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Mapping the Research Landscape of Language Development in Autistic Children: A Preliminary Scientometric Analysis
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作者 Zhonghua WU Le CHENG 《Chinese Journal of Applied Linguistics》 2024年第4期670-686,688,共18页
Children with autism spectrum disorder(ASD)often encounter difficulties in language learning and utilization,a concern that has gained significant academic attention,particularly given the widespread occurrence of ASD... Children with autism spectrum disorder(ASD)often encounter difficulties in language learning and utilization,a concern that has gained significant academic attention,particularly given the widespread occurrence of ASD globally.Previous reviews,however,have relied on empirical observations rather than a more rigorous selection criterion.This preliminary study seeks to systematize the scientific knowledge base regarding language development in autistic children by utilizing the analysis tool Citespace 6.2.R5.We visualized and analyzed research patterns and trends regarding autism by drawing data from the Web of Science.Through document citation and emerging trend analyses,seven key research clusters and their chronological associations are identified,along with research hotspots such as language disorder diagnosis and intervention,social communication,language acquisition,and multilingual and multicultural influences.Research findings show that there exist some issues with the current research,including small sample sizes,the need for further investigation into receptive language development,and a lack of cross-cultural comparative studies.Meanwhile,the scope and depth of interdisciplinary research on language development in autistic children also need to be further enhanced.The research contributes to the extant literature by providing valuable references for autism researchers and practitioners. 展开更多
关键词 language development autistic children scientometric analysis ASD tentative study
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Prediction of Outcomes in Mini-Basketball Training Program for Preschool Children with Autism Using Machine Learning Models 被引量:2
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作者 Zhiyuan Sun Fabian Herold +6 位作者 Kelong Cai Qian Yu Xiaoxiao Dong Zhimei Liu Jinming Li Aiguo Chen Liye Zou 《International Journal of Mental Health Promotion》 2022年第2期143-158,共16页
In recent years evidence has emerged suggesting that Mini-basketball training program(MBTP)can be an effec-tive intervention method to improve social communication(SC)impairments and restricted and repetitive beha-vio... In recent years evidence has emerged suggesting that Mini-basketball training program(MBTP)can be an effec-tive intervention method to improve social communication(SC)impairments and restricted and repetitive beha-viors(RRBs)in preschool children suffering from autism spectrum disorder(ASD).However,there is a considerable degree if interindividual variability concerning these social outcomes and thus not all preschool chil-dren with ASD profit from a MBTP intervention to the same extent.In order to make more accurate predictions which preschool children with ASD can benefit from an MBTP intervention or which preschool children with ASD need additional interventions to achieve behavioral improvements,further research is required.This study aimed to investigate which individual factors of preschool children with ASD can predict MBTP intervention out-comes concerning SC impairments and RRBs.Then,test the performance of machine learning models in predict-ing intervention outcomes based on these factors.Participants were 26 preschool children with ASD who enrolled in a quasi-experiment and received MBTP intervention.Baseline demographic variables(e.g.,age,body,mass index[BMI]),indicators of physicalfitness(e.g.,handgrip strength,balance performance),performance in execu-tive function,severity of ASD symptoms,level of SC impairments,and severity of RRBs were obtained to predict treatment outcomes after MBTP intervention.Machine learning models were established based on support vector machine algorithm were implemented.For comparison,we also employed multiple linear regression models in statistics.Ourfindings suggest that in preschool children with ASD symptomatic severity(r=0.712,p<0.001)and baseline SC impairments(r=0.713,p<0.001)are predictors for intervention outcomes of SC impair-ments.Furthermore,BMI(r=-0.430,p=0.028),symptomatic severity(r=0.656,p<0.001),baseline SC impair-ments(r=0.504,p=0.009)and baseline RRBs(r=0.647,p<0.001)can predict intervention outcomes of RRBs.Statistical models