Correction to:J.For.Res.(2020)31(6):2581-2587 https://doi.org/10.1007/s11676-019-01036-2 After publication of this article,it was brought to our atten-tion that the legend to Figure 1 did not state that Figure 1d was ...Correction to:J.For.Res.(2020)31(6):2581-2587 https://doi.org/10.1007/s11676-019-01036-2 After publication of this article,it was brought to our atten-tion that the legend to Figure 1 did not state that Figure 1d was adapted from Figure 1d of Makarikov and Tkach(2013).In addition,Makarikov and Tkach(2013)should have been cited in the methods section.展开更多
As the English language gains its popularity with the day, every learner tries to find agood way of learning it. What is the best way to it has become a decades’ question. It is a pity that What a linguistic expert c...As the English language gains its popularity with the day, every learner tries to find agood way of learning it. What is the best way to it has become a decades’ question. It is a pity that What a linguistic expert can offer is but some pieces of advice. The keyfactor in language lies in hard work. No short way can be found. Theoretically, an expert展开更多
Coxsackievirus(CV)B belongs to the species Enterovirus B,genus Enterovirus of the family Picornaviridae.Enterovirus B(EV-B)includes 63 serotypes:CVB1-6;CVA9;echoviruses E1-7,9,11-21,24-27,and 29-33;EV-B69,EV-B 73-75,E...Coxsackievirus(CV)B belongs to the species Enterovirus B,genus Enterovirus of the family Picornaviridae.Enterovirus B(EV-B)includes 63 serotypes:CVB1-6;CVA9;echoviruses E1-7,9,11-21,24-27,and 29-33;EV-B69,EV-B 73-75,EV-B77-88,EV-B 93,EV-B 97-101,EV-B 106-107.展开更多
Professor Beger is one of the most renowned general and gastrointestinal surgeons in Germany.His worldwide reputation is based on his expertise in surgery of the pancreas.He belongs to the group of the 100most cited s...Professor Beger is one of the most renowned general and gastrointestinal surgeons in Germany.His worldwide reputation is based on his expertise in surgery of the pancreas.He belongs to the group of the 100most cited surgeons worldwide.展开更多
This essay analyses Theodore Dreiser’s Sister Carrie through the lens of cultural studies,examining the portrayal of domesticity and the quest for an ideal home in late-nineteenth-century America.It explores the comp...This essay analyses Theodore Dreiser’s Sister Carrie through the lens of cultural studies,examining the portrayal of domesticity and the quest for an ideal home in late-nineteenth-century America.It explores the complex relationships between the main characters,Carrie and Hurstwood,and their families,as well as their struggles with materialism and alienation.Through close analysis of societal context,the characters’familial backgrounds and emotional yearnings,the essay delves into the characters’longing for stability and belonging and their journey toward understanding the true essence of dwelling amidst the changing urban landscape.It argues that Dreiser’s novel critiques the superficial pursuit of material comforts and highlights the importance of introspection and self-discovery in finding lasting happiness amidst societal turmoil.Ultimately,through the prism of domesticity,the essay delves into broader themes of identity,belonging,and existential fulfillment in a heartless society marked by materialism and alienation.展开更多
On the view point of herb research in the world traditional medicines, Digeda is used to vary the plants originated from different species and families, such as India Digeda (Hurghada) is Swertie chirayita (Buch. -...On the view point of herb research in the world traditional medicines, Digeda is used to vary the plants originated from different species and families, such as India Digeda (Hurghada) is Swertie chirayita (Buch. -Ham.), Nepal Digeda (Hurghada) is Swertia cliete. Tibetan Digeda (Geda) are Saxifrage umbellulate Hook. f. &Thoms. and 5axifraga umbelluleta Hook. f. &Thoms. var. pectinata (C. Marq. & Airy-Shaw) J. T. Pan. Alatan Digeda (Hurghada) is Saxifrage unguiculata Engl. Menken Digeda (Hurghada) now differs greatly. In