基于“微生物-肠-脑轴”探讨补肾通腑方对APP/PS1小鼠肠道菌群及LPS/TLR4/NF-κB通路的影响

目的探讨补肾通腑方调控肠道菌群,改善阿尔茨海默病(Alzheimer’s disease,AD)模型小鼠学习记忆能力的作用机制。方法以APP/PS1小鼠为研究对象,给予补肾通腑方治疗8周,采用Morris水迷宫法观察小鼠空间学习记忆能力变化;16S rDNA检测小鼠肠道菌群丰度、多样性变化;HE染色观察海马病理形态学变化;免疫荧光检测海马区小胶质细胞活化情况;Western blot检测TLR4、NF-κB、IL-6等炎症因子表达。结果与模型组相比,补肾通腑方可以缩短AD模型小鼠逃避潜伏期、游泳路径,增加跨越平台次数(P<0.05),提升肠道菌群多样性,调节肠道菌群丰度,促进海马神经元细胞损伤修复,降低iNOS/Iba1共表达,提高Arg1/Iba1共表达(P<0.01),促进小胶质细胞从M1型向M2型转化,下调TLR4、NF-κB、IL-6等促炎因子的表达。结论补肾通腑方改善AD模型小鼠学习记忆能力的作用机制可能与调节肠道菌群介导的LPS/TLR4/NF-κB通路,从而抑制促炎型小胶质细胞活化、减轻中枢神经系统炎症、改善海马区神经元细胞损伤有关。

基于s和B样条曲线的传输机构分段轨迹规划

为了改善Pecvd设备在运输石墨舟过程中遇到的振动、过量损耗等问题,提出一种分段式作业轨迹规划方法。分别采用自适应的s曲线以及B样条曲线对传输机构的两段作业轨迹进行轨迹规划,并对较复杂的B样条曲线轨迹采用自适应遗传算法进行优化;同时采用模糊PID控制方法,将机构控制误差限制在合理范围之内。通过石墨舟传输机构模型轨迹仿真实验,验证了所提出的分段轨迹规划方法可使机构运动平稳;实际样机实验验证了该方法控制信号误差在5%以内。实验结果表明,所提出的轨迹规划方法在效率、误差控制方面均符合生产需求,可用于实际生产。

老年急性进展性脑梗死患者血清磷脂酶A2、S100钙结合蛋白B水平与颈动脉斑块的联系

目的探讨老年急性进展性脑梗死患者血清磷脂酶A2(PLA2)、S100钙结合蛋白B(S100B)和颈动脉斑块的关系。方法将2021年1月至2022年6月收治的120例老年急性进展性脑梗死患者纳入观察组,同期将115例非进展性脑梗死患者为非进展组,100例健康人员为健康组。将观察组分为无斑块组34例、斑块稳定组45例和斑块不稳定组41例。分析血清PLA2、S100B水平与颈动脉斑块的关系。ROC分析二者对颈动脉斑块的预测价值。随访1年,以复发和死亡为终点事件分析生存率。结果斑块稳定组、斑块不稳定组血清PLA2、S100B高于无斑块组,差异有统计学意义(P<0.05)。血清PLA2、S100B与颈动脉斑块呈正相关。ROC显示二者联合预测的价值更高(P<0.05)。结论血清PLA2、S100B在老年急性进展性脑梗死患者水平升高,与颈动脉斑块关系密切。

基于B/S端的风电场规划设计平台开发

随着清洁能源的发展,风电作为一种清洁、可再生的能源,具有巨大的发展潜力。然而,风电的开发需要精确的风能资源测量和评估,以及选择适当的风电场址。因此,开发了基于B/S(Browser/Server,浏览器/服务器)端的风电场规划设计平台。该平台提供了多种功能,包括项目管理、风能资源评估、风电场选址、中尺度数据处理和方案管理等。该平台利用GIS(Geographic Information System,地理信息系统)技术和模型计算方法,能够对风能资源进行多方面评估和分析,根据地理信息、环境和建设要求等因素,优化风电场选址。同时,该平台具有用户友好的界面和数据交互功能,使得开发者可以更加便捷地实现风电项目开发。实际应用结果表明,该平台在风电场选址、风电资源评估等方面具有较强的竞争力,能够有效促进风电产业的发展。

