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Research on Audit Risks in the Recognition of Data Assets on Financial Statements
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作者 Xia Xiao 《Proceedings of Business and Economic Studies》 2024年第5期81-88,共8页
This paper explores the audit risks associated with the recognition of data assets on financial statements,focusing on the complexities arising from their replicability,unique valuation patterns,and contextual depende... This paper explores the audit risks associated with the recognition of data assets on financial statements,focusing on the complexities arising from their replicability,unique valuation patterns,and contextual dependencies.It identifies major misstatement risks at both the financial statement and assertion levels,including the potential for management to exaggerate data asset values,uncertainties in valuation methods,and deficiencies in data governance and internal controls.Additionally,auditors’lack of professional knowledge and inappropriate audit methods can lead to inspection risks.The paper emphasizes the urgent need for enhanced accounting standards for data assets,effective guidelines for their recognition and measurement,and robust internal controls.Furthermore,it advocates for the exploration of effective valuation methods and the incorporation of advanced technologies,such as big data and AI,into auditing practices.By improving auditor training and methodologies,organizations can better manage the inherent risks associated with data asset auditing. 展开更多
关键词 audit risks Data assets RECOGNITION DIsCLOsURE
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Health risk assessment of trace metal(loid)s in agricultural soils based on Monte Carlo simulation coupled with positive matrix factorization model in Chongqing, southwest China 被引量:1
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作者 MA Jie CHU Lijuan +3 位作者 SUN Jing WANG Shenglan GE Miao DENG Li 《Journal of Mountain Science》 SCIE CSCD 2024年第1期100-112,共13页
This study aimed to investigate the pollution characteristics, source apportionment, and health risks associated with trace metal(loid)s(TMs) in the major agricultural producing areas in Chongqing, China. We analyzed ... This study aimed to investigate the pollution characteristics, source apportionment, and health risks associated with trace metal(loid)s(TMs) in the major agricultural producing areas in Chongqing, China. We analyzed the source apportionment and assessed the health risk of TMs in agricultural soils by using positive matrix factorization(PMF) model and health risk assessment(HRA) model based on Monte Carlo simulation. Meanwhile, we combined PMF and HRA models to explore the health risks of TMs in agricultural soils by different pollution sources to determine the priority control factors. Results showed that the average contents of cadmium(Cd), arsenic (As), lead(Pb), chromium(Cr), copper(Cu), nickel(Ni), and zinc(Zn) in the soil were found to be 0.26, 5.93, 27.14, 61.32, 23.81, 32.45, and 78.65 mg/kg, respectively. Spatial analysis and source apportionment analysis revealed that urban and industrial sources, agricultural sources, and natural sources accounted for 33.0%, 27.7%, and 39.3% of TM accumulation in the soil, respectively. In the HRA model based on Monte Carlo simulation, noncarcinogenic risks were deemed negligible(hazard index <1), the carcinogenic risks were at acceptable level(10^(-6)<total carcinogenic risk ≤ 10^(-4)), with higher risks observed for children compared to adults. The relationship between TMs, their sources, and health risks indicated that urban and industrial sources were primarily associated with As, contributing to 75.1% of carcinogenic risks and 55.7% of non-carcinogenic risks, making them the primary control factors. Meanwhile, agricultural sources were primarily linked to Cd and Pb, contributing to 13.1% of carcinogenic risks and 21.8% of non-carcinogenic risks, designating them as secondary control factors. 展开更多
关键词 Monte Carlo simulation Health risk assessment Trace metal(loid)s Positive matrix factorization Agricultural soils
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Prevalence and risk factors of depression among patients with perianal fistulizing Crohn’s disease
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作者 Jing Li Wing-Yi Ng +5 位作者 Li-Chao Qiao Fen Yuan Xing Lan Li-Bei Zhu Bo-Lin Yang Zhong-Qiu Wang 《World Journal of Psychiatry》 SCIE 2024年第5期715-725,共11页
