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原发性皮肤B细胞淋巴瘤的研究进展(二) 被引量:4
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作者 邱丙森 《临床皮肤科杂志》 CAS CSCD 北大核心 2000年第5期315-317,共3页
阐述了原发性皮肤边缘区淋巴瘤、免疫细胞瘤和小腿原发性大 B细胞淋巴瘤的临床、组织病理学等特征、相关性及其与慢性 B淋巴细胞白血病、原发性皮肤滤泡中心细胞性淋巴瘤和浆细胞瘤等鉴别诊断。,
关键词 皮肤b细胞淋巴病 诊断 鉴别诊断 理学
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慢性B淋巴细胞增殖病的细胞遗传学进展
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作者 李丹 王晓敏 《医学综述》 2014年第5期784-787,共4页
慢性B淋巴细胞增殖性疾病(BCLPD)是一组在细胞形态学和免疫表型上具有成熟淋巴细胞特征的克隆性淋巴细胞增殖性疾病,正确诊断BCLPD必须要结合临床特征、形态学、免疫表型、细胞遗传学和受累组织的病理学等方面综合考虑。随着细胞遗传学... 慢性B淋巴细胞增殖性疾病(BCLPD)是一组在细胞形态学和免疫表型上具有成熟淋巴细胞特征的克隆性淋巴细胞增殖性疾病,正确诊断BCLPD必须要结合临床特征、形态学、免疫表型、细胞遗传学和受累组织的病理学等方面综合考虑。随着细胞遗传学分析方法和荧光原位杂交的应用,认识BCLPD的细胞遗传学研究新成果,可进一步认识研究BCLPD的发病机制,以及协助诊断、鉴别诊断、指导临床治疗和预后判断。 展开更多
关键词 慢性b淋巴细胞增殖 细胞遗传学 癌基因 抑癌基因
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口腔鳞状细胞癌中ErbB4和Bcl-2的表达及临床意义 被引量:3
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作者 薛浩伟 刘金丽 +2 位作者 李莉 杨懿 后军 《安徽卫生职业技术学院学报》 2013年第1期21-23,共3页
目的:探讨表皮生长因子受体(ErbB4)和B细胞淋巴瘤\白细胞病基因-2(Bcl-2)在口腔鳞状细胞癌中的表达及意义。方法:应用免疫组织化学SP方法检测了10例正常口腔黏膜组织和58例口腔鳞癌中的ErbB4和Bcl-2的表达。结果:ErbB4在正常口腔黏膜组... 目的:探讨表皮生长因子受体(ErbB4)和B细胞淋巴瘤\白细胞病基因-2(Bcl-2)在口腔鳞状细胞癌中的表达及意义。方法:应用免疫组织化学SP方法检测了10例正常口腔黏膜组织和58例口腔鳞癌中的ErbB4和Bcl-2的表达。结果:ErbB4在正常口腔黏膜组织中未见表达,在口腔鳞癌中表达较强,阳性率为58.6%,与临床分期、病理分级、淋巴结转移有相关性(P<0.05)。Bcl-2在正常口腔黏膜组织中未见表达,与临床分期、淋巴结转移无相关性(P>0.05),而与病理分级有关(P<0.05)。相关分析显示口腔鳞癌中ErbB4的表达与Bcl-2呈正相关(P<0.05)。结论:ErbB4和Bcl-2的表达可作为评估和判断口腔鳞癌恶性潜能的重要参考指标。 展开更多
关键词 口腔鳞状细胞 表皮生长因子受体 b细胞淋巴瘤\白细胞基因-2
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The Clinical Pathologic Analysis of Radiotherapy for Cutaneous B-cell Lymphoma
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作者 王晓伟 潘琼 +1 位作者 Lagrange JL 张良明 《Chinese Journal of Clinical Oncology》 CSCD 2008年第1期40-43,共4页
OBJECTIVE To report results of radiation therapy treatment of 30 B-cell lymphoma patients with an initial cutaneous presentation according to the new classification by the WHO/EORTC. METHODS Thirty patients with cutan... OBJECTIVE To report results of radiation therapy treatment of 30 B-cell lymphoma patients with an initial cutaneous presentation according to the new classification by the WHO/EORTC. METHODS Thirty patients with cutaneous B-cell lymphoma (CBCL) were treated by cutaneous irradiation based on the number and location of the lesions and the stage of their tumor. Treatment was conducted using a Satume Clinac. RESULTS A complete response (CR) from the treatment for our series was 86%. The length of complete remission ranged from 4 to 301 months. Three patients (11%) developed a partial response (PR). One patient was progressive. Disease-free survival(DFS) at 10 years was 87%. Three patiens died [One PCMZL two PCLBCL leg type (29%)]. Radiotherapy was generally well tolerated. CONCLUSION According to the WHO/EORTC classification, the survivor results were good for PCMZL and PCFCL. The PCLBCL leg type had a poor prognosis. Localized field irradiation is an effective treatment for some localized forms of primary cutaneous B-cell lymphoma, and this mode of therapy can produce prolonged remissions.The patients with wide-spread skin involvement are usually candidates for extended field irradiation and/or chemotherapy. For advanced stages of cutaneous B-cell lymphoma, where chemotherapy is the treatment of choice, a degree of palliation can be achieved using local field irradation. 展开更多
关键词 WHO/EORTC classification cutaneous b-cell lymphoma radiotherapy.