Mongolia, Mongolian doctors use Parnassia palustris as the Digeda; Gisborne to Hurghada (Sandinista) are Swertia erythrosticta and Gentiana Ioureirii. Temuco uses Swertia pseudochineis as Digeda (Baghdad). In Inner Mongolia Autonomous Region of China, Mongolian medicine Digeda is mainly originated from the three kinds of medicinal plants in Gentianaceae, Swertie pseudochinensis Hara, Gentianopsis barbata Froel Ma, and Lomatogonium rotetwn (L.) Friesex Nym. Additionally, in Inner Mongolia and Tibetan Autonomous Regions of China, the used Digeda is different from Inner Mongolia fork Medicine, Parnassia palustris and P. orepohila, Tibetan fork medicine is different from G. gilvostriata Flat Lei, G. barbara and G. paludosa. Halenia sibirica is recorded in Inner Mongolian Medicine 5tanderds. Therefore, herbal medicine Digede belongs to not only the nationality, but also the world.展开更多
Xibei tree peony is a distinctive cultivar group that features red–purple blotches in petals.Interestingly,the pigmentations of blotches and non-blotches are largely independent of one another.The underlying molecula...Xibei tree peony is a distinctive cultivar group that features red–purple blotches in petals.Interestingly,the pigmentations of blotches and non-blotches are largely independent of one another.The underlying molecular mechanism had attracted lots of attention from investigators,but was still uncertain.Our present work demonstrates the factors that are closely related to blotch formation in Paeonia rockii‘Shu Sheng Peng Mo’.Non-blotch pigmentation is prevented by the silencing of anthocyanin structural genes,among which PrF3H,PrDFR,and PrANS are the three major genes.We characterized two R2R3-MYBs as the key transcription factors that control the early and late anthocyanin biosynthetic pathways.PrMYBa1,which belongs to MYB subgroup 7(SG7)was found to activate the early biosynthetic gene(EBG)PrF3H by interacting with SG5 member PrMYBa2 to form an‘MM’complex.The SG6 member PrMYBa3 interacts with two SG5(IIIf)bHLHs to synergistically activate the late biosynthetic genes(LBGs)PrDFR and PrANS,which is essential for anthocyanin accumulation in petal blotches.The comparison of methylation levels of the PrANS and PrF3H promoters between blotch and non-blotch indicated a correlation between hypermethylation and gene silencing.The methylation dynamics of PrANS promoter during flower development revealed a potential early demethylating reaction,which may have contributed to the particular expression of PrANS solely in the blotch area.We suggest that the formation of petal blotch may be highly associated with the cooperation of transcriptional activation and DNA methylation of structural gene promoters.展开更多
Mpox virus (MPXV) belongs to the family Poxviridae,subfamily Chordopoxvirinae,and genus Orthopoxvirus,which also includes Variola virus(VARV),Cowpox virus (CPXV),and Vaccinia virus(VACV).Clinical symptoms of mpox are ...Mpox virus (MPXV) belongs to the family Poxviridae,subfamily Chordopoxvirinae,and genus Orthopoxvirus,which also includes Variola virus(VARV),Cowpox virus (CPXV),and Vaccinia virus(VACV).Clinical symptoms of mpox are similar to smallpox but are relatively milder^([1]).MPXV was first isolated from crab-eating monkeys in the tropical rainforests of Africa in 1958^([2]).The first human case of MPXV infection was reported in the Congo in1970^([3]).Following the eradication of smallpox in1977,mpox has emerged as one of the prominent viral members of the Poxviridae family,significantly impacting public health^([4]),mainly prevalent in Central and West Africa.Starting from May 2022.展开更多
Dear Editor,Understanding the evolution and survival mechanisms of endangered wild medicinal herbs is crucial for their cultivation,utilization,and conservation.The snow lotus species Saussurea involucrata(Kar.&Ki...Dear Editor,Understanding the evolution and survival mechanisms of endangered wild medicinal herbs is crucial for their cultivation,utilization,and conservation.The snow lotus species Saussurea involucrata(Kar.&Kir.)Sch.Bip.(2n=32)(i.e.the well-known Tianshan snow lotus)which belongs to the eudicot family Asteraceae,is a famous traditional Chinese medicinal herb having anti-inflammatory.展开更多
