TAX1BP1 and FIP200 orchestrate non-canonical autophagy of p62 aggregates for mouse neural stem cell maintenance

Autophagy plays a pivotal role in diverse biological processes,including the maintenance and differentiation of neural stem cells(NSCs).Interestingly,while complete deletion of Fip200 severely impairs NSC maintenance and differentiation,inhibiting canonical autophagy via deletion of core genes,such as Atg5,Atg16l1,and Atg7,or blockade of canonical interactions between FIP200 and ATG13(designated as FIP200-4A mutant or FIP200 KI)does not produce comparable detrimental effects.This highlights the likely critical involvement of the non-canonical functions of FIP200,the mechanisms of which have remained elusive.Here,utilizing genetic mouse models,we demonstrated that FIP200 mediates non-canonical autophagic degradation of p62/sequestome1,primarily via TAX1BP1 in NSCs.Conditional deletion of Tax1bp1 in fip200hGFAP conditional knock-in(cKI)mice led to NSC deficiency,resembling the fip200hGFAP conditional knockout(cKO)mouse phenotype.Notably,reintroducing wild-type TAX1BP1 not only restored the maintenance of NSCs derived from tax1bp1-knockout fip200hGFAP cKI mice but also led to a marked reduction in p62 aggregate accumulation.Conversely,a TAX1BP1 mutant incapable of binding to FIP200 or NBR1/p62 failed to achieve this restoration.Furthermore,conditional deletion of Tax1bp1 in fip200hGFAP cKO mice exacerbated NSC deficiency and p62 aggregate accumulation compared to fip200hGFAP cKO mice.Collectively,these findings illustrate the essential role of the FIP200-TAX1BP1 axis in mediating the non-canonical autophagic degradation of p62 aggregates towards NSC maintenance and function,presenting novel therapeutic targets for neurodegenerative diseases.

基于图像处理和BP神经网络的森林防火无人机系统

对无人机设计方案、图像处理和火焰分割算法的技术原理进行了介绍,并利用BP神经网络对图像中的火焰面积变化率和火焰尖角等特征进行识别,实现了对森林火灾的快速监测。实验结果表明:系统的准确率为98.5%,比普通神经网络的84.5%更高;耗时仅22 s,比普通神经网络159 s缩短很多。这表明,BP神经网络是更可靠且更有效率的火灾识别方案。

基于PSO-BP模糊PID的变距取苗机构控制系统设计

为满足番茄、辣椒等蔬菜作物的移栽需求,基于向下取苗原理设计了一种适用72穴和128穴两种主要番茄钵苗穴盘规格的变距取苗机构,通过建立数学模型获得了取苗机械手参数的目标函数,并利用粒子群和模拟退火混合算法对其结构参数进行优化。同时,为实现变距取苗机构的精确控制,提出了一种基于PSO-BP的模糊PID算法以提高控制精度,介绍了系统的结构与工作原理,并通过选型计算与分析建模建立了控制系统的数学模型。针对传统PID控制器稳定性差、响应速度慢等不足之处,利用PSO-BP模糊PID对控制器的参数进行在线调整,以满足控制过程中对参数的不同需求。仿真结果与试验数据的分析表明:在参数相同条件下,基于PSO-BP模糊PID控制系统系统稳定性更好、响应速度更快,具有良好的鲁棒性,提升取苗成功率的同时降低了基质损伤率,能够满足变距取苗机构高精度快速稳定控制的需求。

Analysis of Factors Related to Vasovagal Response in Apheresis Blood Donors and the Establishment of Prediction Model Based on BP Neural Network Algorithm

Objective:To analyze the factors related to vessel vasovagal reaction(VVR)in apheresis donors,establish a mathematical model for predicting the correlation factors and occurrence risk,and use the prediction model to intervene in high-risk VVR blood donors,improve the blood donation experience,and retain blood donors.Methods:A total of 316 blood donors from the Xi'an Central Blood Bank from June to September 2022 were selected to statistically analyze VVR-related factors.A BP neural network prediction model is established with relevant factors as input and DRVR risk as output.Results:First-time blood donors had a high risk of VVR,female risk was high,and sex difference was significant(P value<0.05).The blood pressure before donation and intergroup differences were also significant(P value<0.05).After training,the established BP neural network model has a minimum RMS error of o.116,a correlation coefficient R=0.75,and a test model accuracy of 66.7%.Conclusion:First-time blood donors,women,and relatively low blood pressure are all high-risk groups for VVR.The BP neural network prediction model established in this paper has certain prediction accuracy and can be used as a means to evaluate the risk degree of clinical blood donors.

