The experimental investigation of axial-flow pump has been rapidly developed to meet the needs of South-to-North Water Diversion Project of China. Owing to the boundary conditions of hub, blade tip clearance, much of ...The experimental investigation of axial-flow pump has been rapidly developed to meet the needs of South-to-North Water Diversion Project of China. Owing to the boundary conditions of hub, blade tip clearance, much of the physical phenomena and laws involved in this complex flow field can't be fully determined. The flow characteristics of the high efficiency axial-flow pump have been simulated by RNG k-e turbulence model and SIMPLEC arithmetic based on FLUENT software. Numerical results indicate that the data from the prediction show agreement with the experimental results, static pressure on pressure side of blades increases slightly at circumferential direction with radius increasing, and keep almost constant at the same radial while increasing gradually from inlet to exit on the suction side along flow direction at design conditions. The static pressure, total pressure and velocity at inlet, impeller outlet and vane outlet were measured by a five-hole probe, and a contrastive experiment was done to investigate the influence of hub leakage. The experimental results show that inlet flow is almost axial and the prerotation is very small at various conditions. The meridional velocity and circulation distribution are almost identical at impeller outlet at design conditions due to steady flow and high efficiency. The residual circulation exits at downstream of the guide vane, and the circumferential velocity component increases linearly from hub to tip at small flow rate conditions. Hub leakage in adjustable blades results in the decrease of the meridional velocity and circulation at blade exit near hub. The results of numerical simulation and experiments supply important flow structure information for the high-efficiency axial-flow pump.展开更多
BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related disorders.Recent evidence suggests associations between long-term...BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related disorders.Recent evidence suggests associations between long-term PPI use and higher risks for various adverse health outcomes,including greater mortality.AIM To investigate the association between PPI use and all-cause mortality among cancer patients by a comprehensive analysis after adjustment for various confounders and a robust methodological approach to minimize bias.METHODS This retrospective cohort study used data from the TriNetX research network,with electronic health records from multiple healthcare organizations.The study employed a new-user,active comparator design,which compared newly treated PPI users with non-users and newly treated histamine2 receptor antagonists(H2RA)users among adult cancer patients.Newly prescribed PPIs(esomeprazole,lansoprazole,omeprazole,pantoprazole,or rabeprazole)users were compared to non-users or newly prescribed H2RAs(cimetidine,famotidine,nizatidine,or ranitidine)users.The primary outcome was all-cause mortality.Each patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding effects.Multivariable Cox regression models were used to estimate hazard ratios(HRs)and 95% confidence interval(CI).RESULTS During the follow-up period(median 5.4±1.8 years for PPI users and 6.5±1.0 years for non-users),PPI users demonstrated a higher all-cause mortality rate than non-users after 1 year,2 years,and at the end of follow up(HRs:2.34-2.72).Compared with H2RA users,PPI users demonstrated a higher rate of all-cause mortality HR:1.51(95%CI:1.41-1.69).Similar results were observed across sensitivity analyses by excluding deaths from the first 9 months and 1-year post-exposure,confirming the robustness of these findings.In a sensitivity analysis,we analyzed all-cause mortality outcomes between former PPI users and individuals who have never used PPIs,providing insights into the long-term effects of past PPI use.In addition,at 1-year follow-up,the analysis revealed a significant difference in mortality rates between former PPI users and non-users(HR:1.84;95%CI:1.82-1.96).CONCLUSION PPI use among cancer patients was associated with a higher risk of all-cause mortality compared to non-users or H2RA users.These findings emphasize the need for cautious use of PPIs in cancer patients and suggest that alternative treatments should be considered when clinically feasible.However,further studies are needed to corroborate our findings,given the significant adverse outcomes in cancer patients.展开更多
We present experimental results on kilojoule ultraviolet laser output with 1%spectral broadening.Through stimulated rotational Raman scattering(SRRS)with signal laser injection,we achieve effective spectral broadening...We present experimental results on kilojoule ultraviolet laser output with 1%spectral broadening.Through stimulated rotational Raman scattering(SRRS)with signal laser injection,we achieve effective spectral broadening in short-range propagation,with good retention of the original near-field distribution and time waveform.Theoretical calculations show that 2%bandwidth spectral broadening can be achieved by injecting 20 kW~cm^(2) signal light at 2.2 GW~cm^(2) flux of the pump laser.In addition,high-frequency modulation in the near field can be effectively avoided through replacement of the original random noise signal light by the controllable signal light.The SRRS in the atmospheric environment excited with signal laser injection can provide wide-band light output with controllable beam quality without long-distance propagation,representing an important potential route to realization of broadband laser drivers.展开更多
