前言:在急性心肌梗死等致死性较高的疾病中,ST段抬高型急性心肌梗死(ST-segment elevation myocardial infarction, STEMI)是胸痛中心主要的救治对象,目前经皮冠状动脉介入治疗(percutaneous coronary intervention, PCI)是STEMI再灌注...前言:在急性心肌梗死等致死性较高的疾病中,ST段抬高型急性心肌梗死(ST-segment elevation myocardial infarction, STEMI)是胸痛中心主要的救治对象,目前经皮冠状动脉介入治疗(percutaneous coronary intervention, PCI)是STEMI再灌注治疗的首选方案,而患者从到达医院以后到手术中首次球囊扩张的时间即门–球时间(door to balloon time,D to B时间)与院内的疾病死亡率是呈明显相关的。目的:分析优化院内综合急救流程后对行直接冠状动脉介入治疗的急性ST段抬高型心肌梗死门–球时间的影响,探究院内综合急救流程的主要因素和改进措施,探索在救治中影响结果最为重要的时间节点,为进一步完善院内综合急救流程提供理论指导和建议。方法:选取2017.07~2018.03期间青岛大学附属医院在常规流程下92例行急诊PCI且符合纳入标准的STEMI患者组成改进前组,选取2018.04~2018.12在我院建设胸痛中心背景下,优化综合急救流程后的87例行直接PCI且符合纳入标准的STEMI患者组成改进后组。通过观察D to B时间,并将D to B时间分为6个时间节点,将节点进行相关性分析。结果:研究结果显示改进前组和改进后组的一般资料差异均无统计学意义(P 】0.05)。改进后组节点1、节点2、节点3、节点4、节点5、D-to-B时间短于改进前组,两组差异有统计学意义(P 0.05)。改进前组结果显示,节点2与D to B之间存在正相关关系,rs = 0.233,P 【0.05;节点3与D to B之间存在正相关关系,rs = 0.873,P 【0.01;节点4与D to B之间存在正相关关系,rs = 0.653,P 【0.01;节点5与D to B之间存在正相关关系,rs = 0.293,P 【0.01;改进后组结果显示,节点1与D to B之间存在正相关关系,rs = 0.333,P 【0.01;节点3与D to B之间存在正相关关系,rs = 0.549,P 【0.01;节点4与D to B之间存在正相关关系,rs = 0.270,P 【0.05;节点5与D to B之间存在正相关关系,rs = 0.245,P 【0.05。结论:优化院内综合急救流程明显缩短了首D to B时间。先行ECG后挂号、零费用办理入院、接诊医师直接术前谈话、急救绿道手机APP的使用、胸痛门诊护士送入导管室等改进措施在综合急救流程优化中起到明显的效果,明显缩短了D to B时间。改进措施中仍存在不足,应进一步改进诊断明确后与患者谈话的技巧方式、优化激活导管室流程及加快患者进入导管室后术前准备以及手术操作的时间。改进前组与改进后组中均提示节点3和D to B的相关关系最强,提示从医生初步诊断至签署知情同意时间的间隔对于整个流程的时间影响最大。展开更多
InterRange Instrumentation Group(IRIG-B(AC))code is usually used in the shooting range test for time information transmission and systems time synchronization.According to IRIG-B(AC)code format and modulation pr...InterRange Instrumentation Group(IRIG-B(AC))code is usually used in the shooting range test for time information transmission and systems time synchronization.According to IRIG-B(AC)code format and modulation principle,this paper presents IRIG-B(AC)coding circuit design scheme based on field programmable gate array(FPGA).The B(AC)code signal is generated by AD7245,a digital-to-analog(D/A)converter.After amplified,the signal can be used directly for system time synchronization,and the amplitude of the signal can be adjusted according to different requirements.The IRIG-B(AC)encoder designed has been verified by test.The test results show that it can output accurate time information and has higher practicality.展开更多
In this work,the effects of degradation time,temperature,and pH value on the degradation of Salvianolic acid B in aqueous solution were determined.Higher pH values,higher extraction temperature,and longer extraction t...In this work,the effects of degradation time,temperature,and pH value on the degradation of Salvianolic acid B in aqueous solution were determined.Higher pH values,higher extraction temperature,and longer extraction time led to more degradation of Salvianolic acid B.Danshensu concentration increased as Salvianolic acid B degraded.A mechanism model was developed considering the degradation of