Hydrocarbon accumulation characteristics in basement reservoirs and exploration targets of deep basement reservoirs in onshore China

Based on the global basement reservoir database and the dissection of basement reservoirs in China,the characteristics of hydrocarbon accumulation in basement reservoirs are analyzed,and the favorable conditions for hydrocarbon accumulation in deep basement reservoirs are investigated to highlight the exploration targets.The discovered basement reservoirs worldwide are mainly buried in the Archean and Precambrian granitic and metamorphic formations with depths less than 4500 m,and the relatively large reservoirs have been found in rift,back-arc and foreland basins in tectonic active zones of the Meso-Cenozoic plates.The hydrocarbon accumulation in basement reservoirs exhibits the characteristics in three aspects.First,the porous-fractured reservoirs with low porosity and ultra-low permeability are dominant,where extensive hydrocarbon accumulation occurred during the weathering denudation and later tectonic reworking of the basin basement.High resistance to compaction allows the physical properties of these highly heterogeneous reservoirs to be independent of the buried depth.Second,the hydrocarbons were sourced from the formations outside the basement.The source-reservoir assemblages are divided into contacted source rock-basement and separated source rock-basement patterns.Third,the abnormal high pressure in the source rock and the normal–low pressure in the basement reservoirs cause a large pressure difference between the source rock and the reservoirs,which is conducive to the pumping effect of hydrocarbons in the deep basement.The deep basement prospects are mainly evaluated by the factors such as tectonic activity of basement,source-reservoir combination,development of large deep faults(especially strike-slip faults),and regional seals.The Precambrian crystalline basements at the margin of the intracontinental rifts in cratonic basins,as well as the Paleozoic folded basements and the Meso-Cenozoic fault-block basements adjacent to the hydrocarbon generation depressions,have favorable conditions for hydrocarbon accumulation,and thus they are considered as the main targets for future exploration of deep basement reservoirs.

Platform Evolution in an Oligo-Miocene Back-arc Basin:An Example from the Central Iran Basin

The Qom Formation is the most important hydrocarbon reservoir target in Central Iran.The Qom platform developed in a back-arc basin during the Oligo-Miocene due to the closing of the Tethyan Seaway.This formation consists of a variety of carbonate and non-carbonate facies deposited on a platform ranging from supratidal to basin.A combination of tectonic and eustatic events led to some lateral and vertical facies variations in the study area.Six third-order depositional sequences and related surfaces were identified regarding vertical facies changes in the studied sections of this Oligo-Miocene succession.According to all results and data,this succession was initially deposited during the Chattian upon a distally steepened ramp of siliciclastic-carbonate composition,including the Bouma sequence.Then,from the late Chattian to the Aquitanian,the platform changed into a homoclinal carbonate ramp with a gentle profile.With respect to tectonic activity,this phase was a calm period during the deposition of the Qom Formation.Finally,a drowned carbonate platform and a rimmed shelf emerged during the Burdigalian,terminated by the continental deposits of the Upper Red Formation.Regarding all geological characteristics,three main tectono-eustatic evolutionary phases have been recognized in the Qom back-arcbasin.

Early Paleozoic basement diorite of arc-magmatism from Kutch basin, Western India

In this study,we report for thefirst time an Early Palaeozoic basement diorite from the drilled well Nirona-A in the Banni Half-Graben of the Kutch basin,western India.The 40Ar–39Ar dates provided a plateau age of 441.84±2.66 Ma and another pseudo plateau of 441.28±5.82 to 388.08±16.65 Ma for the basement diorite.These ages constrain the basement formation age to the Late Ordovician-Early Silurian period.The obtained basement ages are correlatable with the later part of Cambro-Ordovician alkaline magmatism that has been reported from the Huqf area in Central Oman,whereas their lithological and petrographic correlativity with base-ment diorites occurring in the Dinsi Body of Nagar Parkar igneous complex in Pakistan can also be envisaged.The geochemical studies characterized the diorite with enrich-ment of LILE(Rb,Ba,and K)and LREE(La,Ce,Nd),strong depletion of HFSE(Nb,Sr,P,and Ti),along with weakly negative Eu anomalies.The geochemical signatures indicate their petrogenetic affiliation with mantle-derived magmas,as well as their tectonic setting to be arc-related,having post-collisional continental-arc type affinity.The*440 Ma basement of Kutch,therefore,appears to rep-resent the later thermal event associated with the reworked Neoproterozoic subduction-related suite from Greater India’s northwest edge,which has implications for Gond-wana assembly in the northwest Indian subcontinent.

