In iron-based superconductor Fe(Se,Te), a flat band-like feature near the Fermi level was observed around the Brillouin zone center in the superconducting state. It is under debate whether this is the evidence on the ...In iron-based superconductor Fe(Se,Te), a flat band-like feature near the Fermi level was observed around the Brillouin zone center in the superconducting state. It is under debate whether this is the evidence on the presence of the BCS–BEC[Bardeen–Cooper–Schrieffer(BCS), Bose–Einstein condensation(BEC)] crossover in the superconductor. High-resolution laser-based angle-resolved photoemission measurements are carried out on high quality single crystals of FeSe_(0.45)Te_(0.55) superconductor to address the issue. By employing different polarization geometries, we have resolved and isolated the dyz band and the topological surface band, making it possible to study their superconducting behaviors separately. The dyz band alone does not form a flat band-like feature in the superconducting state and the measured dispersion can be well described by the BCS picture. We find that the flat band-like feature is formed from the combination of the dyz band and the topological surface state band in the superconducting state. These results reveal the origin of the flat band-like feature and rule out the presence of BCS-BEC crossover in Fe(Se,Te) superconductor.展开更多
The incidences of nonmelanoma skin cancer are increasing worldwide, and the ongoing war on its treatment necessitates the development of effective and non-invasive methods. Through basic and clinical research, non-inv...The incidences of nonmelanoma skin cancer are increasing worldwide, and the ongoing war on its treatment necessitates the development of effective and non-invasive methods. Through basic and clinical research, non-invasive treatments like Curaderm have been developed, leading to improved quality of life for patients. Excipients, previously considered inactive ingredients, play a crucial role in enhancing the performance of topical formulations. The development of Curaderm emphasizes the importance of understanding the interactions between active ingredients, excipients, and the biological system to create effective and affordable pharmaceutical formulations. The systematic approach taken in the development of Curaderm, starting from the observation of the anticancer activity of natural solasodine glycosides and progressing through toxicological and efficacy studies in cell culture, animals, and humans, has provided insights into the pharmacokinetics and pharmacodynamics of solasodine glycosides. It is crucial to determine these pharmacological parameters within the skin’s biological system for maximal effectiveness and cost-effectiveness of a skin cancer treatment. Curaderm, as a topical treatment for nonmelanoma skin cancer, offers benefits beyond those obtained from other topical treatments, providing hope for improved quality of life for patients.展开更多
Basal cell carcinoma is the most common form of skin cancer and the most frequently occurring form of all cancers. Conventional treatments to remove or destroy basal cell carcinoma are indiscriminate and also remove o...Basal cell carcinoma is the most common form of skin cancer and the most frequently occurring form of all cancers. Conventional treatments to remove or destroy basal cell carcinoma are indiscriminate and also remove or destroy normal skin cells resulting in compromised cosmetic outcomes. Consequences of these treatments include body-image issues, anxiety, post-traumatic stress disorder, depression, and poorer quality of social and family life. A progressive topical cream formulation, Curaderm, containing the natural BEC glycoalkaloids, have shown to have advantages over conventional treatments. However, comprehensive clinical features of the skin cancer lesions during treatment with Curaderm have to date not been reported. This report shows that using unpublished data from a large number of patients with varying sizes, types and locations of basal cell carcinomas when treated with Curaderm in a phase 3 trial, an initial increase in size of the lesions occur, followed by a reverse course, leading to complete removal of the skin cancer. The specificity and mode of action of Curaderm explains the superior cosmetic outcomes when compared with conventional therapies.展开更多
In this work, the influence of imparity on BECs in optical lattices is investigated, and the possibility of MI-SF transition induced by impurity is verified. After the numerical calculation, the schematic phase diagra...In this work, the influence of imparity on BECs in optical lattices is investigated, and the possibility of MI-SF transition induced by impurity is verified. After the numerical calculation, the schematic phase diagram is discussed with an emphasis on the role of impurity. When n10 = n20, the phase boundaries coincide with each other; when n10 < n20 and U12 < 0, the phase boundaries do not intersect at all; when n10 < n20 and U12 > 0, the phase boundaries may or may not intersect, depending on the values of U12, n10 and n20.展开更多
