Activation of endogenous neurogenesis and angiogenesis by basic fibroblast growth factor-chitosan gel in an adult rat model of ischemic stroke

Attempts have been made to use cell transplantation and biomaterials to promote cell proliferation,differentiation,migration,and survival,as well as angiogenesis,in the context of brain injury.However,whether bioactive materials can repair the damage caused by ischemic stroke by activating endogenous neurogenesis and angiogenesis is still unknown.In this study,we applied chitosan gel loaded with basic fibroblast growth factor to the stroke cavity 7 days after ischemic stroke in rats.The gel slowly released basic fibroblast growth factor,which improved the local microenvironment,activated endogenous neural stem/progenitor cells,and recruited these cells to migrate toward the penumbra and stroke cavity and subsequently differentiate into neurons,while enhancing angiogenesis in the penumbra and stroke cavity and ultimately leading to partial functional recovery.This study revealed the mechanism by which bioactive materials repair ischemic strokes,thus providing a new strategy for the clinical application of bioactive materials in the treatment of ischemic stroke.

Analysis of Stability and Large Deflection Buckle of Rolled Strip by Third Power B-Spline Function Method

A new method——the third power B-spline function method is developed to analyse the stability and the buckle of rolled strip under residual stress.The large deflection theory of thin plate is used to calculate the buckle of rolled strip and criterion of critical buckle is given.The computed results tally with those of experiment well,which provides theoretical basis and method for developing the mathematical model of flatness control.

Numerical Solution of Functional Integral and Integro-Differential Equations by Using B-Splines

This paper describes an approximating solution, based on Lagrange interpolation and spline functions, to treat functional integral equations of Fredholm type and Volterra type. This method extended to functional integral and integro-differential equations. For showing efficiency of the method we give some numerical examples.

Effect and function mechanism of sinter basicity on softening-melting behaviors of mixed burden made from chromium-bearing vanadium-titanium magnetite

The effect of sinter basicity on softening-melting behaviors of mixed burden made from chromium-bearing vanadium-titanium magnetite(Cr-V-Ti magnetite) was investigated and the function mechanism was simultaneously analyzed.The results show that with increasing sinter basicity from 1.71 to 2.36,the softening interval tends to increase from 149.3 ℃ to 181.7 ℃while the melting interval tends to decrease from 178.0 ℃ to 136.7 ℃.The location of cohesive zone moves downwards firstly and then ascends slightly,but the cohesive zone becomes thinner.The softening-melting characteristic value becomes small,which indicates that the permeability of burden column is improved.The dripping ratio of mixed burden tends to increase firstly and then decrease,which comes to the highest value of 74.50%when the sinter basicity is 2.13.The content and the recovery of V and Cr in dripping iron are all increased.The generation amount of components with high melting point in slag becomes little with the increase of sinter basicity,which could improve the permeability of mixed burden.Taking softening-melting behaviors of mixed burden and recovery of valuable elements into account,the proper sinter basicity is no less than 2.13 for smelting mixed burden made from Cr-V-Ti magnetite in blast furnace.

The Investigation and Study of Hydrogen Atom in Spherical Cavity Using B-Spline Basis Functions: A Mathematical Approach

The following article has been retracted due to the investigation of complaints received against it. The Editorial Board found that substantial portions of the text came from other published papers. The scientific community takes a very strong view on this matter, and the Health treats all unethical behavior such as plagiarism seriously. This paper published in Vol.3 No. 4, 334-339, 2012, has been removed from this site.

Basic Functions for Computational Implementation of the Box-Cox Symmetric Class of Distributions

A class of distributions called Box-Cox symmetric was proposed for random variables with asymmetric distributions. This class allows through its structure an interpretation of the parameters in terms of quantiles (in particular, the median), relative dispersion and skewness. This study presents the initial results of the computational development of basic functions of each of the distributions that make up the Box-Cox symmetric class. Four functions have been developed to compose a routine in software R up to now. These functions are related to random numbers generation, probability density function, cumulative distribution function, and quantile function associated to a given probability. Examples of implemented functions were presented. The gamlss routine was used to check the performance of developed functions.