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SUBTYPES OF B LYMPHOCYTES IN PATIENTS WITH AUTOIMMUNE HEMOCYTOPENIA 被引量:3
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作者 Li-min Xing Zong-hong Shao +9 位作者 Rong Fu Hong Liu Jun Shi Jie Bai Mei-feng Tu Hua-quan Wang Zhen-zhu Cui Hai-rong Jia Juan Sun Chong-li Yang 《Chinese Medical Sciences Journal》 CAS CSCD 2007年第2期128-131,共4页
Objective To investigate the quantities of bone marrow CD5+ B lymphocytes in the patients with autoimmune hemocytopenia and the relationship between quantities of CD5+ B lymphocytes and clinical or laboratorial parame... Objective To investigate the quantities of bone marrow CD5+ B lymphocytes in the patients with autoimmune hemocytopenia and the relationship between quantities of CD5+ B lymphocytes and clinical or laboratorial parameters. Methods Quantities of CD5+ B lymphocytes in the bone marrow of 14 patients with autoimmune hemolytic anemia (AIHA) or Evans syndrome, 22 immunorelated pancytopenia (IRP) patients, and 10 normal controls were assayed by flow cytometry. The correlation between their clinical or laboratorial parameters and CD5+ B lymphocytes was analyzed. Results The quantity of CD5+ B lymphocytes of AIHA/Evans syndrome (34.64%±19.81%) or IRP patients (35.81%±16.83%) was significantly higher than that of normal controls (12.00%±1.97%, P<0.05). However, there was no significant difference between AIHA/Evans syndrome and IRP patients (P>0.05). In all hemocytopenic patients, the quantity of bone marrow CD5+ B lymphocytes showed significantly negative correlation with serum complement C3 level (r=-0.416, P<0.05). In the patients with AIHA/Evans syndrome, the quantity of bone marrow CD5+ B lymphocytes showed significantly positive correlation with serum indirect bilirubin level (r=1.00, P<0.05). In Evans syndrome patients, the quantity of CD5+ B lymphocytes in bone marrow showed significantly positive correlation with platelet-associated immunoglobulin G (r=0.761, P<0.05) and platelet-associated immunoglobulin M (r=0.925, P<0.05). The quantity of CD5+ B lymphocytes in bone marrow of all hemocytopenic patients showed significantly negative correlation with treatment response (tau-b=-0.289, P<0.05), but had no correlation with colony forming unit-erythroid (r=-0.205, P>0.05) or colony forming unit-granulocyte-macrophage colonies (r=-0.214, P>0.05). Conclusions The quantity of bone marrow CD5+ B lymphocytes in the patients with autoimmune hemocytopenia significantly increases and is correlated with disease severity and clinical response, which suggest that CD5+ B lymphocytes might play an important role in the pathogenesis of autoimmune hemocytopenia. 展开更多
关键词 autoimmune hemocytopenia b lymphocyte SUbTYPE
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B-cell clonality in the liver of hepatitis C virus-infected patients 被引量:4
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作者 He-Bin Fan You-Fu Zhu +4 位作者 An-Shen Chen Mu-Xiu Zhou Fu-Ming Yan Xiao-Ju Ma Hao Zhou 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第13期1636-1640,共5页
AIM:The association of hepatitis C virus(HCV) infection with typeⅡmixed cryoglobulinemia is well established,but the role of HCV in B-cell lymphoma remains controversial.In patients with HCV infection,B-cell clonal e... AIM:The association of hepatitis C virus(HCV) infection with typeⅡmixed cryoglobulinemia is well established,but the role of HCV in B-cell lymphoma remains controversial.In patients with HCV infection,B-cell clonal expansions have been detected in peripheral blood and bone marrow,and a high prevalence of B-cell non-Hodgkin's lymphomas has been documented.Liver biopsies in chronic HCV infection frequently show portal lymphoid infiltrates with features of B follicles,whose clonality has not yet been investigated.The object of this study was to determine the frequency