In order to develop new antibiotics effective against resistant bacteria,a series of novel 15-membered macrolide derivatives were designed and synthesized by the modification of hydroxyl groups at C-11,C-12 and C-4＂ ...In order to develop new antibiotics effective against resistant bacteria,a series of novel 15-membered macrolide derivatives were designed and synthesized by the modification of hydroxyl groups at C-11,C-12 and C-4＂ positions.Their structures were confirmed by MS,IR,^1H NMR or ^13C NMR.展开更多
A series of novel dimers of 15-membered macrolides was synthesized and evaluated. The dimers exhibited excellent activity against erythromycin-susceptible S. pneumonia, but did not show any improved activity against e...A series of novel dimers of 15-membered macrolides was synthesized and evaluated. The dimers exhibited excellent activity against erythromycin-susceptible S. pneumonia, but did not show any improved activity against erythromycin-resistant S. pneumoniae encoded by erm gene. ？2009 Shu Tao Ma. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.展开更多
基金supported by NNSFC(No.20372043),Shandong Science and Technology Promotion Project(No.2005GG3202098)Natural Science Foundation of Shandong Province(No.Y2006C31).
文摘In order to develop new antibiotics effective against resistant bacteria,a series of novel 15-membered macrolide derivatives were designed and synthesized by the modification of hydroxyl groups at C-11,C-12 and C-4＂ positions.Their structures were confirmed by MS,IR,^1H NMR or ^13C NMR.
基金supported by the National Natural Science Foundation of China(No.2087208 1)Natural Science Foundation of Shandong(No.Y2006C3 1)Shandong Science and Technology Promotion Project(No.2005GG3202098).
文摘A series of novel dimers of 15-membered macrolides was synthesized and evaluated. The dimers exhibited excellent activity against erythromycin-susceptible S. pneumonia, but did not show any improved activity against erythromycin-resistant S. pneumoniae encoded by erm gene. ？2009 Shu Tao Ma. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.
