Lentivirus carrying the Atohl gene can infect Corti＇s organ and express a hair-like cell surface marker in the supporting cell area. However, expression of the gene carried by adenovirus is instantaneous, which undou...Lentivirus carrying the Atohl gene can infect Corti＇s organ and express a hair-like cell surface marker in the supporting cell area. However, expression of the gene carried by adenovirus is instantaneous, which undoubtedly limits its clinical application. Lentivirus acts as a carrier that can stably and continuously express genes. In this study, the cochlear structure and hearing level were not affected, and Atohl gene carried by lentivirus promoted the production of hair-like cells in the cochlear supporting cell area. This led to expression of the hair-like cell surface marker myosin 7a 30 days after lentivirus carrying Atohl was microinjected into the cochlear round window of rats.展开更多
目的探讨放射治疗对早期鼻咽癌患者骨导听阈的影响。方法收集2006年2月至2012年3月在我院治疗且资料完整的32例早期鼻咽癌患者,分别记录患者放疗前、放疗后1.5年及放疗后2年双耳0.5、1、2、4 k Hz四个语言频率骨导听阈值及畸变产物耳声...目的探讨放射治疗对早期鼻咽癌患者骨导听阈的影响。方法收集2006年2月至2012年3月在我院治疗且资料完整的32例早期鼻咽癌患者,分别记录患者放疗前、放疗后1.5年及放疗后2年双耳0.5、1、2、4 k Hz四个语言频率骨导听阈值及畸变产物耳声发射,并对记录的数据进行统计分析。结果患者双耳0.5、1、2、4 k Hz四个语言频率骨导阈值放疗后1.5年及放疗后2年均高于放疗前,且三者差异有统计学意义(P<0.05)。放疗后1.5年及放疗后2年患者DPOAE检查未通过率增高,且差异有统计学意义(P<0.05)。结论放疗可以使早期鼻咽癌患者骨导阈值提高,对于鼻咽癌放疗患者应尽早积极防治,避免感音神经性听力损失。展开更多
Objective： To investigate the relationship between clinical effects of acupuncture for elderly patients with sensorineural deafness and ear distending sensation. Methods： A total of 120 elderly patients with sensori...Objective： To investigate the relationship between clinical effects of acupuncture for elderly patients with sensorineural deafness and ear distending sensation. Methods： A total of 120 elderly patients with sensorineural deafness were randomly divided into a comprehensive treatment group, an acupuncture group and a Western medicine group, with 40 cases in each group. The acupuncture group received acupuncture treatment, the Western medicine group received oral mecobalamin tablets and the comprehensive treatment group received acupuncture plus acupoint injection and auricular acupoint sticking. The values of pure tone hearing threshold test of the three groups were observed before and after treatment, and the relationship between clinical effects and ear distending sensation was compared. Results： The total effective rate of the comprehensive treatment group was 82.5% versus 67.0% in the acupuncture group and 62.5% in the Western medicine group. The inter-group comparisons showed statistically significant differences in the comprehensive treatment group versus the Western medicine group （P〈0.01） and the acupuncture group （P〈0.05）. In the comprehensive treatment group, there were 23 cases （57.5%） with ear distending sensation, the clinical total effective rate was 86.9%; there were 17 cases （42.5%） without the sensation, the clinical total effective rate was 76.5%. In the acupuncture group, there were 24 cases （60.0%） with ear distending sensation, the clinical total effective rate was 71.0%; there were 16 cases （40.0%） without the sensation, the clinical total effective rate was 63.0%. In the Western medicine group, there were 21 cases （52.5%） with ear distending sensation, the clinical total effective rate was 66.7%; there were 19 cases （47.5%） without the sensation, the clinical total effective rate was 57.9%. The total effective rate of patients with ear distending sensation were higher than the rates of those without ear distending sensation in the three groups, but the differences were insignificant （all P〉0.05）. Conclusion： The comprehensive therapy is one of the effective methods to treat elderly patients with sensorineural deafness. In the three groups of elderly patients with sensorineural deafness, the relief of ear distending sensation and the hearing loss were basically simultaneous, and the hearing recovery in the patients with ear distending sensation may be slightly better than that in those without ear distending sensation. Nevertheless, further research is needed.展开更多
基金supported by grants from the National Basic Research Program of China (973 Program), No. 2012CB967900, 2012CB967904the National Natural Science Foundation of China, No. 81070782+2 种基金the Natural Science Foundation of Zhejiang Province, China, No. 30672308the Qianjiang Talent Project of Science and Technology Ministry in Zhejiang Province, No. 2011R10014the Natural Science Foundation of Ningbo, No. 2011A610042
文摘Lentivirus carrying the Atohl gene can infect Corti＇s organ and express a hair-like cell surface marker in the supporting cell area. However, expression of the gene carried by adenovirus is instantaneous, which undoubtedly limits its clinical application. Lentivirus acts as a carrier that can stably and continuously express genes. In this study, the cochlear structure and hearing level were not affected, and Atohl gene carried by lentivirus promoted the production of hair-like cells in the cochlear supporting cell area. This led to expression of the hair-like cell surface marker myosin 7a 30 days after lentivirus carrying Atohl was microinjected into the cochlear round window of rats.
