Objective:To investigate the correlation of BI-RADS grading with cancer cell proliferation and invasion.Methods: A total of 138 patients who were diagnosed with breast cancer in our hospital between August 2015 and Oc...Objective:To investigate the correlation of BI-RADS grading with cancer cell proliferation and invasion.Methods: A total of 138 patients who were diagnosed with breast cancer in our hospital between August 2015 and October 2017 were divided into 2 cases at stage Ⅲ, 51 cases at stage Ⅳ and 85 cases at stage Ⅴ after the BI-RADS grading was reviewed. Differences in the expression of proliferation-related genes and invasion-related genes were compared among the three groups of patients.Results: Expressions of pro-proliferation genes MTA2, mTOR, PKM2, Notch1 and FSCN1 mRNA in lesion tissue of patients at stage Ⅴ and Ⅳ were higher than those of patients at stage Ⅲ whereas expressions of anti-proliferation genes BRCA1 and PTEN mRNA were lower than those of patients at stage Ⅲ;expressions of pro-invasion genes Gab2 and NUAK1 mRNA were higher than those of patients at stage Ⅲ whereas expressions of anti-invasion genes EBP50, EDN3, FBXW7 and NDRG1 mRNA were lower than those of patients at stage Ⅲ. With the increase of BI-RADS grades, the expression levels of pro-proliferation genes and pro-invasion genes further increased while the expression levels of anti-proliferation and anti-invasion genes further decreased in the lesion tissue.Conclusions: BI-RADS grading of patients with breast cancer is positively correlated with the proliferation and invasion activity of cancer cells.展开更多
目的分析乳腺影像报告及数据系统(breast imaging reporting and data system,BI-RADS)4类乳腺良恶性结节采用超声弹性成像(ultrasonic elastography,UE)技术诊断的价值。方法选择2023年1—11月济南市章丘区人民医院收治的102例疑似BI-R...目的分析乳腺影像报告及数据系统(breast imaging reporting and data system,BI-RADS)4类乳腺良恶性结节采用超声弹性成像(ultrasonic elastography,UE)技术诊断的价值。方法选择2023年1—11月济南市章丘区人民医院收治的102例疑似BI-RADS 4类乳腺实性结节患者为研究对象,全部患者均接受彩色多普勒超声与UE检查。以病理结果为“金标准”,针对BI-RADS 4类乳腺良恶性结节经常规超声与UE技术诊断的结果及效能,以及对UE技术诊断结果与病理结果的一致性进行评价。结果BI-RADS 4类乳腺良恶性结节经穿刺活检结果证实为恶性36例,良性66例,UE技术诊断结果与病理诊断结果具有极好的一致性(kappa=0.890)。UE技术对BI-RADS 4类乳腺良恶性结节诊断的灵敏度94.44%、特异度95.45%、准确度95.10%均高于常规超声的72.22%、81.82%、78.43%,差异有统计学意义(χ^(2)=6.400、6.092、12.337,P均<0.05)。结论UE在BI-RADS 4类乳腺良恶性结节中具有较为理想的诊断价值,进一步提高了诊断效能,为临床提供可靠的参考信息。展开更多
文摘Objective:To investigate the correlation of BI-RADS grading with cancer cell proliferation and invasion.Methods: A total of 138 patients who were diagnosed with breast cancer in our hospital between August 2015 and October 2017 were divided into 2 cases at stage Ⅲ, 51 cases at stage Ⅳ and 85 cases at stage Ⅴ after the BI-RADS grading was reviewed. Differences in the expression of proliferation-related genes and invasion-related genes were compared among the three groups of patients.Results: Expressions of pro-proliferation genes MTA2, mTOR, PKM2, Notch1 and FSCN1 mRNA in lesion tissue of patients at stage Ⅴ and Ⅳ were higher than those of patients at stage Ⅲ whereas expressions of anti-proliferation genes BRCA1 and PTEN mRNA were lower than those of patients at stage Ⅲ;expressions of pro-invasion genes Gab2 and NUAK1 mRNA were higher than those of patients at stage Ⅲ whereas expressions of anti-invasion genes EBP50, EDN3, FBXW7 and NDRG1 mRNA were lower than those of patients at stage Ⅲ. With the increase of BI-RADS grades, the expression levels of pro-proliferation genes and pro-invasion genes further increased while the expression levels of anti-proliferation and anti-invasion genes further decreased in the lesion tissue.Conclusions: BI-RADS grading of patients with breast cancer is positively correlated with the proliferation and invasion activity of cancer cells.