predicted 59.6%of variance in post-treatment SC impairments(MSE=0.455,RMSE=0.675,R2=0.596)and 58.9%of variance in post-treatment RRBs(MSE=0.464,RMSE=0.681,R2=0.589).Machine learning models predicted 83%of variance in post-treatment SC impairments(MSE=0.188,RMSE=0.434,R2=0.83)and 85.9%of variance in post-treatment RRBs(MSE=0.051,RMSE=0.226,R2=0.859),which were better than statistical models.Ourfindings suggest that baseline characteristics such as symptomatic severity of 144 IJMHP,2022,vol.24,no.2 ASD symptoms and SC impairments are important predictors determining MBTP intervention-induced improvements concerning SC impairments and RBBs.Furthermore,the current study revealed that machine learning models can successfully be applied to predict the MBTP intervention-related outcomes in preschool chil-dren with ASD,and performed better than statistical models.Ourfindings can help to inform which preschool children with ASD are most likely to benefit from an MBTP intervention,and they might provide a reference for the development of personalized intervention programs for preschool children with ASD. 展开更多
关键词 Prediction OUTCOMES mini-basketball training program autistic children machine learning models
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The Effects of Therapeutic Horseback Riding Program on Motor Skills inChildren with Autism Spectrum Disorder 被引量:1
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作者 Mengxian Zhao Yonghao You +5 位作者 Jinming Li Sean Healy Alyx Taylor Zhihao Zhang Linlin Li Liye Zou 《International Journal of Mental Health Promotion》 2022年第4期475-489,共15页
Therapeutic horseback riding(THR)as an animal-assisted intervention is one of the innovative approaches emer-ging in the treatment for children with autism spectrum disorder(ASD).The current study was designed to inve... Therapeutic horseback riding(THR)as an animal-assisted intervention is one of the innovative approaches emer-ging in the treatment for children with autism spectrum disorder(ASD).The current study was designed to inves-tigate the effects of a 12-week,twice a week THR program on motor skills in sixty-eight children with ASD aged 5–10 years old.All participants selected met the DSM-V criteria for ASD,and a total offifty-three participants completed the study.A randomized controlled trial design was utilized for the study.Data was collected via a pre-THR test,interim-THR test,and post-THR test to investigate the possible changes in motor skills throughout the 12-week THR program.Results showed that the THR program significantly improved overall motor skills across time points(p<0.05)and sub-skills of run,gallop and two-hand catch(as compared to the control group,p<0.05).In conclusion,the THR program may be an effective option for improving motor skills in children with ASD and further investigation with a longer period of intervention is warranted. 展开更多
关键词 Therapeutic horseback riding animal-assisted intervention motor skills children with ASD AUTISTIC developmental disability equine-assisted activities and therapies
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Auditory symptoms and autistic spectrum disorder:A scoping review and recommendations for future research
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作者 Sara Timms Sirat Lodhi +1 位作者 Jack Bruce Emma Stapleton 《Journal of Otology》 CSCD 2022年第4期239-246,共8页
Introduction:Auditory symptoms in individuals with Autistic Spectrum Disorder(ASD)are well described within the neurodevelopmental literature,yet there is minimal mention of ASD in Otolaryngology literature.This is su... Introduction:Auditory symptoms in individuals with Autistic Spectrum Disorder(ASD)are well described within the neurodevelopmental literature,yet there is minimal mention of ASD in Otolaryngology literature.This is surprising considering the potential clinical and diagnostic implications of this link,and the potential for ASD to present to Otolaryngologists in the form of unexplained auditory symptoms.The aims of this literature review were to explore the intersection of auditory symptoms and ASD from the perspective of clinical Otolaryngology,and to outline a clinically focused research agenda based on emerging themes relevant to Otolaryngology.Methods:We searched Pubmed,Embase,Ovid and Cochrane library for studies until November 2021.Four authors independently reviewed 227 publications identified.39 were filtered into the final analysis.The PRISMA 2020 guidelines were followed.The heterogeneity of literature meant that a Systematic Review was not feasible.Included studies were therefore classified thematically,forming the basis of the scoping review.Results:Diagnostic theories for auditory symptoms in ASD include the entire auditory pathway and brain.There is a growing body of literature on auditory symptoms in ASD,suggesting that a primary diagnosis of ASD should be considered in patients presenting with otherwise unexplained auditory symptoms,and indicating a learning need for Otolaryngologists and audiologists,to whom these patients may present.Conclusion:We recommend a research agenda focusing on multidisciplinary collaboration,stakeholder engagement,responsible clinical screening,and clarification of pathophysiological mechanisms and terminology. 展开更多