BACKGROUND Psychological distress,especially depression,associated with perianal fistulizing Crohn’s disease(PFCD)is widespread and refractory.However,there is a surprising paucity of studies to date that have sought... BACKGROUND Psychological distress,especially depression,associated with perianal fistulizing Crohn’s disease(PFCD)is widespread and refractory.However,there is a surprising paucity of studies to date that have sought to identify the prevalence and risk factors of depression associated with PFCD.AIM To estimate the prevalence of depressive symptoms and investigate the depression-related risk factors in patients with PFCD.METHODS The study was conducted in the form of survey and clinical data collection via questionnaire and specialized medical staff.Depressive symptoms,life quality,and fatigue severity of patients with PFCD were assessed by Patient Health Questionnaire-9,Inflammatory Bowel Disease Patient Quality of Life Questionnaire(IBDQ),and Inflammatory Bowel Disease(IBD)Fatigue Patient Self-assessment Scale.The basic demographic information,overall disease features,perianal clinical information,and laboratory inflammation indicators were also gathered.Multivariate regression analysis was ultimately used to ascertain the risk factors of depression associated with PFCD.RESULTS A total of 123 patients with PFCD were involved,and 56.91%were suffering from depression.According to multivariate logistic regression analysis,Perianal Disease Activity Index(PDAI)score[odds ratio(OR)=0.69,95%confidence interval(CI):0.50 to 0.95],IBDQ score(OR=0.93,95%CI:0.88 to 0.97),modified Van Assche index(OR=1.24,95%CI:1.01 to 1.53),and IBD Fatigue score(OR=1.72,95%CI:1.23 to 2.42)were independent risk factors of depression-related prevalence among patients with PFCD(P<0.05).Multiple linear regression analysis revealed that the increasing perianal modified Van Assche index(βvalue=0.166,95%CI:0.02 to 0.31)and decreasing IBDQ score(βvalue=-0.116,95%CI:-0.14 to-0.09)were independently associated with the severity of depression(P<0.05).CONCLUSION Depressive symptoms in PFCD patients have significantly high prevalence.PDAI score,modified Van Assche index,quality of life,and fatigue severity were the main independent risk factors. 展开更多
关键词 Crohn’s disease FIsTULA DEPREssION Inflammatory bowel diseases risk factors
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Epidemiological Aspects of Obesity, Overweight and Cardiovascular Risk Factors at Associes in Semi-Urban Areas (Case of Sébikotane)
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作者 Djiby Sow Nafy Ndiaye +11 位作者 Mouhamed Yakham Leye Maty Diagne Camara Michel Assane Ndour Mouhamed Dieng Houleye Saou Ndiouga Fall Boundia Djiba Demba Diédhiou Im Diallo Anna Sarr Mbaye Maimouna Ndour Abdoulaye Leye 《Food and Nutrition Sciences》 CAS 2024年第5期390-400,共11页
Introduction: Obesity and overweight are a public health problem. The general objective was to determine the epidemiological aspects of obesity, overweight and associated risk factors in a semi-urban environment. Pati... Introduction: Obesity and overweight are a public health problem. The general objective was to determine the epidemiological aspects of obesity, overweight and associated risk factors in a semi-urban environment. Patients and Methods: This was a cross-sectional, descriptive study conducted on November 28 and 29, 2023 in Sébikotane. It focused on volunteers for screening for chronic non-communicable diseases. Epidemiological and clinical data were evaluated. Results: One hundred and twenty-nine cases of obesity were recorded (28%). Two hundred and eighty-two cases were overweight or obese (61.3%). The mean age was 49.55 years, with a standard deviation of 12.41 years. The age group [40 - 49 years] was the most representative, with 85 cases (30.1%), and the majority were female, with 264 cases (93.6%). Primary education was the most common, with 75 cases (46.3%). Grade 1 obesity concerned ninety-seven cases (75.2%), and diabetes was present in thirty cases (23%). Hypertension was present in ninety-five cases (33.7%). Obesity was more marked in the age group [40 - 49 years] with 45 cases (36%). Conclusion: Obesity and overweight are a major cause of morbidity and mortality. The development and implementation of a prevention and management program is essential. 展开更多