of liver-infiltrating monoclonal B-cells in 40 patients with HCV infection.METHODS:Eight hundred and forty-eight patients were studied prospectively,including 40 HCV-positive patients and 808 patients with chronic hepatitis B virus(HBV)infection.Immunohistochemical study for B-and T-cell markers was performed on the paraffin-embedded liver tissue sections.The clonality of lymphoid B-cells was tested using a polymerase chain reaction(PCR)approach designed to identify immunoglobulin heavy chain gene(IgH) rearrangements.RESULTS:Liver-infiltrating monoclonal B-cells were detected in the liver for 4(10%)of 40 HCV-positive patients but were present in only 3(0.37%)of 808 liver biopsy specimens with chronic HBV infection.Chi-square testing showed that the monoclonal B-cells infiltration in the liver was more frequent in the HCV-infected patients(P=0.000).A clonal IgH rearrangement was detected in 5(71.4%)of 7 liver biopsy specimens with monoclonal B-cells infiltration.In 2 of 5 patients with both a clonal B-cell expansion and monoclonal B-cells infiltration in the liver,a definite B-cell malignancy was finally diagnosed.CONCLUSION:Liver-infiltrating monoclonal B-cells are detected in the liver of patients with chronic HCV and HBV infection.A high percentage of patients with monoclonal B-cells infiltration and B-cell clonality in the liver were finally diagnosed as having a definite B-cell malignancy. 展开更多
关键词 HEPATITIS Hepatitis C virus b-LYMPHOCYTES Polymerase chain reaction Gene rearrangement CIonality
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CLINICAL SIGNIFICANCE OF THE DETECTION OF MINIMAL RESIDUAL DISEASE IN CHILDHOOD B-ALL BY FLOW CYTOMETRY 被引量:1
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作者 沈立松 赵惠君 +3 位作者 徐翀 吴政宏 汤静燕 陈静 《Journal of Shanghai Second Medical University(Foreign Language Edition)》 2003年第2期100-104,111,共6页
Objective To detect the minimal residual disease in children with B-ALL and to evaluate its clinical significance by flow cytometry. Methods 58 childhood B-ALL cases were enrolled into this study and 33 MRD analyses w... Objective To detect the minimal residual disease in children with B-ALL and to evaluate its clinical significance by flow cytometry. Methods 58 childhood B-ALL cases were enrolled into this study and 33 MRD analyses were performed after remission induction therapy.Four-color combinations of fluorochrome labeled monoclonal antibodies against lymphocyte lineage related phenotypes were used to analyze leukemic cells with flow cytometry.The cells from normal bone marrow were used as controls.The combinations of phenotypes that reflect the antigen expression differences between leukemic and normal bone marrow cells on flow cytometry were considered to be the effective phenotype combinations in the first step screening.The effective phenotype combinations were then used to monitor MRD during the disease course after therapy began. Results 58 cases of childhood B-ALL were screened for MRD effective phenotype combinations.The effective phenotype combinations were identified in 89.7% of B-ALL cases in this study.Four-color phenotype combinations were composed of CD10/CD34/CD19 plus another effective marker such as CD38,CD58,CD66c,CD21.The senstitivity of this method was 0.01%,much higher than that of microscopic inspection.In 8 cases,their bone marrow microscopic inspection results showed no remaining leukemic cells;but with flow cytometry,the percentage of leukemic cells were 5.66%,0.36%,1.43%,0.069%,1.55%,2.7%,0.028% and 0.015%,respectively.In risk stratification,all these MRD positive cases were classified into high risk group for relapse and 1 case showed early relapse within 6 months. Conclusion The application of flow cytometry in MRD measurement can significantly improve the sensitivity of detection of remained leukemic cells in childhood B-ALL,and can provide more accurate information on disease progression as well as the efficacy of therapy,thus facilitate future treatment decisions and follow ups. 展开更多