Study on Remote Sensing of Water Depths Based on BP Artificial Neural Network

A momentum BP neural network model （MBPNNM） was constructed to retrieve the water depth information for the South Channel of the Yangtze River Estuary using the relationship between the reflectance derived from Landsat 7 satellite data and the water depth information. Results showed that MBPNNM, which exhibited a strong capability of nonlinear mapping, allowed the water depth information in the study area to be retrieved at a relatively high level of accuracy. Affected by the sediment concentration of water in the estuary, MBPNNM enabled the retrieval of water depth of less than 5 meters accurately. However, the accuracy was not ideal for the water depths of more than 10 meters.

Quantitative Detection Model of Pernicious Gases in Pig House Based on BP Neural Network

To find a neural network model suitable to identify the concentration of mixed pernicious gases in pig house, the quantitative detection model of pernicious gases in pig house was set up based on BP （ Back propagation） neural network. The BP neural network was trained separately by the three functions, trainbr, traingdm and trainlm, in order to identify the concentration of mixed pernicious gases composed of ammonia gas and hepatic gas. The neural network toolbox in MATLAB software was used to simulate the detection. The results showed that the neural network trained by trainbr function has high average identification accuracy and faster detection speed, and it is also insensitive to noise; therefore, it is suitable to identify the concentration of pemidous gases in pig house. These data provide a reference for intelligent monitoring of pemicious gases in pigsty.

Study on the Model of Excessive Staminate Catkin Thinning of Proterandrous Walnut Based on Quadratic Polynomial Regression Equation and BP Artificial Neural Network

The excessive staminate catkin thinning （emasculation） of proterandrous walnut is an important management measure for improving yield. To improve the excessive staminate catkin thinning efficiency, the model of quadratic polynomial regression equation and BP artificial neural network was developed. The effects of ethephon, gibberel in and mepiquat on shedding rate of staminate catkin of pro-terandrous walnut were investigated by modeling field test. Based on the modeling test results, the excessive staminate catkin thinning model of quadratic polynomial regression equation and BP artificial neural network was established, and it was validated by field test next year. The test data were divided into training set, vali-dation set and test set. The total 20 sets of data obtained from the modeling field test were randomly divided into training set （17） and validation set （3） by central composite design （quadric rotational regression test design）, and the data obtained from the next-year field test were divided into the test set. The topological struc-ture of BP artificial neural network was 3-5-1. The results showed that the pre-diction errors of BP neural network for samples from the validation set were 1.355 0%, 0.429 1% and 0.353 8%, respectively; the difference between the predicted value by the BP neural network and validated value by field test was 2.04%, and the difference between the predicted value by the regression equation and validated value by field test was 3.12%; the prediction accuracy of BP neural network was over 1.0% higher than that of regression equation. The effective combination of quadratic polynomial stepwise regression and BP artificial neural network wil not only help to determine the effect of independent parameter but also improve the prediction accuracy.

Prediction of Injection-Production Ratio with BP Neural Network

Injection of water to enhance oil production is commonplace, and improvements in understanding the process are economically important. This study examines predictive models of the injection-to-production ratio. Firstly, the error between the fitting and actual injection-production ratio is calculated with such methods as the injection-production ratio and water-oil ratio method, the material balance method, the multiple regression method, the gray theory GM (1,1) model and the back-propogation (BP) neural network method by computer applications in this paper. The relative average errors calculated are respectively 1.67%, 1.08%, 19.2%, 1.38% and 0.88%. Secondly, the reasons for the errors from different prediction methods are analyzed theoretically, indicating that the prediction precision of the BP neural network method is high, and that it has a better self-adaptability, so that it can reflect the internal relationship between the injection-production ratio and the influencing factors. Therefore, the BP neural network method is suitable to the prediction of injection-production ratio.