ISOTOPIC AGE DETERMINATION ON MIGMATITE IN SHAOXING-JIANGSHAN RIFT ZONE AND ITS METAMORPHIC ROCK AT BOTH SIDE-BASEMENTS

Ⅰ. INTRODUCTION Shaoxing-Jiangshan rift zone is on the boundary of geotectonic units of first order in Zhejiang Province (Fig. 1). The basement complex of 'epicontinental basin', called as Shuangxiwu Group, is composed mainly of the metamorphic rock series on its north side within Zhejiang, and can be correlated to Presinian system in

The importance of laminin at the blood-brain barrier

The blood-brain barrier is a unique property of central nervous system blood vessels that protects sensitive central nervous system cells from potentially harmful blood components.The mechanistic basis of this barrier is found at multiple levels,including the adherens and tight junction proteins that tightly bind adjacent endothelial cells and the influence of neighboring pericytes,microglia,and astrocyte endfeet.In addition,extracellular matrix components of the vascular basement membrane play a critical role in establishing and maintaining blood-brain barrier integrity,not only by providing an adhesive substrate for blood-brain barrier cells to adhere to,but also by providing guidance cues that strongly influence vascular cell behavior.The extracellular matrix protein laminin is one of the most abundant components of the basement membrane,and several lines of evidence suggest that it plays a key role in directing blood-brain barrier behavior.In this review,we describe the basic structure of laminin and its receptors,the expression patterns of these molecules in central nervous system blood vessels and how they are altered in disease states,and most importantly,how genetic deletion of different laminin isoforms or their receptors reveals the contribution of these molecules to blood-brain barrier function and integrity.Finally,we discuss some of the important unanswered questions in the field and provide a“to-do”list of some of the critical outstanding experiments.

Zircon U-Pb geochronology,Hf isotopes,and geochemistry constraints on the age and tectonic affinity of the basement granitoids from the Qiongdongnan Basin,northern South China Sea

Studies in the northern South China Sea(SCS)basement remain important for understanding the evolution of the Southeast Asian continental margin.Due to a thick cover of sediments and scarce borehole penetration,little is known about the age and tectonic affinity of this basement.In this study,an integrated study of zircon U-Pb geochronology,Hf isotopes,and whole-rock major and trace elements on seven basement granitoids from seven boreholes of Qiongdongnan Basin has been carried out.New zircon U-Pb results for these granitoids present middle-late Permian((270.0±1.2)Ma;(253±3.4)Ma),middle to late Triassic((246.2±3.4)Ma;(239.3±0.96)Ma;(237.9±0.99)Ma;(228.9±1.0)Ma)and Late Cretaceous ages((120.6±0.6)Ma).New data from this study,in combination with the previous dataset,indicates that granitoid ages in northern SCS basement vary from 270 Ma to 70.5 Ma,with three age groups of 270–196 Ma,162–142 Ma,and 137–71 Ma,respectively.Except for the late Paleozoic-Mesozoic rocks in the basement of the northern SCS,a few old zircon grains with the age of(2708.1±17)Ma to(2166.6±19)Ma provide clues to the existence of the pre-Proterozoic components.The geochemical signatures indicate that the middle Permian-early Cretaceous granitoids from the Qiongdongnan Basin are I-type granites formed in a volcanic arc environment,which were probably related to the subduction of the Paleo-Pacific Plate.