关键词 b-ALL immunophenotyping minimal residual disease flow cytometry
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Loss of CD20 expression in relapsed diffuse large B cell lymphoma after rituximab therapy:a case report and review of the literature
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作者 Yao Jiang Yingchao Zhao +3 位作者 Xiaorong Dong Sheng Zhang Yan Li Gang Wu 《The Chinese-German Journal of Clinical Oncology》 CAS 2013年第3期148-151,共4页
Nowadays, resistance to rituximab has become a major issue in clinical practice. And loss of CD20 may contribute to it. Here we presented a case of loss of CD20 expression in relapsed diffuse large B cell lymphoma tre... Nowadays, resistance to rituximab has become a major issue in clinical practice. And loss of CD20 may contribute to it. Here we presented a case of loss of CD20 expression in relapsed diffuse large B cell lymphoma treated with rituximab and discuss the incidence, mechanism, influence factors, specific markers, prognosis and treatment of this disease. These results suggested that a post-relapse biopsy after rituximab treatment shguld be performed. CD79a and Pax-5 should be used as the first-line B lineage-specific markers for these patients. Though mechanisms of CD20 decrement are not fully elucidated, the down-regulation of CD20 mRNA is the most probable hypothesis. Recently various new agents are developed, but the prognosis is still poor. Further studies for new treatments are needed. 展开更多
关键词 LYMPHOMA RITUXIMAb CD20 RECURRENCE
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Retrospective analysis of hepatitis B virus reactivation after rituximab combination chemotherapy in patients with B-cell lymphoma
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作者 Yun Fan Chong Luo Lvhong Luo Zhiyu Huang Haifeng Yu 《The Chinese-German Journal of Clinical Oncology》 CAS 2011年第12期721-725,共5页
Objective: The aim of the study was to investigate the reactivations of hepatitis B virus (HBV) after rituximab- containing chemotherapy in patients with B-cell lymphoma with surface antigen of hepatitis B virus (... Objective: The aim of the study was to investigate the reactivations of hepatitis B virus (HBV) after rituximab- containing chemotherapy in patients with B-cell lymphoma with surface antigen of hepatitis B virus (HBsAg)-positive, or hepatitis B core antibody (HBcAb)-positive. Methods: A retrospective study of HBV-related markers was performed before and after dtuximab-containing treatment in 189 consecutive patients with CD20-positive B-cell lymphoma. Results: Among the 189 non-Hodgkin's lymphoma (NHL) patients who received rituximab combination chemotherapy, 31 (16.6%) were HBsAg positive and 82 (43.9%) HBsAg negative/HBcAb positive, and 76 were HBsAg and HBcAb negative. Of the 31 HBsAg positive patients, 3 (9.7%) experienced reactivation of HBV. The prevalence of HBV reactivation was 4.0% (1/25) in patients who received prophylactic antiviral treatment and 33.3% (2/6) in those who did not receive prophylactic antiviral treatment (P = 0.032). Prophylactic antiviral treatment decreased the rate of HBV reactivation. Among the 82 HBsAg negative/HBcAb positive patients, 1 (1.2%) experienced HBV reactivation leading to serious hepatitis. Conclusion: Our experience indicates that rituximab-based therapy may cause serious HBV-related complications and even death in HBsAg-positive patients. Preemp- tive use of antiviral treatment enabled successful management of HBV reactivation. In HBsAg-negative and HBcAb-positive lymphoma patients the prevalence of HBV reactivation is low (1.2%). Close monitoring HBV until at least 6 months after anticancer therapy is required, prophylactic antiviral therapy needs to be evaluated further. 展开更多