关键词 Autistic disorder AUDIOLOGY OTOLARYNGOLOGY TINNITUS HYPERACUSIS
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Towards Defining the Pathophysiology of Autistic Behavior (Z4)
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《Neural Regeneration Research》 SCIE CAS CSCD 2010年第7期524-524,共1页
Meeting Summary Autism is a neurodevelopmental disorder defined by the of a set of characteristic behavioral features. One of the most common neurodevelopmental disorders, autism is recognized as heterogeneous in etio... Meeting Summary Autism is a neurodevelopmental disorder defined by the of a set of characteristic behavioral features. One of the most common neurodevelopmental disorders, autism is recognized as heterogeneous in etiology, phenotype, behavioral trajectory and response to treatment. While the etiology and specific pathogenetic mechanisms underlying autism are unknown, those mechanisms which underlie a small subset of etiologically-defined neurodevelopmental disorders (e.g., Fragile X Syndrome, tuberous sclerosis), that are associated with autism and autistic behaviors, have been well described. 展开更多
关键词 gene 2010 Towards Defining the Pathophysiology of Autistic Behavior Z4
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Measures of empathy in children and adolescents:A systematic review of questionnaires
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作者 Gianluca Sesso Giulio Emilio Brancati +3 位作者 Pamela Fantozzi Emanuela Inguaggiato Annarita Milone Gabriele Masi 《World Journal of Psychiatry》 SCIE 2021年第10期876-896,共21页
BACKGROUND Empathy has long been considered a multidimensional construct,encompassing cognitive,affective and behavioral domains.Deficits in empathic competences in early childhood contribute to psychopathology,and ha... BACKGROUND Empathy has long been considered a multidimensional construct,encompassing cognitive,affective and behavioral domains.Deficits in empathic competences in early childhood contribute to psychopathology,and have been variably implicated in several clinical conditions,such as autism spectrum disorders(ASD)and conduct disorders.AIM To identify and describe empirically validated questionnaires assessing empathy in children and adolescents and to provide a summary of related theoretical perspectives on empathy definitional issues.METHODS A systematic review of the literature was conducted.Three bibliographic databases were searched.A total of 47 studies were selected for final analysis and 16 distinct measures were identified and described.RESULTS Questionable to excellent levels of internal consistency were observed,while few studies assessed test-retest reliability.Although construct definitions only partially overlapped,affective and cognitive domains of empathy were the commonest internal factors that were often separately evaluated.New facets of the construct(i.e.,somatic empathy and sympathy)and specific clinical populations(i.e.,ASD)could be specifically addressed through more recent instruments.CONCLUSION The combination of different assessment methods is recommended in order to foresee further improvements in this field and try to overcome the problem of limited convergence with more objective measures. 展开更多
关键词 EMPATHY ASSESSMENT CHILD ADOLESCENT Autistic disorder Conduct disorder
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Parents of Children with Autistic Spectrum Disorder (ASD) as Co-therapists: The Therapists’ View
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作者 Angelique Kotsopoulou Ermioni Papadaki +9 位作者 Irene Florou Antigoni Troupou Dimitra Kolosioni Anastasia Georgiou Maria Gyftogianni Aikaterini Gyftogianni Athina Iliopoulou Eleonora Paleodimou Marigo Sakellari Efthimia Koumanioti 《Psychology Research》 2021年第2期44-55,共12页