This research investigates the design and optimization of a photovoltaic(PV)water pumping system to address seasonal water demands across five locations with varying elevation heads.The systemdraws water froma deep we...This research investigates the design and optimization of a photovoltaic(PV)water pumping system to address seasonal water demands across five locations with varying elevation heads.The systemdraws water froma deep well with a static water level of 30mand a dynamic level of 50m,serving agricultural and livestock needs.The objective of this study is to accurately size a PV system that balances energy generation and demand while minimizing grid dependency.Meanwhile,the study presents a comprehensivemethodology to calculate flowrates,pumping power,daily energy consumption,and system capacity.Therefore,the PV system rating,energy output,and economic performance were evaluated using metrics such as discounted payback period(DPP),net present value(NPV),and sensitivity analysis.The results show that a 2.74 kWp PV system is optimal,producing 4767 kWh/year to meet the system’s annual energy demand of 4686 kWh.In summer,energy demand peaks at 1532.7 kWh,while in winter,it drops to 692.1 kWh.Meanwhile,flow rates range from 11.71 m3/h at 57 m head to 10.49 m^(3)/h at 70 m head,demonstrating the system’s adaptability to diverse hydraulic conditions.Economic analysis reveals that at a 5%interest rate and an electricity price of$0.15/kWh,the NPV is$6981.82 with a DPP of 3.76 years.However,a 30%increase in electricity prices improves the NPV to$10,005.18 and shortens the DPP to 2.76 years,whereas a 20%interest rate reduces the NPV to$1038.79 and extends the DPP to 6.08 years.Nevertheless,the annual PV energy generation exceeds total energy demand by 81 kWh,reducing grid dependency and lowering electricity costs.Additionally,the PV system avoids approximately 3956.6 kg of CO_(2) emissions annually,underscoring its environmental benefits over traditional pumping systems.As a result,this study highlights the economic and environmental viability of PV-powered water pumping systems,offering actionable insights for sustainable energy solutions in agriculture.展开更多
Large-scale new energy grid connection leads to the weakening of the system frequency regulation capability,and the system frequency stability is facing unprecedented challenges.In order to solve rapid frequency fluct...Large-scale new energy grid connection leads to the weakening of the system frequency regulation capability,and the system frequency stability is facing unprecedented challenges.In order to solve rapid frequency fluctuation caused by new energy units,this paper proposes a new energy power system frequency regulation strategy with multiple units including the doubly-fed pumped storage unit(DFPSU).Firstly,based on the model predictive control(MPC)theory,the state space equations are established by considering the operating characteristics of the units and the dynamic behavior of the system;secondly,the proportional-differential control link is introduced to minimize the frequency deviation to further optimize the frequency modulation(FM)output of the DFPSU and inhibit the rapid fluctuation of the frequency;lastly,it is verified on theMatlab/Simulink simulation platform,and the results show that the model predictive control with proportional-differential control link can further release the FM potential of the DFPSU,increase the depth of its FM,effectively reduce the frequency deviation of the system and its rate of change,realize the optimization of the active output of the DFPSU and that of other units,and improve the frequency response capability of the system.展开更多
The three-dimensional unsteady turbulent flow in axial-flow pumps was simulated based on Navier-Stoke solver embedded with k - ε RNG turbulence model and SIMPLEC algorithm. Numerical results show that the unsteady pr...The three-dimensional unsteady turbulent flow in axial-flow pumps was simulated based on Navier-Stoke solver embedded with k - ε RNG turbulence model and SIMPLEC algorithm. Numerical results show that the unsteady prediction results are more accurate than the steady results, and the maximal error of unsteady prediction is only 4.54%. The time-domain spectrums show that the static pressure fluctuation curves at the inlet and outlet of the rotor and the outlet of the stator are periodic, and all have four peaks and four valleys. The pressure fluctuation amplitude increases from the hub to the tip at the inlet and outlet of the rotor, but decreases at the outlet of the stator. The pressure fluctuation amplitude is the greatest at the inlet of the rotor, and the average amplitude decreases sharply from the inlet to the outlet. The frequency spectrums obtained by Fast Fourier Transform (FFT) show that the dominant frequency is approximately equal to the blade passing frequency. The static pressure on the pressure side of hydrofoil on different stream surfaces remains almost consistent, and increases gradually from the blade inlet to the exit on the suction side at different time steps. The axial velocity distribution is periodic and is affected by the stator blade number at the rotor exit. The experimental results show that the flow is almost axial and the pre-rotation is very small at the rotor inlet under the conditions of 0.8 QN -1.2 QN Due to the clearance leakage, the pressure, circulation and meridional velocity at the rotor outlet all decrease near the hub leakage and tip clearance regions.展开更多
The interaction of flow through the inducer and impeller of an axial-flow pump equipped with an inducer has significant effect on its performance. This article presents a recent numerical investigation on this topic. ...The interaction of flow through the inducer and impeller of an axial-flow pump equipped with an inducer has significant effect on its performance. This article presents a recent numerical investigation on this topic. The studied pump has an inducer with 3 blades mounted on a conical hub and a 6-blade impeller. The blade angle of the impeller is adjustable to generate different relative circumferential angles between the inducer blade trailing edge and the impeller blade leading edge. A computational fluid dynamics code was used to investigate the flow characteristics and performance of the axial-flow pump. For turbulence closure, the RNG k-ε model was applied with an unstructured grid system. The rotor-stator interaction was treated with a Multiple Reference Frame (MRF) strategy. Computations were performed in different cases: 7 different relative circumferential angles ( Δθ ) between the inducer blade trailing edge and the impeller blade leading edge, and 3 different axial gaps (G) between the inducer and the impeller. The variation of the hydraulic loss in the rotator was obtained by changing Δθ . The numerical results show that the pressure generated is minimum in the case of ( G = 3%D), which indicates that the interference between inducer and impeller is strong if the axial gap is small. The pump performances were predicted and compared to the experimental measurements. Recommendations for future modifications and improvements to the pump design were also given.展开更多