基于小波变换和GA-BP神经网络的电力电缆故障定位

由于电力电缆敷设于地下,当发生故障时难以快速且准确定位,出现了故障定位问题。因此,提出一种基于小波变换和遗传算法反向传播(Genetic algorithm back propagation,GA-BP)神经网络的电力电缆故障定位方法,在分析对比各小波能量集中程度和波动次数的基础上,选择多贝西小波(Daubechies wavelet 6,Db6)作为小波基函数,对于各故障位置,采集正向故障行波的α模分量,并对其进行小波分解。选取在d1尺度下的模极大值点作为特征值,同时将故障距离作为标签值,从而构建了训练和测试样本数据集;利用遗传算法(Genetic algorithm,GA)的种群进化和全局最优搜寻能力来改善误差逆传播(Back propagation,BP)网络对初始权重敏感的缺点,并使用优化后的权值、阈值重新对BP神经网络进行训练和预测,最后通过与传统双端行波定位算法、BP算法、粒子群优化BP算法(Particle swarm optimization BP,PSO-BP)相比较,证明了所提方法在测距性能方面的优越性。

正交实验结合AHP和GA-BP神经网络优化益黄散醇提工艺

目的 优化益黄散的醇提工艺。方法 采用回流提取法,以乙醇体积分数、液料比、提取时间为考察因素设计正交实验,以橙皮苷、川陈皮素、橘皮素、没食子酸、诃黎勒酸、诃子酸、甘草苷、甘草酸、丁香酚含量和干浸膏得率为指标,采用层次分析法(AHP)进行赋权并计算综合评分。通过验证正交实验和遗传算法(GA)-反向传播神经网络(BP神经网络)所预测的结果确定益黄散最佳醇提工艺参数。结果 正交实验优选的最佳醇提工艺参数为乙醇体积分数60%、液料比14∶1(mL/g)、提取时间90 min、提取2次,验证所得综合评分为79.19分;GA-BP神经网络优选的最佳醇提工艺参数为乙醇体积分数65%、液料比14∶1(mL/g)、提取时间60 min、提取2次,验证所得综合评分为85.30分,高于正交实验所得结果。结论 采用正交实验结合GA-BP神经网络的寻优方法较传统的正交实验寻优方法效果更佳,其优选出的益黄散最佳醇提工艺稳定可靠。

基于BP神经网络的测量设备无关协议参数预测

针对传统参数优化方法计算开销大,不能满足实时性要求高、计算量大等应用场景的问题,结合当今主流的机器学习方法,提出了一种改进的基于BP神经网络的参数优化方法,利用本地搜索算法的数据训练网络并对参数进行预测,替代传统的查找算法,从而获得更好的实时性和更低的计算复杂度,随后与基于随机森林和XGBoost的方法进行了比较。仿真结果表明,BP神经网络预测所得各参数的均方误差数量级为10^(-6)或更小,由该参数计算所得密钥生成率与最优密钥生成率比值的均值为0.998 8,且该应用中BP神经网络相对随机森林和XGBoost具有更好的预测性能。

基于BP神经网络的九寨沟地区地震滑坡危险性预测研究

BP神经网络因具有良好的精度和拟合能力,被广泛地运用在区域性滑坡危险性预测中。本文建立了基于BP神经网络的地震滑坡危险性评价模型并应用于四川九寨沟地区,以2017年8月8日的九寨沟MS7.0地震引发的4834个历史滑坡为例,将其随机划分为70%的训练样本集用于九寨沟地区地震滑坡危险性预测,以及30%的验证样本集对预测结果的精度进行评估。选取高程、坡度、坡向、平行发震断层距离、垂直发震断层距离、震中距离、距道路距离、地面峰值加速度(PGA)以及岩性共9个影响因子,分析发震断层对地震滑坡的控制作用,并总结九寨沟地区地震滑坡空间分布规律特征,其中发震断层、岩性和坡度对九寨沟地区地震滑坡分布产生重要影响。利用模型得到九寨沟地震滑坡危险性预测图,结果显示73.19%的滑坡位于极高和高危险区域,与实际地震滑坡分布基本相符。通过30%的验证样本集来绘制预测成功率曲线,结果表明模型预测成功率(AUC值)为0.90,证实了BP神经网络在九寨沟地区地震滑坡危险性预测中具有良好的精度和拟合能力,评价结果为后续地震滑坡灾害预测和防震减灾工作提供了科学的参考。