Studies on the evaluation by therapists of parental behavior towards their children with Autistic Spectrum Disorder(ASD)and towards the therapists of their children are scarce.They are necessary,however,for enabling p... Studies on the evaluation by therapists of parental behavior towards their children with Autistic Spectrum Disorder(ASD)and towards the therapists of their children are scarce.They are necessary,however,for enabling parents to become co-therapists.The present study’s purpose was the evaluation by therapists of the behavior of parents towards their children,of their relationship to therapists,and therapy outcome.The sample consisted of 178 parents of 89 children(72 boys)with ASD,who underwent intensive early intervention at a day centre for developmental disabilities.The professional team completed a questionnaire,separately for the mother and father,evaluating the parental attitude towards their children and towards the therapists.The behavior of parents was less satisfactory than expected.The fathers had difficulties in understanding their child’s problems,and had unrealistic expectations;mothers’behavior towards their children and therapists was better than the fathers’.Mothers had difficulty mostly in the management of the child’s behavior,and did not do well with feeding.It might be difficult for every parent to become co-therapist.Understanding the child’s difficulties by the mother,adequate handling of feeding and homework,were statistically significant in the good outcome of therapy. 展开更多
关键词 Autistic Spectrum Disorder(ASD) PARENTS co-therapists stress expectations collaboration homework
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Clinical and therapeutic implications of psychiatric comorbidity in high functioning autism/Asperger syndrome: An Italian study
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作者 Silvia Giovinazzo Sara Marciano +2 位作者 Grazia Giana Paolo Curatolo Maria-Cristina Porfirio 《Open Journal of Psychiatry》 2013年第3期329-334,共6页
The present study describes the occurrence of psychiatric comorbid disorders in a cohort of 86 high functioning autism (HFA)/Asperger syndrome (AS) patients, examined at Child Neurology and Psychiatry Unit of Tor Verg... The present study describes the occurrence of psychiatric comorbid disorders in a cohort of 86 high functioning autism (HFA)/Asperger syndrome (AS) patients, examined at Child Neurology and Psychiatry Unit of Tor Vergata University. 38 patients out of 86 (44.2%) presented one or more psychiatric comorbidities, such as mood disorders, Attention Deficit/Hyperactivity Disorder (ADHD), Tourette syndrome (TS), anxiety disorders, including obsessive-compulsive disorder (OCD), and psychotic symptoms. We compared our sample with the evidences from the scientific literature on psychiatric comorbidity in ASD patient, in particular in HFA/AS. In this paper we focus on the high frequency of comorbid psychiatric disorders in HFA/AS patients, such as mood disorders, Attention Deficit/Hyperactivity Disorder (ADHD), Tourette syndrome (TS), anxiety disorders, including obsessive-compulsive disorder (OCD), and psychosis, including schizophrenia. We analyzed rates of all psichiatric comorbidities diagnosed in a sample of HFA/AS subjects and we compared findings from our study with the evidences from the scientific literature on psychiatric comorbidity in ASD patients, in particular HFA/AS. We point out that comorbid psychiatric symptoms can be hardly diagnosed, because they could present atipically in ASDs then in general population. Furthermore, they could be masked by ASD core symptoms. 展开更多
关键词 AUTISTIC Spectrum DISORDERS PSYCHIATRIC COMORBIDITY
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Social Psychology of Architect in the Course of Spatial Creation
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作者 GAO Wei 《Journal of Landscape Research》 2016年第5期62-64,76,共4页
In the course of spatial creation, architect's psychology could be influenced or restricted by the society, and based on this fact this paper summarized the individual psychology of the architect as "autistic... In the course of spatial creation, architect's psychology could be influenced or restricted by the society, and based on this fact this paper summarized the individual psychology of the architect as "autistic thinking" and "controlled consciousness" and analyzed the resulting eight mental dispositions, namely, nostalgia proneness, novelty proneness, interest tendency, flaunt tendency, nihility tendency, political wil, cultural will and economic will. This research argued that the analysis and the example of the social mentality could describe, illustrate and predict the implied creation motivation of the architect as well as how they directly act on the course of spatial creation. 展开更多
关键词 Social mentality Autistic thinking Controlled consciousness
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How different is early-onset childhood disintegrative disorder from autistic disorder with speech loss?