In this paper, the cavitating flow within a slanted axial-flow pump is numerically researched. The hydraulic and cavitation performance of the slanted axial-flow pump under different operation conditions are estimated...In this paper, the cavitating flow within a slanted axial-flow pump is numerically researched. The hydraulic and cavitation performance of the slanted axial-flow pump under different operation conditions are estimated. Compared with the experimental hydraulic performance curves, the numerical results show that the filter-based model is better than the standard k-ε model to predict the parameters of hydraulic performancE. In cavitation simulation, compared with the experimental results, the proposed numerical method has good predicting ability. Under different cavitation conditions, the internal cavitating flow fields within slanted axial-flow pump are investigated. Compared with flow visualization results, the major internal flow features can be effectively grasped. In order to explore the origin of the cavitation performance breakdown, the Boundary Vorticity Flux (BVF) is introduced to diagnose the cavitating flow fields. The analysis results indicate that the cavitation performance drop is relevant to the instability of cavitating flow on the blade suction surface.展开更多
The internal flow field of an axial-flow pump under low flow rate conditions is extremely turbulent. The unstable flow region is formed due to the tip leakage and the rotating stall, and is distinguished by a saddle p...The internal flow field of an axial-flow pump under low flow rate conditions is extremely turbulent. The unstable flow region is formed due to the tip leakage and the rotating stall, and is distinguished by a saddle patterned zone in its flow-head curve that demonstrates restrictions in its workable flow range. It is therefore important to understand and improve the operational characteristics of an axial-flow pump under low flow rate conditions. In this study, experiments are performed for the performances of an axial-flow pump at the flow rate in a range between 0.8Qd and 1.2Qd, with the internal flow field measured by the particle image velocimetry (PIV), and with the pump performances and the internal flow field simulated by the Ansys CFX. The simulation results agree well with the experimental results. From the predicted heads at the flow rate in the range between 0.1Qd and 0.7Qd by the numerical simulation, the complete flow-head curves are obtained. The streamlines and the velocity contours in the region in front of the impeller leading edge under different flow conditions are analyzed. By adopting the double-inlet structures, the flow-head characteristics are studied by varying the values of δ and σ respectively, where δ denotes the gap between the inner cylinder end and the impeller leading edge, and σ denotes the gap between the inner cylinder and the outer cylinder. The findings indicate that with the double-inlet design, the velocity distribution can be effectively improved in the region in front of the impeller leading edge, as well as the head performance under the low flow rate conditions, and the positive slope value of the head curve is reduced in the unstable flow range. The optimal δ and σ values are determined.展开更多
Axial-flow pumps are widely employed in urban flood control and drainage pumping stations.The inlet vortex is one factor that seriously threaten the safe,stable and efficient operation of axial-flow pump units.In this...Axial-flow pumps are widely employed in urban flood control and drainage pumping stations.The inlet vortex is one factor that seriously threaten the safe,stable and efficient operation of axial-flow pump units.In this paper,the vortex recognition performances of two vortex identification methods,the Q—criterion and Liutex methods,are compared based on an axial-flow pump,and the interactions between the impeller and vortex are explored.A flat plate vortex generator is installed in front of the impeller to continuously induce a stable vortex.The numerical simulation results show that the Liutex method can not only simultaneously identify strong and weak vortices but also reduce the influence of shear force at the sidewall.The vortex and the impeller influence each other.Under the influence of rotating blades,the vortex changes from a low frequency to the blade frequency,and the vortex significantly changes the tangential velocity inside the impeller.The accuracy of the numerical simulation results is verified by experiments on the external and internal characteristics.展开更多
The blade tip clearance flow in axial-flow pump is simulated based on three-dimensional N-S equations, RNG k -e turbulence model, and SIMPLEC algorithm. It shows that numerical results agree well with experiment data ...The blade tip clearance flow in axial-flow pump is simulated based on three-dimensional N-S equations, RNG k -e turbulence model, and SIMPLEC algorithm. It shows that numerical results agree well with experiment data measured by 5-hole probe through validation. Flow fields at the blade tip and velocity distribution at the exit of rotor are analyzed in detail. The numerical results show that the increase in tip clearance reduces hydro-head, especially at small flow rate. Experiment equipment is also introduced.展开更多
Numerical simulations of 3D turbulent flow in a large-bore axial-flow pump coupled with half-elbow suction sump were perlbrmed by using CFD approach. The numerical model and velocity and pressure distributions in enti...Numerical simulations of 3D turbulent flow in a large-bore axial-flow pump coupled with half-elbow suction sump were perlbrmed by using CFD approach. The numerical model and velocity and pressure distributions in entire flow passage were presented. The obvious backflow in half-elbow suction sump and strong flow nonuniformity at suction sump outlet were observed, whereas these phenomena were not observed in existing studies performed for a separate suction sump by either experimental or numerical approach. This result indicates that the interaction between half-elbow suction sump and impeller has significant effect on the flow distribution in the pump passage. The change of pump efficiency caused by the interaction was discussed,展开更多
