In this editorial,we comment on the article by Wang et al.This manuscript explores the potential synergistic effects of combining zanubrutinib,a novel oral inhibitor of Bruton’s tyrosine kinase,with high-dose methotr...In this editorial,we comment on the article by Wang et al.This manuscript explores the potential synergistic effects of combining zanubrutinib,a novel oral inhibitor of Bruton’s tyrosine kinase,with high-dose methotrexate(HD-MTX)as a therapeutic intervention for primary central nervous system lymphoma(PCNSL).The study involves a retrospective analysis of 19 PCNSL patients,highlighting clinicopathological characteristics,treatment outcomes,and genomic biomarkers.The results indicate the combination’s good tolerance and strong antitumor activity,with an 84.2%overall response rate.The authors emphasize the potential of zanubrutinib to modulate key genomic features of PCNSL,particularly mutations in myeloid differentiation primary response 88 and cluster of differentiation 79B.Furthermore,the study investigates the role of circulating tumor DNA in cerebrospinal fluid for disease surveillance and treatment response monitoring.In essence,the study provides valuable insights into the potential of combining zanubrutinib with HD-MTX as a frontline therapeutic regimen for PCNSL.The findings underscore the importance of exploring alternative treatment modalities and monitoring genomic and liquid biopsy markers to optimize patient outcomes.While the findings suggest promise,the study’s limitations should be considered,and further research is needed to establish the clinical relevance of this therapeutic approach for PCNSL.展开更多
The most stable isomers of NanBm （m ＋ n = 6） clusters and their hydrogen storage properties are investigated by means of density functional theory with a 6-311＋G（d） basis set. To study the hydrogen storage prope...The most stable isomers of NanBm （m ＋ n = 6） clusters and their hydrogen storage properties are investigated by means of density functional theory with a 6-311＋G（d） basis set. To study the hydrogen storage properties, all of the stable structures of NanBmHx （m ＋ n =6） clusters have been optimized. It shows that boron atoms of NanBm are separated from the other boron atoms, and form satellite BHx （x = 3, 4） clusters around the centre, which attach to the system by a bridging bond of a hydrogen atom or an Na atom. Compared with the hydrogen storage capabilities, the Na3B3 has the highest hydrogen storage capacity among NanBm clusters. The binding energies, interaction energies of hydrogen atom with NanBm clusters and second difference in energy of Na3B3Hx clusters have been calculated. The results show that the stability of the NanBmHx clusters present an odd-even oscillatory effect, as the number of H atoms increases.展开更多
We apply the B3LYP, PBE1PBE and B3PW91 methods of density functional theory and time-dependent density functional theory within the local density approximation to the description of structures and photoabsorption spec...We apply the B3LYP, PBE1PBE and B3PW91 methods of density functional theory and time-dependent density functional theory within the local density approximation to the description of structures and photoabsorption spectra of B10 and B10. Several other properties, such as relative energies, average binding energies, average B-B bond lengths, have been also investigated. It is found that the ground state of B10 is quasi-planar structure with C2h symmetry, while the lowest energy state of B10 anion is quasi-planar structure with C1 symmetry. The average B-B bond lengths of the anion are very close to that of the corresponding neutral clusters. Substantial differences of photoabsorption spectra are observed between different isomers which can be used for comparison against future experimental investigations. And the spectra for the anionic clusters display a red shift with respect to the spectra of their corresponding neutral clusters.展开更多
The B4N4 configurations were designed by using the molecular figure software. The full geometry optimization and harmonic vibration frequency analysis were performed at the 6-31G（d） level using density functional th...The B4N4 configurations were designed by using the molecular figure software. The full geometry optimization and harmonic vibration frequency analysis were performed at the 6-31G（d） level using density functional theory B3LYP method, which indicates that the five isomers are stationary points on the potential energy surface of B4N4 molecules. The geometry structure, frontier molecular orbital （FMO） and mulliken population have been analyzed. The bonding properties and hybrid type were also discussed in detail, showing the addition of hydrogen atoms to boron or nitrogen atom would increase the stabilities of the BN clusters.展开更多