Function of pioneer neurons specified by the basic helix-loop-helix transcription factor atonal in neural development

Basic helix-loop-helix （bHLH） transcription factors regulate the differentiation of various tissues in a vast diversity of species. The bHLH protein Atonal was first identified as a proneural gene involved in the formation of mechanosensory cells and photoreceptor cells in Drosophila （larman et al., 1993, 1994）. Atonal is expressed in sensory organ precursors and is required and sufficient for the development of chordotonal organs （Jar- man et al., 1993）. Moreover, Atonal expression is observed in the developing eye and is essential for the differentiation of R8 photoreceptors, which are the first photoreceptors that appear during development. Atonal is not involved in the formation of other photoreceptors （R1-R7） directly. However, R8 photore- ceptors recruit other photoreceptors from the surrounding cells （Jarman et al., 1994）.

Intensity-curvature functional based digital high pass filter of the bivariate cubic B-spline model polynomial function

This research addresses the design of intensity-curvature functional(ICF)based digital high pass filter(HPF).ICF is calculated from bivariate cubic B-spline model polynomial function and is called ICF-based HPF.In order to calculate ICF,the model function needs to be second order differentiable and to have non-null classic-curvature calculated at the origin(0,0)of the pixel coordinate system.The theoretical basis of this research is called intensitycurvature concept.The concept envisions to replace signal intensity with the product between signal intensity and sum of second order partial derivatives of the model function.Extrapolation of the concept in two-dimensions(2D)makes it possible to calculate the ICF of an image.Theoretical treatise is presented to demonstrate the hypothesis that ICF is HPF signal.Empirical evidence then validates the assumption and also extends the comparison between ICF-based HPF and ten different HPFs among which is traditional HPF and particle swarm optimization(PSO)based HPF.Through comparison of image space and k-space magnitude,results indicate that HPFs behave differently.Traditional HPF filtering and ICF-based filtering are superior to PSO-based filtering.Images filtered with traditional HPF are sharper than images filtered with ICF-based filter.The contribution of this research can be summarized as follows:(1)Math description of the constraints that ICF need to obey to in order to function as HPF;(2)Math of ICF-based HPF of bivariate cubic B-spline;(3)Image space comparisons between HPFs;(4)K-space magnitude comparisons between HPFs.This research provides confirmation on the math procedure to use in order to design 2D HPF from a model bivariate polynomial function.

开放型区域产教融合实践中心的基本特征、功能定位与推进路径

开放型区域产教融合实践中心(简称“产教融合实践中心”)是对标产业发展前沿,由政府搭台、市场驱动,汇集产教资源,政、校、行、企等多元主体参与,旨在推动区域职业教育实训实践资源均衡发展,提升职业学校关键办学能力,为企业培养急需人才和提供技术服务的生产性实践组织形态。产教融合实践中心分为学校实践中心、公共实践中心、企业实践中心,具有参与主体的多元性、服务面向的区域性以及运营模式的多样性等基本特征;具备实践教学、社会培训、真实生产和技术服务等功能。要扎实推进产教融合实践中心建设,必须坚持政府引导,统筹谋划产教融合实践中心建设;坚持市场驱动,以股份制混合所有制推进产教融合实践中心建设;坚持同步发力,分类推进产教融合实践中心建设。

Visual Basic 6.0在农药毒力测定数据处理中的应用

根据Logistic函数法原则,采用VisualBasic6.0编制农药毒力测定数据处理系统。该系统是基于Windows的操作系统。与机值分析法进行比较,运用该系统进行农药毒力测定数据处理的计算简便、快速,其计算结果与机值分析法基本一致。