To study the effect of guide vane outlet angle on pump performance and impeller radial force in an axial-flow heart pump, guide vane outlet angle/34 is considered to be 20°, 15°, 10°, 5° and 3°...To study the effect of guide vane outlet angle on pump performance and impeller radial force in an axial-flow heart pump, guide vane outlet angle/34 is considered to be 20°, 15°, 10°, 5° and 3° respectively. Based on ANSYS Fluent, numerical results of pump head and efficiency are validated by exper/ment results, in which Xanthan gum solutions are used with concentration of 0.06 wt. % as working fluid. Then, the effects of/34 on pump performance and impeller radial force are discussed, the errors of head and efficiency between test and simulation are within 5%. The results a/so indicate that the pump performance and efficiency are much better than those of other angles when guide vane outlet angle/34 is 10°, and the maximum variations in head and efficiency are 1.9% and 2.2%, respectively. With/34 increasing, the pulsation of radial force decreases firstly and then increases, when/34 is 10°, the minimum pulsation is 0. 0392N, which is about 80% of the maximum pulsation amplitude.展开更多
As an emerging technology to convert environmental high-entropy energy into electrical energy,triboelectric nanogenerator(TENG)has great demands for further enhancing the service lifetime and output performance in pra...As an emerging technology to convert environmental high-entropy energy into electrical energy,triboelectric nanogenerator(TENG)has great demands for further enhancing the service lifetime and output performance in practical applications.Here,an ultra-robust and high-performance rotational triboelectric nanogenerator(R-TENG)by bearing charge pumping is proposed.The R-TENG composes of a pumping TENG(P-TENG),an output TENG(O-TENG),a voltage-multiplying circuit(VMC),and a buffer capacitor.The P-TENG is designed with freestanding mode based on a rolling ball bearing,which can also act as the rotating mechanical energy harvester.The output low charge from the P-TENG is accumulated and pumped to the non-contact O-TENG,which can simultaneously realize ultralow mechanical wear and high output performance.The matched instantaneous power of R-TENG is increased by 32 times under 300 r/min.Furthermore,the transferring charge of R-TENG can remain 95%during 15 days(6.4×10^(6)cycles)continuous operation.This work presents a realizable method to further enhance the durability of TENG,which would facilitate the practical applications of high-performance TENG in harvesting distributed ambient micro mechanical energy.展开更多
In order to obtain the transient characteristics of a low-speed centrifugal pump during the start-up and shutdown stages,dedicated experimental tests were conducted with eight different valve opening conditions.The Pe...In order to obtain the transient characteristics of a low-speed centrifugal pump during the start-up and shutdown stages,dedicated experimental tests were conducted with eight different valve opening conditions.The Pearson correlation coefficient was used to reveal the linear correlation between variables.According to the results,the stable rotational speed decreases with increasing valve opening(rotational speed decreases from approximately 1472 to 1453 r/min),while the stable shaft power exhibits an increasing trend(shaft power increases from approximately 0.242 to 0.390 kW).The stable time and zeroing time of each parameter during start-up and shutdown processes vary,with the flow zeroing time significantly increasing with the relative flow,reaching up to 10.468 s,while the shaft power zeroing time is roughly between 1.219 and 1.375 s.The results demonstrate that with increasing valve opening,the stable and zeroing time of flow significantly increase(|r|greater than 0.95),while the stable and zeroing time of rotational speed,power,and head display a smaller sensitivity on the valve opening(|r|less than 0.6).展开更多
Inflammatory bowel disease(IBD)is believed to be caused by various factors,including abnormalities in disease susceptibility genes,environmental factors,immune factors,and intestinal bacteria.Proton pump inhibitors(PP...Inflammatory bowel disease(IBD)is believed to be caused by various factors,including abnormalities in disease susceptibility genes,environmental factors,immune factors,and intestinal bacteria.Proton pump inhibitors(PPIs)are the primary drugs used to treat acid-related diseases.They are also commonly prescribed to patients with IBD.Recent studies have suggested a potential association between the use of certain medications,such as PPIs,and the occurrence and progression of IBD.In this review,we summarize the potential impact of PPIs on IBD and analyze the underlying mechanisms.Our findings may provide insights for conducting further investigations into the effects of PPIs on IBD and serve as an important reminder for physicians to exercise caution when prescribing PPIs to patients with IBD.展开更多
In this paper,an NMOS output-capacitorless low-dropout regulator(OCL-LDO)featuring dual-loop regulation has been proposed,achieving fast transient response with low power consumption.An event-driven charge pump(CP)loo...In this paper,an NMOS output-capacitorless low-dropout regulator(OCL-LDO)featuring dual-loop regulation has been proposed,achieving fast transient response with low power consumption.An event-driven charge pump(CP)loop with the dynamic strength control(DSC),is proposed in this paper,which overcomes trade-offs inherent in conventional structures.The presented design addresses and resolves the large signal stability issue,which has been previously overlooked in the event-driven charge pump structure.This breakthrough allows for the full exploitation of the charge-pump structure's poten-tial,particularly in enhancing transient recovery.Moreover,a dynamic error amplifier is utilized to attain precise regulation of the steady-state output voltage,leading to favorable static characteristics.A prototype chip has been fabricated in 65 nm CMOS technology.The measurement results show that the proposed OCL-LDO achieves a 410 nA low quiescent current(IQ)and can recover within 30 ns under 200 mA/10 ns loading change.展开更多
China has embarked on an extensive and sustained endeavor to harness its coal resources for a substantial period.However,the depletion of coal reserves in mining regions has necessitated the closure or abandonment of ...China has embarked on an extensive and sustained endeavor to harness its coal resources for a substantial period.However,the depletion of coal reserves in mining regions has necessitated the closure or abandonment of numerous mines,resulting in a marked increase in the number of such facilities.Parallel to this,China is vigorously advancing the development of a novel energy power system,aimed at transitioning the power sector from a high-carbon,fossil fuel-dependent paradigm to a low-carbon,clean energy footing.展开更多