关键词 OBEsITY OVERWEIGHT risk Factors sébikotane senegal
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Surgical and non-surgical risk factors affecting the insufficiency of ileocolic anastomosis after first-time surgery in Crohn’s disease patients
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作者 Jaroslaw Cwaliński Filip Lorek +5 位作者 Łukasz Mazurkiewicz MichałMazurkiewicz Wojciech Lizurej Jacek Paszkowski Hanna Cholerzyńska Wiktoria Zasada 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第10期3253-3260,共8页
BACKGROUND Crohn's disease(CD)often necessitates surgical intervention,particularly when it manifests in the terminal ileum and ileocecal valve.Despite undergoing radical surgery,a subset of patients experiences r... BACKGROUND Crohn's disease(CD)often necessitates surgical intervention,particularly when it manifests in the terminal ileum and ileocecal valve.Despite undergoing radical surgery,a subset of patients experiences recurrent inflammation at the anasto-motic site,necessitating further medical attention.AIM To investigate the risk factors associated with anastomotic insufficiency following ileocecal resection in CD patients.METHODS This study enrolled 77 patients who underwent open ileocolic resection with pri-mary stapled anastomosis.Patients were stratified into two groups:Group I co-mprised individuals without anastomotic insufficiency,while Group II included patients exhibiting advanced anastomotic destruction observed endoscopically or those requiring additional surgery during the follow-up period.Surgical and non-surgical factors potentially influencing anastomotic failure were evaluated in both cohorts.RESULTS Anastomotic insufficiency was detected in 12 patients(15.6%),with a mean time interval of 30 months between the initial surgery and recurrence.The predomi-nant reasons for re-intervention included stenosis and excessive perianastomotic lesions.Factors associated with a heightened risk of anastomotic failure encompassed prolonged postoperative obstruction,anastomotic bleeding,and clinically confirmed micro-leakage.Additionally,patients in Group II exhibited preoperative malnutrition and early recurrence of symptoms related to CD.CONCLUSION Successful surgical outcomes hinge on the attainment of a fully functional anastomosis,optimal metabolic status,and clinical remission of the underlying disease.Vigilant endoscopic surveillance following primary resection facilitates the timely identification of anastomotic failure,thereby enabling noninvasive interventions. 展开更多
关键词 Crohn’s disease Ileocolic resection Anastomotic insufficiency Endoscopic surveillance sURGERY risk factors
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Big Data Audit of Banks Based on Fuzzy Set Theory to Evaluate Risk Level 被引量:3
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作者 Yilin Bi Yuxin Ouyang +3 位作者 Guang Sun Peng Guo Jianjun Zhang Yijun Ai 《Journal on Big Data》 2020年第1期9-18,共10页
The arrival of big data era has brought new opportunities and challenges to the development of various industries in China.The explosive growth of commercial bank data has brought great pressure on internal audit.The ... The arrival of big data era has brought new opportunities and challenges to the development of various industries in China.The explosive growth of commercial bank data has brought great pressure on internal audit.The key audit of key products limited to key business areas can no longer meet the needs.It is difficult to find abnormal and exceptional risks only by sampling analysis and static analysis.Exploring the organic integration and business processing methods between big data and bank internal audit,Internal audit work can protect the stable and sustainable development of banks under the new situation.Therefore,based on fuzzy set theory,this paper determines the membership degree of audit data through membership function,and judges the risk level of audit data,and builds a risk level evaluation system.The main features of this paper are as follows.First,it analyzes the necessity of transformation of the bank auditing in the big data environment.The second is to combine the determination of the membership function in the fuzzy set theory with the bank audit analysis,and use the model to calculate the corresponding parameters,thus establishing a risk level assessment system.The third is to propose audit risk assessment recommendations,hoping to help bank audit risk management in the big data environment.There are some shortcomings in this paper.First,the amount of data acquired is not large enough.Second,due to the lack of author’knowledge,there are still some deficiencies in the analysis of audit risk of commercial banks. 展开更多