A three-dimensional(3D) fast fluidized bed with the riser of 3.0 m in height and 0.1 m in inner diameter was established to experimentally study the cluster behaviors of Geldart B particles. Five kinds of quartz sand ...A three-dimensional(3D) fast fluidized bed with the riser of 3.0 m in height and 0.1 m in inner diameter was established to experimentally study the cluster behaviors of Geldart B particles. Five kinds of quartz sand particles(dp= 0.100, 0.139, 0.177, 0.250 and 0.375 mm and ρp= 2480 kg·m^(-3)) were respectively investigated, with the total mass of the bed material kept as 10 kg. The superficial gas velocity in the riser ranges from 2.486 to 5.594 m·s^(-1) and the solid mass flux alters from 30 to 70 kg·((m^(-2)·s))^(-1). Cluster characteristics and evolutionary processes in the different positions of the riser were captured by the cluster visualization systems and analyzed by the self-developed binary image processing. The results found four typical cluster structures in the riser,i.e., the macro stripe-shaped cluster, saddle-shaped cluster, U-shaped cluster and the micro cluster. The increasing superficial gas velocity and particle sizes result in the increasing average cluster size and the decreasing cluster time fraction, while the solid mass flux in the riser have the reverse influences on the cluster size and time fraction. Additionally, clusters in the upper region of the riser often have the larger size and time fraction than that in the lower region. All these effects of operating conditions on clusters become less obvious when particle size is less than 0.100 mm.展开更多
Four isomers of the three-dimensionally connected bare boron cationic cluster B were investigated by using ab initio molecular orbital theory at the HF/6-31G level. The results show that the D5h symmetric isomer of B ...Four isomers of the three-dimensionally connected bare boron cationic cluster B were investigated by using ab initio molecular orbital theory at the HF/6-31G level. The results show that the D5h symmetric isomer of B is a possible isomer candidate of its stable geometries with closed structure.展开更多
We propose a content-based parallel image retrieval system to achieve high responding ability. Our system is developed on cluster architectures. It has several retrieval. servers to supply the service of content-based...We propose a content-based parallel image retrieval system to achieve high responding ability. Our system is developed on cluster architectures. It has several retrieval. servers to supply the service of content-based image retrieval. It adopts the Browser/Server (B/S) mode. The users could visit our system though web pages. It uses the symmetrical color-spatial features (SCSF) to represent the content of an image. The SCSF is effective and efficient for image matching because it is independent of image distortion such as rotation and flip as well as it increases the matching accuracy. The SCSF was organized by M-tree, which could speedup the searching procedure. Our experiments show that the image matching is quickly and efficiently with the use of SCSF. And with the support of several retrieval servers, the system could respond to many users at mean time. Key words content-based image retrieval - cluster architecture - color-spatial feature - B/S mode - task parallel - WWW - Internet CLC number TP391 Foundation item: Supported by the National Natural Science Foundation of China (60173058)Biography: ZHOU Bing (1975-), male, Ph. D candidate, reseach direction: data mining, content-based image retrieval.展开更多
The glass forming ability of the [(Fe12/13Y1/13)100?xBx]96Nb2Zr2 (x=9–26) system was investigated using a series of cluster lines. Three types of clusters, an icosahedron (Fe12Y), a capped Archimedes anti-prism (Fe8B...The glass forming ability of the [(Fe12/13Y1/13)100?xBx]96Nb2Zr2 (x=9–26) system was investigated using a series of cluster lines. Three types of clusters, an icosahedron (Fe12Y), a capped Archimedes anti-prism (Fe8B3) and a capped trigonal prism (Fe9B), as well as a binary eutectic (Fe83B17) were considered. Bulk glassy alloy rods of 3 mm in diameter were synthesized using a copper mold suction-casting method. The glass transition temperature was observed for all samples in the boron range of 15.9at%-25.7at%, with the alloy at 15.9at% of boron having the best thermal properties. The ferrous-based bulk metallic glasses (BMG) obtained have high reduced glass transition temperatures with the maximum reaching 0.63 and large supercooled liquid regions with the maximum reaching 111 K. Magnetic testing revealed a large value of coercive force and remanent magnetization, being 11 kA/m and 0.1 T, re- spectively.展开更多