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作者 Hiroshi Kurita Kanna Inoue 《Open Journal of Psychiatry》 2013年第2期39-45,共7页
To examine the difference between early-onset (< age 3) childhood disintegrative disorder (CDD) and autistic disorder with speech loss (ADSL), 8 children with early-onset CDD (mean age = 7.6 years, SD = 3.8;6 males... To examine the difference between early-onset (< age 3) childhood disintegrative disorder (CDD) and autistic disorder with speech loss (ADSL), 8 children with early-onset CDD (mean age = 7.6 years, SD = 3.8;6 males) were compared with 92 age and gender-ratio comparable children with ADSL (mean age = 6.8 years, SD = 4.1;70 males) on 24 variables not directly related to the key features of CDD (regression after normal development for at least the first 2 years after birth). Compared with the ADSL group, the early-onset CDD group had a tendency to have a higher rate of a psychosocial event before speech loss (SL) (early-onset CDD, 75.0% vs ADSL, 37.0%, p = 0.057;effect size (phi) = 0.211, p < 0.05);a significantly higher rate of fearfulness during SL (62.5% vs 4.3%, p = 0.000;phi = 0.551, p < 0.05);and a tendency to have a higher rate of epilepsy (25.0% vs 3.3%, p = 0.050;phi = 0.271, p < 0.05), a tendency to have a lower rate of the Childhood Autism Rating Scale-Tokyo Version (CARS-TV) total score ≥ 30 (75.0% vs 95.7%, p = 0.072;phi = 0.236, p < 0.05), and a significantly lower rate of CARS-TV item 2 (imitation) score ≥ 2 (50.0% vs 82.6%, p = 0.049;phi = 0.221, p < 0.05) on the first visit. The two groups did not exhibit any significant difference in the other 19 variables. The findings of no significant difference in the great majority and a significant difference in the small minority of the 24 variables between the two groups support integrating CDD into regressive autism spectrum disorder and studying CDD as its prototypical form. 展开更多
关键词 AUTISTIC DISORDER AUTISM Spectrum DISORDER (ASD) CHILDHOOD Disintegrative DISORDER Diagnosis Regression
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Autism spectrum disorder:Review of literature and dental management
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作者 Luiz Fernando M Czornobay Etiene Andrade Munhoz +2 位作者 Mariah L Lisboa Ines Beatriz S Rath Alessandra R de Camargo 《World Journal of Stomatology》 2018年第2期11-18,共8页
With an increase in the number of cases of autism spectrum disorder(ASD),dental professionals need to be aware of the different techniques required to ensure safe dental treatments for affected patients. The concerns ... With an increase in the number of cases of autism spectrum disorder(ASD),dental professionals need to be aware of the different techniques required to ensure safe dental treatments for affected patients. The concerns and preferences of the parents and the medical and dental history of each patient should be considered. The aim of this article was to provide a comprehensive update on the medical and dental health of patients with ASD. A detailed search of the electronic database PubMed/Medline/Lilacs was performed for the terms"Autism", "Autistic", "Autism Spectrum Disorder", "ASD", "Dentistry" and"Dentist", in the period between 2006 and 2017. Systemic reviews, research articles, and literature reviews were included. Expert opinions, case series, and case reports were excluded from the search. A detailed family-centered approach based on the preferences and concerns of parents is an important foundation for appropriate individualized dental treatment of patients with ASD. In addition,the knowledge of disruptive behaviors and patient′s challenges may guide dental practitioners in improving treatment planning, oral management, and the overall oral health of patients with ASD. 展开更多
关键词 AUTISM Autism spectrum disorder AUTISTIC DENTISTRY Dental management
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Inclusive Methods in Art Classroom for Students with Autism in China
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作者 Shiyun Liu 《Review of Educational Theory》 2022年第1期16-32,共17页
Cultivating professional knowledge and developing specific inclusive training has always been important for educators in China.Within the context of special art education in China,art educators are supposed to adjust ... Cultivating professional knowledge and developing specific inclusive training has always been important for educators in China.Within the context of special art education in China,art educators are supposed to adjust the instruction effectively for students with a variety of disabilities.This qualitative study sought to gain insight of the strategies of modifying and adapting art instruction for children with autism.Data were collected and analyzed by comparative method through interviews with three art educators.During the interview,three participants addressed strategies they use when working with autistic students in art classroom and proved the ways to modify and adapt art instruction to enhance autistic children’s pedagogical skills.Art teachers can also identify students’preferred art materials to engage autistic students in learning art.Beyond helping my educational practice,this study could further serve as an impetus to assist other educators in China thus expand teachers’professional knowledge in teaching children with special needs. 展开更多
