Large-conductance calcium-and voltage-dependent potassium(BK)channels are ubiquitously expressed in mammalian cells and participate in various physiological and pathological processes such as neurotransmission and cer...Large-conductance calcium-and voltage-dependent potassium(BK)channels are ubiquitously expressed in mammalian cells and participate in various physiological and pathological processes such as neurotransmission and cerebral ischemia.BK channels comprise up to four pore-formingαsubunits and zero to four accessory subunits.Although microglial BK currents were initially recorded 27 years ago,their roles have long been elusive.Studies have demonstrated that BK channels modulate the activation,phagocytosis,and probably migration of microglia and have associated microglial BK channels with many neurological diseases,including neuropathic pain and stroke.This review summarizes the available information regarding the biophysical,functional,and pathological aspects of microglial BK channels and discusses future directions of research into these channels.展开更多
BK channels are widely expressed in both excitable and non-excitable cells and known to be involved in many physiological processes,such as vascular smooth tone regulation,neuronal firing and endocrine cell secretion[...BK channels are widely expressed in both excitable and non-excitable cells and known to be involved in many physiological processes,such as vascular smooth tone regulation,neuronal firing and endocrine cell secretion[1].Recently, the BK channels have展开更多
A series of hydrazone and N-acylhydrazone derivatives of dehydroabietic acid were synthesized and evaluated for BK channel-opening activities in an assay system of CHO-K1 cells expressing hBKa channels.The assay resul...A series of hydrazone and N-acylhydrazone derivatives of dehydroabietic acid were synthesized and evaluated for BK channel-opening activities in an assay system of CHO-K1 cells expressing hBKa channels.The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at hydrazone moiety.展开更多
Alcohol is the most frequently-used addictive drug. However, the mechanism by which its consumption leads to addiction remains largely elusive. Given the conservation of behavioral reactions to alcohol, Caenorhabitis ...Alcohol is the most frequently-used addictive drug. However, the mechanism by which its consumption leads to addiction remains largely elusive. Given the conservation of behavioral reactions to alcohol, Caenorhabitis elegans （C. elegans） has been effectively used as a model system to investigate the relevant molecular targets and pathways mediating these responses. In this article, we review the roles of BK channels （also called SLO-1）, the lipid microenvironment, receptors, the synaptic machinery, and neurotransmitters in both the acute and chronic effects of alcohol. We provide an overview of the genes and mechanisms involved in alcoholism- related behaviors in C. elegans.展开更多
基金National Natural Science Foundation of China(Grant No.31400924)the Priority Academic Program Development of the Jiangsu Higher Education Institutes(PAPD).
文摘Large-conductance calcium-and voltage-dependent potassium(BK)channels are ubiquitously expressed in mammalian cells and participate in various physiological and pathological processes such as neurotransmission and cerebral ischemia.BK channels comprise up to four pore-formingαsubunits and zero to four accessory subunits.Although microglial BK currents were initially recorded 27 years ago,their roles have long been elusive.Studies have demonstrated that BK channels modulate the activation,phagocytosis,and probably migration of microglia and have associated microglial BK channels with many neurological diseases,including neuropathic pain and stroke.This review summarizes the available information regarding the biophysical,functional,and pathological aspects of microglial BK channels and discusses future directions of research into these channels.
基金supported by Natural Science Foundation of China grants10732070,10602031
文摘BK channels are widely expressed in both excitable and non-excitable cells and known to be involved in many physiological processes,such as vascular smooth tone regulation,neuronal firing and endocrine cell secretion[1].Recently, the BK channels have
基金supports from the National Natural Science Foundation of China (Nos. 81202402 and 21272154)Shanghai Pujiang Program (No. 10PJ1403700)
文摘A series of hydrazone and N-acylhydrazone derivatives of dehydroabietic acid were synthesized and evaluated for BK channel-opening activities in an assay system of CHO-K1 cells expressing hBKa channels.The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at hydrazone moiety.
基金supported by grants from the National Natural Science Foundation of China (31371489)the Shanghai Pujiang Program (13PJ1408100)the 1000 Talents Youth Program
文摘Alcohol is the most frequently-used addictive drug. However, the mechanism by which its consumption leads to addiction remains largely elusive. Given the conservation of behavioral reactions to alcohol, Caenorhabitis elegans （C. elegans） has been effectively used as a model system to investigate the relevant molecular targets and pathways mediating these responses. In this article, we review the roles of BK channels （also called SLO-1）, the lipid microenvironment, receptors, the synaptic machinery, and neurotransmitters in both the acute and chronic effects of alcohol. We provide an overview of the genes and mechanisms involved in alcoholism- related behaviors in C. elegans.