基于B/S架构的防汛防旱抢险数字化管理系统研究

针对传统的防汛防旱抢险管理方式难以实现高效、精准、及时响应的问题,研究了一种基于B/S架构的防汛防旱抢险数字化管理系统。分析了该系统的技术特性,探讨了系统的框架体系、通用业务组件、应用管理平台和开发功能结构等。

基于B/S的高校学生缓考与课程重修管理系统设计与实现

针对高校学生缓考与课程重修统计审核效率低和数据错误率高等问题,研究分析了学生缓考与课程重修管理系统架构,利用B/S架构和SSM框架,应用Spring Security权限控制技术,结合MySQL数据库及Java开发语言,设计了具有高效、准确管理功能的学生缓考与课程重修Web管理系统,实现了学生缓考与课程重修申请、审核、下载以及审批统计与数据分析等功能。实践测试结果表明,系统运行稳定,管理功能全面,操作简单便捷,学生缓考与课程重修的申请与审核、审批统计与数据分析等信息准确,其功能达到了预期需求,为高校学生缓考与课程重修的信息化管理提供了借鉴。

Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial cells.However,the functional role of GGT5 in the development of Alzheimer’s disease remains unclear.This study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying mechanism.We observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse model.Additionally,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive deficits.Interestingly,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 mice.This effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa B.Our findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 mice.These findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

温阳益髓方联合富血小板血浆治疗早中期膝骨关节炎的疗效及对血清S100B、CTX-Ⅱ水平的影响

目的 分析温阳益髓方联合富血小板血浆(PRP)治疗早中期膝骨关节炎(KOA)的疗效及对血清S100B、Ⅱ型胶原C端肽(CTX-Ⅱ)水平的影响。方法 选取2021年4月至2023年1月该院收治的150例早中期KOA患者作为研究对象,根据随机数字表法将其分为观察组和对照组,各75例。对照组给予PRP治疗,观察组在对照组基础上联合温阳益髓方治疗。对比两组临床疗效、不良反应总发生率、复发率,治疗前、治疗1个月后Lysholm膝关节功能量表(LKS)评分,血清S100B、CTX-Ⅱ水平,以及治疗前、治疗1周、1个月后视觉模拟评分法(VAS)评分。结果 观察组总有效率高于对照组,复发率低于对照组,差异均有统计学意义(P<0.05)。治疗1个月后两组LKS评分高于治疗前,且观察组LKS评分高于对照组,差异均有统计学意义(P<0.05)。重复测量方差分析显示,两组治疗期间VAS评分变化有交互效应(F=20.132,P=0.030),故进一步做单独交应分析,对照组和观察组治疗1周、1个月后的VAS评分均低于治疗前,且治疗1个月后的VAS评分低于治疗1周后,差异均有统计学意义(P<0.05)。多变量方差分析结果显示,治疗1周、1个月后观察组VAS评分低于对照组,差异均有统计学意义(P<0.05)。治疗1个月后两组血清S100B、CTX-Ⅱ水平低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 温阳益髓方联合PRP治疗早中期KOA患者的临床效果显著,可有效缓解疼痛症状,改善血清S100B、CTX-Ⅱ水平,促进膝关节功能康复,降低疾病复发率,值得临床推广。

Combinatorial Design of Some Database Application Technologies Based on B/S

Evolving From principal-subordinate structure of C /S to flexible multileveled distributed structure, i.e. B/S architecture so as to form a wide, distributed and orderly Internet/Intranet integrated management inf ormation system, is the trend of development of application software of the whol e world. Advantages and disadvantages of the two modes: C/S and B/S are compared . It is pointed out that at present onefold B/S mode cannot yet fully fullfil th e demands of some complicated data processing, information statistics and analys is, etc, therefore it still awaits further development of technology to achieve 100% Internet. In this paper, a mode of B/S-C/S-blended multileveled architect ure is discussed; the logical levels of B/S mode is studied; Furthermore, combin ing some up-to-date software developing technology, combinatorial design of di fferent database application technology based on B/S is discussed. The expatiati on is made with following points: (1) Organic combination of the network distrib uted object technology of CORBA and the computation technology among different n etwork operating system ─ Java; (2) Organic combination of two modes of ASP and Plug_in; (3) JDBC Server and JDBC Client; (4) An expanded B/S model, i.e. the c lient application of browser communicates directly with Web server, and the serv er application communicates directly with database server through middle ware.