关键词 RITUXIMAb hepatitis b virus (HbV) REACTIVATION LYMPHOMA
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Expression of the B-Cell Lymphoma/Leukemia 11A Gene in Malignant Hematological Cell Lines through Quantitative Reverse Transcription Polymerase Chain Reaction
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作者 Yang-jun GAO Don-g-mei HE +3 位作者 Shao-hua CHEN Xiao-juan YAN Xiao-mao HU Yang-qiu LP 《Clinical oncology and cancer researeh》 CAS CSCD 2011年第4期242-246,共5页
The B-cell lymphoma/leukemia 11A (BCL11A) gene is essential for normal lymphoid development and has been associated with hematological malignancies. In the current study, the relative expression level of BCL11A in m... The B-cell lymphoma/leukemia 11A (BCL11A) gene is essential for normal lymphoid development and has been associated with hematological malignancies. In the current study, the relative expression level of BCL11A in malignant hematological cell lines was evaluated through real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). METHODS The relative expression level of BCLllA mRNA in malignant hematological cell lines was determined through qRT- PCR using SYBR Green I dye. Glyceraldehyde-3-phosphate dehydro- genase was used as the reference gene to confirm the relative expression level of BCL11A gene mRNA. RESULTS The relative expression level of BCL11A mRNA in cell lines from B-cell malignancies was significantly higher compared with that from acute rnyeloid leukemia (P 〈 0.05). Different cell lines with malignant B-cells exhibited a wide range of BCL11A expressions ranging from 27.37 to 93.38. CONCLUSION The overexpression of BCL11A gene mRNA in malignant B-cells might play a role in B-cell lymphoma/leukemia. 展开更多
关键词 b-cell lymphoma/leukemia 11A bCL11A) malignantb-cells real-time quantitative reverse transcription-polymerasechain reaction.
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Diagnosis and therapy of primary lung diffuse large B cell lymphoma: a case report
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作者 Lei Zhou Li Duan Min Hu 《The Chinese-German Journal of Clinical Oncology》 CAS 2009年第8期492-494,共3页
Objective: We studied the diagnosis and therapy of primary lung diffuse large B cell lymphoma (DLBCL). Methods: Analysis the clinical manifestations, pathologic character and immunohistochemical character of one l... Objective: We studied the diagnosis and therapy of primary lung diffuse large B cell lymphoma (DLBCL). Methods: Analysis the clinical manifestations, pathologic character and immunohistochemical character of one lung diffuse B cell lymphoma patent. Results: In visual observation, it's a gray irregular fobulated mass, section was gray, fish-like, and number of necrotic foci. Observed under the microscope, subepithelial respiratory center oocyte-like cells diffuse proliferative, infiltration in lung tissue. Immunohistochemistry: CD20 (+), CD79a (+), CD3 (-), CD45RO (-), PCK (-). Conclusion: Diffuse large B cell lymphoma is the most common subtype in non-Hodgkin lymphoma, but the primary lung diffuse large B cell lymphoma is rare. This disease is lack of typical clinical manifestations, so easily misdiagnosed. The diagnosis of diffuse large B cell lymphoma should be based on pathology and immunohistochemistry. 展开更多
关键词 LUNG diffuse large b cell lymphoma DIAGNOSE THERAPY
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The gene expression patterns of BMPR2,EP300,TGFβ2,and TNFAIP3 in B-Lymphoma cells 被引量:1
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作者 Dong-Mei He Hong Wu +3 位作者 Xiu-Li Wu Li Ding Ling Xu Yang-Qiu Li 《Cancer Biology & Medicine》 SCIE CAS CSCD 2014年第3期202-207,共6页
