Objective: Recent studies on the association between Uridine diphosphoglucuronosyl tranferases (UGT) 2B17 status and risk of prostate cancer (PCa) showed inconclusive results. To clarify this possible association, we ...Objective: Recent studies on the association between Uridine diphosphoglucuronosyl tranferases (UGT) 2B17 status and risk of prostate cancer (PCa) showed inconclusive results. To clarify this possible association, we conducted a meta-analysis of published studies. Methods: We searched published literature from PubMed, Embase, Google Scholar and China National Knowledge Infrastructure (CNKI). According to our inclusion criteria, studies that observed the association between UGT2B17 status and PCa risk were included. The principal outcome measure was the adjusted odds ratio (OR) with 95% confidence interval (CI) for the risk of PCa associated with UGT2B17 status. Results: A total of 6 studies with 7029 subjects (3839 cases and 3190 controls) were eligible for inclusion in the meta-analysis. Overall, there was a significant association between UGT2B17 status and increased risk of prostate cancer (OR = 1.74, 95% CI 1.14 - 2.64, P 0.001). Similar results were found in the subgroup analyses by ethnicity and types of controls. Conclusion: This meta-analysis demonstrates that UGT2B17 status is associated with prostate cancer susceptibility, and it contributes to increased risk of prostate cancer.展开更多
尿苷二磷酸葡萄糖醛酸基转移酶(UDP-g1ucuronosyltransferase,UGT)是人体内重要的Ⅱ相代谢酶,UDP-尿苷二磷酸葡萄糖醛酸为其主要的糖基供体。UGT为多基因编码并且含有大量同工酶的超基因家族,包括UGT1和UGT2两个亚家族。UGT2B17是UGT2B...尿苷二磷酸葡萄糖醛酸基转移酶(UDP-g1ucuronosyltransferase,UGT)是人体内重要的Ⅱ相代谢酶,UDP-尿苷二磷酸葡萄糖醛酸为其主要的糖基供体。UGT为多基因编码并且含有大量同工酶的超基因家族,包括UGT1和UGT2两个亚家族。UGT2B17是UGT2B家族的一员,越来越多的研究发现UGT2B17基因存在普遍遗传缺失现象,其造成的遗传差异对疾病的影响已引起了众多关注。UGT2B17基因拷贝数变异(Copy Number Variants,CNV)源自4号染色体上一段约120 kb的DNA序列缺失和插入,CNV发生频率高,种族差异明显,与器官移植、骨质疏松、肿瘤发生,乃至兴奋剂检测密切相关。UGT2B17的CNV研究及功能意义具有重大遗传药理学及药物基因组学意义。我们将从UGT2B17的基因拷贝数变异与种族差异、移植排斥反应与肿瘤发生发展等几个方面进行探讨。展开更多
文摘Objective: Recent studies on the association between Uridine diphosphoglucuronosyl tranferases (UGT) 2B17 status and risk of prostate cancer (PCa) showed inconclusive results. To clarify this possible association, we conducted a meta-analysis of published studies. Methods: We searched published literature from PubMed, Embase, Google Scholar and China National Knowledge Infrastructure (CNKI). According to our inclusion criteria, studies that observed the association between UGT2B17 status and PCa risk were included. The principal outcome measure was the adjusted odds ratio (OR) with 95% confidence interval (CI) for the risk of PCa associated with UGT2B17 status. Results: A total of 6 studies with 7029 subjects (3839 cases and 3190 controls) were eligible for inclusion in the meta-analysis. Overall, there was a significant association between UGT2B17 status and increased risk of prostate cancer (OR = 1.74, 95% CI 1.14 - 2.64, P 0.001). Similar results were found in the subgroup analyses by ethnicity and types of controls. Conclusion: This meta-analysis demonstrates that UGT2B17 status is associated with prostate cancer susceptibility, and it contributes to increased risk of prostate cancer.
文摘尿苷二磷酸葡萄糖醛酸基转移酶(UDP-g1ucuronosyltransferase,UGT)是人体内重要的Ⅱ相代谢酶,UDP-尿苷二磷酸葡萄糖醛酸为其主要的糖基供体。UGT为多基因编码并且含有大量同工酶的超基因家族,包括UGT1和UGT2两个亚家族。UGT2B17是UGT2B家族的一员,越来越多的研究发现UGT2B17基因存在普遍遗传缺失现象,其造成的遗传差异对疾病的影响已引起了众多关注。UGT2B17基因拷贝数变异(Copy Number Variants,CNV)源自4号染色体上一段约120 kb的DNA序列缺失和插入,CNV发生频率高,种族差异明显,与器官移植、骨质疏松、肿瘤发生,乃至兴奋剂检测密切相关。UGT2B17的CNV研究及功能意义具有重大遗传药理学及药物基因组学意义。我们将从UGT2B17的基因拷贝数变异与种族差异、移植排斥反应与肿瘤发生发展等几个方面进行探讨。