Salvianolic acid E and lithospermic acid,which were two degradation products of Salvianolic acid B.The reverse reactions of Salvianolic acid B degradation were also considered.Degradation kinetic constants were calibrated.The degradation kinetics of Salvianolic acid B,lithospermic acid,and Danshensu in a Salvia miltiorrhiza extract aqueous solution were predicted using the mechanism model.The predicted concentrations agreed well with the experimental results.This model was developed using degradation data obtained from simple composition systems,but it can be applied in a complex botanical mixture with high prediction accuracy.展开更多
A new LDMOST structure, named B-LDMOST that has a buried layer under the drain is proposed. The buried layer is not connected to the drift region, so it can optimize the vertical field distribution and increase breakd...A new LDMOST structure, named B-LDMOST that has a buried layer under the drain is proposed. The buried layer is not connected to the drift region, so it can optimize the vertical field distribution and increase breakdown voltage. The analysis and the simulated results show that B-LDMOST can increase breakdown voltage, with almost negligible influence on the other parameters such as on-resistance, switching time, and so on.展开更多
目的探讨团队资源管理在急性心肌梗死(AMI)再灌注治疗中的应用及效果分析。方法本研究以2017年8-12月我院收治的急性心肌梗死再灌注治疗患者45例为观察组,运用团队资源管理模式进行原因分析、策略拟定、完善急性心肌梗死救治流程。以201...目的探讨团队资源管理在急性心肌梗死(AMI)再灌注治疗中的应用及效果分析。方法本研究以2017年8-12月我院收治的急性心肌梗死再灌注治疗患者45例为观察组,运用团队资源管理模式进行原因分析、策略拟定、完善急性心肌梗死救治流程。以2016年12月-2017年5月未实施团队资源管理前收治的急性心梗患者49例为对照组,对比实施团队资源管理前后的救治效果。结果观察组的心电图时间、口服负荷量时间、D to B时间明显缩短,绕行CCU率达到88.89%。均优于对照组,两组比较差异有统计学意义(P<0.05)。两组住院时间比较差异无统计学意义(P>0.05)。结论团队资源管理的实施可缩短AMI患者的诊断时间,减少院内延误及转运,为患者行急诊经皮冠状动脉介入治疗赢得了宝贵的救治时间。展开更多
文摘前言:在急性心肌梗死等致死性较高的疾病中,ST段抬高型急性心肌梗死(ST-segment elevation myocardial infarction, STEMI)是胸痛中心主要的救治对象,目前经皮冠状动脉介入治疗(percutaneous coronary intervention, PCI)是STEMI再灌注治疗的首选方案,而患者从到达医院以后到手术中首次球囊扩张的时间即门–球时间(door to balloon time,D to B时间)与院内的疾病死亡率是呈明显相关的。目的:分析优化院内综合急救流程后对行直接冠状动脉介入治疗的急性ST段抬高型心肌梗死门–球时间的影响,探究院内综合急救流程的主要因素和改进措施,探索在救治中影响结果最为重要的时间节点,为进一步完善院内综合急救流程提供理论指导和建议。方法:选取2017.07~2018.03期间青岛大学附属医院在常规流程下92例行急诊PCI且符合纳入标准的STEMI患者组成改进前组,选取2018.04~2018.12在我院建设胸痛中心背景下,优化综合急救流程后的87例行直接PCI且符合纳入标准的STEMI患者组成改进后组。通过观察D to B时间,并将D to B时间分为6个时间节点,将节点进行相关性分析。结果:研究结果显示改进前组和改进后组的一般资料差异均无统计学意义(P 】0.05)。改进后组节点1、节点2、节点3、节点4、节点5、D-to-B时间短于改进前组,两组差异有统计学意义(P 0.05)。改进前组结果显示,节点2与D to B之间存在正相关关系,rs = 0.233,P 【0.05;节点3与D to B之间存在正相关关系,rs = 0.873,P 【0.01;节点4与D to B之间存在正相关关系,rs = 0.653,P 【0.01;节点5与D to B之间存在正相关关系,rs = 0.293,P 【0.01;改进后组结果显示,节点1与D to B之间存在正相关关系,rs = 0.333,P 【0.01;节点3与D to B之间存在正相关关系,rs = 0.549,P 【0.01;节点4与D to B之间存在正相关关系,rs = 0.270,P 【0.05;节点5与D to B之间存在正相关关系,rs = 0.245,P 【0.05。结论:优化院内综合急救流程明显缩短了首D to B时间。先行ECG后挂号、零费用办理入院、接诊医师直接术前谈话、急救绿道手机APP的使用、胸痛门诊护士送入导管室等改进措施在综合急救流程优化中起到明显的效果,明显缩短了D to B时间。改进措施中仍存在不足,应进一步改进诊断明确后与患者谈话的技巧方式、优化激活导管室流程及加快患者进入导管室后术前准备以及手术操作的时间。改进前组与改进后组中均提示节点3和D to B的相关关系最强,提示从医生初步诊断至签署知情同意时间的间隔对于整个流程的时间影响最大。