Ultra-deep carbonate basement reservoirs formed by polyphase fracture-related karstification in the Offshore Bohai Bay Basin, China

The Palaeozoic carbonate basement of the Offshore Bohai Bay Basin (OBBB) presents considerable potential for hydrocarbon exploration. However, the multistage tectonism and complex superimposed palaeo-karstification in the area are unclear, which leads to a lack of understanding on the formation mechanism and distribution of the deep carbonate basement reservoirs. In this study, the occurrence of a fracture-vug network and its fillings in carbonate reservoirs were investigated based on borehole cores, thin sections, and image logs from the southwestern slope of the OBBB's Bozhong Sag. Then the diagenetic fluid properties of the carbonate matrix and fillings were analysed via the data of carbon, oxygen, and strontium isotopes, and major, rare elements from coring intervals. The results revealed that fracture-related karst reservoirs have lithologic selectivity inclined toward dolomite strata. The intersecting relationships, widths, and strikes of the fractures and the regional tectonic background indicate three structural fracture families: NW-, NNE-, and NNW- trending, related to the Indosinian, middle Yanshanian, and late Yanshanian orogeny, respectively. The Indosinian NW- and end-Mesozoic NNE-trending fractures produced by compressional tectonic stress mainly contributed to the formation of the basement reservoirs. The geochemistry of the calcite veins filling these fractures suggests two main types of diagenetic fluids. The fluid of autogenic recharge related to the earlier fills is karstification diffuse flow dominated by internal runoff from rainfall in the highland setting of the Indosinian thrusting orogenic belt. The other fluid of allogenic recharge related to the later fills is the main lateral freshwater flow dominated by external runoff from the catchment in the setting of the horst-lowland within the rifting basin, induced by the Yanshanian destruction of the North China Craton. Finally, the relationship between the three fracture families and two kinds of related fluids is revealed. This allows us to propose a model to understand the polyphase-superimposed fracture-related karst reservoir complexes within the deep carbonate basement of tilting fault blocks that neighbour the Bozhong hydrocarbon kitchen and predict the formation of potential plays with high accuracy.

Neoarchean Magmatic Events in the Western Songnen Massif,Central Asian Orogenic Belt:Timing and Tectonic Significance

Whether a Neoarchean basement existing in the Songnen massif is currently debated.Identification of Archean magmatism from the Songnen Massif is helpful to resolve this issue.Here,we report newly discovered Neoarchean Shanquan pluton in the Western Songnen Massif.These Neoarchean Shanquan pluton are mainly composed of granites that are exposed near the town of Shanquan in Heilongjiang Province.LA-ICP-MS zircon U-Pb dating reveals that the sample 2015TW1 has an upper intercept age of 2801±69 Ma and a weighted mean age of 2708±18 Ma,while samples LJ27QY1 and LJ27QY2 have upper intercept ages of 2677±57 Ma and 2653±18 Ma,and weighted mean ages of 2649±10 Ma and 2653±15 Ma,respectively.This indicates that these granites were formed at~2.7 Ga.Most of the~2.7 Ga zircons have older TDM2 ages of 2762–3326 Ma with positiveεHf(t)values ranging from 0 to 6.4,while a few of the zircons have negativeεHf(t)values ranging from-8.1 to-11.5 and older TDM2 ages varying from 3158 to 3264 Ma.The zircon Hf isotopes indicate that Paleo-Mesoarchean crusts might once existed in the Songnen Massif,and the studied Neoarchean magmas were principally derived from partial melting of these Paleo-Mesoarchean ancient crust.Based on the geochronological spectrum of magmatic and detrital zircons,the Songnen,Erguna,Jiamusi,Bureya massifs may have a common basement prior to the Neoproterozoic and may even be linked with the Triam Craton.