S-adenosylmethionine in treatment of cholestasis after total parenteral nutrition: laboratory investigation and clinical application

Objective: To observe the effects of S-adenosylmethio-nine (SAMe) in the treatment of cholestasis after totalparenteral nutrition (TPN).Methods: Thirty SD rats were randomly divided intocontrol group, hypercalorie group, hypercalorie+SAMegroup, sepsis group and sepsis+SAMe group to com-pare their states of cholestasis. Sixteen patients re-ceived SAMe because of cholestasis after prolongedTPN, and the therapeutic efficacy was observed.Results: Bile flow was obviously decreased and theserum levels of total bile acid and gamma-glutamyltranspeptidase(γ-GT) were markedly increased in thehypercalorie and sepsis groups. Meanwhile, hepatocytefatty degeneration, dilatation of cholangioles, and bilesludge could be seen microscopically. SAMe adminis-tration in the hypercalorie+SAMe and sepsis+SAMegroups could increase the bile flow, decrease theserum levels of total bile acid and γ-GT, reduce thepathological damage to the liver, and clear the bilesludge in the cholangioles. Cholestasis and abnormalliver function were the main manifestations of the 16patients before SAMe administration. After SAMe treat-ment for 3 weeks, serum levels of total bilirubin, al-kaline phosphatase(AKP), γ-GT, alanine aminotrans-ferase(ALT), and aspartate aminotransferase(AST)were obviously decreased, and normalized in the 4thweek.Conclusion: SAMe could prevent and treat cholestasiswithout discontinuation of TPN.

Transmission of Meteorological Information to a Cockpit and Application of ADS-B

Unpredictable meteorological information, especially that endangers flight safety, should be transmitted to a cockpit to make a flight crew obtain meteorological early warning that affects flight safety as soon as possible and adopt countermeasures, thereby avoiding the occurrence of flight safety accidents. At present, there are limited ways of transmitting meteorological information to a cockpit, and the application of Automatic Dependent Surveillance-Broadcast （ADS-B） is a new way of transmitting meteorological information to a cockpit.

Application of the BSSF molten steel slag processing technology in POSCO

This study describes an overview of the POSCO＇ s Baosteel＇ s short-flow （BSSF） slag processing project, including process flow, process set-up, equipment composition, auxiliary facilities and relevant parameters, as well as a brief description of its application after commissioning.

Time of Application of <i>S</i>-Metolachlor Affects Growth, Marketable Yield and Quality of Carrot and Red Beet

Tolerance of carrot and red beet to s-metolachlor at three application timings—pre-emergence to crop (PRE), early postemergence (crop at two to four leaf stage-EPOST), and late postemergence (crop at five to seven leaf stage-LPOST) —was determined from 2008 to 2010. LPOST applications of s-metolachlor reduced carrot above ground plant dry weight, marketable yield and grower payment, but did not affect carrot length. PRE and LPOST applications of s-metolachlor reduced red beet above ground plant dry weight, total marketable yield, yield of No. 2 and No. 3 red beet, and grower payment. Our findings indicate that while carrot may be tolerant to PRE applications of s-metolachlor, applications made after the 5 leaf stage reduced plant dry weight enough to impact marketable yield and grower payment. In red beet, the potential reduction in growth, yield and grade would not justify the utility of a PRE or LPOST applica- tion timing.

Study on Application Effect of 6S Management Mode in Infection Control Management of Fangcang Shelter Hospital of National Exhibition and Convention Center