As the most powerful country in the world,the United States claims to be the most advanced nation in natural sciences,humanities,and social sciences.However,why does it repeatedly commit mistakes on common sense issue...As the most powerful country in the world,the United States claims to be the most advanced nation in natural sciences,humanities,and social sciences.However,why does it repeatedly commit mistakes on common sense issues such as“the world belongs to the entire international community”and“making an enemy out of China benefits no one”?An important reason lies in the philosophical origin of its China perception.展开更多
Chinese theatre(戏曲,Xiqu),also known as Chinese operas,not only belongs to China,but also belongs to the world.Since the 18th century,it has been engaged in dialogue,exchange and interaction with the world drama in v...Chinese theatre(戏曲,Xiqu),also known as Chinese operas,not only belongs to China,but also belongs to the world.Since the 18th century,it has been engaged in dialogue,exchange and interaction with the world drama in various forms.With the pace of the overseas dissemination of Chinese theatre art,there will be more platforms for dialogue between Chinese opera and the world.and more communication methods.展开更多
The back half of the 20th century belonged to the United States.One reason is that America’s colleges and universities produced undergraduate,graduate,and doctoral graduates who,with increasing rapidity and sophistic...The back half of the 20th century belonged to the United States.One reason is that America’s colleges and universities produced undergraduate,graduate,and doctoral graduates who,with increasing rapidity and sophistication,turned out one new technology tool after another.Using these and other advantages,the U.S.became the world’s powerhouse,outpacing its allies and adversaries.展开更多
Chlorophylls and carotenoids are essential and bene fi cial substances for both plant and human health.Identifying the regulatory network of these pigments is necessary for improving fruit quality.In a previous study,...Chlorophylls and carotenoids are essential and bene fi cial substances for both plant and human health.Identifying the regulatory network of these pigments is necessary for improving fruit quality.In a previous study,we identi fi ed an R2R3-MYB transcription factor,SlMYB72,that plays an important role in chlorophyll and carotenoid metabolism in tomato fruit.Here,we demonstrated that the SlMYB72-interacting protein SlZHD17,which belongs to the zinc-fi nger homeodomain transcription factor family,also functions in chlorophyll and carotenoid metabolism.Silencing SIZHD 17 in tomato improved multiple bene fi cial agronomic traits,including dwar fi sm,accelerated fl owering,and earlier fruit harvest.More importantly,downregulating SIZHD17 in fruits resulted in larger chloroplasts and a higher chlorophyll content.Dual-luciferase,yeast one-hybrid and electrophoretic mobility shift assays clari fi ed that SlZHD17 regulates the chlorophyll biosynthesis gene SIPOR-B and chloroplast developmental regulator SITKN2 in a direct manner.Chlorophyll degradation and plastid transformation were also retarded after suppression of SIZHD17 in fruits,which was caused by the inhibition of SISGR1,a crucial factor in chlorophyll degradation.On the other hand,the expression of the carotenoid biosynthesis genes SIPSY1 and SIZISO was also suppressed and directly regulated by SlZHD17,which induced uneven pigmentation and decreased the lycopene content in fruits with SIZHD17 suppression at the ripe stage.Furthermore,the protein-protein interactions between SlZHD17 and other pigment regulators,including SlARF4,SlBEL11,and SlTAGL1,were also presented.This study provides new insight into the complex pigment regulatory network and provides new options for breeding strategies aiming to improve fruit quality.展开更多