关键词 Special education AUTISM Autistic children Art education China
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Global Functional Performance and Caregiver Assistance in Autism and Asperger Syndrome
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作者 Michele Gea Guimaraes Pozzato Thais Soares Cianciarullo Minett +1 位作者 Marcelo Rodrigues Masruha Luiz Celso Pereira Vilanova 《Neuroscience & Medicine》 2014年第1期42-48,共7页
Autism and Asperger’s syndrome belong to a family of neuro-developmental disorders called Pervasive Development Disorders. The aims of this study were to 1) quantify the overall functional performance and need for ca... Autism and Asperger’s syndrome belong to a family of neuro-developmental disorders called Pervasive Development Disorders. The aims of this study were to 1) quantify the overall functional performance and need for caregiver assistance in autism (A) and Asperger’s syndrome (AS), 2) compare the findings between groups and to normative data from Brazilian children. Methods: A cross-sectional study was carried out involving 52 children between three and eight years of age diagnosed with either A (n = 26) or SA (n = 26). The Brazilian version of the Pediatric Evaluation of Disability Inventory was administered. Results: The children with A and AS achieved significantly lower scores than that expected for normality. The children with AS had a significantly better social function than that the children with A had. However, those with A achieved significantly better scores than those with AS on activities related to self-care and mobility, requiring less assistance. Conclusion: While patients with AS are better at social interaction than typical autistic children, they exhibit greater deficits with regard to basic tasks, such as self-care and mobility, requiring greater assistance than children with A. 展开更多
关键词 Autistic Disorder Asperger Syndrome Child Development CAREGIVERS
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Study on the Application Effect of Family Follow-Up Rehabilitation Nursing in Elderly Autistic Patients in Community Institutions
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作者 Qing Ji Ronnell D.Dela Rosa +1 位作者 Mingzhu He Minerva B.De Ala 《Journal of Clinical and Nursing Research》 2022年第5期73-78,共6页
Objective:To study the effect of family follow-up nursing in rehabilitation of elderly autistic patients in community institutions.Methods:120 elderly autistic patients from February 2021 to July 2022 were randomly di... Objective:To study the effect of family follow-up nursing in rehabilitation of elderly autistic patients in community institutions.Methods:120 elderly autistic patients from February 2021 to July 2022 were randomly divided into a control group and a test group with 60 cases each.The patients in the control group were cared for at home by their family members,while the patients in the test group were given family follow-up rehabilitation care on the basis of the control group.The compliance of patients in the rehabilitation process,the UCLA loneliness score,the autism treatment assessment scale(ATEC)score of patients after this nursing care,and the quality-of-life scores of patients of the two groups before and after nursing care were compared.Results:The compliance of patients in the process of rehabilitation treatment was better in the experimental group than in the experimental group.The physical function score of patients after nursing was better in the experimental group than in the experimental group.The UCLA loneliness score and ATEC score of patients in the experimental group after nursing were lower than those of the control group(P<0.05);the quality-of-life score was higher in the experimental group(P<0.05).Conclusion:The application of family follow-up nursing in the rehabilitation of elderly autistic patients in community institutions can significantly improve patients’compliance and improve their prognosis,thus having high clinical value. 展开更多
关键词 Elderly autistic patients Rehabilitation care Family follow-up Application effect
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Sex-biased single-cell genetic landscape in mice with autism spectrum disorder
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作者 Qian Zhang Yongjie Wang +4 位作者 Jie Tao Ruixue Xia Yijie Zhang Zhirui Liu Jiwei Cheng 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2024年第3期338-351,共14页
