Guicao Baidu decoction in mitigating chemotherapy-induced myocardial injury:case report and mechanism investigation

To observe the effects of GuiCaoBaiDu Decoction(GCBD)on chemotherapy especially doxorubicin(DOX)-induced myocardial cardiotoxicity(DIC)and explore the mechanisms.The present study presents a case demonstrating the preventive and therapeutic effects of GCBD on myocardial injury following chemotherapy.Then network pharmacology was employed to predict the targets of GCBD.Subsequently,a DOX-induced apoptosis model of H9C2 cardiomyocytes was established and co-cultured with serum containing GCBD serum.The viability and myocardial enzyme levels were evaluated using CCK8 assay and ELISA assay,TUNEL was using for apoptosis test.The GCBD effect was confirmed by tests of ROS andα-actinin levels,evaluation of mitochondrial morphology,and BAX co-localization with mitochondria.Furthermore,the expression levels of apoptosis-related molecules were determined via Western blotting.Additionally,a mouse model exhibiting DOX-induced cardiac functional impairment was generated and subsequently treated with GCBD.Myocardial enzyme level was tested at first,then echocardiography was tested,myocardial apoptosis in mice was observed through HE staining while related proteins were detected using IHC.Network pharmacological analyses revealed that GCBD exerts its effects on BAX,Caspase7,and other related molecules.Initially,we demonstrated the effective amelioration of DIC in cardiomyocyte viability,LDH/CK levels,α-actinin and ROS levels,and apoptosis by GCBD through improvements in TUNEL test,mitochondrial morphology and WB.The efficacy of GCBD in enhancing cardiac function in DIC mice has been validated through animal experiments.Taken together,our study showed that GCBD could significantly alleviate DOX induced myocardial injury by regulating mitochondrial apoptosis.The utilization of GCBD can effectively contribute to the prevention and treatment of chemotherapy-induced myocardial injury when anthracycline chemotherapy is employed in clinical practice.

搜索引擎Baidu(百度)研究

Baidu (百度 )搜索引擎是目前全球最优秀的中文信息检索与传递的网上搜索引擎 ,其强大的中文搜索服务已经成为大多数中文用户使用的首选 ,本文着力探讨其强大的功能和特点 。

基于Baidu地图API的海洋预报显示系统

文章介绍一个海洋预报显示系统,采用php编程语言和Baidu地图API技术开发的产品。系统具有基础GIS信息齐全、人机交互性高、数据信息直观等特点,在海洋防灾减灾中发挥了重要作用,受到用户的好评。

网络搜索引擎GOOGLE和BAIDU的比较研究

GOOGLE是全球最有影响力的网络搜索引擎,而BAIDU是国内最有影响力的网络搜索引擎,本文从检索技术、检索功能、检索方式对它们进行比较和分析,并指出它们各自的优缺点。

基于Google与Baidu的Web图像自动采集与标注的实现

针对日益丰富的网上图像资源,给出一种基于Google与Baidu的Web图像自动采集的实现方法,构架了一种海量Web图像资源自动获取与语义标注模式,在各种图像库的建立和基于语义的图像检索上能有较好的应用。

比较分析中国网民对Google与Baidu的使用

Google与Baidu是我们经常使用的两个搜索引擎,但它们在许多方面都有很大的不同,本文从2009年正望咨询公司对两个引擎的比较数字出发,分析探讨了它们在收录内容、更新速度及使用群体和提供服务方面的不同,使人们在检索信息时能更方便的选择检索工具。

基于Google与Baidu自动采集与标注Web图像

针对日益丰富的网上图像资源,给出了一种基于Google与Baidu的Web图像自动采集的实现方法,构架了一种海量Web图像资源自动获取与语义标注模式,在各种图像库的建立和基于语义的图像检索上能有较好的应用。

Baidu地图崛起的“密码”

核心阅读：百度地图并不是我国最早的数字地图应用产品,它问世以来,之所以能够披荆斩棘,突破谷歌地图、高德地图、凯立德地图、搜狗地图等的重围,快速成为市场的领头羊,与之秉承用户体验至上的互联网理念、成功分享网络用户资源、善于挖掘网民需求、为用户提供各类优质服务是分不开的。

基于Baidu Map/天地图建筑物矢量化方法研究

针对建筑物特点和抗震易损性评估要求,研究了基于ArcGIS平台的天地图建筑物数据加载于Baidu Map的矢量化方法,探讨了Baidu Map与天地图的坐标转换,提出了最佳公共点快速搜索算法,实现了数据批量采集与精确匹配。结合宿迁市宿城区建筑物矢量化实验案例,验证了其有效性和便捷性。

搜索引擎Google与Baidu比较

介绍了因特网上主要的检索工具,搜索引擎Google和Baidu。阐述了搜索引擎的概念,比较搜索引擎Google与Baidu的功能,提出了搜索引擎的未来发展方向。

Accessibility Comparison and Spatial Differentiation of Xi’an Scenic Spots with Different Modes Based on Baidu Real-time Travel