Enteroviruses (EVs) are members of the genus Enteroviruswithin the orderPicornavirales, family Picornaviridae, and consist of 12 species, including EV-A, EV-B, EV-C, and EV-D, which are associated with human infection...Enteroviruses (EVs) are members of the genus Enteroviruswithin the orderPicornavirales, family Picornaviridae, and consist of 12 species, including EV-A, EV-B, EV-C, and EV-D, which are associated with human infections. Coxsackievirus B6 (CV-B6)belongs to the species EV-B, which currently consists of 63 serotypes, including echovirus (serotypes 1–7,9, 11–21, 24–27, 29–33), coxsackievirus group A (CVA9), coxsackievirus group B (CV-B, serotypes 1–6),the newly identified EVs (serotypes EV-B69, B73–75,B77–88, B93, B97–98, B100–101, B106–107, and B110–113), and the simian enterovirus SA5.展开更多
Scalp acupuncture belongs to the cate-gory of small-needle therapy and is themethod of treating general diseases by need-ling Shu acupoints in the hair-area scalp.Since 1970s,it has been widely applied,andbecome so fa...Scalp acupuncture belongs to the cate-gory of small-needle therapy and is themethod of treating general diseases by need-ling Shu acupoints in the hair-area scalp.Since 1970s,it has been widely applied,andbecome so far an effective acupuncturetherapy accepted by acupuncturists all overthe world.Clinically,the therapy can beused to treat more than 80 diseases,with ma-rked therapeutic effects particularly on dis-eases of the central nervous system and onvarious acute or chronic pains.展开更多
Wuxiang virus(WUXV),a new species of Phlebovirus from sandfly specimens(identified as Phlebotomus chinensis)collected in Wuxiang County,Shanxi Province,China,belongs to the order Bunyavirales,family Phenuiviridae.Like...Wuxiang virus(WUXV),a new species of Phlebovirus from sandfly specimens(identified as Phlebotomus chinensis)collected in Wuxiang County,Shanxi Province,China,belongs to the order Bunyavirales,family Phenuiviridae.Like other Bunyavirales,WUXV contains a negative-sense tripartite RNA genome comprising a small(S),a medium(M),and a large(L)segment.The S segment encodes nucleocapsid protein(NP)and a nonstructural protein(NSP).The M segment encodes a glycoprotein precursor(Gp),which is cleaved into mature N and C glycoproteins.The L segment encodes an RNA-dependent RNA polymerase(RdRp).展开更多
SIX1(OMIM 601205),as a member of the SIX homeobox transcription factor family,belongs to homologs of the Drosophila‘sine oculis’gene that expresses primarily in the developing visual system of the fly.The SIX family...SIX1(OMIM 601205),as a member of the SIX homeobox transcription factor family,belongs to homologs of the Drosophila‘sine oculis’gene that expresses primarily in the developing visual system of the fly.The SIX family includes six members(SIX1–SIX6),which share a homologous DNA-binding homeodomain(HD)and a highly conserved protein–protein interacting SIX domain(SD)[1].展开更多
文摘Correction to:J.For.Res.(2020)31(6):2581-2587 https://doi.org/10.1007/s11676-019-01036-2 After publication of this article,it was brought to our atten-tion that the legend to Figure 1 did not state that Figure 1d was adapted from Figure 1d of Makarikov and Tkach(2013).In addition,Makarikov and Tkach(2013)should have been cited in the methods section.
文摘As the English language gains its popularity with the day, every learner tries to find agood way of learning it. What is the best way to it has become a decades’ question. It is a pity that What a linguistic expert can offer is but some pieces of advice. The keyfactor in language lies in hard work. No short way can be found. Theoretically, an expert
基金supported by the Research Projects of Yunnan Province,China[grant numbers:202202AA100016]CAMS Innovation Fund for Medical Sciences[grant numbers:2021-I2M-1-043]General Basic Research Scheme of Yunnan Provincial Department of Science and Technology[grant numbers:202001BB050060]。
文摘Coxsackievirus(CV)B belongs to the species Enterovirus B,genus Enterovirus of the family Picornaviridae.Enterovirus B(EV-B)includes 63 serotypes:CVB1-6;CVA9;echoviruses E1-7,9,11-21,24-27,and 29-33;EV-B69,EV-B 73-75,EV-B77-88,EV-B 93,EV-B 97-101,EV-B 106-107.