关键词 Bank audit fuzzy set theory membership function risk control
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Distribution, Mobility, and Health Risks Assessment of Trace Metals in River Sediments from Intense Agricultural Activity Areas in West Africa
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作者 Ahbeauriet Ahmed Ouattara Maley-Pacôme Soro +2 位作者 Albert Brou Kouadio Horo Koné Albert Trokourey 《Journal of Materials Science and Chemical Engineering》 2024年第8期12-42,共31页
The economy of West African countries is mainly based on agriculture. However, the trace metal(loid)s contamination status in rivers is relatively unknown in the region. In this work, 45 surface sediments collected fr... The economy of West African countries is mainly based on agriculture. However, the trace metal(loid)s contamination status in rivers is relatively unknown in the region. In this work, 45 surface sediments collected from the Bandama, Comoé, and Bia Rivers in south and south eastern Côte d’Ivoire (West Africa), were analyzed for total metal concentrations and chemical speciation. The results showed that the river sediments were considerably contaminated by Cd and moderately contaminated by As, Cu, Pb, and Zn. Significant spatial variations were observed among the stations but not between the rivers. Metals Cd and Cu were likely to cause more ecological risks. The speciation analysis unravelled that the metal(loid)s partitioned mainly in the residual fraction, with the potential mobile fraction varying from 14% to 28%. The study calls for establishment of strict policies relative to the application of fertilizers and agrochemicals and mining activities to protect the environment and human health risks. 展开更多
关键词 River sediment Trace Metal (Loid)s Multivariate Analysis Potential Ecological risk Assessments sequential Extraction Geochemical Indices
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From risk society to audit society
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作者 Olivier de Lagarde 《Journal of Modern Accounting and Auditing》 2010年第4期52-62,共11页
Contrary to what is sometimes claimed, the 2008 banking crisis occurred in an ultra-regulated environment. Legislative and regulatory financial-security regimes have in fact multiplied in recent years. The economic cr... Contrary to what is sometimes claimed, the 2008 banking crisis occurred in an ultra-regulated environment. Legislative and regulatory financial-security regimes have in fact multiplied in recent years. The economic crisis is accelerating the transition of the risk society towards the audit society. But the G20 (Group of Twenty) declarations in Washington and London also reveal a managerial utopia: the march towards a society of confidence or harmony that would make controls superfluous. In this context, the article seeks to call upon philosophical, sociological and managerial references to risk, from Foucault to Power by way of Beck, Giddens & Ewald, to shed light on the official declarations of the leaders of the world's main economies. The documentary corpus examined includes all the G20 works published between November 8, 2008 (preparation for the Washington Summit) and April 2, 2009 (conclusions of the London Summit). The political philosophy underlying the G20's works remains fundamentally liberal, even though saving the worldwide market economy involves established security systems as well as self-control and control of others. In the end, the leaders do not decide between reinforcing the existing tools and inventing new systems. The updating of security technologies is meant to serve the preservation of the capitalist managerial utopia. This gives rise to a new variant of Beck's risk-society paradigm, too often confined to environmental threats alone, in three phases: (1) The crisis is a consequence of financial modernity and in particular of the inefficiency of regulation in the face of growing sophistication in techniques; (2) To restore confidence, the states and international institutions want, paradoxically, both to reinforce regulation and promote flexibility; (3) Thereupon, flexi-security controlled by worldwide economic governance characterizes the second financial modernity. 展开更多