We report a high-average-power acousto-optic(AO)Q-switched intracavity frequency-doubled red laser based on a high-efficiency light-emitting-diode(LED)pumped two-rod Nd,Ce:YAG laser module.Under quasi-continuous wave ...We report a high-average-power acousto-optic(AO)Q-switched intracavity frequency-doubled red laser based on a high-efficiency light-emitting-diode(LED)pumped two-rod Nd,Ce:YAG laser module.Under quasi-continuous wave operation conditions,a maximum output power of 1319.08 nm wavelength was achieved at 11.26 W at a repetition rate of 100 Hz.展开更多
基金supported by National Hi-tech Research and Development Program of China (863 Program, Grant No. 2007AA05Z207)National Science and Technology Support Scheme of China (Grant No. 2008BAF34B10)Jiangsu Provincial Graduate Student Innovation Foundation of China (Grant No. CX08B_064Z)
文摘The experimental investigation of axial-flow pump has been rapidly developed to meet the needs of South-to-North Water Diversion Project of China. Owing to the boundary conditions of hub, blade tip clearance, much of the physical phenomena and laws involved in this complex flow field can't be fully determined. The flow characteristics of the high efficiency axial-flow pump have been simulated by RNG k-e turbulence model and SIMPLEC arithmetic based on FLUENT software. Numerical results indicate that the data from the prediction show agreement with the experimental results, static pressure on pressure side of blades increases slightly at circumferential direction with radius increasing, and keep almost constant at the same radial while increasing gradually from inlet to exit on the suction side along flow direction at design conditions. The static pressure, total pressure and velocity at inlet, impeller outlet and vane outlet were measured by a five-hole probe, and a contrastive experiment was done to investigate the influence of hub leakage. The experimental results show that inlet flow is almost axial and the prerotation is very small at various conditions. The meridional velocity and circulation distribution are almost identical at impeller outlet at design conditions due to steady flow and high efficiency. The residual circulation exits at downstream of the guide vane, and the circumferential velocity component increases linearly from hub to tip at small flow rate conditions. Hub leakage in adjustable blades results in the decrease of the meridional velocity and circulation at blade exit near hub. The results of numerical simulation and experiments supply important flow structure information for the high-efficiency axial-flow pump.
文摘BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related disorders.Recent evidence suggests associations between long-term PPI use and higher risks for various adverse health outcomes,including greater mortality.AIM To investigate the association between PPI use and all-cause mortality among cancer patients by a comprehensive analysis after adjustment for various confounders and a robust methodological approach to minimize bias.METHODS This retrospective cohort study used data from the TriNetX research network,with electronic health records from multiple healthcare organizations.The study employed a new-user,active comparator design,which compared newly treated PPI users with non-users and newly treated histamine2 receptor antagonists(H2RA)users among adult cancer patients.Newly prescribed PPIs(esomeprazole,lansoprazole,omeprazole,pantoprazole,or rabeprazole)users were compared to non-users or newly prescribed H2RAs(cimetidine,famotidine,nizatidine,or ranitidine)users.The primary outcome was all-cause mortality.Each patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding effects.Multivariable Cox regression models were used to estimate hazard ratios(HRs)and 95% confidence interval(CI).RESULTS During the follow-up period(median 5.4±1.8 years for PPI users and 6.5±1.0 years for non-users),PPI users demonstrated a higher all-cause mortality rate than non-users after 1 year,2 years,and at the end of follow up(HRs:2.34-2.72).Compared with H2RA users,PPI users demonstrated a higher rate of all-cause mortality HR:1.51(95%CI:1.41-1.69).Similar results were observed across sensitivity analyses by excluding deaths from the first 9 months and 1-year post-exposure,confirming the robustness of these findings.In a sensitivity analysis,we analyzed all-cause mortality outcomes between former PPI users and individuals who have never used PPIs,providing insights into the long-term effects of past PPI use.In addition,at 1-year follow-up,the analysis revealed a significant difference in mortality rates between former PPI users and non-users(HR:1.84;95%CI:1.82-1.96).CONCLUSION PPI use among cancer patients was associated with a higher risk of all-cause mortality compared to non-users or H2RA users.These findings emphasize the need for cautious use of PPIs in cancer patients and suggest that alternative treatments should be considered when clinically feasible.However,further studies are needed to corroborate our findings,given the significant adverse outcomes in cancer patients.
基金supported by the Presidential Foundation of CAEP(Grant No.YZJJZL2023116)the National Nature Science Foundation of China(Grant No.12275249)the Youth Talent Fund of the Laser Fusion Research Center,CAEP(Grant Nos.RCFCZ7-2024-2 and RCFPD4-2020-4).
文摘We present experimental results on kilojoule ultraviolet laser output with 1%spectral broadening.Through stimulated rotational Raman scattering(SRRS)with signal laser injection,we achieve effective spectral broadening in short-range propagation,with good retention of the original near-field distribution and time waveform.Theoretical calculations show that 2%bandwidth spectral broadening can be achieved by injecting 20 kW~cm^(2) signal light at 2.2 GW~cm^(2) flux of the pump laser.In addition,high-frequency modulation in the near field can be effectively avoided through replacement of the original random noise signal light by the controllable signal light.The SRRS in the atmospheric environment excited with signal laser injection can provide wide-band light output with controllable beam quality without long-distance propagation,representing an important potential route to realization of broadband laser drivers.