Objective:In 2022,a pneumonia caused by novel coronavirus broke out in Shanghai.A large number of medical personnel were deployed nationwide to support the Fangcang Shelter Hospital of National Exhibition and Convention Center(Shanghai).Because the of the underdeveloped infrastructure and the disorganized layout process,the phenomenon of infection among medical personnel was rampant given the highly contagious nature of the Omicron variant.This paper discusses the effect of 6S management in infection control management of Fangcang Shelter Hospital of National Exhibition and Convention Center(Shanghai).Methods:A series of 6S management practices were carried out based on the evaluation of the control management of Fangcang Shelter Hospital of National Exhibition and Convention Center(Shanghai)during the anti-epidemic period,and the effect of the implementation of 6S management was studied based on the rapport among team members and the overall control system process,the management of wearing and stripping channels,the time of wearing protective articles and the psychological and emotional changes of the team members.Results:After the implementation of 6S management mode,the management of dressing room,epidemic prevention materials,and occupational protection awareness and infection control safety were significantly improved.More than 95.5%of the team members believed that improving the working environment in the shelter increased the confidence of victory in the fight against the epidemic,reduced the preparations before entering and leaving the cabin,improved the work efficiency and ensured occupational safety.It ensures the realization of the goal of“zero infection”and is set as a benchmark of control work of Fangcang Shelter Hospital of National Exhibition and Convention Center(Shanghai).Conclusion:The application of 6S management mode to the shelter infection control management can create and maintain a good working environment in the shelter,promote the implementation effect of various systems and processes of infection control,reduce the potential infection risk in the shelter and improve the efficiency of infection control management.

Behavior Targeting Based on Hierarchical Taxonomy Aggregation for Heterogeneous Online Shopping Applications

Behavior targeting(BT)based on individual web-browsing history has become more valuable in precision marketing for many companies through capturing users’interest and preference.It is common in practice that the behavior data collected from different online shopping applications are inconsistent since they are labelled by different item taxonomy,where the same behavior could have different representations and therefore analysis confusion arises.To address this issue,we propose a semantic similarity based strategy to transform the heterogeneous behavior extracted from deep packet inspection(DPI)data of a telecommunication operator into a unique standard one.The Word Mover’s Distance algorithm is exploited to evaluate the semantic similarity of the distributed representations of two web-browsing histories.Moreover,the architecture of the behavior targeting platform on Hadoop is implemented,which is capable of processing data with size of PB level every day.

Magnetic Properties and Applications of Newly-developed Fe_(73.5)Cu_1Nb_(1.5)V_(1.5)Si_(13.5)B_9 Alloy

The synthetical soft magnetic properties including d.c. and a.c. magnetic properties and pulse magnetic property are reported for a newly-developed nanocrystalline Fe73.5Cu1 Nb1.5V1.5Si13.5B9 alloy The new alloy possesses high d.c. relative initial permeability of 12.5×104 and low coerciv ity of 0.54 A/m. Under the conditions of Bm=0.3 T, f=100 kHz and Bm=0.2 T, f=200 kHz the core losses of the new alloy are 543 kW·m-3 and 834 kW.m-3, respectively which can be compa rable with those of nanocrystalline Fe73.5Cu1Nb3Si13.5B9 alloy. The analyses of core losses have been carried out in the wider range of f=20～104 kHz and Bm=0.0025～0.8 T and the approxi mate expression P(kW·m-3)=1.803 B:f1.77 has been obtained. The analyses of core losses in the range of f=20～104 kHz and Bmf=(10～40)×103(T.Hz) have shown that the core loss and the corresponding amplitude permeability roughly vary as P = 2.347×10-6(Bmf)1.97f-0.2231 and μa = 9.56× 105f-0.7464, respectively for the given product B.f. Some practical applica tions have also been mentioned.

Extraction and Application Prospects of Artemisia leucophylla(Turcz. ex Bess.) C.B.Clarke

The main components of Artemisia leucophylla(Turcz.ex Bess.) C.B.Clarke extract are volatile oils,flavonoids,lignans,terpenoids,etc.Studies have shown that A.leucophylla has bactericidal,anti-inflammatory,anti-oxidant,anti-ultraviolet functions,and it has large development space and application value in many fields.This paper first introduced the growth resource distribution,active component extraction method,composition and efficacy of A.leucophylla,and analyzed the application prospects in daily necessities,in order to provide reference for the in-depth research,development and utilization of A.leucophylla.

A Hard Ordeal—On China's Application for ICC Membership

Agroup of foreigners, alighted from an airplane from Paris to Beijing in July 1994 were met by representatives from the China Chamber of International Commerce (CCOIC). This was a high-profile delegation of the International Chamber of Commerce (ICC), consisting of Vice-President Rahmi Koc, and

The Project “Development and Application of FCC Additive for Maximization of Propylene and Isobutylene” Passed SINOPEC's Appraisal

The research project'Development and application of FCC additive for maximization of propylene and isobutylene'jointly undertaken by RIPP,the Baling Petrochemical Company(BPC)and the SINOPEC