文摘Professor Beger is one of the most renowned general and gastrointestinal surgeons in Germany.His worldwide reputation is based on his expertise in surgery of the pancreas.He belongs to the group of the 100most cited surgeons worldwide.
文摘This essay analyses Theodore Dreiser’s Sister Carrie through the lens of cultural studies,examining the portrayal of domesticity and the quest for an ideal home in late-nineteenth-century America.It explores the complex relationships between the main characters,Carrie and Hurstwood,and their families,as well as their struggles with materialism and alienation.Through close analysis of societal context,the characters’familial backgrounds and emotional yearnings,the essay delves into the characters’longing for stability and belonging and their journey toward understanding the true essence of dwelling amidst the changing urban landscape.It argues that Dreiser’s novel critiques the superficial pursuit of material comforts and highlights the importance of introspection and self-discovery in finding lasting happiness amidst societal turmoil.Ultimately,through the prism of domesticity,the essay delves into broader themes of identity,belonging,and existential fulfillment in a heartless society marked by materialism and alienation.
文摘On the view point of herb research in the world traditional medicines, Digeda is used to vary the plants originated from different species and families, such as India Digeda (Hurghada) is Swertie chirayita (Buch. -Ham.), Nepal Digeda (Hurghada) is Swertia cliete. Tibetan Digeda (Geda) are Saxifrage umbellulate Hook. f. &Thoms. and 5axifraga umbelluleta Hook. f. &Thoms. var. pectinata (C. Marq. & Airy-Shaw) J. T. Pan. Alatan Digeda (Hurghada) is Saxifrage unguiculata Engl. Menken Digeda (Hurghada) now differs greatly. In Mongolia, Mongolian doctors use Parnassia palustris as the Digeda; Gisborne to Hurghada (Sandinista) are Swertia erythrosticta and Gentiana Ioureirii. Temuco uses Swertia pseudochineis as Digeda (Baghdad). In Inner Mongolia Autonomous Region of China, Mongolian medicine Digeda is mainly originated from the three kinds of medicinal plants in Gentianaceae, Swertie pseudochinensis Hara, Gentianopsis barbata Froel Ma, and Lomatogonium rotetwn (L.) Friesex Nym. Additionally, in Inner Mongolia and Tibetan Autonomous Regions of China, the used Digeda is different from Inner Mongolia fork Medicine, Parnassia palustris and P. orepohila, Tibetan fork medicine is different from G. gilvostriata Flat Lei, G. barbara and G. paludosa. Halenia sibirica is recorded in Inner Mongolian Medicine 5tanderds. Therefore, herbal medicine Digede belongs to not only the nationality, but also the world.
基金This work was supported by the National Natural Science Foundation of China(No.32030095).
文摘Xibei tree peony is a distinctive cultivar group that features red–purple blotches in petals.Interestingly,the pigmentations of blotches and non-blotches are largely independent of one another.The underlying molecular mechanism had attracted lots of attention from investigators,but was still uncertain.Our present work demonstrates the factors that are closely related to blotch formation in Paeonia rockii‘Shu Sheng Peng Mo’.Non-blotch pigmentation is prevented by the silencing of anthocyanin structural genes,among which PrF3H,PrDFR,and PrANS are the three major genes.We characterized two R2R3-MYBs as the key transcription factors that control the early and late anthocyanin biosynthetic pathways.PrMYBa1,which belongs to MYB subgroup 7(SG7)was found to activate the early biosynthetic gene(EBG)PrF3H by interacting with SG5 member PrMYBa2 to form an‘MM’complex.The SG6 member PrMYBa3 interacts with two SG5(IIIf)bHLHs to synergistically activate the late biosynthetic genes(LBGs)PrDFR and PrANS,which is essential for anthocyanin accumulation in petal blotches.The comparison of methylation levels of the PrANS and PrF3H promoters between blotch and non-blotch indicated a correlation between hypermethylation and gene silencing.The methylation dynamics of PrANS promoter during flower development revealed a potential early demethylating reaction,which may have contributed to the particular expression of PrANS solely in the blotch area.We suggest that the formation of petal blotch may be highly associated with the cooperation of transcriptional activation and DNA methylation of structural gene promoters.