动态法提取可溶性大豆多糖的纯化及其性能分析

旨在为可溶性大豆多糖(SSPS)的纯化工艺改进和豆渣资源综合利用提供参考,采用动态法从干豆渣中提取得到SSPS粗品后,通过酶解、活性炭吸附以及醇沉等步骤进行纯化,优化了纯化工艺,并考察了纯化对SSPS的基本成分、理化指标、挥发性成分、结构和性能的影响。结果表明,最适酶解条件为木瓜蛋白酶添加量1.0%、酶解pH 6、酶解温度60℃、酶解时间2 h;活性炭吸附最适条件为活性炭添加量1.0%、吸附pH 5、吸附温度65℃、吸附时间30 min;纯化处理后SSPS的蛋白质及灰分含量分别从3.60%、5.13%下降至2.19%、4.73%;纯化SSPS的透明度提高了71.94%,黏度降低,挥发性成分的数量减少了18种,而分子质量未发生显著性变化;纯化SSPS与市售SSPS在分子结构方面相似,但是结晶度存在一些差异;纯化SSPS的起泡性和乳化性分别达到213.70%和0.76,泡沫稳定性和乳化稳定性均优于市售SSPS和阿拉伯胶的。综上,经动态法提取的SSPS纯化后产品性能均有不同程度改善。

Visual Basic中操作指针的技术及应用

由于Visual Basic语言中缺少指针这种现代编程语言中很重要的数据类型,使一些程序的编制复杂而运行低效。介绍了在VisualBasic语言中,通过API函数调用间接实现指针操作的技术,并将常用的指针操作集成到一个标准模块中。在未来的软件开发中,只需要简单调用这个标准模块,就可以编写出简洁高效的程序。给出并分析了一些实际利用指针操作的程序源代码,这些源代码解决了软件开发中经常遇到的几个问题。最后讨论了这些利用指针可能带来的弊端。

Microsoft Agent语音技术在Visual Basic中的处理

充分调用Microsoft Agent技术,增添了多媒体应用软件的智能性、趣味性和人性化特征。通过对微软公司Agent角色开发文档及国内外相关文献的研究,分析了Agent的LanguageID、TTSModeID和SRModeID等的语音关键特征。借助于Add()方法和Command事件添加语音命令实现了在VB中自由进行语音识别与输出。另外,必须安装SAPI4.0运行期支持文件才能在Windows XP坏境下进行输出语音。

基于WGKSOM-DRCA自适应即时学习的转炉炼钢终点碳温软测量方法

转炉炼钢终点碳温的准确预测是实现转炉终点控制的关键。针对转炉生产过程数据存在波动性大和非线性特点引起传统即时学习度量的算法学习集质量低,进而削弱模型预测性能的问题,提出了一种基于加权高斯核自组织映射动态相关成分分析(WGKSOM-DRCA)自适应即时学习软测量建模方法用于转炉炼钢终点碳温预测。首先,采用引入标签信息的WGK度量准则构造WGKSOM聚类算法引导聚类方向,提高算法的聚类质量并降低类簇数据波动性对于建模的影响;其次,利用高斯后验概率计算待测样本的隶属度并通过引入动态因子构建DRCA度量策略,从而实现自适应的样本选择,进一步提升待测样本对应的局部算法学习集质量并用于局部模型训练,最终输出终点碳温的预测结果。实验表明,所提算法在转炉炼钢终点碳温预测上相对于其他算法有更好的表现,在±0.02%的预测误差范围,碳含量的预测精度为92%,在±10℃的误差范围,温度的预测精度为93.5%。