文摘This research investigates the design and optimization of a photovoltaic(PV)water pumping system to address seasonal water demands across five locations with varying elevation heads.The systemdraws water froma deep well with a static water level of 30mand a dynamic level of 50m,serving agricultural and livestock needs.The objective of this study is to accurately size a PV system that balances energy generation and demand while minimizing grid dependency.Meanwhile,the study presents a comprehensivemethodology to calculate flowrates,pumping power,daily energy consumption,and system capacity.Therefore,the PV system rating,energy output,and economic performance were evaluated using metrics such as discounted payback period(DPP),net present value(NPV),and sensitivity analysis.The results show that a 2.74 kWp PV system is optimal,producing 4767 kWh/year to meet the system’s annual energy demand of 4686 kWh.In summer,energy demand peaks at 1532.7 kWh,while in winter,it drops to 692.1 kWh.Meanwhile,flow rates range from 11.71 m3/h at 57 m head to 10.49 m^(3)/h at 70 m head,demonstrating the system’s adaptability to diverse hydraulic conditions.Economic analysis reveals that at a 5%interest rate and an electricity price of$0.15/kWh,the NPV is$6981.82 with a DPP of 3.76 years.However,a 30%increase in electricity prices improves the NPV to$10,005.18 and shortens the DPP to 2.76 years,whereas a 20%interest rate reduces the NPV to$1038.79 and extends the DPP to 6.08 years.Nevertheless,the annual PV energy generation exceeds total energy demand by 81 kWh,reducing grid dependency and lowering electricity costs.Additionally,the PV system avoids approximately 3956.6 kg of CO_(2) emissions annually,underscoring its environmental benefits over traditional pumping systems.As a result,this study highlights the economic and environmental viability of PV-powered water pumping systems,offering actionable insights for sustainable energy solutions in agriculture.
基金supported by the National Natural Science Foundation of China(Project No.52377082)the Scientific Research Program of Jilin Provincial Department of Education(Project No.JJKH20230123KJ).
文摘Large-scale new energy grid connection leads to the weakening of the system frequency regulation capability,and the system frequency stability is facing unprecedented challenges.In order to solve rapid frequency fluctuation caused by new energy units,this paper proposes a new energy power system frequency regulation strategy with multiple units including the doubly-fed pumped storage unit(DFPSU).Firstly,based on the model predictive control(MPC)theory,the state space equations are established by considering the operating characteristics of the units and the dynamic behavior of the system;secondly,the proportional-differential control link is introduced to minimize the frequency deviation to further optimize the frequency modulation(FM)output of the DFPSU and inhibit the rapid fluctuation of the frequency;lastly,it is verified on theMatlab/Simulink simulation platform,and the results show that the model predictive control with proportional-differential control link can further release the FM potential of the DFPSU,increase the depth of its FM,effectively reduce the frequency deviation of the system and its rate of change,realize the optimization of the active output of the DFPSU and that of other units,and improve the frequency response capability of the system.
基金Project supported by the National High Technology Research and Development Program of China (863 Program,Grant No.2007AA05Z207)the Graduate Student Innovation Foundation of Jiangsu Province (Grant No.CX08B_064Z)the National Science and Technology Support Program (Grant No.2008BAF34B15)
文摘The three-dimensional unsteady turbulent flow in axial-flow pumps was simulated based on Navier-Stoke solver embedded with k - ε RNG turbulence model and SIMPLEC algorithm. Numerical results show that the unsteady prediction results are more accurate than the steady results, and the maximal error of unsteady prediction is only 4.54%. The time-domain spectrums show that the static pressure fluctuation curves at the inlet and outlet of the rotor and the outlet of the stator are periodic, and all have four peaks and four valleys. The pressure fluctuation amplitude increases from the hub to the tip at the inlet and outlet of the rotor, but decreases at the outlet of the stator. The pressure fluctuation amplitude is the greatest at the inlet of the rotor, and the average amplitude decreases sharply from the inlet to the outlet. The frequency spectrums obtained by Fast Fourier Transform (FFT) show that the dominant frequency is approximately equal to the blade passing frequency. The static pressure on the pressure side of hydrofoil on different stream surfaces remains almost consistent, and increases gradually from the blade inlet to the exit on the suction side at different time steps. The axial velocity distribution is periodic and is affected by the stator blade number at the rotor exit. The experimental results show that the flow is almost axial and the pre-rotation is very small at the rotor inlet under the conditions of 0.8 QN -1.2 QN Due to the clearance leakage, the pressure, circulation and meridional velocity at the rotor outlet all decrease near the hub leakage and tip clearance regions.
基金the National Nature Science Foundation of China (Grant No. 90510007) Beijing Nature Science Foundation of China (Grant No. 3071002)the National Key Technology R and D Program (Grant No. 2006BAD11B07).
文摘The interaction of flow through the inducer and impeller of an axial-flow pump equipped with an inducer has significant effect on its performance. This article presents a recent numerical investigation on this topic. The studied pump has an inducer with 3 blades mounted on a conical hub and a 6-blade impeller. The blade angle of the impeller is adjustable to generate different relative circumferential angles between the inducer blade trailing edge and the impeller blade leading edge. A computational fluid dynamics code was used to investigate the flow characteristics and performance of the axial-flow pump. For turbulence closure, the RNG k-ε model was applied with an unstructured grid system. The rotor-stator interaction was treated with a Multiple Reference Frame (MRF) strategy. Computations were performed in different cases: 7 different relative circumferential angles ( Δθ ) between the inducer blade trailing edge and the impeller blade leading edge, and 3 different axial gaps (G) between the inducer and the impeller. The variation of the hydraulic loss in the rotator was obtained by changing Δθ . The numerical results show that the pressure generated is minimum in the case of ( G = 3%D), which indicates that the interference between inducer and impeller is strong if the axial gap is small. The pump performances were predicted and compared to the experimental measurements. Recommendations for future modifications and improvements to the pump design were also given.