Effect of tectonic-climatic controllers on the transition of Endorheic to Exorheic Basins in the Zagros mountain range

Endorheic basins(ENBs) are inland drainage basins allowing no outflow to oceans.These basins in the active mountain chains of the convergence zones are under the influence of compressional tectonic activity and climate condition.The Zagros Mountains of Iran is one of the youngest convergence zones in which continental-continental collision has occurred.In this paper we hypothesize the formation of ENBs among the Zagros range after the epeirogenic stage in the Late Paleogene-Early Neogene.Due to tectonic activity and Quaternary climatic conditions,the ENBs pass the transition stage to exorheic,and still,some tectonic depressions are not linked to the evolutionary process of exorheic drainage of Zagros.The geometry of the drainage network of Kul and Mond basins in Fars arch shows that 67% of their water gaps are located along the thrusts and transverse basement faults in the east and west of the Fars arch.Geometrically,the Kul and Mond basins form triangles with their sides matching with the edges of the Arabian Plate where the major inherited faults of Arabian plate controls the shape of the Zagros basin and a low strain zone along the Razak fault with lower salt tectonic activity,where the wind gaps are created.The ENBs are located in the rainshadow slopes,but the Kul and Mond basins are located in the upwind slopes of rain waves.This factor and the heavy rains of the basin lead to increase of the erosion potential,destruction of depressions,and floods and consequently,the funnel-shaped gaps have a significant impact on the flood flow.

Discovery of~2.5 Ga zircon U-Pb age from the diabase,Ar Horqin Banner Area,Inner Mongolia:Implications for Neoarchean crystalline basement of Bainaimiao Arc Belt

1.Objective The Bainaimiao Arc Belt(BAB),one of the most important units of the southeastern Central Asian Orogenic Belt(CAOB),locates along the northern margin of the North China Craton(NCC).There is a lack of understanding on the existence,scale,and affinity of the crystalline basement of the BAB.Based on the recent geochronologic studies.

Identification of major sources controlling groundwater geochemistry in Mount Makabaï in the Far-North of Cameroon(the northernmost part of the Pan-African Belt)

The present work focuses on the volcanic basement rock geochemistry of Mount Makabaï(MarouaCameroon city)in relation to groundwater geochemistry.Investigations were centered on an approach involving an association of several methods such as geological cartography,hydrogeology,and geochemistry.Three rock samples,four disturbed soil samples,three undisturbed soil samples,and 20 samples of groundwater in 10 wells were collected during fieldwork and prepared for laboratory analyses.Bedrocks exhibit porphyritic,aphyric,and subaphiric textures.The phenocryst phases are mainly olivine,clinopyroxene,and plagioclase.Based on whole rock major element chemical compositions,the Makabaï samples,plotted on Na_(2)O+K_(2)O versus SiO_(2)diagram,are mugearite,hawaiite,and basalt.The ratio of(MgO+CaO)/(Na_(2)O+K_(2)O)exceeds unity and shows dominance of alkaline Earth metals(MgO:2.99-4.48%;CaO:6.19-9.80%)relatively to alkali metals(Na_(2)O:2.27-4.46%;K_(2)O:2.09-2.51%).Exchangeable base contents are high,mostly represented by Ca and Mg,whose contents vary from 14.6 to 35.28 cmol(+)kg^(-1)and from 3.28 to9.48 cmol(+)kg^(-1)respectively.The CECclayis likewise high,fluctuating between 116.80 and181.38 cmol(+)kg^(-1),values in line with the presence of 2:1 clay minerals represented in the study area by montmorillonite.In the water samples,the Ca2+and Na+contents are generally higher than K^(+)and Mg^(2+),reflecting the relative abundance of Na_(2)O and CaO oxides to K_(2)O and MgO oxides in rocks where different waters were sampled.The waters of Makabaï are acidic to neutral(6.3≤pH≤7.4)and weakly to highly mineralized(110.0≤EC≤1190.0μS/cm).Hydro-geochemical classification by using the Piper diagram revealed two water types:(1)CaMg-HCO_(3)(40%)and(2)CaMg-Cl or CaMg-SO4(60%).The average content of ions in all the analyzed samples was HCO_(3)^(-)>>NO_(3)^(-)>SO_(4)^(2-)>Cl-for anions and Ca^(2+)>>Mg^(2+)>Na^(+)>K^(+)for cations.Major mechanisms governing ionic constituents of groundwater in the study area are water-rock interactions,silicate weathering,and ion exchange.

