Lanthanum is one of the rare earth metals which due to specific chemio-physical properties,has wide applications in different industries.In this research,the ability of the synthesized metal-organic framework(MOF),[Zn...Lanthanum is one of the rare earth metals which due to specific chemio-physical properties,has wide applications in different industries.In this research,the ability of the synthesized metal-organic framework(MOF),[Zn(bim)_(2)(bdc)]_(n)(ZBB) for the removal of lanthanum ions from the aqueous stream was investigated in the batch and column processes.The synthesized MOF was characterized by using scanning electron microscopy(SEM),Brunauer-Emmett-Teller(BET),Fourier transform infrared spectroscopy(FTIR) and thermogravimetric analysis(TGA).The effect of pH on lanthanum ions adsorption was evaluated in the range from 1 to 7.Moreover,isothermal,kinetic,and thermodynamic parameters for adsorption of La(Ⅲ) ions onto the synthesized MOF were evaluated.The adsorption capacity of lanthanum ions onto the synthesized MOF was calculated to be about 130 mg/g.Thermodynamic studies demonstrate the endothermic and chemical nature of lanthanum adsorption,while kinetic studies suggest the pseudo-first-order of reaction.In column mode,the effect of solution flow rate passing through the fixed-bed was studied.Experimental data confirm that increasing the bed flow rate causes a decrease in the adsorption capacity of lanthanum ions on the synthesized MOF.展开更多
The BH3 mimetics targeting the interaction between the BH3-only proteins and their prosurvival Bcl-2family proteins have shown enormous potential as cancer therapeutics. Herein, seven analogues targeting anti-apoptoti...The BH3 mimetics targeting the interaction between the BH3-only proteins and their prosurvival Bcl-2family proteins have shown enormous potential as cancer therapeutics. Herein, seven analogues targeting anti-apoptotic Bcl-2 proteins derived from the Bim BH3 domain via sequence simplification and/or modification are described. The in vitro binding affinity on anti-apoptotic Bcl-2 proteins and cell killing activity were evaluated. The results showed that analogues could significantly bind to target proteins and exhibited anti-cancer effect against three cancer cell lines. Of particular interest were the analogue SM-5（KD= 9.48 nmol/L for Bcl-2） and SM-6（KD= 0.08 nmol/L for Bcl-xL）, which exhibited improved binding affinity compared with the lead Bim（KD= 16.90 nmol/L for Bcl-2 and 22.2 nmol/L for Bcl-xL, respectively）. These results indicated that the peptide sequence containing the four hydrophobic side chains occupying pockets within the BH3-recognition cleft of anti-apoptotic Bcl-2 proteins might be the minimum sequence required for the bioactivity and the active core region of Bim. Promising inhibitors of anti-apoptotic Bcl-2 proteins with high bioactivity might be designed based on the active core.展开更多
文摘Lanthanum is one of the rare earth metals which due to specific chemio-physical properties,has wide applications in different industries.In this research,the ability of the synthesized metal-organic framework(MOF),[Zn(bim)_(2)(bdc)]_(n)(ZBB) for the removal of lanthanum ions from the aqueous stream was investigated in the batch and column processes.The synthesized MOF was characterized by using scanning electron microscopy(SEM),Brunauer-Emmett-Teller(BET),Fourier transform infrared spectroscopy(FTIR) and thermogravimetric analysis(TGA).The effect of pH on lanthanum ions adsorption was evaluated in the range from 1 to 7.Moreover,isothermal,kinetic,and thermodynamic parameters for adsorption of La(Ⅲ) ions onto the synthesized MOF were evaluated.The adsorption capacity of lanthanum ions onto the synthesized MOF was calculated to be about 130 mg/g.Thermodynamic studies demonstrate the endothermic and chemical nature of lanthanum adsorption,while kinetic studies suggest the pseudo-first-order of reaction.In column mode,the effect of solution flow rate passing through the fixed-bed was studied.Experimental data confirm that increasing the bed flow rate causes a decrease in the adsorption capacity of lanthanum ions on the synthesized MOF.
基金financially supported by Postdoctoral Applied Research Project of Qingdao(No.861605040085,to CZ,SW)Grant of Innovation Plan in Biomedical Research of Qingdao City(No.15-10-3-15-(28)-zch,to SW)
文摘The BH3 mimetics targeting the interaction between the BH3-only proteins and their prosurvival Bcl-2family proteins have shown enormous potential as cancer therapeutics. Herein, seven analogues targeting anti-apoptotic Bcl-2 proteins derived from the Bim BH3 domain via sequence simplification and/or modification are described. The in vitro binding affinity on anti-apoptotic Bcl-2 proteins and cell killing activity were evaluated. The results showed that analogues could significantly bind to target proteins and exhibited anti-cancer effect against three cancer cell lines. Of particular interest were the analogue SM-5（KD= 9.48 nmol/L for Bcl-2） and SM-6（KD= 0.08 nmol/L for Bcl-xL）, which exhibited improved binding affinity compared with the lead Bim（KD= 16.90 nmol/L for Bcl-2 and 22.2 nmol/L for Bcl-xL, respectively）. These results indicated that the peptide sequence containing the four hydrophobic side chains occupying pockets within the BH3-recognition cleft of anti-apoptotic Bcl-2 proteins might be the minimum sequence required for the bioactivity and the active core region of Bim. Promising inhibitors of anti-apoptotic Bcl-2 proteins with high bioactivity might be designed based on the active core.