基金Project supported by the Key Research Projects of Shanghai Science and Technology Commission(GrantNo.10100500200)the Science and Technology Plan of Zhejiang Province(Grant No.2011C11068)the Shanghai Program for Innovative Research Team in Universities
文摘In this paper, the cavitating flow within a slanted axial-flow pump is numerically researched. The hydraulic and cavitation performance of the slanted axial-flow pump under different operation conditions are estimated. Compared with the experimental hydraulic performance curves, the numerical results show that the filter-based model is better than the standard k-ε model to predict the parameters of hydraulic performancE. In cavitation simulation, compared with the experimental results, the proposed numerical method has good predicting ability. Under different cavitation conditions, the internal cavitating flow fields within slanted axial-flow pump are investigated. Compared with flow visualization results, the major internal flow features can be effectively grasped. In order to explore the origin of the cavitation performance breakdown, the Boundary Vorticity Flux (BVF) is introduced to diagnose the cavitating flow fields. The analysis results indicate that the cavitation performance drop is relevant to the instability of cavitating flow on the blade suction surface.
基金This work was supported by the Fundamental Research Fund for Central Universities(Grant No.JZ2015HGBZ0129)the Open End Fund of Jiangsu University(Grant No.NRCP201603).
文摘The internal flow field of an axial-flow pump under low flow rate conditions is extremely turbulent. The unstable flow region is formed due to the tip leakage and the rotating stall, and is distinguished by a saddle patterned zone in its flow-head curve that demonstrates restrictions in its workable flow range. It is therefore important to understand and improve the operational characteristics of an axial-flow pump under low flow rate conditions. In this study, experiments are performed for the performances of an axial-flow pump at the flow rate in a range between 0.8Qd and 1.2Qd, with the internal flow field measured by the particle image velocimetry (PIV), and with the pump performances and the internal flow field simulated by the Ansys CFX. The simulation results agree well with the experimental results. From the predicted heads at the flow rate in the range between 0.1Qd and 0.7Qd by the numerical simulation, the complete flow-head curves are obtained. The streamlines and the velocity contours in the region in front of the impeller leading edge under different flow conditions are analyzed. By adopting the double-inlet structures, the flow-head characteristics are studied by varying the values of δ and σ respectively, where δ denotes the gap between the inner cylinder end and the impeller leading edge, and σ denotes the gap between the inner cylinder and the outer cylinder. The findings indicate that with the double-inlet design, the velocity distribution can be effectively improved in the region in front of the impeller leading edge, as well as the head performance under the low flow rate conditions, and the positive slope value of the head curve is reduced in the unstable flow range. The optimal δ and σ values are determined.
基金supported by the National Natural Science Foundation of China(Grant No.51376155).
文摘Axial-flow pumps are widely employed in urban flood control and drainage pumping stations.The inlet vortex is one factor that seriously threaten the safe,stable and efficient operation of axial-flow pump units.In this paper,the vortex recognition performances of two vortex identification methods,the Q—criterion and Liutex methods,are compared based on an axial-flow pump,and the interactions between the impeller and vortex are explored.A flat plate vortex generator is installed in front of the impeller to continuously induce a stable vortex.The numerical simulation results show that the Liutex method can not only simultaneously identify strong and weak vortices but also reduce the influence of shear force at the sidewall.The vortex and the impeller influence each other.Under the influence of rotating blades,the vortex changes from a low frequency to the blade frequency,and the vortex significantly changes the tangential velocity inside the impeller.The accuracy of the numerical simulation results is verified by experiments on the external and internal characteristics.
文摘The blade tip clearance flow in axial-flow pump is simulated based on three-dimensional N-S equations, RNG k -e turbulence model, and SIMPLEC algorithm. It shows that numerical results agree well with experiment data measured by 5-hole probe through validation. Flow fields at the blade tip and velocity distribution at the exit of rotor are analyzed in detail. The numerical results show that the increase in tip clearance reduces hydro-head, especially at small flow rate. Experiment equipment is also introduced.
基金Project supported by the National Nature Science Foundation of China (Grant Nos: 10372114, 50479008 and 90510007) and Program for New Century Excellent Talents in Universities of China (Grant No: NCET-04-0133).
文摘Numerical simulations of 3D turbulent flow in a large-bore axial-flow pump coupled with half-elbow suction sump were perlbrmed by using CFD approach. The numerical model and velocity and pressure distributions in entire flow passage were presented. The obvious backflow in half-elbow suction sump and strong flow nonuniformity at suction sump outlet were observed, whereas these phenomena were not observed in existing studies performed for a separate suction sump by either experimental or numerical approach. This result indicates that the interaction between half-elbow suction sump and impeller has significant effect on the flow distribution in the pump passage. The change of pump efficiency caused by the interaction was discussed,
基金Supported by the National Natural Science Foundation of China(No.51574161)the Education Science Project of Young and Middle-aged Teachers of Universities in Fujian Province(No.JZ160396)
文摘To study the effect of guide vane outlet angle on pump performance and impeller radial force in an axial-flow heart pump, guide vane outlet angle/34 is considered to be 20°, 15°, 10°, 5° and 3° respectively. Based on ANSYS Fluent, numerical results of pump head and efficiency are validated by exper/ment results, in which Xanthan gum solutions are used with concentration of 0.06 wt. % as working fluid. Then, the effects of/34 on pump performance and impeller radial force are discussed, the errors of head and efficiency between test and simulation are within 5%. The results a/so indicate that the pump performance and efficiency are much better than those of other angles when guide vane outlet angle/34 is 10°, and the maximum variations in head and efficiency are 1.9% and 2.2%, respectively. With/34 increasing, the pulsation of radial force decreases firstly and then increases, when/34 is 10°, the minimum pulsation is 0. 0392N, which is about 80% of the maximum pulsation amplitude.
