Objective: To clarify the firing characteristics of the hippocampal pyramidal cells and in-terneurons in the auditory discrimination cognition. Methods: Thirteen guinea pigs were studied by the paired (active cognitio...Objective: To clarify the firing characteristics of the hippocampal pyramidal cells and in-terneurons in the auditory discrimination cognition. Methods: Thirteen guinea pigs were studied by the paired (active cognition group. n=10) or unpaired (passive cognition group. n = 3) training with 1 kHz (CS+)and 500 Hz tones (CS- ) and the air puff (US) applied 250 ms after the CS+ onset. Results: In active group. 32 pyramidal cells showed exciting response to the CS+ tone. 16 cells inhibited response and 4 cells revealed no response to the high frequency tone and 18 interneurons almost unchanged. In passive group, the pyramidal cells responded to the tone casually and 10 out of the 13 interneurons remained invariably. Conclusion: The result suggests that the pyramidal cells play a major role in coding auditory information by the networks, and the interneuons may modulate it via forward and feedback.展开更多
Experimental evidence in the rat suggests that perinatal undernutrition, associated with sensory and hormonal deficiencies, interferes with brain network integrative actions. We review peripheral and central morpho-fu...Experimental evidence in the rat suggests that perinatal undernutrition, associated with sensory and hormonal deficiencies, interferes with brain network integrative actions. We review peripheral and central morpho-functional alterations related to early food restriction along with the auditory relays, and their connections with the limbic system, which are essential for motivation-emotional arousal. The findings indicated that different morpho-functional alterations in the auditory system permanently affect the brainstem, the reticular thalamic nucleus, and the prefrontal and auditory cortices. Moreover, data showed the noxious role of early food restriction and the external ear occlusion on the distal portions of dendritic arbor measurements, in the cochlea, nucleus ambiguous and motor cortical pyramids. These anatomical alterations also correlated with deficiencies in the dynamic motor and auditory cognitive brain plasticity. Food restriction-related deficiencies in the motor-emotional-behavioral arousal systems may be useful to understand long-term cognitive disorders in humans.展开更多
文摘Objective: To clarify the firing characteristics of the hippocampal pyramidal cells and in-terneurons in the auditory discrimination cognition. Methods: Thirteen guinea pigs were studied by the paired (active cognition group. n=10) or unpaired (passive cognition group. n = 3) training with 1 kHz (CS+)and 500 Hz tones (CS- ) and the air puff (US) applied 250 ms after the CS+ onset. Results: In active group. 32 pyramidal cells showed exciting response to the CS+ tone. 16 cells inhibited response and 4 cells revealed no response to the high frequency tone and 18 interneurons almost unchanged. In passive group, the pyramidal cells responded to the tone casually and 10 out of the 13 interneurons remained invariably. Conclusion: The result suggests that the pyramidal cells play a major role in coding auditory information by the networks, and the interneuons may modulate it via forward and feedback.
文摘Experimental evidence in the rat suggests that perinatal undernutrition, associated with sensory and hormonal deficiencies, interferes with brain network integrative actions. We review peripheral and central morpho-functional alterations related to early food restriction along with the auditory relays, and their connections with the limbic system, which are essential for motivation-emotional arousal. The findings indicated that different morpho-functional alterations in the auditory system permanently affect the brainstem, the reticular thalamic nucleus, and the prefrontal and auditory cortices. Moreover, data showed the noxious role of early food restriction and the external ear occlusion on the distal portions of dendritic arbor measurements, in the cochlea, nucleus ambiguous and motor cortical pyramids. These anatomical alterations also correlated with deficiencies in the dynamic motor and auditory cognitive brain plasticity. Food restriction-related deficiencies in the motor-emotional-behavioral arousal systems may be useful to understand long-term cognitive disorders in humans.