Visual Basic中串口通讯的应用

详细介绍了VB在串口通讯中的重要应用,以及VB通讯控件和系统API函数,并用实例说明VB开发串口通讯的两种方法。

康复机器人辅助治疗对脑性瘫痪运动功能影响的系统评价及Meta分析

目的:系统评价康复机器人辅助治疗对脑性瘫痪患者运动功能和平衡功能以及基本日常生活能力的影响。方法:使用计算机全面检索各大中外文数据库,纳入康复机器人辅助治疗脑性瘫痪的随机对照试验,对符合纳入标准的文献进行数据提取,采用Cochrane系统评价员手册5.0版进行质量评价,采用Revman 5.4统计软件进行Meta分析。结果:共纳入12项随机对照试验,合计797例患者。Meta分析结果显示,与传统康复治疗方法相比,康复机器人辅助治疗能显著提高脑性瘫痪的平衡功能(SMD=0.67,95%CI0.16~1.18,P=0.010),并能显著提高脑瘫患者粗大运动功能测试量表-D区评分(SMD=0.70,95%CI 0.28~1.12,P=0.001)和E区评分(SMD=0.50,95%CI 0.26~0.75,P<0.0001),以及基本日常生活能力(MD=8.77,95%CI 2.64~14.89,P=0.005)。结论:康复机器人辅助治疗同传统的康复治疗方法相比,能显著提高脑性瘫痪患者的平衡性评分、运动功能评分及基本日常生活能力。

高等美术院校在社会美育建设中的功能研究

该文围绕当前国内美育发展过程中的具体情况,结合我国本土社会美育的特征,探讨以中国美术学院为代表的高等美术院校在社会美育建设中发挥的基础功能和拓展功能。高等美术院校本身能够提供丰富的美术作品、美育人才、学术研究、活动展出等,这也是高等美术院校所具有的基础功能。在深入推进中国式现代化背景下,高等美术院校在社会美育建设中的功能逐渐由单一向复合转变,从被动转向主动,从阶段性迈向终身性、全民性,高等美术院校在社会美育建设中功能得到延伸。该研究进一步厘清高等美术院校在社会美育建设中发挥的职能,以更好地发挥其在社会美育建设中的功能价值。

一类具有媒体报道和环境传播的SEVIQBR传染病模型的动力学分析

考虑媒体报道以及环境传播对疾病传播的影响,建立了一类受媒体报道和环境传播影响的SEVIQBR传染病模型.首先,通过下一代矩阵的方法得到了模型的基本再生数R0,基于基本再生数讨论模型无病平衡点以及地方病平衡点的存在性.接着,借助Hurwitz判据研究了无病平衡点的局部稳定性,并构造适当的Lyapunov函数证明无病平衡点的全局渐近稳定性.结果表明:当基本再生数R0<1时,模型的无病平衡点是全局渐近稳定的,当R0满足一定条件时,模型的地方病平衡点是存在的.最后,通过数值模拟验证了理论结果.

利用Visual Basic语言模拟“用正弦线作正弦函数图象”的课件开发

本文根据教学设计中“呈现过程”是掌握原理性知识的最高“境界”的思想,介绍利用Visual Basic语言模拟单位圆、正弦线和标准正弦函数图象于同一动画的设计思想,并为实现该模拟过程提供技术支持。

球类身体活动干预对注意缺陷多动障碍儿童基本动作技能和执行功能的效果

目的探讨球类身体活动干预对注意缺陷多动障碍(ADHD)儿童基本动作技能和执行功能的效果。方法2023年9月,从上海市两所普通公立小学招募28例6~12岁的ADHD儿童,分为对照组(n=12)和试验组(n=16),同时选取同年龄段健康儿童作为健康对照组(n=14)。对照组和健康对照组进行常规体育活动,试验组采用球类身体活动方案进行干预,共8周。干预前后,采用粗大运动发展评估量表第3版(TGMD-3)对所有被试的基本动作技能得分(位移得分、控制得分)进行评估;分别采用n-back任务、Stroop色词测验和Task switching任务测量被试者执行功能3个子功能,即工作记忆、抑制控制和认知灵活性。结果干预后,试验组TGMD-3总分(t=-14.867,P<0.001,Cohen d=3.72)、位移技能得分(t=-8.081,P<0.001,Cohen d=2.02)和控制技能得分(t=-7.290,P<0.001,Cohen d=1.82)均高于干预前;试验组1-back反应时(t=3.009,P=0.009,Cohen d=0.02),Task switching任务中正确率(t=-2.657,P=0.018,Cohen d=0.66)和反应时(t=-2.657,P=0.025,Cohen d=0.62)优于干预前。结论球类身体活动干预后可以改善ADHD儿童的基本动作技能水平和执行功能。