Objective:To explore the target gene and mechanism of effective components of Renshen-Gansong in the treatment of paroxysmal atrial fibrillation based on network pharmacology.Methods:The chemical constituents of Rensh...Objective:To explore the target gene and mechanism of effective components of Renshen-Gansong in the treatment of paroxysmal atrial fibrillation based on network pharmacology.Methods:The chemical constituents of Renshen-Gansong drug pairs were searched by TCMSP traditional Chinese medicine database.The potentially effective components were screened under the conditions of bioavailability(OB)≥30%and drug-like(DL)≥0.18,and the potential targets were predicted by TCMSP database.The human gene name corresponding to the potential target was found by Uniprot database,and the disease target of paroxysmal atrial fibrillation was searched by Genecards database,the intersection target was mapped with the potential target of drug pair,the Wayne diagram was drawn,and the disease-drug-component-target network map was constructed by Cytoscape3.7.2.The PPI protein interaction network map was constructed by STRING database to select the core targets,and finally GO analysis and KEGG analysis were carried out.Results:A total of 28 active components and 45 effective targets were obtained.GO enrichment analysis showed that the main pathways were neurotransmitter receptor activity,ion gated channel activity,passive transmembrane transporter activity,G protein coupled neurotransmitter receptor activity and so on.KEGG pathway enrichment analysis showed that the main pathways were IL-17 signal pathway,calcium signal pathway,TNF signal pathway and so on.Conclusion:Renshen-Gansong has a synergistic effect on the treatment of paroxysmal atrial fibrillation through multi-targets,multi-pathways and multiple signal pathways,which provides a basis for further study of drug mechanism and clinical guidance.展开更多
目的探究厄贝沙坦+胺碘酮对高血压伴阵发性心房颤动患者血清B型钠尿肽(B type natriuretic peptide,BNP)、血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)、心肌酶谱的影响。方法选择2019年12月—2021年1月邹城市人民医院收治的高血压伴阵发性心房...目的探究厄贝沙坦+胺碘酮对高血压伴阵发性心房颤动患者血清B型钠尿肽(B type natriuretic peptide,BNP)、血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)、心肌酶谱的影响。方法选择2019年12月—2021年1月邹城市人民医院收治的高血压伴阵发性心房颤动患者82例,按随机数表法分为两组,各41例。对照组口服胺碘酮,观察组在对照组的基础上加用厄贝沙坦治疗,均持续治疗1年。比较两组治疗效果、心房颤动发作情况、BNP及AngⅡ水平、心肌酶谱指标、炎症反应指标及不良反应发生情况。结果观察组治疗总有效率为97.56%,高于对照组的80.49%,差异有统计学意义(χ^(2)=4.493,P<0.05);治疗后,观察组心房颤动发作持续时间短于对照组,发作次数少于对照组,BNP、AngⅡ、肌酸激酶(CK)、肌酸激酶-同工酶(CK-MB)、心肌肌钙蛋白T(cTnT)及超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生情况比较,差异无统计学意义(P>0.05)。结论在高血压伴阵发性心房颤动患者中采用厄贝沙坦+胺碘酮治疗效果确切,能够减少房颤发作时间、次数,降低BNP、AngⅡ水平,减轻炎症反应,促进心肌酶谱指标复常,且具有较高安全性。展开更多
基金National Science and Technology Major Special Project on Major New Drug Innovation(No.2017ZX09301003)。
文摘Objective:To explore the target gene and mechanism of effective components of Renshen-Gansong in the treatment of paroxysmal atrial fibrillation based on network pharmacology.Methods:The chemical constituents of Renshen-Gansong drug pairs were searched by TCMSP traditional Chinese medicine database.The potentially effective components were screened under the conditions of bioavailability(OB)≥30%and drug-like(DL)≥0.18,and the potential targets were predicted by TCMSP database.The human gene name corresponding to the potential target was found by Uniprot database,and the disease target of paroxysmal atrial fibrillation was searched by Genecards database,the intersection target was mapped with the potential target of drug pair,the Wayne diagram was drawn,and the disease-drug-component-target network map was constructed by Cytoscape3.7.2.The PPI protein interaction network map was constructed by STRING database to select the core targets,and finally GO analysis and KEGG analysis were carried out.Results:A total of 28 active components and 45 effective targets were obtained.GO enrichment analysis showed that the main pathways were neurotransmitter receptor activity,ion gated channel activity,passive transmembrane transporter activity,G protein coupled neurotransmitter receptor activity and so on.KEGG pathway enrichment analysis showed that the main pathways were IL-17 signal pathway,calcium signal pathway,TNF signal pathway and so on.Conclusion:Renshen-Gansong has a synergistic effect on the treatment of paroxysmal atrial fibrillation through multi-targets,multi-pathways and multiple signal pathways,which provides a basis for further study of drug mechanism and clinical guidance.
文摘目的探究厄贝沙坦+胺碘酮对高血压伴阵发性心房颤动患者血清B型钠尿肽(B type natriuretic peptide,BNP)、血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)、心肌酶谱的影响。方法选择2019年12月—2021年1月邹城市人民医院收治的高血压伴阵发性心房颤动患者82例,按随机数表法分为两组,各41例。对照组口服胺碘酮,观察组在对照组的基础上加用厄贝沙坦治疗,均持续治疗1年。比较两组治疗效果、心房颤动发作情况、BNP及AngⅡ水平、心肌酶谱指标、炎症反应指标及不良反应发生情况。结果观察组治疗总有效率为97.56%,高于对照组的80.49%,差异有统计学意义(χ^(2)=4.493,P<0.05);治疗后,观察组心房颤动发作持续时间短于对照组,发作次数少于对照组,BNP、AngⅡ、肌酸激酶(CK)、肌酸激酶-同工酶(CK-MB)、心肌肌钙蛋白T(cTnT)及超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生情况比较,差异无统计学意义(P>0.05)。结论在高血压伴阵发性心房颤动患者中采用厄贝沙坦+胺碘酮治疗效果确切,能够减少房颤发作时间、次数,降低BNP、AngⅡ水平,减轻炎症反应,促进心肌酶谱指标复常,且具有较高安全性。
