study P-glycoprotein(P-gp)expression in the Caco-2 cell line.RESULTS:Papp and Ka of brucine and strychnine were significantly increased in the presence of a P-gp inhibitor,but no significant increase was noted in the presence of a tight junction regulator.The RAM extract inhibited the absorption of brucine and strychnine and enhanced P-gp expression.CONCLUSION:The primary absorption mechanism for brucine and strychnine is passive transport,which is affected by P-gp.展开更多
基金supported by the National Natural Science Foundation of China (No.82304722)Hubei Provincial Natural Science Foundation of China (No.2023AFD154).
文摘Atractylodis Rhizoma,a traditional Chinese medicine with an extensive history of treating gastrointestinal disorders and other diseases,undergoes various processing methods in China to enhance its therapeutic efficacy for specific conditions.However,a comprehensive report detailing the changes in chemical composition and pharmacological effects due to these processing methods is currently lacking.This article provides a systematic review of the commonly employed processing techniques for Atractylodis Rhizoma,including raw Atractylodis Rhizoma(SCZ),bran-fried Atractylodis Rhizoma(FCZ),deep-fried Atractylodis Rhizoma(JCZ),and rice water-processed Atractylodis Rhizoma(MCZ).It examines the alterations in chemical constituents and pharmacological activities resulting from these processes and elucidates the mechanisms of action of the primary components in the various processed forms of Atractylodis Rhizoma in the treatment of gastrointestinal diseases.
基金Supported by Key R&D Plan of Guangxi Science and Technology Department(Gui Ke AB21196057)Self-Funded Scientific Research Project of Guangxi Zhuang Autonomous Region Administration of Traditional Chinese Medicine(Contract Number:GXZYA20220154)+3 种基金Qingmiao Talent Cultivation Project of Guangxi International Zhuang Medicine Hospital(2022001)Guangxi Traditional Chinese Medicine Multidisciplinary Innovation Team Project(GZKJ2309)High-level Key Discipline of Traditional Chinese Medicine(Zhuang Pharmacy)Construction Project of the State Administration of Traditional Chinese Medicine(Guo Zhong Yi Yao Ren Jiao Han[2022]No.226)Funding Project of High-level Talent Cultivation and Innovation Team of Guangxi University of Chinese Medicine(2022A008).
文摘This paper summarizes the Epidemic Lung Preventive Mixture from three aspects of research status, development trends and prospects, so as to deepen the understanding of Epidemic Lung Preventive Mixture and provide a more detailed theoretical basis for its further clinical research and development.
基金the National Natural Science Foundation of China(No.81660757 and No.81303237)the Academic and Technological Foregoer Funds of Jiangxi Province,China(No.20162BCB22015)+3 种基金the Project on Cultivation of Medical Elite(Gan Po Ying Cai 555)(2013296)the Youth Science Funds of Jiangxi Province,China(No.20153BCB23019)the National Natural Science Foundation of Jiangxi Province(No.20161ACB21020)the Natural Science Research Project of Huaian(No.HAB201716)。
文摘OBJECTIVE:To investigate the antagonistic effect of the extract of Baizhu(Rhizoma Atractylodis Macrocephalae)(RAM)on the intestinal absorption of brucine and strychnine in Strychnos nux-vomica(NUX)and propose the mechanism of these effects.METHODS:The apparent permeability value(Papp)and absorption rate constant(Ka)were chosen as indices.The everted intestinal sac model and in situ single-pass intestinal perfusion model were used to study the effects of the RAM extract on the absorption of brucine and strychnine.To confirm the results,the brucine and strychnine concentrations in hepatic portal venous blood were determined.Western blotting was used to study P-glycoprotein(P-gp)expression in the Caco-2 cell line.RESULTS:Papp and Ka of brucine and strychnine were significantly increased in the presence of a P-gp inhibitor,but no significant increase was noted in the presence of a tight junction regulator.The RAM extract inhibited the absorption of brucine and strychnine and enhanced P-gp expression.CONCLUSION:The primary absorption mechanism for brucine and strychnine is passive transport,which is affected by P-gp.