基金The 10th Postgraduate Science and Technology Fund of North University of China(No.20131020)
文摘InterRange Instrumentation Group(IRIG-B(AC))code is usually used in the shooting range test for time information transmission and systems time synchronization.According to IRIG-B(AC)code format and modulation principle,this paper presents IRIG-B(AC)coding circuit design scheme based on field programmable gate array(FPGA).The B(AC)code signal is generated by AD7245,a digital-to-analog(D/A)converter.After amplified,the signal can be used directly for system time synchronization,and the amplitude of the signal can be adjusted according to different requirements.The IRIG-B(AC)encoder designed has been verified by test.The test results show that it can output accurate time information and has higher practicality.
基金Supported by the National Natural Science Foundation of China(No.81273992)the Public Service Technology Research and Social Development Project of Science Technology Department of Zhejiang Province of China(2015C33128)
文摘In this work,the effects of degradation time,temperature,and pH value on the degradation of Salvianolic acid B in aqueous solution were determined.Higher pH values,higher extraction temperature,and longer extraction time led to more degradation of Salvianolic acid B.Danshensu concentration increased as Salvianolic acid B degraded.A mechanism model was developed considering the degradation of Salvianolic acid E and lithospermic acid,which were two degradation products of Salvianolic acid B.The reverse reactions of Salvianolic acid B degradation were also considered.Degradation kinetic constants were calibrated.The degradation kinetics of Salvianolic acid B,lithospermic acid,and Danshensu in a Salvia miltiorrhiza extract aqueous solution were predicted using the mechanism model.The predicted concentrations agreed well with the experimental results.This model was developed using degradation data obtained from simple composition systems,but it can be applied in a complex botanical mixture with high prediction accuracy.
基金Supported by the National Natural Science Foundation of China(No.69776041)
文摘A new LDMOST structure, named B-LDMOST that has a buried layer under the drain is proposed. The buried layer is not connected to the drift region, so it can optimize the vertical field distribution and increase breakdown voltage. The analysis and the simulated results show that B-LDMOST can increase breakdown voltage, with almost negligible influence on the other parameters such as on-resistance, switching time, and so on.
文摘目的探讨团队资源管理在急性心肌梗死(AMI)再灌注治疗中的应用及效果分析。方法本研究以2017年8-12月我院收治的急性心肌梗死再灌注治疗患者45例为观察组,运用团队资源管理模式进行原因分析、策略拟定、完善急性心肌梗死救治流程。以2016年12月-2017年5月未实施团队资源管理前收治的急性心梗患者49例为对照组,对比实施团队资源管理前后的救治效果。结果观察组的心电图时间、口服负荷量时间、D to B时间明显缩短,绕行CCU率达到88.89%。均优于对照组,两组比较差异有统计学意义(P<0.05)。两组住院时间比较差异无统计学意义(P>0.05)。结论团队资源管理的实施可缩短AMI患者的诊断时间,减少院内延误及转运,为患者行急诊经皮冠状动脉介入治疗赢得了宝贵的救治时间。