冀东油田南堡3号构造储量大、埋藏深,该地区部署的深井、超深井存在井温高、位移大的特点。通过实验优选出了氯化钾抗高温钻井液体系(BH-KSM)。该钻井液抗温达200℃;具备优良的抑制封堵性和抗CO2污染能力,解决了南堡3号构造深井存在的...冀东油田南堡3号构造储量大、埋藏深,该地区部署的深井、超深井存在井温高、位移大的特点。通过实验优选出了氯化钾抗高温钻井液体系(BH-KSM)。该钻井液抗温达200℃;具备优良的抑制封堵性和抗CO2污染能力,解决了南堡3号构造深井存在的井壁失稳、高温蠕变、地层流体污染等技术难题,形成了适合该构造深井的配套钻井液技术。现场应用的10口井东营组易垮塌地层井眼扩大率均小于7%,最小的仅为3.98%;现场钻井液流变性能稳定,高温高压滤失量小于12 m L;包被抑制能力强,返出岩屑完整不分散;携砂、携岩能力强,解决了三开大井眼、裸眼段长的井眼净化问题,提高了机械钻速。展开更多
The evasion from controlled cell death induction has been considered as one of the hallmarks of cancer cells. Defects in cell death signaling are a fundamental phenomenon in colorectal cancer. Nearly any non-invasive ...The evasion from controlled cell death induction has been considered as one of the hallmarks of cancer cells. Defects in cell death signaling are a fundamental phenomenon in colorectal cancer. Nearly any non-invasive cancer treatment finally aims to induce cell death. However, apoptosis resistance is the major cause for insufficient therapeutic success and disease relapse in gastrointestinal oncology. Various compounds have been developed and evaluated with the aim to meet with this obstacle by triggering cell death in cancer cells. The aim of this review is to illustrate current approaches and future directions in targeting cell death signaling in colorectal cancer. The complex signaling network of apoptosis will be demonstrated and the “druggability” of targets will be identified. In detail, proteins regulating mitochondrial cell death in colorectal cancer, such as Bcl-2 and survivin, will be discussed with respect to potential therapeutic exploitation. Death receptor signaling and targeting in colorectal cancer will be outlined. Encouraging clinical trials including cell death based targeted therapies for colorectal cancer are under way and will be demonstrated. Our conceptual understanding of cell death in cancer is rapidly emerging and new types of controlled cellular death have been identified. To meet this progress in cell death research, the implication of autophagy and necroptosis for colorectal carcinogenesis and therapeutic approaches will also be depicted. The main focus of this topic highlight will be on the revelation of the complex cell death concepts in colorectal cancer and the bridging from basic research to clinical use.展开更多
文摘冀东油田南堡3号构造储量大、埋藏深,该地区部署的深井、超深井存在井温高、位移大的特点。通过实验优选出了氯化钾抗高温钻井液体系(BH-KSM)。该钻井液抗温达200℃;具备优良的抑制封堵性和抗CO2污染能力,解决了南堡3号构造深井存在的井壁失稳、高温蠕变、地层流体污染等技术难题,形成了适合该构造深井的配套钻井液技术。现场应用的10口井东营组易垮塌地层井眼扩大率均小于7%,最小的仅为3.98%;现场钻井液流变性能稳定,高温高压滤失量小于12 m L;包被抑制能力强,返出岩屑完整不分散;携砂、携岩能力强,解决了三开大井眼、裸眼段长的井眼净化问题,提高了机械钻速。
基金BCK holds a Postdoctoral-Fellowship from the Medical Faculty of the University of Heidelberg,GermanyHSB receives grants from the German Research Foundation (DFG SCHU 1443/4-1)
文摘The evasion from controlled cell death induction has been considered as one of the hallmarks of cancer cells. Defects in cell death signaling are a fundamental phenomenon in colorectal cancer. Nearly any non-invasive cancer treatment finally aims to induce cell death. However, apoptosis resistance is the major cause for insufficient therapeutic success and disease relapse in gastrointestinal oncology. Various compounds have been developed and evaluated with the aim to meet with this obstacle by triggering cell death in cancer cells. The aim of this review is to illustrate current approaches and future directions in targeting cell death signaling in colorectal cancer. The complex signaling network of apoptosis will be demonstrated and the “druggability” of targets will be identified. In detail, proteins regulating mitochondrial cell death in colorectal cancer, such as Bcl-2 and survivin, will be discussed with respect to potential therapeutic exploitation. Death receptor signaling and targeting in colorectal cancer will be outlined. Encouraging clinical trials including cell death based targeted therapies for colorectal cancer are under way and will be demonstrated. Our conceptual understanding of cell death in cancer is rapidly emerging and new types of controlled cellular death have been identified. To meet this progress in cell death research, the implication of autophagy and necroptosis for colorectal carcinogenesis and therapeutic approaches will also be depicted. The main focus of this topic highlight will be on the revelation of the complex cell death concepts in colorectal cancer and the bridging from basic research to clinical use.