Autistic spectrum disorder(ASD)is a male-biased,heterogeneous neurodevelopmental disorder that affects approximately 1%e2%of the population.Prenatal exposure to valproic acid(VPA)is a recognized risk factor for ASD,bu... Autistic spectrum disorder(ASD)is a male-biased,heterogeneous neurodevelopmental disorder that affects approximately 1%e2%of the population.Prenatal exposure to valproic acid(VPA)is a recognized risk factor for ASD,but the cellular and molecular basis of VPA-induced ASD at the single-cell resolution is unclear.Here,we aim to compare the cellular and molecular differences in the hippocampus between male and female prenatal mice with ASD at the single-cell transcriptomic level.The transcriptomes of more than 45,000 cells are assigned to 12 major cell types,including neurons,glial cells,vascular cells,and immune cells.Cell type-specific genes with altered expression after prenatal VPA exposure are analyzed,and the largest number of differentially expressed genes(DEGs)are found in neurons,choroid plexus epithelial cells,and microglia.In microglia,several pathways related to inflammation are found in both males and females,including the tumor necrosis factor(TNF),nuclear factor kappa B(NF-kB),toll-like receptor(TLR),and mitogen-activated protein kinase(MAPK)signaling pathways,which are important for the induction of autistic-like behavior.Additionally,we note that several X-linked genes,including Bex1,Bex3,and Gria3,were among the male-specific DEGs of neurons.This pioneering study describes the landscape of the transcriptome in the hippocampus of autistic mice.The elucidation of sexual differences could provide innovative strategies for the prevention and treatment of ASD. 展开更多
关键词 Autistic spectrum disorder(ASD) SEX Single cell NEURONS MICROGLIA
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Data-driven,client-centric applied behavior analysis treatment-dose optimization improves functional outcomes
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作者 Andrey Ostrovsky Melissa Willa +3 位作者 Ted Cho Maxwell Strandberg Sage Howard Colin Davitian 《World Journal of Pediatrics》 SCIE CSCD 2023年第8期753-760,共8页
Background With increasing numbers of individuals diagnosed with autism spectrum disorder(ASD)and with affirmation of applied behavior analysis(ABA)as an evidence-based standard of care for ASD,there has been a prolif... Background With increasing numbers of individuals diagnosed with autism spectrum disorder(ASD)and with affirmation of applied behavior analysis(ABA)as an evidence-based standard of care for ASD,there has been a proliferation of agencies offering ABA services over the last several decades.Disagreement exists among ABA providers and health plans that reimburse those providers on the optimal number of hours of ABA services that should be reimbursed.This study aims to understand whether children who receive more hours of ABA therapy achieve better outcomes and to evaluate the impact of the COVID-19-induced shift to telehealth clinical supervision on outcomes.Methods A retrospective cohort analysis was performed using data from the Vineland 3 Comprehensive Interview Form to assess function throughout ABA treatment.Paired sample t tests,independent sample t tests,Cohen’s D,and Pearson correlations were used to determine relationships between Vineland scores and input variables including hours of service and modality of supervision(in-person vs.telehealth).Results While statistically and clinically significant improvements in function were observed,children appear to have improved outcomes independent of the number of hours of service received.There were also no significant associations between modality of supervision and Vineland standard scores.Conclusions These findings challenge prior research that demonstrated a linear dose–response relationship.By tailoring treatment dosage to the individual client’s needs,providers may be able to better maximize functional progress of the client,to preserve family time,and to utilize health plan dollars more efficiently. 展开更多
关键词 Autism spectrum disorder(ASD) Autistic disorder Autistic rehabilitation Autistic therapy TELEMEDICINE
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Clinical observation on acupuncture at thirteen ghost acupoints for children with autism spectrum disorder 被引量:14
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作者 李诺 黎洁玲 +6 位作者 刘振寰 赵勇 金炳旭 符文杰 梁碧琪 庞碧徽 贾一凡 《Journal of Acupuncture and Tuina Science》 CSCD 2017年第5期344-348,共5页
Objective: To observe the clinical efficacy of needling thirteen ghost acupoints for children with autism spectrum disorder. Methods: A total of 90 cases with autism spectrum disorder (ASD) aged between 2 and 6 ye... Objective: To observe the clinical efficacy of needling thirteen ghost acupoints for children with autism spectrum disorder. Methods: A total of 90 cases with autism spectrum disorder (ASD) aged between 2 and 6 years were randomly allocated into 2 groups by random number table. The control group (n=45) received routine rehabilitative training, and the treatment group (n=45) received acupuncture at thirteen ghost acupoints plus routine rehabilitative training. The Beijing Gesell developmental (Gesell) scale and autism behavior checklist (ABC) were used to assess the intellectual, language and behavior development before and 3 months after the treatment. Results: After the treatment, the total effective rate in the treatment group was 82.2%, versus 55.6% in the control group, showing a statistical significance (P〈0.05). As for the scores of social, emotional and language in Gesell scale, there were significant intra-group differences in the treatment group (all P〈0.05), and all the five subscales in the Gesell scale in the treatment group were significantly better than those in the control group (all P〈0.05). As for the scores of ABC, there were significant intra-group differences in the treatment group (P〈0.05), and the scores in the treatment group were significantly better than those in the control group (all P〈0.05). Conclusion: Rehabilitation training plus acupuncture at thirteen ghost acupoints can significantly improve the intellectual, language and abnormal behavior in autism spectrum disorder children. 展开更多