文摘In this editorial,we comment on the article by Wang et al.This manuscript explores the potential synergistic effects of combining zanubrutinib,a novel oral inhibitor of Bruton’s tyrosine kinase,with high-dose methotrexate(HD-MTX)as a therapeutic intervention for primary central nervous system lymphoma(PCNSL).The study involves a retrospective analysis of 19 PCNSL patients,highlighting clinicopathological characteristics,treatment outcomes,and genomic biomarkers.The results indicate the combination’s good tolerance and strong antitumor activity,with an 84.2%overall response rate.The authors emphasize the potential of zanubrutinib to modulate key genomic features of PCNSL,particularly mutations in myeloid differentiation primary response 88 and cluster of differentiation 79B.Furthermore,the study investigates the role of circulating tumor DNA in cerebrospinal fluid for disease surveillance and treatment response monitoring.In essence,the study provides valuable insights into the potential of combining zanubrutinib with HD-MTX as a frontline therapeutic regimen for PCNSL.The findings underscore the importance of exploring alternative treatment modalities and monitoring genomic and liquid biopsy markers to optimize patient outcomes.While the findings suggest promise,the study’s limitations should be considered,and further research is needed to establish the clinical relevance of this therapeutic approach for PCNSL.
基金supported by the National Natural Science Foundation of China (Grant Nos. 10965002 and 30960031)the Science Foundation of Education Committee of Jiangxi Province,China (Grant No. GJJ10540)the Doctoral Startup Fund of Jinggangshan University
文摘The most stable isomers of NanBm （m ＋ n = 6） clusters and their hydrogen storage properties are investigated by means of density functional theory with a 6-311＋G（d） basis set. To study the hydrogen storage properties, all of the stable structures of NanBmHx （m ＋ n =6） clusters have been optimized. It shows that boron atoms of NanBm are separated from the other boron atoms, and form satellite BHx （x = 3, 4） clusters around the centre, which attach to the system by a bridging bond of a hydrogen atom or an Na atom. Compared with the hydrogen storage capabilities, the Na3B3 has the highest hydrogen storage capacity among NanBm clusters. The binding energies, interaction energies of hydrogen atom with NanBm clusters and second difference in energy of Na3B3Hx clusters have been calculated. The results show that the stability of the NanBmHx clusters present an odd-even oscillatory effect, as the number of H atoms increases.
基金Supported by the National Natural Science Foundation of China and China Academy of Engineering Physics(No.10676025)
文摘We apply the B3LYP, PBE1PBE and B3PW91 methods of density functional theory and time-dependent density functional theory within the local density approximation to the description of structures and photoabsorption spectra of B10 and B10. Several other properties, such as relative energies, average binding energies, average B-B bond lengths, have been also investigated. It is found that the ground state of B10 is quasi-planar structure with C2h symmetry, while the lowest energy state of B10 anion is quasi-planar structure with C1 symmetry. The average B-B bond lengths of the anion are very close to that of the corresponding neutral clusters. Substantial differences of photoabsorption spectra are observed between different isomers which can be used for comparison against future experimental investigations. And the spectra for the anionic clusters display a red shift with respect to the spectra of their corresponding neutral clusters.
文摘The B4N4 configurations were designed by using the molecular figure software. The full geometry optimization and harmonic vibration frequency analysis were performed at the 6-31G（d） level using density functional theory B3LYP method, which indicates that the five isomers are stationary points on the potential energy surface of B4N4 molecules. The geometry structure, frontier molecular orbital （FMO） and mulliken population have been analyzed. The bonding properties and hybrid type were also discussed in detail, showing the addition of hydrogen atoms to boron or nitrogen atom would increase the stabilities of the BN clusters.