Objective: The results of a previous study showed that a clear dysregulation was evident in the global gene expression of the BCL11A-suppressed B-lymphoma cells. In this study, the bone morphogenetic protein receptor,... Objective: The results of a previous study showed that a clear dysregulation was evident in the global gene expression of the BCL11A-suppressed B-lymphoma cells. In this study, the bone morphogenetic protein receptor, type II(BMPR2), E1 A binding protein p300(EP300), transforming growth factor-β2(TGFβ2), and tumor necrosis factor, and alpha-induced protein 3(TNFAIP3) gene expression patterns in B-cell malignancies were studied. Methods: The relative expression levels of BMPR2, EP300, TGFβ2, and TNFAIP3 mRNA in B-lymphoma cell lines, myeloid cell lines, as well as in cells from healthy volunteers, were determined by real-time quantitative reverse transcriptpolymerase chain reaction(qRT-PCR) with SYBR Green Dye. Glyceraldehyde-3-phosphate dehydrogenase(GAPDH) was used as reference. Results: The expression level of TGFβ2 mRNA in B-lymphoma cell lines was significantly higher than those in the cells from the healthy control(P<0.05). However, the expression level of TNFAIP3 mRNA in B-malignant cells was significantly lower than that of the healthy control(P<0.05). The expression levels of BMPR2 and EP300 mRNA showed no significant difference between B-malignant cell lines and the healthy group(P>0.05). In B-lymphoma cell lines, correlation analyses revealed that the expression of BMPR2 and TNFAIP3(r=0.882, P=0.04) had significant positive relation. The expression levels of BMPR2, EP300, and TNFAIP3 mRNA in cell lines from myeloid leukemia were significantly lower than those in the cells from the healthy control(P<0.05). The expression levels of TGFβ2 mRNA showed no significant difference between myeloid leukemia cell lines and the healthy control or B-malignant cell lines(P>0.05). The expression levels of BMPR2, EP300, and TNFAIP3 mRNA in B-lymphoma cells were significantly higher than those of the myeloid leukemia cells(P<0.05).Conclusion: Different expression patterns of BMPR2, EP300, TGFβ2, and TNFAIP3 genes in B-lymphoma cells exist. 展开更多
关键词 bone morphogenetic protein receptor type II(bMPR2) E1A binding protein p300(EP300) transforming growth factor-β2(TGFβ2) tumor necrosis factor and alpha-induced protein 3(TNFAIP3) b-lymphoma cells myeloid leukemia cells quantitative reverse transcription polymerase chain reaction(qRT-PCR)
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Gastric Diffuse Large B-Cell Lymphoma after the Diagnosis of Primary MALT Lymphoma of the Breast One Case Report
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作者 Ling LI Guang-ru XIE 《Clinical oncology and cancer researeh》 CAS CSCD 2011年第4期254-256,共3页
Primary breast and gastric lymphomas as manifesta-tions of primary extranodal lymphomas are rare malignancies, and their diagnosis, prognosis, and treatment modalities remain unclear. We report for the first time the ... Primary breast and gastric lymphomas as manifesta-tions of primary extranodal lymphomas are rare malignancies, and their diagnosis, prognosis, and treatment modalities remain unclear. We report for the first time the simultaneous co-occurrence of these diseases in one patient. A 60-year-old woman was diagnosed with gastric diffuse large B-cell lymphoma (DLBCL) 2.5 years after she was found to have primary mucosa-associated lymphoid tissue (MALT) lymphoma of the breast. Although the patient underwent che-motherapy, she died of leukemia that caused irreversible cytopenia of three lineages. The data show that her MALT lymphoma apparently transfigured into gastric DLBCL. This case highlights the importance of evaluating patients for Helicobacter pylori infection when they present with extranodal MALT lymphomas, except gastric ones. Positive test findings should prompt anti-H, pylori therapy to prevent MALT lymphomas from transforming into DLBCLs. 展开更多
关键词 primary breast lymphoma primary gastriciymphoma MALT DLbCL.