基金supported by the following funds:Research Project of Hunan Provincial Health Commission[NO.202112061732]Research Project of Hunan Provincial Health Commission [No. A202312066016]Hunan Provincial Natural Science Foundation [No. 2021JJ70010]。
文摘Mpox virus (MPXV) belongs to the family Poxviridae,subfamily Chordopoxvirinae,and genus Orthopoxvirus,which also includes Variola virus(VARV),Cowpox virus (CPXV),and Vaccinia virus(VACV).Clinical symptoms of mpox are similar to smallpox but are relatively milder^([1]).MPXV was first isolated from crab-eating monkeys in the tropical rainforests of Africa in 1958^([2]).The first human case of MPXV infection was reported in the Congo in1970^([3]).Following the eradication of smallpox in1977,mpox has emerged as one of the prominent viral members of the Poxviridae family,significantly impacting public health^([4]),mainly prevalent in Central and West Africa.Starting from May 2022.
基金This work was supported by grants from the National Natural Science Foundation of China(U2003122)the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(2019QZKK0502).Sequencing service was provided by Bioyi Biotechnology Co.,Ltd.Wuhan,China。
文摘Dear Editor,Understanding the evolution and survival mechanisms of endangered wild medicinal herbs is crucial for their cultivation,utilization,and conservation.The snow lotus species Saussurea involucrata(Kar.&Kir.)Sch.Bip.(2n=32)(i.e.the well-known Tianshan snow lotus)which belongs to the eudicot family Asteraceae,is a famous traditional Chinese medicinal herb having anti-inflammatory.
文摘As the most powerful country in the world,the United States claims to be the most advanced nation in natural sciences,humanities,and social sciences.However,why does it repeatedly commit mistakes on common sense issues such as“the world belongs to the entire international community”and“making an enemy out of China benefits no one”?An important reason lies in the philosophical origin of its China perception.
文摘Chinese theatre(戏曲,Xiqu),also known as Chinese operas,not only belongs to China,but also belongs to the world.Since the 18th century,it has been engaged in dialogue,exchange and interaction with the world drama in various forms.With the pace of the overseas dissemination of Chinese theatre art,there will be more platforms for dialogue between Chinese opera and the world.and more communication methods.
文摘The back half of the 20th century belonged to the United States.One reason is that America’s colleges and universities produced undergraduate,graduate,and doctoral graduates who,with increasing rapidity and sophistication,turned out one new technology tool after another.Using these and other advantages,the U.S.became the world’s powerhouse,outpacing its allies and adversaries.
基金This work was sponsored by the National Natural Science Foundation of China(No.32002100,31772370,31972470).
文摘Chlorophylls and carotenoids are essential and bene fi cial substances for both plant and human health.Identifying the regulatory network of these pigments is necessary for improving fruit quality.In a previous study,we identi fi ed an R2R3-MYB transcription factor,SlMYB72,that plays an important role in chlorophyll and carotenoid metabolism in tomato fruit.Here,we demonstrated that the SlMYB72-interacting protein SlZHD17,which belongs to the zinc-fi nger homeodomain transcription factor family,also functions in chlorophyll and carotenoid metabolism.Silencing SIZHD 17 in tomato improved multiple bene fi cial agronomic traits,including dwar fi sm,accelerated fl owering,and earlier fruit harvest.More importantly,downregulating SIZHD17 in fruits resulted in larger chloroplasts and a higher chlorophyll content.Dual-luciferase,yeast one-hybrid and electrophoretic mobility shift assays clari fi ed that SlZHD17 regulates the chlorophyll biosynthesis gene SIPOR-B and chloroplast developmental regulator SITKN2 in a direct manner.Chlorophyll degradation and plastid transformation were also retarded after suppression of SIZHD17 in fruits,which was caused by the inhibition of SISGR1,a crucial factor in chlorophyll degradation.On the other hand,the expression of the carotenoid biosynthesis genes SIPSY1 and SIZISO was also suppressed and directly regulated by SlZHD17,which induced uneven pigmentation and decreased the lycopene content in fruits with SIZHD17 suppression at the ripe stage.Furthermore,the protein-protein interactions between SlZHD17 and other pigment regulators,including SlARF4,SlBEL11,and SlTAGL1,were also presented.This study provides new insight into the complex pigment regulatory network and provides new options for breeding strategies aiming to improve fruit quality.