关键词 auditability REGULATION risk society G20 financial crisis flexi-security audit society
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The discussion on audit risk and prevention of accounting firm
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作者 JIA Xian-wei 《Journal of Modern Accounting and Auditing》 2009年第7期56-61,共6页
This paper analyses audit quality control, brain gain, time pressure of CPA, follow-up education of auditors by firms. The reasons of audit risk rising of CPA are discussed. Based on the foregoing analysis, the author... This paper analyses audit quality control, brain gain, time pressure of CPA, follow-up education of auditors by firms. The reasons of audit risk rising of CPA are discussed. Based on the foregoing analysis, the author puts forward some measures about self-construction, processes and others of firms and CPA to reduce audit risk of CPA. 展开更多
关键词 CPA audit risk accounting firm
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Implications of Financial and Non-financial Measures on the Refinement of the Assessments of Audit Risk: An Empirical Investigation
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作者 Abdelmoneim A. Awadallah Haitham Mohamed El-Said 《Journal of Modern Accounting and Auditing》 2016年第7期365-378,共14页
Identifying and assessing audit risk is a key part of the audit process. Prior research documented that auditors primarily look at financial data, information, and measures when assessing the audit risk for an audit e... Identifying and assessing audit risk is a key part of the audit process. Prior research documented that auditors primarily look at financial data, information, and measures when assessing the audit risk for an audit engagement. However, professional standard setters, regulators, and academic researchers have discussed the potential for non-financial data, information, and measures to provide a powerful and independent benchmark for evaluating the validity of the numbers of financial statements of an audit client. A field study was conducted in Egypt during the years 2013 and 2014 to explore how auditors perceive and assess audit risk for an audit engagement in the period following the Egyptian revolution of January 25, 2011. The results of the field study indicated that auditors appear not to give sufficient attention to non-financial data, information, and measures when assessing the audit risk during an audit engagement. Auditors seem to rely on financial data, information, and measures when assessing the audit risk of an audit engagement. Furthermore, auditors do not seem to consider the inconsistencies between financial and non-financial data, information, and measures of an audit client as an indicator of the existence of fraud or material misstatements in the financial statements of an audit client. 展开更多
关键词 non-financial measures financial measures audit risk
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Research on the CPA Audit Independence Risk Assessment Based on the Rough Set Theory
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作者 Xiumei Ren Jikun Shi Guangbao Zhang 《Journal of Modern Accounting and Auditing》 2006年第6期56-63,共8页
The assessment mode of the CPA audit independence risk based on the Rough Set Theory is a risk assessment method and using the Analytical Hierarchy Process, whose aim is to solve the bid management in the process of t... The assessment mode of the CPA audit independence risk based on the Rough Set Theory is a risk assessment method and using the Analytical Hierarchy Process, whose aim is to solve the bid management in the process of the Financial Statement Insurance. Firstly, according to the general instance of the accountant office, the experts grade the risk elements to establish the decision-making table; secondly, construct the judgment matrix using the attribution dependence degree of Variable Precision Rough Set to obtain relative importance, and further get the general importance for all of risk elements; Finally, establish the general assessment mode of the audit independence risk. 展开更多
关键词 rough set theory audit independence risk assessment mode
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Gender disparities and woman-specific trends in Barrett’s esophagus in the United States:An 11-year nationwide populationbased study