A study of the accessibility of a city’s scenic spots via different travel modes can contribute to optimization of tourism-related transportation while improving tourists’ travel-related satisfaction levels and advancing tourism. We systematically analyzed the accessibility of 56 scenic spots in Xi’an City, China, via car and public transport travel modes using the real-time travel function of the Baidu Maps API(Application Programming Interface) along with spatial analysis methods and the modal accessibility gap index of scenic spots. We obtained the following results. First, maximum and minimum travel times using public transport exceeded those using cars. Moreover, the accessibility of scenic spots via cars and public transport presented a circular spatial pattern of increasing travel time from the center to the periphery. Contrasting with travel by public transport, car travel showed a clear time-space compression effect. Second, accessibility of the scenic spots via cars and public transport showed some spatial heterogeneity, with no clear advantages of car accessibility in the central urban area. However, advantages of car accessibility were increasingly evident moving from the center to the periphery. Third, whereas the correlation of the modal accessibility gap index of scenic spots in Xi’an with global space was significantly positive, local spatial interdependence was only evident in some inner city areas and in marginal areas. Moreover, spatial heterogeneity was evident in two regions but was insignificant in other areas, indicating that the spatial interdependence of the modal accessibility gap index in most scenic spots was not apparent in terms of the overall effect of public transport routes, road networks, and the distribution of scenic spots. The improvement of public transport coverage in marginal areas and the optimization of public transport routes in central urban areas are essential tasks for improving travel using public transport in the future.

基于Baidu地图的移动机器人监控平台

利用Baidu公司推出的Baidu Maps API和Visual Studio 2008 IDE平台完成了基于Baidu Maps API的移动机器人监控平台。由于Baidu Maps API功能丰富、交互性强、接口开放、免费开源等特性,得以完成了整个监控平台的设计。移动机器人监控平台运行在WinCE的移动设备上,更具灵活性。随着技术的不断进步,移动式机器人监控平台将会在机器人监控平台的开发进程中体现其独特的优势。

Can the Baidu Index predict realized volatility in the Chinese stock market?

This paper incorporates the Baidu Index into various heterogeneous autoregressive type time series models and shows that the Baidu Index is a superior predictor of realized volatility in the SSE 50 Index.Furthermore,the predictability of the Baidu Index is found to rise as the forecasting horizon increases.We also find that continuous components enhance predictive power across all horizons,but that increases are only sustained in the short and medium terms,as the long-term impact on volatility is less persistent.Our findings should be expected to influence investors interested in constructing trading strategies based on realized volatility.

Determination of Berberine Hydrochloride Content in Qingwen Baidu Granule by HPLC

The paper was to establish a simple and sensitive HPLC method for determination of berbefine hydrochloride content in Qingwen Baidu granule. The HPLC system consisted of Stable Bond - C18 column （4.6 × 150 mm, 5um） and with a mobile phase of acetonitrile -0.05mol/L potassium dihydrogen phosphate solution （50：50,v：v） mixture. Berberine hydrochloride was detected at the wavelength of 345 nm, with a flow rate of 1.0 ml/min and a column temperature of 30 ℃. The excipients and solvents in the granule could be well separated from the drug under such a designated chromatogram condition and did not interfere with the assay. A good linear relationship was found between peak area and the concentration of berberine hydrochloride in the range of 16.0 -48.0 I^g/mL. The average recovery of berberine hydrochloride was 99.09%. The established approach was specific, accurate, reliable, prompt, sensitive and applicable, and could be used to control the quality of Qingwen Baidu granule.

Baidu Maps在移动震情信息接收中的应用

地震发生后,快速为社会公众提供震情服务及其重要。通过分析震情短信,应用Baidu Maps API、Android、SQLite数据库等技术,开发了基于Android的移动震情信息接收系统,用于集中管理震情信息并在地图上显示,以实现震情的可视化应用。

Baidu index and predictability of Chinese stock returns

A number of studies have investigated the predictability of Chinese stock returns with economic variables.Given the newly emerged dataset from the Internet,this paper investigates whether the Baidu Index can be employed to predict Chinese stock returns.The empirical results show that 1)the Search Frequency of Baidu Index(SFBI)can predict next day’s price changes;2)the stock prices go up when individual investors pay less attention to the stocks and go down when individual investors pay more attention to the stocks;3)the trading strategy constructed by shorting on the most SFBI and longing on the least SFBI outperforms the corresponding market index returns without consideration of the transaction costs.These results complement the existing literature on the predictability of Chinese stock returns and have potential implications for asset pricing and risk management.