Upregulation of histone H3 caused by CRYAA may contribute to the development of age-related cataract

Objective:Age-relate cataract(ARC)is a disease of the eyes with no effective drugs to prevent or treat patients.The aim of the present study is to determine whether histone H3,αA-crystallin(CRYAA),β-galactosidase(GLB1),and p53 are involved in the pathogenesis of ARC.Methods:A total of 99 anterior lens capsules(ALCs)of patients with ARC of various nuclear grades,ultraviolet models of ALCs,and two human lens epithelial cell lines(FHL-124 and SRA01/04)were used,and the expression of histone H3,CRYAA,GLB1,and p53 were detected by immunoblotting and reverse transcription and real time-quantitative polymerase chain reaction.The association between CRYAA with histone H3,GLB1,and p53 was assessed in FHL-124 and SRA01/04 cells following CRYAA overexpression.Results:Histone H3 and p53 in ALCs of patients with ARC were up-regulated in a grade-dependent manner,and the expression of CRYAA showed a positive association with histone H3,p53,and GLB1.In UV models of ALCs and human lens epithelial cell lines,the expression levels of histone H3,cell apoptosis factors(Bax/Bcl-2,cleaved caspase-3),and inflammation factors(interleukin-6,tumor necrosis factor-α)were all up-regulated.Furthermore,transfection of CRYAA in FHL-124 cells induced overexpression of histone H3.Conclusion:CRYAA-mediated upregulation of histone H3 may be involved in the pathogenesis of ARC.p53 may also have a role in ARC development,but not via the CRYAA-histone H3 axis.The results of the present study may assist in improving our understanding of the pathogenesis of ARC and in identifying potential targets for treatment.

Application of Spatial Techniques for the Identification of Discontinuous Aquifers of the Basement in Semi-Arid Environment: A Case of Bagzan Mount Plateau, Aïr Massif (North, Niger)

Bagzan mount is located in the Aïr massifs region. This locality, which is constituted only by the granites and volcanic formations, knows the difficulty of water supply that depends on rainfall. This present study has the objective of fracture mapping that allowed to the fractured aquifer in Bagzan mount. The methodological approach used has a treatment of Digital Elevation Model (DEM imagery), hydrogeological and geological approach in the field. This process allowed us to map the lineaments and elaborate a fracturing map after the validation stage. The fracturing map showed that the fractures network is distributed in the N70°-N80°, N60°-N70°, N50°-N60°, and two secondary directions N90°-N100° and N120°-N140°. These fracturing maps allowed us to have precious information in groundwater research in Bagzan mount, due to their geological and hydrogeological complexity.

Spatial Analysis of Gravity Data in the Basement of the Yaoundé-Yoko Area from the Global Gravity Model: Implication on the Sanaga Fault (South-Cameroon)

In this work, gravity anomalies from the XGM2016 global gravity model are used to study the basement of the Yaounde, Yoko area. The aim is to locate the characteristic tectonic faults and to characterize the geometry of the basement of these localities in order to improve the knowledge of the structural and tectonic basement of the study area. Numerical filters (vertical gradient, horizontal gradient, upward continuation) and Euler deconvolution were applied to the gravity anomalies respectively for qualitative and quantitative analysis. The results of the qualitative analysis allowed us to establish the lineament map of the study area;ranging from 0 to 35 km depth. For the quantitative analysis, the work is done in two parts: 1) highlighting the distribution of depths of geological structures in the basement of the study area;2) 2D1/2 modeling of geological structures to highlight the geometry of the basement of Yaounde, Yoko area. Thus, from five suitably selected profiles, the established models reveal the presence of eight blocks of geological structures of different densities and analyze their implications on the Sanaga Fault. Moreover, the models show that the positive anomalies characteristics for the Sanaga Fault reflect the anomalous character due to the strong dominance of the shale intrusion in the basement.