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免疫治疗:过去,现在和将来(二)
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作者 ThomasA.Waldmann 杨月 《传染病网络动态》 2003年第7期39-41,共3页
关键词 免疫治疗 被动免疫治疗 单克隆抗体 b细胞淋巴病
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Clinicopathologic features of 112 cases with mantle cell lymphoma 被引量:2
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作者 Dong-Mei Zhou Gang Chen +2 位作者 Xiong-Wei Zheng Wei-Feng Zhu Bao-Zhen Chen 《Cancer Biology & Medicine》 SCIE CAS CSCD 2015年第1期46-52,共7页
Objective: This study aims to explore the clinicopathologic features of 112 patients with mantle cell lymphoma (MCL). Methods: Data from 112 MCL cases were collected, and immunohistochemical assay was conducted. F... Objective: This study aims to explore the clinicopathologic features of 112 patients with mantle cell lymphoma (MCL). Methods: Data from 112 MCL cases were collected, and immunohistochemical assay was conducted. Fluorescence in situ hybridization (FISH) detected a break in the CCND 1 gene. The t-test was used in the statistical analysis. Results: All tumor cells in the 112 cases expressed B cell-related antigen, including 1 blastoid subtype and 1 polymorphic subtype. Among all cases, 106 expressed CD5 and 104 expressed cyclin D1. A break in the CCND1 gene was not found in 3 cases with CDS-MCL. IgH/CCND 1 polyploid was observed in 2 classic cases. Conclusion: MCL is a type of special immunophenotypic B-cell lymphoma, The prognoses ofblastoid and polymorphic subtypes are poor. Special subtypes should be classified during diagnosis. 展开更多
关键词 Mantle cell lymphoma (MCL) IMMUNOHISTOCHEMISTRY fluorescence in situ hybridization (FISH) PROGNOSIS
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Primary gastrointestinal lymphoma 被引量:64
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作者 Prasanna Ghimire 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第6期697-707,共11页
Gastrointestinal tract is the most common extranodal site involved by lymphoma with the majority being non-Hodgkin type.Although lymphoma can involve any part of the gastrointestinal tract,the most frequent sites in o... Gastrointestinal tract is the most common extranodal site involved by lymphoma with the majority being non-Hodgkin type.Although lymphoma can involve any part of the gastrointestinal tract,the most frequent sites in order of its occurrence are the stomach followed by small intestine and ileocecal region.Gastrointestinal tract lymphoma is usually secondary to the widespread nodal diseases and primary gastrointestinal tract lymphoma is relatively rare.Gastrointestinal lymphomas are usually not clinically specific and indistinguishable from other benign and malignant conditions.Diffuse large B-cell lymphoma is the most common pathological type of gastrointestinal lymphoma in essentially all sites of the gastrointestinal tract,although recently the frequency of other forms has also increased in certain regions of the world.Although some radiological features such as bulky lymph nodes and maintenance of fat plane are more suggestive of lymphoma,they are not specific,thus mandating histopathological analysis for its definitive diagnosis.There has been a tremendous leap in the diagnosis,staging and management of gastrointestinal lymphoma in the last two decades attributed to a better insight into its etiology and molecular aspect as well as the knowledge about its critical signaling pathways. 展开更多