Trying to Explain the Theoretical Basis of Traditional Chinese Medicine “Huashi Baidu Fang” in the Treatment of Coronavirus Disease 2019 with Western Medical Theory: A Review

Purpose: This work is aimed to explain the theoretical basis of “Huashi Baidu Fang” in the treatment of coronavirus disease 2019 (COVID-19) with western medical theory. Methods: We analyze the “Diagnosis and Treatment Protocol for COVID-19 (Version 1 to Version 7)” made by China, “Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected—Interim guidance” made by World Health Organization (WHO), “Therapeutic Guidelines: Respiratory (Version 5)”, “Therapeutic Guidelines: Gastrointestinal (Version 5)” and “Therapeutic Guidelines: Antibiotic (Version 15)” published by Australia, and the origin of classical prescription of “Huashi Baidu Fang”: “Shanghanlun (Treatise on Febrile Diseases)”, “Jinkui Yaolue (Synopsis of Golden Chamber)” and “Wenyi Lun (The Epidemic Febrile Disease)”. We search the dictionary of traditional Chinese medicine (Version II) manually. And we search literatures from 2001 to 2020 on Wiley online library. We conduct a comparative study among the symptoms of TCM formulations in “Huashi Baidu Fang”, the pathogenesis and clinical manifestation of COVID-19 and COPD with acute gastrointestinal inflammation. And we carry out pharmacological inquiry of “Huashi Baidu Fang”. Results: The clinical manifestations of respiratory symptoms and gastrointestinal tract of syndrome of lung obstruction due to epidemic toxin and acute exacerbation of COPD are almost the same;The formulations used in “Huashi Baidu Fang” are consistent with the pharmacological activity of the drug recommended in the Therapeutic Guidelines. Conclusion: “Huashi Baidu Fang” may play a positive role in COVID-19.

搜索引擎Google、Bing及Baidu的比较

阐述了搜索引擎的含义和发展现状,从界面风格、搜索特点、更新速度、搜索侧重点等方面对Google、Baidu和Bing这3种搜索引擎进行了比较和评价。

Identification of Gardenoside and Sarsasapogenin from Qingwen Baidu Granules by TLC

[ Objective ] We aimed to establish the identification method of gardenoside and sarsasapogenin in Qingwen baidu granules. [ Method] With ethyl ace- tate-acetone-formic acid-water （10：7：2：0.5） as the developer and 10% sulfuric acid ethanol solution as the chromogenic reagent, the samples were heated at 100 ~C until the spots were clearly visible, and the existence of gardenoside was checked under natural light. With toluene-acetone（9：l ） as the developer and 5% vanillin sulfuric acid solution as the chromogenic reagent, the samples were heated at 105 ~C until the spots were clearly visible, and the existence of sarsasapogenin was checked under natural light. [Result] Qingwen baidu granules had the same spots with gardenoside and sarsasapogenin at the same Rfvalue under natural light. [ Conclusion] A TLC method detecting gardenoside and sarsasapogenin in Qingwen baidu granules was established, which had good specificity and repeatability, suitable for rapid detection of gardenoside and sarsasapogenin.

Effectiveness and Safety of Jinye Baidu Granules(金叶败毒颗粒)for Acute Upper Respiratory Tract Infection:A Systematic Review and Meta-analysis

To evaluate the effectiveness and safety of Jinye Baidu Granules(金叶败毒颗粒)for acute upper respiratory tract infection(AURTI).Database such as CNKI,Wan-fang,VIP,Sino Med,Web of science,Clinical Trials gov,Medline、EMBASE,CENTRAL,Cochrane Library were retrieved to collect randomized controlled trials(RCTs)on Jinye Baidu Granules(金叶败毒颗粒)in treating AURTI from the estabslishment of the database to March 2019.A total of 2 reviewers independently screened the literature according to the inclusion and exclusion criteria,and extracted material and the quality evaluation of the included studies.Quality evaluation adopted Cochrane Handbook 5.1 evaluation standards and tools.Rev Man5.3 was used to perform Meta-analysis for the adopted study.Finally a total of 4 RCTs involving 636 patients were included.Meta-analysis results showed that:compared with conventional Western medicine alone,Jinye Baidu Granules(金叶败毒颗粒)combined with Western medicine in the treatment of acute upper respiratory tract infection can improve the total effective rate of clinical efficacy[RR=0.13,95%CI(0.06,0.29),P<0.00001],shorten the time of antipyretic time for acute upper respiratory tract infection[MD=–1.22,95%CI(–1.43,–1.00),P<0.00001],shorten the time of pharyngeal pain[MD=–1.97,95%CI(–2.97,–0.96),P<0.0001]and shorten the cough disappear time[MD=–1.97,95%CI(–2.97,–0.96),P<0.0001].There were 2 papers reporting adverse reactions during the study period,and one of them specifically reported diarrhea,nausea,vomiting and stomachache in the experimental group.In the control group:diarrhea,nausea and adverse reactions disappeared after drug withdrawal;the incidence of adverse reactions was 3.92%in the control group and 5.88%in the observation group.There was no significant difference between the 2 groups(P>0.05).Based on existing data and methods,the systematic evaluation showed that,compared with Western medicine alone,Jinye Baidu Granules(金叶败毒颗粒)combined with Western medicine alone could improve the total effective rate of clinical efficacy,reduce the time of fever,sore throat,and the disappearance of cough with less adverse reactions.However,due to the low quality of the included study,large samples,multicenter,randomized,double-blind trials and trials are still needed to randomized controlled trials with reference to the CONSORT standard and the STRICTA statement.