Nanopharmaceuticals containing quantum dot nanoparticles (Q-Dot NPs) for treating serious cancers such as breast cancer have made fantastic proposals. In this study, ZnO quantum dot NPs are formulated via ZnO@PVP nano...Nanopharmaceuticals containing quantum dot nanoparticles (Q-Dot NPs) for treating serious cancers such as breast cancer have made fantastic proposals. In this study, ZnO quantum dot NPs are formulated via ZnO@PVP nanopolymer as co-assistants coordinating with efficacious suitable wetting agents, PEG-binding compound, and W/O emulsifier for producing eco-friendly water-based nanodrug. Several characterization techniques containing SEM, TEM, FTIR, photoluminescence, zeta potential, and UV-Vis absorption were employed for ZnO Q-Dot NPs in nanodrug. This work aims to investigate the anti-tumor effects of such nanomedicine on the 4T1 breast cancer cell line in BALB/c mice, being elaborated through intraperitoneal, injection (IVP) and oral therapy. The impressive findings showed that ZnO nanodrug caused changes in blood factors, having the most effectiveness at 40 μg/ml concentration after two weeks of oral treatments. The significant increase in white blood cells (WBC) neutrophils and meaningful decreases in lymphocytes and especially cholesterol were powerful simultaneous impacts, successfully treating malignant breast cancer masses. In this significant animal model research for breast cancer, the sick mice recovered entirely and even had a safe space to mate. Histopathological results showed no evidence of breast tumor formation or metastasis in the group treated with nanodrug and their children. This nanomedicine has a therapeutic effect, and is ready to be applied for treating volunteer breast cancer patients. However, its prevention (inhibitory) effect can also be analyzed and added to current data in future studies.展开更多
目的:研究维甲酸诱导BALB/C近交系小鼠产生腭裂所需的剂量。方法:将40只BALB/C近交系小鼠分成四组,每组10只,在妊娠10 d时分别给予不同剂量的维甲酸,给药后观察所有孕鼠的反应,在妊娠15 d时解剖部分孕鼠,取胎鼠头部,行冠状切片,苏木精-...目的:研究维甲酸诱导BALB/C近交系小鼠产生腭裂所需的剂量。方法:将40只BALB/C近交系小鼠分成四组,每组10只,在妊娠10 d时分别给予不同剂量的维甲酸,给药后观察所有孕鼠的反应,在妊娠15 d时解剖部分孕鼠,取胎鼠头部,行冠状切片,苏木精-伊红染色法(HE染色),进行观察。剩余孕鼠任其自然分娩,观察子鼠情况。结果:给予70 m g/kg维甲酸后,孕鼠组绝大多数表现腭裂动物模型所需特征。结论:70 m g/kg剂量维甲酸能够诱导BALB/C近交系小鼠产生可靠的腭裂动物模型。展开更多
文摘Nanopharmaceuticals containing quantum dot nanoparticles (Q-Dot NPs) for treating serious cancers such as breast cancer have made fantastic proposals. In this study, ZnO quantum dot NPs are formulated via ZnO@PVP nanopolymer as co-assistants coordinating with efficacious suitable wetting agents, PEG-binding compound, and W/O emulsifier for producing eco-friendly water-based nanodrug. Several characterization techniques containing SEM, TEM, FTIR, photoluminescence, zeta potential, and UV-Vis absorption were employed for ZnO Q-Dot NPs in nanodrug. This work aims to investigate the anti-tumor effects of such nanomedicine on the 4T1 breast cancer cell line in BALB/c mice, being elaborated through intraperitoneal, injection (IVP) and oral therapy. The impressive findings showed that ZnO nanodrug caused changes in blood factors, having the most effectiveness at 40 μg/ml concentration after two weeks of oral treatments. The significant increase in white blood cells (WBC) neutrophils and meaningful decreases in lymphocytes and especially cholesterol were powerful simultaneous impacts, successfully treating malignant breast cancer masses. In this significant animal model research for breast cancer, the sick mice recovered entirely and even had a safe space to mate. Histopathological results showed no evidence of breast tumor formation or metastasis in the group treated with nanodrug and their children. This nanomedicine has a therapeutic effect, and is ready to be applied for treating volunteer breast cancer patients. However, its prevention (inhibitory) effect can also be analyzed and added to current data in future studies.
文摘目的:研究维甲酸诱导BALB/C近交系小鼠产生腭裂所需的剂量。方法:将40只BALB/C近交系小鼠分成四组,每组10只,在妊娠10 d时分别给予不同剂量的维甲酸,给药后观察所有孕鼠的反应,在妊娠15 d时解剖部分孕鼠,取胎鼠头部,行冠状切片,苏木精-伊红染色法(HE染色),进行观察。剩余孕鼠任其自然分娩,观察子鼠情况。结果:给予70 m g/kg维甲酸后,孕鼠组绝大多数表现腭裂动物模型所需特征。结论:70 m g/kg剂量维甲酸能够诱导BALB/C近交系小鼠产生可靠的腭裂动物模型。
