We calculate the new physics contributions to the neutral Bd^o and Ba^o meson mass splitting △Md and △Ma induced by the box diagrams involving the charged-Higgs bosons in the top quark two-Higgs doublet model （T2HD...We calculate the new physics contributions to the neutral Bd^o and Ba^o meson mass splitting △Md and △Ma induced by the box diagrams involving the charged-Higgs bosons in the top quark two-Higgs doublet model （T2HDM）. Using the precision data, we obtain the bounds on the parameter space of the T2HDM： （a） For fixed MH = 400 GeV and 5= [0°, 60°], the upper bound on tan β is tan β≤ 30 after the inclusion of major theoretical uncertainties; （b） For the case of tan β≤ 20, a light charged Higgs boson with a mass around 300 GeV is allowed; and （c） The bounds on tan β and MH are strongly correlated： a smaller （larger） tan β means a lighter （heavier） charged Higgs boson.展开更多
Coxsackie A virus is one of the major pathogens associated with hand, foot and mouth disease (HFMD). The etiological characteristics of Coxsackie A virus type 16 (CA16) are thought to correlate with the pathological p...Coxsackie A virus is one of the major pathogens associated with hand, foot and mouth disease (HFMD). The etiological characteristics of Coxsackie A virus type 16 (CA16) are thought to correlate with the pathological process of its infection. Two CA16 strains that were isolated from a severe HFMD patient presented with different plaque forms. This observation, along with biological analysis, indicated that the differences in the strains' biological characteristics, such as proliferation kinetics and immunogenicity, correlate with differences in their pathogenicity toward neonatal mice. Furthermore, these differences are thought to be associated with the sequence of the 5′ non-coding region of the viral genome and the VP1 structural region sequence. The results suggest that the biological and genetic characteristics of the CA16 viral strains are relevant to their pathogenicity.展开更多
Abacavir is an effective nucleoside analog reverse transcriptase inhibitor used to treat human immunodeficiency virus(HIV) infected patients.Its main side effect is hypersensitivity reaction(HSR).The incidence of the ...Abacavir is an effective nucleoside analog reverse transcriptase inhibitor used to treat human immunodeficiency virus(HIV) infected patients.Its main side effect is hypersensitivity reaction(HSR).The incidence of the HSR is associated with ethnicity among patients exposed to abacavir,and retrospective and prospective studies show a significantly increased risk of abacavir-induced HSR in human leukocyte antigen(HLA)-B*57:01-carrying patients.Immunological studies indicated that abacavir interacts specifically with HLA-B*57:01 and changed the binding specificity between the HLA molecule and the HLA-presented endogenous peptide repertoire,leading to a systemic autoimmune reaction.HLA-B*57:01 screening,combined with patch testing,had clinically predictive value and cost-effective impact in reducing the incidence of abacavir-induced HSR regardless of the HLA-B*57:01 prevalence in the population.Therefore,the US Food and Drug Administration(FDA) and international HIV treatment guidelines recommend a routine HLA-B*57:01 screening prior to abacavir treatment to decrease false positive diagnosis and prevent abacavir-induced HSR.The studies of abacavir-induced HSR and the implementation of the HLA-B*57:01 screening in the clinic represent a successful example of the use of pharmacogenetics for personalized diagnosis and therapy.展开更多
基金The project partly supported by National Natural Science Foundation of China under Grant No. 10575052 and the Specialized Research Fund for the Doctoral Program of Higher Education （SRFDP） under Grant No. 20050319008.Acknowledgments 0ne of the authors Lin-Xia Lü would like to thank Prof. C.S. Huang for his valuable help.
文摘We calculate the new physics contributions to the neutral Bd^o and Ba^o meson mass splitting △Md and △Ma induced by the box diagrams involving the charged-Higgs bosons in the top quark two-Higgs doublet model （T2HDM）. Using the precision data, we obtain the bounds on the parameter space of the T2HDM： （a） For fixed MH = 400 GeV and 5= [0°, 60°], the upper bound on tan β is tan β≤ 30 after the inclusion of major theoretical uncertainties; （b） For the case of tan β≤ 20, a light charged Higgs boson with a mass around 300 GeV is allowed; and （c） The bounds on tan β and MH are strongly correlated： a smaller （larger） tan β means a lighter （heavier） charged Higgs boson.
基金supported by the National Basic Research Program of China (Grant No. 2011CB504903)the National Natural Science Foundation of China (Grant No. 81171573)+1 种基金the Important National Science & Technology Specific Projects (Grant No. 2009ZX10004-308)the General Program of Applied Basic Research Programs Commission, Foundation of Yunnan Province (Grant No. 2011FB116)
文摘Coxsackie A virus is one of the major pathogens associated with hand, foot and mouth disease (HFMD). The etiological characteristics of Coxsackie A virus type 16 (CA16) are thought to correlate with the pathological process of its infection. Two CA16 strains that were isolated from a severe HFMD patient presented with different plaque forms. This observation, along with biological analysis, indicated that the differences in the strains' biological characteristics, such as proliferation kinetics and immunogenicity, correlate with differences in their pathogenicity toward neonatal mice. Furthermore, these differences are thought to be associated with the sequence of the 5′ non-coding region of the viral genome and the VP1 structural region sequence. The results suggest that the biological and genetic characteristics of the CA16 viral strains are relevant to their pathogenicity.
文摘Abacavir is an effective nucleoside analog reverse transcriptase inhibitor used to treat human immunodeficiency virus(HIV) infected patients.Its main side effect is hypersensitivity reaction(HSR).The incidence of the HSR is associated with ethnicity among patients exposed to abacavir,and retrospective and prospective studies show a significantly increased risk of abacavir-induced HSR in human leukocyte antigen(HLA)-B*57:01-carrying patients.Immunological studies indicated that abacavir interacts specifically with HLA-B*57:01 and changed the binding specificity between the HLA molecule and the HLA-presented endogenous peptide repertoire,leading to a systemic autoimmune reaction.HLA-B*57:01 screening,combined with patch testing,had clinically predictive value and cost-effective impact in reducing the incidence of abacavir-induced HSR regardless of the HLA-B*57:01 prevalence in the population.Therefore,the US Food and Drug Administration(FDA) and international HIV treatment guidelines recommend a routine HLA-B*57:01 screening prior to abacavir treatment to decrease false positive diagnosis and prevent abacavir-induced HSR.The studies of abacavir-induced HSR and the implementation of the HLA-B*57:01 screening in the clinic represent a successful example of the use of pharmacogenetics for personalized diagnosis and therapy.
