Aim: To investigate the roles of the BGR-like gene in testicular development/spermatogenesis. Methods: A human testis cDNA microarray was hybridized with probes from human adult testes and embryo testes. The different...Aim: To investigate the roles of the BGR-like gene in testicular development/spermatogenesis. Methods: A human testis cDNA microarray was hybridized with probes from human adult testes and embryo testes. The differentially expressed clones were sequenced and analyzed. Expression of the BGR-like gene was analyzed by reverse transcription-polymerase chain reaction (RT-PCR). Results: A new gene exhibiting 50-fold difference in expression level between adult and fetal human testes was cloned and named the BGR-like gene. The cDNA consisted of 2500 nucleotides and had an open reading frame of 1437 nucleotides encoding a putative protein of 497 amino acid residues. Homologous comparison showed that the BGR-like gene was a new alternative splicing variant of the BGR gene and had sequence homology with the bubblegum gene of human, mouse, rat and Drosophilia. Protein motif analysis of the BGR-like gene revealed that it contained a conserved adenosine monophosphate (AMP)-binding domain and a fatty acyl-CoA synthetase signature motif which existed in all acyl-CoA synthetases. The BGR-like gene transcript was imperceptibly expressed in human fetal testes, highly in human adult testes and moderately in elderly testes and human Leydig cells. RT-PCR-based tissue distribution experiments showed that the BGR-like gene was exclusively expressed in testes and was a testes-specific isoform of the BGR gene. A BGR-like gene transcript was not detected in some azoospermic testes. Conclusion: The BGR-like gene may play an important role in spermatogenesis/testicular development and may be correlated with male infertility.展开更多
为分析排气管内压力波动对发动机二冲程制动功率的影响,以某重型柴油机为研究对象,利用GT-Power建立发动机二冲程制动一维模型,通过修改排气型线开展排气道压力波动对制动性能影响的研究。结果表明:第二次减压制动(the second compressi...为分析排气管内压力波动对发动机二冲程制动功率的影响,以某重型柴油机为研究对象,利用GT-Power建立发动机二冲程制动一维模型,通过修改排气型线开展排气道压力波动对制动性能影响的研究。结果表明:第二次减压制动(the second compression release braking,2nd CRB)相位开启时的压力波动会影响到其他气缸的排气回流,进而影响发动机的制动功率。进一步对排气管进行三维流场计算,证明了其他气缸2nd CRB相位排气门开启时的压力波传递对排气回流阶段排气回流的影响。最后通过试验设计(design of experiment,DoE),结合响应面拟合和粒子群算法对排气管几何尺寸进行优化,优化后该柴油机二冲程减压制动模式下2100 r/min工况的最大制动功率可达到395.08 kW。展开更多
A 14-bit low power self-timed differential successive approximation（SAR） ADC with an on-chip multisegment bandgap reference（BGR） is described.An on-chip multi-segment BGR,which has a temperature coefficient of 1.3...A 14-bit low power self-timed differential successive approximation（SAR） ADC with an on-chip multisegment bandgap reference（BGR） is described.An on-chip multi-segment BGR,which has a temperature coefficient of 1.3 ppm/℃and a thermal drift of about 100μV over the temperature range of -40 to 120℃is implemented to provide a high precision reference voltage for the SAR ADC.The Gray code form is utilized instead of binary form mode control to reduce substrate noise and enhance the linearity of the whole system.Self-timed bit-cycling is adopted to enhance the time efficiency.The 14-bit ADC was fabricated in a TSMC 0.13μm CMOS process. With the on-chip BGR,the SAR ADC achieves an SNDR of 81.2 dB（13.2 ENOB） and an SFDR of 85.2 dB with a conversion rate of 2 MS/s at room temperature and can keep an ENOB of more than 12 bits at a conversion rate of 2 MS/s over the temperature range from -40 to 120℃.展开更多
基于0.18μm CMOS工艺设计了一种低噪声、高电源电压抑制比(PSRR)的新型带隙基准源(BGR)。使用低噪声的垂直双极结型晶体管取代MOS晶体管作为运算放大器输入,削减了低频闪烁噪声;通过引入三输入的运算放大器将电源扰动传递到电流管的栅...基于0.18μm CMOS工艺设计了一种低噪声、高电源电压抑制比(PSRR)的新型带隙基准源(BGR)。使用低噪声的垂直双极结型晶体管取代MOS晶体管作为运算放大器输入,削减了低频闪烁噪声;通过引入三输入的运算放大器将电源扰动传递到电流管的栅极,极大程度地降低了电源纹波对输出基准电压的干扰;并通过RC低通滤波器进一步改善噪声和PSRR性能;利用修调电路修调工艺偏差,实现了良好的温度特性。实测结果表明,该BGR的PSRR在57.7 Hz下为-108 d B,与仿真结果基本一致(-102.3 d B@50 Hz);输出电压噪声在10 Hz时为42.20 n V/√Hz,通过新提出的测试方法在0.1~1 k Hz测得总噪声电压有效值低于0.503 5μV;在-40~125℃,基准电压温度系数可以修调至20×10^(-6)/℃以下,最小值仅14.09×10^(-6)/℃;BGR面积为254.1μm×370.0μm,功耗约为8.6μA@3 V。展开更多