Analysis of high-resolution airborne-magnetic data for hydrocarbon generation and preservation potential evaluation of Yola sub-basins,northern Benue Trough,northeastern Nigeria

High-resolution airborne-magnetic data acquired over the Yola extension of the northern Benue Trough,northeastern Nigeria,were analyzed to delineate rock distribution,define basement geometry,determine sedimentary thicknesses,and highlight structural framework among others for the hydrocarbon prospect evaluation of sub-basins in the extension.Filtered and refined magnetic intensity data were subjected to Analytic Signal,Horizontal and Vertical Tilt Derivatives and Euler deconvolution depth weighting analyses to enhance various geological features requisite for petroleum prospect evaluation.Sedimentary rock units flanked the northeast and south widely occur in the central part with volcanic rock intrusions delineated within the sedimentary terrain.Extracted lineaments(less than 5 km and up to 45 km)were observed to dominantly follow the established Benue Trough and Yola sub-basin evolutionary trend along the NEeSW and ESEeWNW directions,respectively.Three prominent subbasins with sedimentary thicknesses in excess of 3 km and width of more than 60 km,separated by basement highs of mostly volcanic intrusions origin,were identified.The occurrence of relatively thick and extensive sub-basins which are underlain by structurally active basement rocks suggests relatively high geothermal gradient for generation of hydrocarbon from organic matter rich source rocks while the generated oil and gas are preserved within intra-sedimentary structural traps created when the basement fractures were reactivated.

Petrology and Geochemical Features of Crystalline Rocks in Ora-Ekiti,Southwestern Nigeria

This research investigates and reports on the petrology and geochemical characteristics of crystalline basement rocks in Ora-Ekiti,Southwestern Nigeria.Exhaustive geological investigation reveals migmatite,banded gneiss,gran­ite gneiss and biotite gneiss underlie the area.In reducing order of abundance,petrographic examination reveals that migmatite contains quartz,muscovite and opaque minerals.Banded geniuses contain quartz,biotite,plagioclase,and opaque minerals.Granite geniuses contain quartz,plagioclase,biotite,microcline and opaque;while biotite geniuses contain biotite,plagioclase,opaque minerals,and quartz.Silica contents in migmatite(69.50%-72.66%;ca.71.23%),banded gneiss(71.66%-77.1%;ca.75.23%),biotite gneiss(72.32%-76.18%;ca.73.83%)and granite gneiss(69.82%-73.15%;ca.71.95%)indicate the rocks are siliceous.High alumina contents in migmatite(12.18%),banded gneiss(10.28%),biotite gneiss(11.46%)and granite gneiss(9.97%)are comparable to similar rocks in the basement com­plex.All the rocks show Ba,Sr and Rb enrichment.Harker diagrams of Al_(2)O_(3)versus SiO_(2)and CaO versus SiO_(2)show negative trends while Na_(2)O versus SiO_(2),K_(2)O versus SiO_(2)and TiO_(2)versus SiO_(2)plots showed positive trends.This var­iation probably depicts extensive crystal fractionation in the magmatic systems that produced the rocks prior to meta­morphism or partial melting of the precursor rock.SiO_(2)versus(Na_(2)O+K_(2)O)classifies the rocks as granite to granodi­orite.The rocks are high K-calc-alkaline and calc-alkalic on SiO_(2)-K_(2)O plot.This shows the rocks are potassic meaning that they are formed from a potassium-rich source.The plot of Al_(2)O_(3)/(Na_(2)O+K_(2)O)versus Al_(2)O_(3)/(CaO+Na_(2)O+K_(2)O)reveals the crystalline rocks are orogenic and originated from granitoid with meta luminous affinity.The rocks consist of gneisses of no economic minerals,but the petrology reveals them as common rocks typical of metamorphic terrains and geochemical features of the rocks reveal they are felsic and of granitic composition.

Contribution of Geophysical Prospecting (1D) to Characterize a Precambrian Basement Aquifers Agadez Region (North, Niger)

In the A?r massif, and more particularly in the Iférouane area, the basement is flush. Thus, the essential of water resources is contained in the discontinuous aquifers of basement. Indeed, the weathered and cracked basement is an excellent reservoir of groundwater. The objective of this study is to determine the areas favorable to establishment of productive drilling in the village of Ebourkoum. A methodological approach based on the combination of remote sensing and geophysics methods was implemented. The fracturing map developed highlighted three main accidents of directions N0° - N10°, N30° - N50° and N130° - N140° in the said locality. The geophysical investigation mainly electrical prospecting has allowed to locate structures with high hydraulic potential below alluvium and alterites. Subsequently, drilling will be carried out in the areas retained.