Business Email Compromise (BEC) attacks have emerged as a significant cybersecurity threat, leading to substantial financial losses for organizations. According to the FBI’s Internet Crime Complaint Center (IC3), BEC...Business Email Compromise (BEC) attacks have emerged as a significant cybersecurity threat, leading to substantial financial losses for organizations. According to the FBI’s Internet Crime Complaint Center (IC3), BEC attacks resulted in financial losses exceeding $1.8 billion in the USA in 2019 alone. Business Email Compromise (BEC) attacks have emerged as a significant cybersecurity threat, leading to substantial financial losses for organizations. According to the FBI’s Internet Crime Complaint Center (IC3), BEC attacks resulted in financial losses exceeding $1.8 billion in the USA in 2019 alone. BEC attacks target a wide range of sectors. No industry is immune to these attacks, which emphasizes the need for increased vigilance across all sectors. Attackers often impersonate high-level executives or vendors to gain credibility and manipulate employees into complying with fraudulent requests. BEC attacks have a global reach, with threat actors operating from various countries, including Nigeria, Russia, China, and Eastern European nations. We will examine the unique difficulties SMEs encounter in relation to BEC attacks. This study provides a more excellent knowledge of the severity of the problem and offers ideas for efficient mitigation solutions through an investigation of attack characteristics, tactics, and impacts.展开更多
We propose that the exotic meson tetraquark u<sub>d</sub>~</sup>dũintroduced in previous papers, may be a pseudo-Goldstone boson having a tetrahedron geometry and symmetry. The transition ...We propose that the exotic meson tetraquark u<sub>d</sub>~</sup>dũintroduced in previous papers, may be a pseudo-Goldstone boson having a tetrahedron geometry and symmetry. The transition from the neutral pion superposition of two free mesons, d<sub>d</sub>~</sup> and uũ, to the tetrahedron geometry with optional two chiral states may be the symmetry breaking of the QCD ground state. The u<sub>d</sub>~</sup>dũtetrahedron mass may be calculated by measuring the β decay rate variability. We assume that electrons and positrons are composite particle exotic tetraquarks, dũd<sub>d</sub>~</sup> for the electrons and u<sub>d</sub>~</sup>d<sub>d</sub>~</sup> for the positrons and confined by the strong force. We propose that the QCD tetrahedrons play a central role in electron pairing mechanism in both chemical bond forming and superconductor Cooper pairs. We propose a hypothesis where the QCD ground state tetrahedrons play a central role in low energy physics where quark exchange reactions between particles and the QCD tetrahedrons via gluon junctions transfer all the forces. The QCD ground state u<sub>d</sub>~</sup>dũtetrahedrons hypothesis provides a symmetry breaking and a mass gap may be created by the ground state QCD tetrahedrons Bose-Einstein condensate.展开更多
基金Projects supported by the National Key Research and Development Program of China(GrantNos.2021YFA1401800,2022YFA1604200,2022YFA1403900,and2023YFA1406000)the National Natural Science Foundation of China(Grant Nos.12488201,12374066,12074411,and 12374154)+3 种基金the Strategic Priority Research Program(B)of the Chinese Academy of Sciences(Grant Nos.XDB25000000 and XDB33000000)the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0301800)the Youth Innovation Promotion Association of the Chinese Academy of Sciences(Grant No.Y2021006)the Synergetic Extreme Condition User Facility(SECUF)。
文摘In iron-based superconductor Fe(Se,Te), a flat band-like feature near the Fermi level was observed around the Brillouin zone center in the superconducting state. It is under debate whether this is the evidence on the presence of the BCS–BEC[Bardeen–Cooper–Schrieffer(BCS), Bose–Einstein condensation(BEC)] crossover in the superconductor. High-resolution laser-based angle-resolved photoemission measurements are carried out on high quality single crystals of FeSe_(0.45)Te_(0.55) superconductor to address the issue. By employing different polarization geometries, we have resolved and isolated the dyz band and the topological surface band, making it possible to study their superconducting behaviors separately. The dyz band alone does not form a flat band-like feature in the superconducting state and the measured dispersion can be well described by the BCS picture. We find that the flat band-like feature is formed from the combination of the dyz band and the topological surface state band in the superconducting state. These results reveal the origin of the flat band-like feature and rule out the presence of BCS-BEC crossover in Fe(Se,Te) superconductor.