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作者 Karina Fatakhova Faisal Inayat +12 位作者 Hassam Ali Pratik Patel Attiq Ur Rehman Arslan Afzal Muhammad Sarfraz Shiza Sarfraz Gul Nawaz Ahtshamullah Chaudhry Rubaid Dhillon Arthur Dilibe Benjamin Glazebnik Lindsey Jones Emily Glazer 《World Journal of Methodology》 2025年第1期60-71,共12页
BACKGROUND Barrett's esophagus(BE)is a known premalignant precursor to esophageal adenocarcinoma(EAC).The prevalence rates continue to rise in the United States,but many patients who are at risk of EAC are not scr... BACKGROUND Barrett's esophagus(BE)is a known premalignant precursor to esophageal adenocarcinoma(EAC).The prevalence rates continue to rise in the United States,but many patients who are at risk of EAC are not screened.Current practice guidelines include male gender as a predisposing factor for BE and EAC.The population-based clinical evidence regarding female gender remains limited.AIM To study comparative trends of gender disparities in patients with BE in the United States.METHODS A nationwide retrospective study was conducted using the 2009-2019 National Inpatient Sample(NIS)database.Patients with a primary or secondary diagnosis code of BE were identified.The major outcome of interest was determining the gender disparities in patients with BE.Trend analysis for respective outcomes for females was also reported to ascertain any time-based shifts.RESULTS We identified 1204190 patients with BE for the study period.Among the included patients,717439(59.6%)were men and 486751(40.4%)were women.The mean age was higher in women than in men(67.1±0.4 vs 66.6±0.3 years,P<0.001).The rate of BE per 100000 total NIS hospitalizations for males increased from 144.6 in 2009 to 213.4 in 2019(P<0.001).The rate for females increased from 96.8 in 2009 to 148.7 in 2019(P<0.001).There was a higher frequency of obesity among women compared to men(17.4%vs 12.6%,P<0.001).Obesity prevalence among females increased from 12.3%in 2009 to 21.9%in 2019(P<0.001).A lower prevalence of smoking was noted in women than in men(20.8%vs 35.7%,P<0.001).However,trend analysis showed an increasing prevalence of smoking among women,from 12.9%in 2009 to 30.7%in 2019(P<0.001).Additionally,there was a lower prevalence of alcohol abuse,Helicobacter pylori(H.pylori),and diabetes mellitus among females than males(P<0.001).Trend analysis showed an increasing prevalence of alcohol use disorder and a decreasing prevalence of H.pylori and diabetes mellitus among women(P<0.001).CONCLUSION The prevalence of BE among women has steadily increased from 2009 to 2019.The existing knowledge concerning BE development has historically focused on men,but our findings show that the risk in women is not insignificant. 展开更多
关键词 Barrett’s esophagus Gender disparity Epidemiological trends Esophageal adenocarcinoma screening endoscopy Female gender risk factors
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The Self-inspections(Internal Audits)Process as a Part of the Pharmaceutical Quality System:Formation of a Risk-Based Approach to Internal Audits Planning
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作者 Valeriy Nikityuk Tetiana Karamavrova V.Lebedynets 《Journal of Pharmacy and Pharmacology》 2019年第7期385-397,共13页
The quality system of any modern pharmaceutical company is the pharmaceutical quality system(PQS),which extends the GMP standards to all stages of the medicinal productslife cycle,from pharmaceutical development to it... The quality system of any modern pharmaceutical company is the pharmaceutical quality system(PQS),which extends the GMP standards to all stages of the medicinal productslife cycle,from pharmaceutical development to its withdrawal from production.The principal difference between PQS and GxP rules from other quality systems is that the medicinal product,its safety and efficacy is put at the forefront.At the same time,PQS implies a process approach to all components that should be aimed at achieving the main goal—ensuring and guaranteeing the quality of the medicinal product for the end user(patient)—and should be based on the quality risk management system.An integral part of PQS,as well as the GxP rules adopted in the European Union and PIC/S,is a process for self-inspections and/or quality audits,which regularly appraises the effectiveness and applicability of the PQS.This publication is dedicated to the definition of self-inspections(internal audits)as one of the PQS’s processes.The article defines the main standard stages and develops a model of a risk-based approach to the self-inspections’planning in relation to processes of the pharmaceutical quality system. 展开更多