基金supported by the National Key Science and Technology Projects of China [Project Nos.2017ZX10104001,2018ZX10711001,and 2018ZX10713002]
文摘Enteroviruses (EVs) are members of the genus Enteroviruswithin the orderPicornavirales, family Picornaviridae, and consist of 12 species, including EV-A, EV-B, EV-C, and EV-D, which are associated with human infections. Coxsackievirus B6 (CV-B6)belongs to the species EV-B, which currently consists of 63 serotypes, including echovirus (serotypes 1–7,9, 11–21, 24–27, 29–33), coxsackievirus group A (CVA9), coxsackievirus group B (CV-B, serotypes 1–6),the newly identified EVs (serotypes EV-B69, B73–75,B77–88, B93, B97–98, B100–101, B106–107, and B110–113), and the simian enterovirus SA5.
文摘Scalp acupuncture belongs to the cate-gory of small-needle therapy and is themethod of treating general diseases by need-ling Shu acupoints in the hair-area scalp.Since 1970s,it has been widely applied,andbecome so far an effective acupuncturetherapy accepted by acupuncturists all overthe world.Clinically,the therapy can beused to treat more than 80 diseases,with ma-rked therapeutic effects particularly on dis-eases of the central nervous system and onvarious acute or chronic pains.
基金funded by a development grant from the State Key Laboratory of Infectious Disease Prevention and Control [2015SKLID505 to HW]the project of the Priority Academic Program Development of Jiangsu Higher Education Institutions [PAPD]the United States National Institutes of Health U01 [AI151810]
文摘Wuxiang virus(WUXV),a new species of Phlebovirus from sandfly specimens(identified as Phlebotomus chinensis)collected in Wuxiang County,Shanxi Province,China,belongs to the order Bunyavirales,family Phenuiviridae.Like other Bunyavirales,WUXV contains a negative-sense tripartite RNA genome comprising a small(S),a medium(M),and a large(L)segment.The S segment encodes nucleocapsid protein(NP)and a nonstructural protein(NSP).The M segment encodes a glycoprotein precursor(Gp),which is cleaved into mature N and C glycoproteins.The L segment encodes an RNA-dependent RNA polymerase(RdRp).
基金supported by grants from National Natural Science Foundation of China[81700920,81970894,and81870725]Natural Science Foundation of Jiangsu Province[BK20191229,BK20180048,and 17KJA180008]+3 种基金the Fifth‘333Project’Scientific Research Foundation of Jiangsu Province[BRA2019192 and BRA2019278]Medical Scientific Research Project from Health and Family Planning Commission of Jiangsu Province[H201666]Shanghai Municipal Education Commission–Gaofeng Clinical Medicine Grant[20152519]Science and Technology Commission of Shanghai Municipality[14DZ2260300]。
文摘SIX1(OMIM 601205),as a member of the SIX homeobox transcription factor family,belongs to homologs of the Drosophila‘sine oculis’gene that expresses primarily in the developing visual system of the fly.The SIX family includes six members(SIX1–SIX6),which share a homologous DNA-binding homeodomain(HD)and a highly conserved protein–protein interacting SIX domain(SD)[1].