在世界卫生组织疾病统计中,肿瘤的发生率和病死率均很高,肿瘤的诊断和治疗已成为当今医学研究的热点和难点。肿瘤细胞中特异和异常表达的因子是肿瘤诊疗的潜在靶标。肿瘤睾丸抗原(cancer-testis antigen,CTA)印记位点调节物兄弟因子(the...在世界卫生组织疾病统计中,肿瘤的发生率和病死率均很高,肿瘤的诊断和治疗已成为当今医学研究的热点和难点。肿瘤细胞中特异和异常表达的因子是肿瘤诊疗的潜在靶标。肿瘤睾丸抗原(cancer-testis antigen,CTA)印记位点调节物兄弟因子(the brother of the regulator of imprinted sites,BORIS)在多种肿瘤组织中特异性高表达,与肿瘤发生、发展以及恶性程度密切相关。BORIS通过调节启动子区域的甲基化水平影响原癌基因c MYC、乳腺癌基因BRCA1等下游靶基因的表达,改变肿瘤细胞生物学活性和分化干性,促进肿瘤细胞的增殖、转移、侵袭。本文综述了BORIS在癌症发生、发展中的作用,阐述了BORIS在癌症诊疗中的研究价值和应用前景。展开更多
Boris numerical scheme due to its long-time stability,accuracy and conservative properties has been widely applied in many studies of magnetized plasmas.Such algorithms conserve the phase space volume and hence provid...Boris numerical scheme due to its long-time stability,accuracy and conservative properties has been widely applied in many studies of magnetized plasmas.Such algorithms conserve the phase space volume and hence provide accurate charge particle orbits.However,this algorithm does not conserve the energy in some special electromagnetic configurations,particularly for long simulation times.Here,we empirically analyze the energy behavior of Boris algorithm by applying it to a 2D autonomous Hamiltonian.The energy behavior of the Boris method is found to be strongly related to the integrability of our Hamiltonian system.We find that if the invariant tori is preserved under Boris discretization,the energy error can be bounded for an exponentially long time,otherwise the said error will show a linear growth.On the contrary,for a non-integrable Hamiltonian system,a random walk pattern has been observed in the energy error.展开更多
目的探讨分析印痕位点调节因子样(brother of regulator of imprinted sites, BORIS)蛋白在结直肠癌中的表达情况及其预后意义。方法通过免疫组织化学的方法分析BORIS蛋白在77例结直肠癌组织和20例癌旁正常组织中的表达,并分析BORIS的...目的探讨分析印痕位点调节因子样(brother of regulator of imprinted sites, BORIS)蛋白在结直肠癌中的表达情况及其预后意义。方法通过免疫组织化学的方法分析BORIS蛋白在77例结直肠癌组织和20例癌旁正常组织中的表达,并分析BORIS的表达状态与结直肠癌患者的临床病理特点与患者预后的关系。结果在癌旁正常组织中无BORIS蛋白表达,而在结直肠癌患者中BORIS的阳性率为66.2%。BORIS阳性更多见于以下患者:肿瘤直径较大、组织分化较差、进展期T分期、淋巴结转移和进展期TNM分期。BORIS阴性组的患者总体生存预后明显优于BORIS阳性组的患者,两组患者的5年生存率分别为73.1%和29.2%。多因素Cox回归分析的结果显示组织分化类型、T分期、远处转移和BORIS表达状态是影响本组结直肠癌患者的独立预后因素。结论 BORIS在结直肠组织中呈过表达状态,并与进展期TNM密切相关。BORIS可能可以作为结直肠患者的潜在预后预测指标。展开更多
文摘在世界卫生组织疾病统计中,肿瘤的发生率和病死率均很高,肿瘤的诊断和治疗已成为当今医学研究的热点和难点。肿瘤细胞中特异和异常表达的因子是肿瘤诊疗的潜在靶标。肿瘤睾丸抗原(cancer-testis antigen,CTA)印记位点调节物兄弟因子(the brother of the regulator of imprinted sites,BORIS)在多种肿瘤组织中特异性高表达,与肿瘤发生、发展以及恶性程度密切相关。BORIS通过调节启动子区域的甲基化水平影响原癌基因c MYC、乳腺癌基因BRCA1等下游靶基因的表达,改变肿瘤细胞生物学活性和分化干性,促进肿瘤细胞的增殖、转移、侵袭。本文综述了BORIS在癌症发生、发展中的作用,阐述了BORIS在癌症诊疗中的研究价值和应用前景。
基金Abdullah Zafar acknowledges the Chinese Scholarship Council(CSC)to support him as the 2015 CSC awardee(CSC No.2015GXZQ56).
文摘Boris numerical scheme due to its long-time stability,accuracy and conservative properties has been widely applied in many studies of magnetized plasmas.Such algorithms conserve the phase space volume and hence provide accurate charge particle orbits.However,this algorithm does not conserve the energy in some special electromagnetic configurations,particularly for long simulation times.Here,we empirically analyze the energy behavior of Boris algorithm by applying it to a 2D autonomous Hamiltonian.The energy behavior of the Boris method is found to be strongly related to the integrability of our Hamiltonian system.We find that if the invariant tori is preserved under Boris discretization,the energy error can be bounded for an exponentially long time,otherwise the said error will show a linear growth.On the contrary,for a non-integrable Hamiltonian system,a random walk pattern has been observed in the energy error.
文摘目的探讨分析印痕位点调节因子样(brother of regulator of imprinted sites, BORIS)蛋白在结直肠癌中的表达情况及其预后意义。方法通过免疫组织化学的方法分析BORIS蛋白在77例结直肠癌组织和20例癌旁正常组织中的表达,并分析BORIS的表达状态与结直肠癌患者的临床病理特点与患者预后的关系。结果在癌旁正常组织中无BORIS蛋白表达,而在结直肠癌患者中BORIS的阳性率为66.2%。BORIS阳性更多见于以下患者:肿瘤直径较大、组织分化较差、进展期T分期、淋巴结转移和进展期TNM分期。BORIS阴性组的患者总体生存预后明显优于BORIS阳性组的患者,两组患者的5年生存率分别为73.1%和29.2%。多因素Cox回归分析的结果显示组织分化类型、T分期、远处转移和BORIS表达状态是影响本组结直肠癌患者的独立预后因素。结论 BORIS在结直肠组织中呈过表达状态,并与进展期TNM密切相关。BORIS可能可以作为结直肠患者的潜在预后预测指标。