关键词 Acupuncture Therapy Autistic Disorder Autism Spectrum Disorder Thirteen Ghost Acupoints Rehabilitation Children Preschool
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Parenting stress and affective symptoms in parents of autistic children 被引量:3
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作者 GONG Yun DU YaSong +3 位作者 LI HuiLin ZHANG XiYan AN Yu WU Bai-Lin 《Science China(Life Sciences)》 SCIE CAS CSCD 2015年第10期1036-1043,共8页
We examined parenting stress and mental health status in parents of autistic children and assessed factors associated with such stress. Participants were parents of 188 autistic children diagnosed with DSM-IV criteria... We examined parenting stress and mental health status in parents of autistic children and assessed factors associated with such stress. Participants were parents of 188 autistic children diagnosed with DSM-IV criteria and parents of 144 normally developing children. Parents of autistic children reported higher levels of stress, depression, and anxiety than parents of normally developing children. Mothers of autistic children had a higher risk of depression and anxiety than that did parents of normally developing children. Mothers compared to fathers of autistic children were more vulnerable to depression. Age, behavior problems of autistic children, and mothers' anxiety were significantly associated with parenting stress. 展开更多
关键词 autistic children parenting stress mental health parenting stress index
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Autism genetics: Methodological issues and experimental design 被引量:1
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作者 Roberto SACCO Carla LINTAS Antonio M.PERSICO 《Science China(Life Sciences)》 SCIE CAS CSCD 2015年第10期946-957,共12页
Autism is a complex neuropsychiatric disorder of developmental origin, where multiple genetic and environmental factors likely interact resulting in a clinical continuum between "affected" and "unaffect... Autism is a complex neuropsychiatric disorder of developmental origin, where multiple genetic and environmental factors likely interact resulting in a clinical continuum between "affected" and "unaffected" individuals in the general population. During the last two decades, relevant progress has been made in identifying chromosomal regions and genes in linkage or association with autism, but no single gene has emerged as a major cause of disease in a large number of patients. The purpose of this paper is to discuss specific methodological issues and experimental strategies in autism genetic research, based on fourteen years of experience in patient recruitment and association studies of autism spectrum disorder in Italy. 展开更多
关键词 autistic disorder ENDOPHENOTYPE genetic association GENETICS pervasive developmental disorders
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Association of neonatal blood levels of brain-derived neurotrophic factor with development of autism spectrum disorder:a systematic review and meta-analysis 被引量:1
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作者 Ya-Kun Liu Hua Gao +2 位作者 Shao-Bin Jin Wen-Jun Tu Ya-Jun Chen 《World Journal of Pediatrics》 SCIE CAS CSCD 2021年第2期164-170,共7页
Background Our goal was to evaluate the association between neonatal blood brain-derived neurotrophic factor(BDNF)level and autism spectrum disorder(ASD)diagnosis later in life.Methods MEDLINE and Web of Science datab... Background Our goal was to evaluate the association between neonatal blood brain-derived neurotrophic factor(BDNF)level and autism spectrum disorder(ASD)diagnosis later in life.Methods MEDLINE and Web of Science databases were searched from inception until September 16,2020.Reference lists of all relevant articles also were reviewed.Mean blood BDNF concentrations,standard deviations,sample sizes,and other data needed for calculation of effect sizes were extracted by two independent investigators.The quality of the included studies was appraised using the Newcastle-Ottawa Scale for case-control studies.Data were pooled using the random-effects model.Results Five case-control studies involving 1341 cases and 3395 controls were included in the meta-analysis.The meta-analysis of all included studies showed no significant difference in blood BDNF levels between neonates diagnosed with ASD later in life and healthy controls[standardized mean difference(SMD)=0.261;95%confidence interval(CI)-0.052 to 0.573;P=0.102],with high level of heterogeneity(Q=64.346;I2=93.784;P<0.001).A subgroup analysis by assay type showed decreased blood BDNF levels in ASDs compared to controls(SMD=—0.070;95%CI-0.114 to-0.026;P=0.002),with high level of homogeneity(Q=0.894;I2=0.000;P=0.827).No evidence of publication bias was observed.Conclusions Neonates diagnosed with ASD later in life have decreased blood levels of BDNF measured by double-antibody immunoassay.More studies are warranted to facilitate a more robust conclusion. 展开更多
关键词 Autism spectrum disorder Autistic disorder Brain-derived neurotrophic factor NEONATES NEUROTROPHINS
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