迄今为止的免疫疗法研究主要集中于T淋巴细胞,但越来越多的证据表明,肿瘤浸润B淋巴细胞和浆细胞[统称为肿瘤浸润B淋巴细胞(tumor-infiltrating B lymphocyte,TIL-B)]在肿瘤控制中具有至关重要的协同作用。在许多癌症中,TIL-B在标准治疗...迄今为止的免疫疗法研究主要集中于T淋巴细胞,但越来越多的证据表明,肿瘤浸润B淋巴细胞和浆细胞[统称为肿瘤浸润B淋巴细胞(tumor-infiltrating B lymphocyte,TIL-B)]在肿瘤控制中具有至关重要的协同作用。在许多癌症中,TIL-B在标准治疗和免疫检查点阻断的背景下均显示出较高的预测和预后意义,为利用其独特的免疫学特性提供了新的治疗机会的前景。本文旨在综述实体瘤浸润B淋巴细胞的研究进展。展开更多
Diffuse large B-cell lymphoma (DLBCL) is the most common histologic subtype of the non-Hodgkin’s lymphoma (NHL) accounting for about 40% of all NHLs. This is a case report about the endoscopic appearance of a DLBCL w...Diffuse large B-cell lymphoma (DLBCL) is the most common histologic subtype of the non-Hodgkin’s lymphoma (NHL) accounting for about 40% of all NHLs. This is a case report about the endoscopic appearance of a DLBCL with infiltration to the stomach in a 39-year-old female. She had a 6-mo history of lumbar and left upper quadrant pain with intermittent episodes of melena. A computer tomograghy (CT) scan showed mural thickening of the gastric antrum. Endoscopic examination revealed multiple gastric ulcers. Definite diagnosis could be made by endoscopic biopsies and the patient had a good response to chemotherapy. This response correlated well with a further endoscopic follow-up. A follow-up endoscopic examination could be considered to evaluate a good response to chemotherapy in DLBCL patients with secondary gastric dissemination.展开更多
文摘迄今为止的免疫疗法研究主要集中于T淋巴细胞,但越来越多的证据表明,肿瘤浸润B淋巴细胞和浆细胞[统称为肿瘤浸润B淋巴细胞(tumor-infiltrating B lymphocyte,TIL-B)]在肿瘤控制中具有至关重要的协同作用。在许多癌症中,TIL-B在标准治疗和免疫检查点阻断的背景下均显示出较高的预测和预后意义,为利用其独特的免疫学特性提供了新的治疗机会的前景。本文旨在综述实体瘤浸润B淋巴细胞的研究进展。
文摘Diffuse large B-cell lymphoma (DLBCL) is the most common histologic subtype of the non-Hodgkin’s lymphoma (NHL) accounting for about 40% of all NHLs. This is a case report about the endoscopic appearance of a DLBCL with infiltration to the stomach in a 39-year-old female. She had a 6-mo history of lumbar and left upper quadrant pain with intermittent episodes of melena. A computer tomograghy (CT) scan showed mural thickening of the gastric antrum. Endoscopic examination revealed multiple gastric ulcers. Definite diagnosis could be made by endoscopic biopsies and the patient had a good response to chemotherapy. This response correlated well with a further endoscopic follow-up. A follow-up endoscopic examination could be considered to evaluate a good response to chemotherapy in DLBCL patients with secondary gastric dissemination.