陈以平教授治疗儿童特发性膜性肾病经验撷英

膜性肾病是以肾小球基底膜（glomerular basement membrane,GMB）上皮下免疫复合物沉积伴GMB弥漫增厚为特征的一组疾病,排除继发性因素及家族性因素者称为特发性膜性肾病（idiopathic membranous nephropathy,IMN）。成年人特发性膜性肾病占成年人肾病综合征的20%左右,通过大样本、前瞻性、多中心、随机对照临床试验证实,陈以平教授采用单纯中药方案“益气活血化湿”法治疗成人特发性膜性肾病疗效达73％，与经典的激素＋环磷酰胺方案疗效相同，且单纯中药方案无与药物相关的严重不良事件发生，该研究结果发表于美国肾脏病杂志（american journal kidneydisease，AJKD）。

Cambro-Silurian magmatisms at the northern Gondwana margin(Penninic basement of the Ligurian Alps)

The Early Paleozoic evolution of the northern margin of Gondwana is characterized by several episodes of bimodal magmatism intruded or outpoured within thick sedimentary basins. These processes are well recorded in the Variscan blocks incorporated in the Ligurian Alps because they experienced low temperature Alpine metamorphism. During the Paleozoic, these blocks, together with the other Alpine basements, were placed between the Corsica-Sardinia and the Bohemian Massif along the northern margin of Gondwana. In this framework, they host several a variegated lithostratigraphy forming two main complexes(Complexs I and II) that can be distinguished by both the protoliths and their crosscutting relationships, which indicate that the acidic and mafic intrusives of Complex II cut an already folded sequence made of sediments, basalts and granitoids of Complex I. Both complexes were involved in the Variscan orogenic phases as highlighted by the pervasive eclogite-amphibolite facies schistosity(foliation II). However, rare relicts of a metamorphic foliation at amphibolite facies conditions(foliation I)is locally preserved only in the rocks of Complex I. It is debatable if this schistosity was produced during the early folding event e occurred between the emplacement of Complex I and II e rather than during an early stage of the Variscan metamorphic cycle.New SHRIMP and LA ICP-MS Ue Pb zircon dating integrated with literature data, provide emplacement ages of the several volcanic or intrusive bodies of both complexes. The igneous activity of Complex I is dated between 507 ± 15 Ma and 494 ± 5 Ma, while Complex II between 467 ± 12 Ma and 445.5 ± 12 Ma.The folding event recorded only by the Complex I should therefore have occurred between 494 ± 5 Ma and 467 ± 12 Ma. The Variscan eclogite-amphibolite facies metamorphism is instead constrained between ~420 Ma and ~300 Ma. These ages and the geochemical signature of these rocks allow constraining the Early Paleozoic tectono-magmatic evolution of the Ligurian blocks, from a middleeupper Cambrian rifting stage, through the formation of an Early Ordovician volcanic arc during the Rheic Ocean subduction, until a Late Ordovician extension related to the arc collapse and subsequent rifting of the PaleoThetys. Furthermore, the ~420-350 Ma ages from zircon rims testify to thermal perturbations that may be associated with the Silurian rifting-related magmatism, followed by the subduction-collisional phases of the Variscan orogeny.

儿童特发性膜性肾病的研究进展

膜性肾病（Membranous nephropathy,MN）是以肾小球基底膜（Glomerular basement membrance,GBM）上皮细胞下免疫复合物沉积伴GBM弥漫增厚为特征的一组疾病,根据病因可分为特发性膜性肾病（Idiopathic membranous nephropathy,IMN）和继发性MN两大类。在成人肾病综合征患者中MN约占20%～35%,是最常见的病理类型，而在儿科肾病综合征患者中MN仅占1％～5％，且儿童以继发性MN为主。目前临床上对儿童IMN的认识不够，本文就发病机制、临床表现、病理特点、治疗进展及预后几方面来探讨儿童IMN的特点，以供临床医生参考。