文摘目的探讨放射治疗对早期鼻咽癌患者骨导听阈的影响。方法收集2006年2月至2012年3月在我院治疗且资料完整的32例早期鼻咽癌患者,分别记录患者放疗前、放疗后1.5年及放疗后2年双耳0.5、1、2、4 k Hz四个语言频率骨导听阈值及畸变产物耳声发射,并对记录的数据进行统计分析。结果患者双耳0.5、1、2、4 k Hz四个语言频率骨导阈值放疗后1.5年及放疗后2年均高于放疗前,且三者差异有统计学意义(P<0.05)。放疗后1.5年及放疗后2年患者DPOAE检查未通过率增高,且差异有统计学意义(P<0.05)。结论放疗可以使早期鼻咽癌患者骨导阈值提高,对于鼻咽癌放疗患者应尽早积极防治,避免感音神经性听力损失。
文摘Objective： To investigate the relationship between clinical effects of acupuncture for elderly patients with sensorineural deafness and ear distending sensation. Methods： A total of 120 elderly patients with sensorineural deafness were randomly divided into a comprehensive treatment group, an acupuncture group and a Western medicine group, with 40 cases in each group. The acupuncture group received acupuncture treatment, the Western medicine group received oral mecobalamin tablets and the comprehensive treatment group received acupuncture plus acupoint injection and auricular acupoint sticking. The values of pure tone hearing threshold test of the three groups were observed before and after treatment, and the relationship between clinical effects and ear distending sensation was compared. Results： The total effective rate of the comprehensive treatment group was 82.5% versus 67.0% in the acupuncture group and 62.5% in the Western medicine group. The inter-group comparisons showed statistically significant differences in the comprehensive treatment group versus the Western medicine group （P〈0.01） and the acupuncture group （P〈0.05）. In the comprehensive treatment group, there were 23 cases （57.5%） with ear distending sensation, the clinical total effective rate was 86.9%; there were 17 cases （42.5%） without the sensation, the clinical total effective rate was 76.5%. In the acupuncture group, there were 24 cases （60.0%） with ear distending sensation, the clinical total effective rate was 71.0%; there were 16 cases （40.0%） without the sensation, the clinical total effective rate was 63.0%. In the Western medicine group, there were 21 cases （52.5%） with ear distending sensation, the clinical total effective rate was 66.7%; there were 19 cases （47.5%） without the sensation, the clinical total effective rate was 57.9%. The total effective rate of patients with ear distending sensation were higher than the rates of those without ear distending sensation in the three groups, but the differences were insignificant （all P〉0.05）. Conclusion： The comprehensive therapy is one of the effective methods to treat elderly patients with sensorineural deafness. In the three groups of elderly patients with sensorineural deafness, the relief of ear distending sensation and the hearing loss were basically simultaneous, and the hearing recovery in the patients with ear distending sensation may be slightly better than that in those without ear distending sensation. Nevertheless, further research is needed.
