Effects of Cigarette Auxiliary Material Parameters on Release Amounts of Tar, CO and Free Radicals in Cigarette Mainstream Smoke

[Objective] This study aimed to investigate the effects of cigarette auxiliary material parameters on release amounts of tar, CO and free radicals in cigarette mainstream smoke. [Method] The effects of cigarette paper air-permeability, cigarette paper gram weight, filter rod pressure drop and filter tip ventilating strength parameters on the release amounts of tar, CO and free radicals in cigarette mainstream smoke were investigated by single factor experiment and orthogonal experiment. [Result] The cigarette paper air-permeability, filter rod pressure drop and filter tip ventilating strength showed significantly negative correlation with the release amounts of tar, CO and free radicals in cigarette mainstream smoke, to be specific, the cigarette paper air-permeability showed the greatest effect on the release amounts of tar and CO, filter tip ventilating strength showed the greatest effect on the release amounts of gaseous-phase free radicals and particulate-phase free radicals, while cigarette paper gram weight showed relatively slight effect on the release amounts of tar, CO and free radicals. Within the orthogonal experimental range, the optimal program is identified as cigarette paper airpermeability of 70 CU, filter rod pressure drop of 4500 Pa/unit, and filter tip ventilating strength of 60 CU. Compared to the results without optimization, the release amounts of tar, CO and free radicals after optimization were all reduced. [Conclusion] This study laid the foundation for the research of cigarette tar reduction and harm reduction.

Property of Dual-purposed Maca Powder as Medicine and Food

[Objective] The aim was to research property of maca and three plants＇ powders and process parameters of compound maca direct compression. [Method] Based on analysis data from SAS, bulk density, tap density, angle of repose and swelling of powders were studied as per single factor method and orthogonal exper- imental design. [Result] The test indicated that fillibilities of plant A and B, and maca powders are better and flowability plays an important role in fractional close of compound maca powder; plant A and B powders have a significant effect on bulk density of maca （P=0.0125）, an extremely significant effect on swelling volume ratio （P=0.008 9） and little effect on tap density （g/ml）; the optimal process condition of compound maca powder is as follows： A at 0.15 share; B at 0.10 share; C at 0.05 share; the optimal swelling volume ratio is at 2.459. [Conclusion] The technology is reasonable in formulation and satisfactory in fillibility, swelling ability, flowability, and it could serve as theoretical basis for the industrial production of maca tablets.

Dynamic DNA nanomachines for amplification imaging of diseased cells based on stimuli-responsive mechanism

As a basic functional unit,living cell with sophisticated structures play an indispensable role in life activities.Since the abnormality of important molecules inside cells is closely related to diseases,the dynamic analysis and spatio-temporal monitoring of specific molecules in living cells can provide precious information for the diagnosis and treatment of diseases.More recently,DNA has not only been recognized as the carrier of genetic information,but has also used as a robust building block for the assembly of multitudinous nanoscale structures due to the intrinsic advantages of high programmability of classic Watson–Crick base-pairing rule.Intensive study promotes the rapid progress of nanotechnology in various fields,such as bioimaging,diagnosis,and therapeutics.Among numerous well-defined DNA nanomaterials,DNA nanomachines have been widely exploited in cell imaging owing to their desirable ability to achieve high-resolution temporal and spatial images in response to endogenous or exogenous stimuli.In brief,elaborate DNA nanomachines can undergo structural changes upon the stimuli of target analytes or environmental factors,resulting in rapid increase or reduction of output signals and thereby indirectly reflecting the expression level of targets.DNA nanomachines with high sensitivity and specificity contribute to the recognition of diseased tissues.In this review,we introduce the basic assembly modules of DNA nanomachines and summarize the recent advances in dynamic DNA nanomachines for diseased-cell imaging.Finally,the current challenges and future directions of DNA nanomachines for bioimaging are discussed.