关键词 Medicinal products PQs sELF-INsPECTION internal audit quality risk management risk-based APPROACH
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Computer Audit Risk Control Research
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作者 CHAI Qin 《International English Education Research》 2018年第2期10-12,共3页
The development of computer information technology makes the information of the audited unit more and more high. The introduction of accounting computerization information system makes the processing of enterprise eco... The development of computer information technology makes the information of the audited unit more and more high. The introduction of accounting computerization information system makes the processing of enterprise economic business more convenient and efficient. Here came the computer controlled environment audit new risks, of course, the computer technology applied to the audit work to improve the audit efficiency by a lot, but also increased the complex information technology environment audit risk. Starting from the concept of computer audit risk, this paper analyzes and discusses the new risks and causes of audit under the computer condition, and puts forward some constructive risk control measures. 展开更多
关键词 Computer audit risk control The intemal control
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A Brief Discussion of Audit Risks and Their Causes
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作者 Zhihua Xie 《Proceedings of Business and Economic Studies》 2023年第6期98-103,共6页
As a crucial supervisory department overseeing economic operations,the audit department plays a pivotal role in safeguarding the healthy development of the country’s economy,exposing corruption,and effectively mainta... As a crucial supervisory department overseeing economic operations,the audit department plays a pivotal role in safeguarding the healthy development of the country’s economy,exposing corruption,and effectively maintaining social and economic peace and stability.The work of auditing involves detecting existing issues,providing remedies,and consistently contributing to national governance.However,as the market economic environment undergoes continuous changes,legal systems advance,and the audit environment becomes more complex,audit risks have gradually gained prominence.The prevention of audit risks has increasingly captured the attention of audit agencies at all levels.This necessitates audit institutions to continually adapt to new challenges,comprehend risks,and exert effective control over them.This article delves into the causes of audit risks,exploring ways to effectively identify and respond to these risks within a complex and ever-changing environment.The objective is to ensure the objectivity and accuracy of audit reports,allowing the audit function to truly serve as an“immune”system,protecting public interests. 展开更多
关键词 audit risk REAsONs audit environment
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RISK信号通路在1-磷酸鞘氨醇后适应减轻心肌细胞缺氧/复氧损伤中的作用 被引量:9
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作者 王雨晴 吴艳娜 +4 位作者 李欣 尹永强 康毅 娄建石 温克 《中国药理学通报》 CAS CSCD 北大核心 2015年第2期181-185,共5页
目的研究再灌注损伤挽救激酶(reperfusion injury salvage kinase,RISK)信号通路在1-磷酸鞘氨醇(sphingosine-1-phosphate,S1P)后适应减轻H9c2心肌细胞缺氧/复氧损伤中的作用。方法将H9c2细胞随机分为7组,即(1)正常对照组(C);(2)缺氧/... 目的研究再灌注损伤挽救激酶(reperfusion injury salvage kinase,RISK)信号通路在1-磷酸鞘氨醇(sphingosine-1-phosphate,S1P)后适应减轻H9c2心肌细胞缺氧/复氧损伤中的作用。方法将H9c2细胞随机分为7组,即(1)正常对照组(C);(2)缺氧/复氧组(H/R);(3)S1P组;(4)S1P+LY294002组(S1P+LY);(5)LY组;(6)S1P+PD98059组(S1P+PD);(7)PD组。采用MTT法测定各组细胞存活率;比色法测定丙二醛(MDA)含量、总超氧化物歧化酶(TSOD)和锰超氧化物歧化酶(Mn-SOD)活力;采用激光共聚焦显微镜技术检测细胞内游离钙离子浓度变化;流式细胞仪检测心肌细胞凋亡率;Western blot法测定Akt和ERK1/2蛋白的磷酸化水平。结果与H/R组比较,S1P组可明显增加H9c2细胞缺氧/复氧损伤后细胞存活率及凋亡率,增加TSOD及Mn-SOD活力,降低MDA含量,降低钙离子浓度,增加Akt和ERK1/2磷酸化水平,而PI3K/Akt信号通路阻断剂LY294002或ERK1/2阻断剂PD98059可阻断S1P对H9c2的上述作用。结论 S1P能够减轻H9c2细胞缺氧/复氧损伤,加入PI3K/Akt抑制剂LY294002和ERK1/2抑制剂PD98059均使S1P的保护作用被取消,表明S1P通过RISK信号通路发挥抗H9c2细胞缺氧/复氧损伤作用。 展开更多
关键词 s1P 缺氧/复氧 H9C2细胞 PI3K/Akt ERK1/2 risk
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基于模糊交叉熵与TOPSIS的碳审计风险评估 被引量:1
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作者 刘国城 陈意正 陈婕妤 《深圳社会科学》 2024年第3期83-95,共13页