关键词 Gastrointestinal lymphoma Epstein-barr virus Helicobacter pylori Celiac disease Diffuse large b-cell lymphoma
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Primary cardiac lymphoma:a case report and review of the literature 被引量:3
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作者 Liqiang Zhong Sihao Yang +1 位作者 Kaijian Lei Yumin Jia 《The Chinese-German Journal of Clinical Oncology》 CAS 2013年第1期43-45,共3页
Primary cardiac lymphoma (PCL) is an extremely rare neoplasm and usually defined as a non-Hodgkin's lymphoma being exclusively located in the heart and/or the pericardium. It is particularly difficult to diagnose ... Primary cardiac lymphoma (PCL) is an extremely rare neoplasm and usually defined as a non-Hodgkin's lymphoma being exclusively located in the heart and/or the pericardium. It is particularly difficult to diagnose this rare disease due to its nonspecific clinical manifestations. The prognosis of this disease is poor. In this diffuse large B-cell lymphoma, the patient finally died of heart failure after 2 courses of chemotherapy with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone). 展开更多
关键词 primary cardiac lymphoma non-Hodgkin's lymphoma PERICARDIUM
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刺五加叶总黄酮和电针对大鼠脑缺血后Bcl-2蛋白表达的影响 被引量:7
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作者 张晓莉 石学魁 +1 位作者 蔡文辉 王亚贤 《中国实验方剂学杂志》 CAS 北大核心 2011年第5期177-180,共4页
目的:研究脑缺血与B细胞淋巴瘤/白血病-2(B cell lymphoma/leukemia-2,Bcl-2)蛋白的关系及刺五加总黄酮和针刺联合治疗作用。方法:雄性Wistar大鼠线栓大脑中动脉建立脑缺血动物模型,观察大鼠脑缺血后神经功能缺损评分;应用免疫组化法测... 目的:研究脑缺血与B细胞淋巴瘤/白血病-2(B cell lymphoma/leukemia-2,Bcl-2)蛋白的关系及刺五加总黄酮和针刺联合治疗作用。方法:雄性Wistar大鼠线栓大脑中动脉建立脑缺血动物模型,观察大鼠脑缺血后神经功能缺损评分;应用免疫组化法测定模型组(A组)、电针组(B组)、总黄酮组(C组)、针药结合组(D组)、假手术组(E组)、正常对照组(F组)Bcl-2的表达。结果:电针和刺五加总黄酮及其联合治疗组大鼠脑缺血后神经功能缺损评分显著低于单纯缺血组(P<0.01及P<0.05)。与E,F组比较,A,B,C,D组Bcl-2明显增加(P<0.01);与B,C组比较,D组表达明显增多(P<0.01及P<0.05)。结论:刺五加总黄酮和电针能提高Bcl-2蛋白表达,减少脑缺血区细胞凋亡的发生,尤其针药结合治疗有良好的疗效。 展开更多
关键词 急性脑梗死 刺五加叶总黄酮 电针 b细胞淋巴病/白血-2
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百事乐胶囊对慢性应激抑郁模型大鼠海马神经元凋亡的影响 被引量:10
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作者 孟盼 王宇红 +3 位作者 张秀丽 向韵 尹玲桃 韩远山 《中国实验方剂学杂志》 CAS 北大核心 2013年第19期203-207,共5页
目的:探讨百事乐胶囊对慢性应激抑郁模型大鼠行为活动、海马神经元凋亡及凋亡因子B细胞淋巴瘤/白血病2(Bcl-2),Bcl-2相关x蛋白(Bax)表达的影响。方法:将SD大鼠随机分为6组,即空白对照、抑郁模型、氟西汀、百事乐胶囊高、中、低(2.88,1.4... 目的:探讨百事乐胶囊对慢性应激抑郁模型大鼠行为活动、海马神经元凋亡及凋亡因子B细胞淋巴瘤/白血病2(Bcl-2),Bcl-2相关x蛋白(Bax)表达的影响。方法:将SD大鼠随机分为6组,即空白对照、抑郁模型、氟西汀、百事乐胶囊高、中、低(2.88,1.44,0.72 g·kg-1)剂量组,采用慢性温和不可预见性应激加孤养的方式建立抑郁模型,造模同时ig给药,连续21d,测定各组大鼠体重变化,Open-field、1%蔗糖偏食度测定大鼠行为学变化,TUNEL染色测定海马神经元凋亡变化,免疫组化检测海马Bcl-2,Bax的表达。结果:与正常组比较,模型组体重增加、水平及垂直活动次数、蔗糖偏食度明显下降(P<0.01),凋亡细胞所占比例及凋亡细胞计数明显增加(P<0.01);Bcl-2表达下降(P<0.01),Bax表达上升(P<0.01)。百事乐胶囊高剂量在第14、21天提升模型大鼠体重(P<0.01),中剂量在第21天升高模型大鼠体重(P<0.05);高、中剂量能提升模型大鼠水平或垂直活动次数(P<0.01或P<0.05);高、中剂量能提高模型大鼠蔗糖偏食度,降低CA1,CA3区凋亡细胞所占比例及凋亡细胞计数(P<0.01或P<0.05),且高剂量能降低模型大鼠DG区凋亡细胞所占比例及凋亡细胞计数,升高海马CA3区Bcl-2并降低Bax的表达(P<0.05)。结论:百事乐胶囊能通过减少海马神经元的凋亡而达到抗抑郁的作用。 展开更多
关键词 百事乐胶囊 抑郁症 海马 凋亡 b细胞淋巴病 白血2
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