文摘The incidences of nonmelanoma skin cancer are increasing worldwide, and the ongoing war on its treatment necessitates the development of effective and non-invasive methods. Through basic and clinical research, non-invasive treatments like Curaderm have been developed, leading to improved quality of life for patients. Excipients, previously considered inactive ingredients, play a crucial role in enhancing the performance of topical formulations. The development of Curaderm emphasizes the importance of understanding the interactions between active ingredients, excipients, and the biological system to create effective and affordable pharmaceutical formulations. The systematic approach taken in the development of Curaderm, starting from the observation of the anticancer activity of natural solasodine glycosides and progressing through toxicological and efficacy studies in cell culture, animals, and humans, has provided insights into the pharmacokinetics and pharmacodynamics of solasodine glycosides. It is crucial to determine these pharmacological parameters within the skin’s biological system for maximal effectiveness and cost-effectiveness of a skin cancer treatment. Curaderm, as a topical treatment for nonmelanoma skin cancer, offers benefits beyond those obtained from other topical treatments, providing hope for improved quality of life for patients.
文摘Basal cell carcinoma is the most common form of skin cancer and the most frequently occurring form of all cancers. Conventional treatments to remove or destroy basal cell carcinoma are indiscriminate and also remove or destroy normal skin cells resulting in compromised cosmetic outcomes. Consequences of these treatments include body-image issues, anxiety, post-traumatic stress disorder, depression, and poorer quality of social and family life. A progressive topical cream formulation, Curaderm, containing the natural BEC glycoalkaloids, have shown to have advantages over conventional treatments. However, comprehensive clinical features of the skin cancer lesions during treatment with Curaderm have to date not been reported. This report shows that using unpublished data from a large number of patients with varying sizes, types and locations of basal cell carcinomas when treated with Curaderm in a phase 3 trial, an initial increase in size of the lesions occur, followed by a reverse course, leading to complete removal of the skin cancer. The specificity and mode of action of Curaderm explains the superior cosmetic outcomes when compared with conventional therapies.
文摘In this work, the influence of imparity on BECs in optical lattices is investigated, and the possibility of MI-SF transition induced by impurity is verified. After the numerical calculation, the schematic phase diagram is discussed with an emphasis on the role of impurity. When n10 = n20, the phase boundaries coincide with each other; when n10 < n20 and U12 < 0, the phase boundaries do not intersect at all; when n10 < n20 and U12 > 0, the phase boundaries may or may not intersect, depending on the values of U12, n10 and n20.
文摘Business Email Compromise (BEC) attacks have emerged as a significant cybersecurity threat, leading to substantial financial losses for organizations. According to the FBI’s Internet Crime Complaint Center (IC3), BEC attacks resulted in financial losses exceeding $1.8 billion in the USA in 2019 alone. Business Email Compromise (BEC) attacks have emerged as a significant cybersecurity threat, leading to substantial financial losses for organizations. According to the FBI’s Internet Crime Complaint Center (IC3), BEC attacks resulted in financial losses exceeding $1.8 billion in the USA in 2019 alone. BEC attacks target a wide range of sectors. No industry is immune to these attacks, which emphasizes the need for increased vigilance across all sectors. Attackers often impersonate high-level executives or vendors to gain credibility and manipulate employees into complying with fraudulent requests. BEC attacks have a global reach, with threat actors operating from various countries, including Nigeria, Russia, China, and Eastern European nations. We will examine the unique difficulties SMEs encounter in relation to BEC attacks. This study provides a more excellent knowledge of the severity of the problem and offers ideas for efficient mitigation solutions through an investigation of attack characteristics, tactics, and impacts.
文摘We propose that the exotic meson tetraquark u<sub>d</sub>~</sup>dũintroduced in previous papers, may be a pseudo-Goldstone boson having a tetrahedron geometry and symmetry. The transition from the neutral pion superposition of two free mesons, d<sub>d</sub>~</sup> and uũ, to the tetrahedron geometry with optional two chiral states may be the symmetry breaking of the QCD ground state. The u<sub>d</sub>~</sup>dũtetrahedron mass may be calculated by measuring the β decay rate variability. We assume that electrons and positrons are composite particle exotic tetraquarks, dũd<sub>d</sub>~</sup> for the electrons and u<sub>d</sub>~</sup>d<sub>d</sub>~</sup> for the positrons and confined by the strong force. We propose that the QCD tetrahedrons play a central role in electron pairing mechanism in both chemical bond forming and superconductor Cooper pairs. We propose a hypothesis where the QCD ground state tetrahedrons play a central role in low energy physics where quark exchange reactions between particles and the QCD tetrahedrons via gluon junctions transfer all the forces. The QCD ground state u<sub>d</sub>~</sup>dũtetrahedrons hypothesis provides a symmetry breaking and a mass gap may be created by the ground state QCD tetrahedrons Bose-Einstein condensate.