审计在促进“双碳”目标实现的过程中发挥着重要的监督与评价作用,有效规范了企业的碳排放行为,推动了企业生产方式的绿色转型。当前,我国的碳审计发展尚处起步阶段,存在着诸如制度不健全、碳数据核算困难、碳审计人才缺乏等一系列问题... 审计在促进“双碳”目标实现的过程中发挥着重要的监督与评价作用,有效规范了企业的碳排放行为,推动了企业生产方式的绿色转型。当前,我国的碳审计发展尚处起步阶段,存在着诸如制度不健全、碳数据核算困难、碳审计人才缺乏等一系列问题,多种因素的叠加使得碳审计工作面临着极大的风险与挑战。在文献梳理的基础上,本文依托传统风险导向审计理论,首先从环境风险、固有风险、控制风险、检查风险四个层面建立碳审计风险评估指标体系;其次,借助模糊交叉熵和TOPSIS算法构架新型的碳审计风险评估模型,探索碳审计风险评估模型的运行步骤,明晰风险评估模型中的决策方案排序策略;再次,通过对特定案例的深入分析,阐释模糊交叉熵和TOPSIS风险评估模型在碳审计风险评估中的具体应用流程,全方位探究风险评估模型中各类运算结果的分析方法;最后,针对碳审计所面临的各种风险,相应地从碳审计模式设计、双碳大数据中心构建、人才队伍建设三个方面提出管理碳审计检查风险的措施与建议。有关研究思路和结论能够为审计组织如何发现碳审计存在的关键风险因素、衡量碳审计风险水平、评价和控制碳审计风险提供理论支持。 展开更多
关键词 模糊交叉熵 TOPsIs 碳审计 风险评估 风险控制
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上市公司ESG信息披露与审计延迟
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作者 欧理平 赵长琦 但莉萍 《重庆理工大学学报(社会科学)》 2024年第6期141-158,共18页
绿色低碳可持续发展背景下,ESG信息披露在企业管理和资本市场投资决策领域掀起一股热潮,但ESG信息披露对审计师行为的影响尚不明确。基于此,以2010—2020年中国A股上市公司为样本,探析上市公司ESG信息披露与审计延迟的关系。研究发现:... 绿色低碳可持续发展背景下,ESG信息披露在企业管理和资本市场投资决策领域掀起一股热潮,但ESG信息披露对审计师行为的影响尚不明确。基于此,以2010—2020年中国A股上市公司为样本,探析上市公司ESG信息披露与审计延迟的关系。研究发现:上市公司ESG信息披露能够改善年报审计延迟;良好的ESG信息表现可以通过提高企业透明度、降低财务风险而缓解审计延迟;企业内部治理(高内部控制水平、低代理成本)和外部监管(高媒体关注、高分析师关注、高政府环境监管)能够增强ESG信息披露对审计延迟的抑制作用。研究结论丰富了ESG经济后果和审计延迟影响因素的相关文献,为提升企业年报信息价值、完善ESG信息体系建设、提高资本市场信息沟通效率提供了有效建议。 展开更多
关键词 EsG信息披露 审计延迟 企业透明度 财务风险 企业内部治理
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Has the risk of colorectal cancer in inflammatory bowel disease decreased? 被引量:7
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作者 Nynne Nyboe Andersen Tine Jess 《World Journal of Gastroenterology》 SCIE CAS 2013年第43期7561-7568,共8页
The association between inflammatory bowel disease(IBD)and colorectal cancer(CRC)has been acknowledged for almost a century and is assumedly promoted by a chronic inflammation-driven carcinogenic process in the intest... The association between inflammatory bowel disease(IBD)and colorectal cancer(CRC)has been acknowledged for almost a century and is assumedly promoted by a chronic inflammation-driven carcinogenic process in the intestine in combination with a genetic predisposition.The magnitude of the risk of CRC in IBD remains a continuing subject of debate.The early,high risk estimates for CRC in IBD were most likely overestimated due to selected patient populations originating from tertiary referral centers with a disproportional high percentage of patients with severe disease.Later population-based studies calculating risk estimates from a broad spectrum of IBD patients have found the risk to be significantly lower.At present,there is evidence that IBD patients with longstanding and extensive disease with uncontrolled inflammation are those at increased risk.Additional,other recognized risk factors include early age at onset,family history of CRC,and concomitant primary sclerosing cholangitis.A significant amount of effort is put into identifying potential preventive factors of CRC in IBD,including surveillance programs and chemopreventive agents but the individual effect of these remains uncertain.Interestingly,recent studies have reported a decline in risk of CRC over time.Surveillance programs and the new treatment strategies,particular biological treatment might be part of the reason for the observed decline in risk of CRC in IBD over time but future studies will have investigate this assumption. 展开更多
关键词 Inflammatory BOWEL DIsEAsE Colorectal cancer risk ULCERATIVE COLITIs Crohn’s DIsEAsE
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S-100β CysC和NF-κB对急性缺血性脑卒中患者静脉溶栓后出血转化的预测价值
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作者 李鹤 李樱 李磊 《中国实用神经疾病杂志》 2024年第4期415-419,共5页
目的 探讨急性缺血性脑卒中(AIS)外周血中S-100β、CysC和NF-κB水平对静脉溶栓后出血转化的影响及预测价值。方法 收集2019-03—2022-03接受溶栓治疗的AIS患者140例,根据溶栓后24 h是否发生出血转化(HT)将患者分为非HT组(n=112)和HT组(... 目的 探讨急性缺血性脑卒中(AIS)外周血中S-100β、CysC和NF-κB水平对静脉溶栓后出血转化的影响及预测价值。方法 收集2019-03—2022-03接受溶栓治疗的AIS患者140例,根据溶栓后24 h是否发生出血转化(HT)将患者分为非HT组(n=112)和HT组(n=28)。比较2组一般临床资料,采用多因Logistic回归分析影响HT发生的危险因素,受试者工作特征(ROC)曲线评估S-100β、CysC和NF-κB预测HT发生的价值。结果 HT组与非HT组相比,患者年龄、发病至溶栓时间、房颤、TOAST分型、C反应蛋白、凝血酶原时间、S-100β、CysC、NF-κB、白质高信号和脑微出血等均有统计学差异(P<0.05)。Logistic多因素回归分析显示,房颤、S-100β、CysC和NF-κB为影响HT发生的危险因素。S-100β、CysC和NF-κB预测AIS患者静脉溶栓后出血转化的曲线下面积分别为0.915(0.902~0.923)、0.874(0.856~0.882)和0.789(0.771~0.796),均具有一定的预测价值。结论 S-100β、CysC和NF-κB为AIS患者静脉溶栓后HT发生的危险因素,对HT发生具有一定的预测价值。 展开更多
关键词 急性缺血性脑卒中 静脉溶栓 出血转化 中枢神经特异蛋白 胱抑素C 核因子ΚB 外周血 危险因素 预测价值
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