基金Supported by the National Key R&D Program of China[2016YFB0600802]the National Natural Science Foundation of China[51390492,51325601]
文摘A three-dimensional(3D) fast fluidized bed with the riser of 3.0 m in height and 0.1 m in inner diameter was established to experimentally study the cluster behaviors of Geldart B particles. Five kinds of quartz sand particles(dp= 0.100, 0.139, 0.177, 0.250 and 0.375 mm and ρp= 2480 kg·m^(-3)) were respectively investigated, with the total mass of the bed material kept as 10 kg. The superficial gas velocity in the riser ranges from 2.486 to 5.594 m·s^(-1) and the solid mass flux alters from 30 to 70 kg·((m^(-2)·s))^(-1). Cluster characteristics and evolutionary processes in the different positions of the riser were captured by the cluster visualization systems and analyzed by the self-developed binary image processing. The results found four typical cluster structures in the riser,i.e., the macro stripe-shaped cluster, saddle-shaped cluster, U-shaped cluster and the micro cluster. The increasing superficial gas velocity and particle sizes result in the increasing average cluster size and the decreasing cluster time fraction, while the solid mass flux in the riser have the reverse influences on the cluster size and time fraction. Additionally, clusters in the upper region of the riser often have the larger size and time fraction than that in the lower region. All these effects of operating conditions on clusters become less obvious when particle size is less than 0.100 mm.
文摘Four isomers of the three-dimensionally connected bare boron cationic cluster B were investigated by using ab initio molecular orbital theory at the HF/6-31G level. The results show that the D5h symmetric isomer of B is a possible isomer candidate of its stable geometries with closed structure.
文摘We propose a content-based parallel image retrieval system to achieve high responding ability. Our system is developed on cluster architectures. It has several retrieval. servers to supply the service of content-based image retrieval. It adopts the Browser/Server (B/S) mode. The users could visit our system though web pages. It uses the symmetrical color-spatial features (SCSF) to represent the content of an image. The SCSF is effective and efficient for image matching because it is independent of image distortion such as rotation and flip as well as it increases the matching accuracy. The SCSF was organized by M-tree, which could speedup the searching procedure. Our experiments show that the image matching is quickly and efficiently with the use of SCSF. And with the support of several retrieval servers, the system could respond to many users at mean time. Key words content-based image retrieval - cluster architecture - color-spatial feature - B/S mode - task parallel - WWW - Internet CLC number TP391 Foundation item: Supported by the National Natural Science Foundation of China (60173058)Biography: ZHOU Bing (1975-), male, Ph. D candidate, reseach direction: data mining, content-based image retrieval.
基金This project was financially supported by the National Natural Science Foundation of China (No.50401020, 50671018, 50631010)the Provincial Science and Technology Foundation of Liaoning, China.
文摘The glass forming ability of the [(Fe12/13Y1/13)100?xBx]96Nb2Zr2 (x=9–26) system was investigated using a series of cluster lines. Three types of clusters, an icosahedron (Fe12Y), a capped Archimedes anti-prism (Fe8B3) and a capped trigonal prism (Fe9B), as well as a binary eutectic (Fe83B17) were considered. Bulk glassy alloy rods of 3 mm in diameter were synthesized using a copper mold suction-casting method. The glass transition temperature was observed for all samples in the boron range of 15.9at%-25.7at%, with the alloy at 15.9at% of boron having the best thermal properties. The ferrous-based bulk metallic glasses (BMG) obtained have high reduced glass transition temperatures with the maximum reaching 0.63 and large supercooled liquid regions with the maximum reaching 111 K. Magnetic testing revealed a large value of coercive force and remanent magnetization, being 11 kA/m and 0.1 T, re- spectively.