基金supported by the National Natural Science Foundation of China(Nos.51922023,61874011)Fundamental Research Funds for the Central Universities(E1EG6804)
文摘As an emerging technology to convert environmental high-entropy energy into electrical energy,triboelectric nanogenerator(TENG)has great demands for further enhancing the service lifetime and output performance in practical applications.Here,an ultra-robust and high-performance rotational triboelectric nanogenerator(R-TENG)by bearing charge pumping is proposed.The R-TENG composes of a pumping TENG(P-TENG),an output TENG(O-TENG),a voltage-multiplying circuit(VMC),and a buffer capacitor.The P-TENG is designed with freestanding mode based on a rolling ball bearing,which can also act as the rotating mechanical energy harvester.The output low charge from the P-TENG is accumulated and pumped to the non-contact O-TENG,which can simultaneously realize ultralow mechanical wear and high output performance.The matched instantaneous power of R-TENG is increased by 32 times under 300 r/min.Furthermore,the transferring charge of R-TENG can remain 95%during 15 days(6.4×10^(6)cycles)continuous operation.This work presents a realizable method to further enhance the durability of TENG,which would facilitate the practical applications of high-performance TENG in harvesting distributed ambient micro mechanical energy.
基金supported by Science and Technology Project of Quzhou(Grant Nos.2023K256,2023NC08)Zhejiang Provincial Natural Science Foundation of China(Grant No.LZY21E050001)Hunan Province Key Field R&D Plan Project(Grant No.2022GK2068).
文摘In order to obtain the transient characteristics of a low-speed centrifugal pump during the start-up and shutdown stages,dedicated experimental tests were conducted with eight different valve opening conditions.The Pearson correlation coefficient was used to reveal the linear correlation between variables.According to the results,the stable rotational speed decreases with increasing valve opening(rotational speed decreases from approximately 1472 to 1453 r/min),while the stable shaft power exhibits an increasing trend(shaft power increases from approximately 0.242 to 0.390 kW).The stable time and zeroing time of each parameter during start-up and shutdown processes vary,with the flow zeroing time significantly increasing with the relative flow,reaching up to 10.468 s,while the shaft power zeroing time is roughly between 1.219 and 1.375 s.The results demonstrate that with increasing valve opening,the stable and zeroing time of flow significantly increase(|r|greater than 0.95),while the stable and zeroing time of rotational speed,power,and head display a smaller sensitivity on the valve opening(|r|less than 0.6).
文摘Inflammatory bowel disease(IBD)is believed to be caused by various factors,including abnormalities in disease susceptibility genes,environmental factors,immune factors,and intestinal bacteria.Proton pump inhibitors(PPIs)are the primary drugs used to treat acid-related diseases.They are also commonly prescribed to patients with IBD.Recent studies have suggested a potential association between the use of certain medications,such as PPIs,and the occurrence and progression of IBD.In this review,we summarize the potential impact of PPIs on IBD and analyze the underlying mechanisms.Our findings may provide insights for conducting further investigations into the effects of PPIs on IBD and serve as an important reminder for physicians to exercise caution when prescribing PPIs to patients with IBD.
基金supported by the National Natural Science Foundation of China under Grant 62274189the Natural Science Foundation of Guangdong Province,China,under Grant 2022A1515011054the Key Area R&D Program of Guangdong Province under Grant 2022B0701180001.
文摘In this paper,an NMOS output-capacitorless low-dropout regulator(OCL-LDO)featuring dual-loop regulation has been proposed,achieving fast transient response with low power consumption.An event-driven charge pump(CP)loop with the dynamic strength control(DSC),is proposed in this paper,which overcomes trade-offs inherent in conventional structures.The presented design addresses and resolves the large signal stability issue,which has been previously overlooked in the event-driven charge pump structure.This breakthrough allows for the full exploitation of the charge-pump structure's poten-tial,particularly in enhancing transient recovery.Moreover,a dynamic error amplifier is utilized to attain precise regulation of the steady-state output voltage,leading to favorable static characteristics.A prototype chip has been fabricated in 65 nm CMOS technology.The measurement results show that the proposed OCL-LDO achieves a 410 nA low quiescent current(IQ)and can recover within 30 ns under 200 mA/10 ns loading change.
文摘China has embarked on an extensive and sustained endeavor to harness its coal resources for a substantial period.However,the depletion of coal reserves in mining regions has necessitated the closure or abandonment of numerous mines,resulting in a marked increase in the number of such facilities.Parallel to this,China is vigorously advancing the development of a novel energy power system,aimed at transitioning the power sector from a high-carbon,fossil fuel-dependent paradigm to a low-carbon,clean energy footing.
基金Nanjing University of Posts and Telecommunications Foundation(Grant Nos.JUH219002 and JUH219007)Key Laboratory of Functional Crystals and Laser Technology,TIPC,CAS Foundation(Grant No.FCLT 202201)。
文摘We report a high-average-power acousto-optic(AO)Q-switched intracavity frequency-doubled red laser based on a high-efficiency light-emitting-diode(LED)pumped two-rod Nd,Ce:YAG laser module.Under quasi-continuous wave operation conditions,a maximum output power of 1319.08 nm wavelength was achieved at 11.26 W at a repetition rate of 100 Hz.