基于DIC(Deviance Information Criterion)信息准则、BGR(Brooks-Gelman-Rubin)诊断原理、蒙特卡洛仿真误差及模型参数和可靠性指标后验估计的区间长度,提出了数控机床贝叶斯可靠性模型的综合评价方法.给出了不同先验下用于Gibbs抽样的...基于DIC(Deviance Information Criterion)信息准则、BGR(Brooks-Gelman-Rubin)诊断原理、蒙特卡洛仿真误差及模型参数和可靠性指标后验估计的区间长度,提出了数控机床贝叶斯可靠性模型的综合评价方法.给出了不同先验下用于Gibbs抽样的幂律过程模型参数的后验分布,并利用马尔科夫链蒙特卡洛法获得了模型参数和可靠性指标的贝叶斯点估计和区间估计.通过2个工程实例进行验证,结果表明,幂律过程模型各项评价指标均优于Weibull分布模型,适用于小样本故障数据数控机床的可靠性评估.展开更多
文摘Aim: To investigate the roles of the BGR-like gene in testicular development/spermatogenesis. Methods: A human testis cDNA microarray was hybridized with probes from human adult testes and embryo testes. The differentially expressed clones were sequenced and analyzed. Expression of the BGR-like gene was analyzed by reverse transcription-polymerase chain reaction (RT-PCR). Results: A new gene exhibiting 50-fold difference in expression level between adult and fetal human testes was cloned and named the BGR-like gene. The cDNA consisted of 2500 nucleotides and had an open reading frame of 1437 nucleotides encoding a putative protein of 497 amino acid residues. Homologous comparison showed that the BGR-like gene was a new alternative splicing variant of the BGR gene and had sequence homology with the bubblegum gene of human, mouse, rat and Drosophilia. Protein motif analysis of the BGR-like gene revealed that it contained a conserved adenosine monophosphate (AMP)-binding domain and a fatty acyl-CoA synthetase signature motif which existed in all acyl-CoA synthetases. The BGR-like gene transcript was imperceptibly expressed in human fetal testes, highly in human adult testes and moderately in elderly testes and human Leydig cells. RT-PCR-based tissue distribution experiments showed that the BGR-like gene was exclusively expressed in testes and was a testes-specific isoform of the BGR gene. A BGR-like gene transcript was not detected in some azoospermic testes. Conclusion: The BGR-like gene may play an important role in spermatogenesis/testicular development and may be correlated with male infertility.
文摘A 14-bit low power self-timed differential successive approximation（SAR） ADC with an on-chip multisegment bandgap reference（BGR） is described.An on-chip multi-segment BGR,which has a temperature coefficient of 1.3 ppm/℃and a thermal drift of about 100μV over the temperature range of -40 to 120℃is implemented to provide a high precision reference voltage for the SAR ADC.The Gray code form is utilized instead of binary form mode control to reduce substrate noise and enhance the linearity of the whole system.Self-timed bit-cycling is adopted to enhance the time efficiency.The 14-bit ADC was fabricated in a TSMC 0.13μm CMOS process. With the on-chip BGR,the SAR ADC achieves an SNDR of 81.2 dB（13.2 ENOB） and an SFDR of 85.2 dB with a conversion rate of 2 MS/s at room temperature and can keep an ENOB of more than 12 bits at a conversion rate of 2 MS/s over the temperature range from -40 to 120℃.
文摘基于0.18μm CMOS工艺设计了一种低噪声、高电源电压抑制比(PSRR)的新型带隙基准源(BGR)。使用低噪声的垂直双极结型晶体管取代MOS晶体管作为运算放大器输入,削减了低频闪烁噪声;通过引入三输入的运算放大器将电源扰动传递到电流管的栅极,极大程度地降低了电源纹波对输出基准电压的干扰;并通过RC低通滤波器进一步改善噪声和PSRR性能;利用修调电路修调工艺偏差,实现了良好的温度特性。实测结果表明,该BGR的PSRR在57.7 Hz下为-108 d B,与仿真结果基本一致(-102.3 d B@50 Hz);输出电压噪声在10 Hz时为42.20 n V/√Hz,通过新提出的测试方法在0.1~1 k Hz测得总噪声电压有效值低于0.503 5μV;在-40~125℃,基准电压温度系数可以修调至20×10^(-6)/℃以下,最小值仅14.09×10^(-6)/℃;BGR面积为254.1μm×370.0μm,功耗约为8.6μA@3 V。
文摘基于DIC(Deviance Information Criterion)信息准则、BGR(Brooks-Gelman-Rubin)诊断原理、蒙特卡洛仿真误差及模型参数和可靠性指标后验估计的区间长度,提出了数控机床贝叶斯可靠性模型的综合评价方法.给出了不同先验下用于Gibbs抽样的幂律过程模型参数的后验分布,并利用马尔科夫链蒙特卡洛法获得了模型参数和可靠性指标的贝叶斯点估计和区间估计.通过2个工程实例进行验证,结果表明,幂律过程模型各项评价指标均优于Weibull分布模型,适用于小样本故障数据数控机床的可靠性评估.
文摘利用两个工作在亚阈区的MOS管的栅源电压差ΔVGS产生高阶补偿量,对传统的BJT带隙基准源进行高阶温度补偿。设计一种基于ΔVGS高阶温度补偿的高精度CMOS带隙基准。电路基于CSMC 0.5μm标准CMOS工艺设计,仿真结果表明:在5 V电源电压下,基准输出电压为1.258 V;在-40℃~125℃的温度范围内,温度系数为1.24×10-6/℃;低频时电源抑制比PSRR为-68 d B;电源电压在3.5 V^6.5 V范围内工作,线性调整率为0.4 m V/V。适用于高精度带隙基准源。