基于PSO-BP神经网络的分拣机器人视觉反馈跟踪

针对分拣机器人视觉反馈跟踪精度差、耗时较长的问题,研究基于粒子群算法-反向传播(particle swarm optimization-back propagation,PSO-BP)神经网络的分拣机器人视觉反馈跟踪方法,以提升视觉反馈跟踪效果。依据分拣机器人的视觉反馈信息,建立分拣机器人运动学模型,并求解分拣机器人机械臂输出位置和输入位置的误差函数;利用PSO算法优化BP神经网络的权值与偏置;在权值与偏置优化后的BP神经网络内,输入误差函数,预测分拣机器人视觉反馈跟踪控制量;利用预测视觉反馈跟踪控制量,在线调整增量式比例-积分-微分(proportional-integral-derivative,PID)的参数,输出高精度的分拣机器人视觉反馈跟踪控制量,实现分拣机器人视觉反馈跟踪。实验结果表明,该方法可有效视觉反馈跟踪分拣机器人机械臂的关节角;存在干扰情况下,在运行时间为10 s左右时,阶跃响应趋于稳定;有干扰情况下,视觉反馈跟踪的平均误差为0.09 cm,耗时平均值为0.10 ms;无干扰情况下,平均误差为0.03 cm,耗时平均值为0.04 ms。

基于BP神经网络的高桩码头基桩损伤识别研究

针对高桩码头基桩的损伤识别问题,基于BP神经网络开展了损伤定位研究。传统损伤定位方法在识别过程中受到人为主观因素的干扰,且对于只有一阶模态数据的情况定位效果有限。为克服这些问题,构建了不受人为因素影响的损伤定位神经网络,以第三类损伤指标ULSC和δFC作为训练样本,实现了对基桩局部损伤的准确定位。在建立合理的高桩码头有限元模型的基础上,构建了基于BP神经网络的损伤定位模型,并使用ABAQUS模拟数据和实测振动信号数据进行训练和测试。实验结果表明,该神经网络模型具有较高的定位准确性和鲁棒性,在不同损伤工况和10%噪声水平下仍表现优异。

基于GRU-CNN双网络输出构建BP模型的径流预测方法

提高径流预测精度是避免洪水灾害发生的重要手段,由于预测阶段并无已知有效样本,给预测工作带来难度,因此,提出以双网络输出为预测阶段提供数据参考,结合训练阶段双网络输出与真实值之间的关系,对预测阶段采用二次多变量建模实现径流预测。首先,构建GRU和CNN深度学习网络,同步输出2条径流预测序列;其次,在已知时段内,构建2条预测结果与实测值之间的多变量BP模型;最后,基于双网络输出预测值,通过确定的BP模型输出径流预测结果。经测试,该方法给预测时段提供了可靠的先验样本,高效学习了网络输出与真实值之间关系,预测精度显著提升。

基于拌和生产数据的BP神经网络混凝土抗压强度预测

为解决混凝土生产中抗压强度试验周期长及工程管理存在滞后性的问题,提出了一种基于混凝土拌和生产实时监控数据的BP神经网络混凝土抗压强度预测模型。以混凝土拌和生产中的8项物料生产称重数据和5项生产配比数据作为预测输入变量,建立200组混凝土拌和站生产监控数据和对应的抗压强度试验数据样本集,按照6∶2∶2比例划分为训练集、验证集和测试集;分别以C40配比混凝土拌和生产的8项物料称重数据和全部13项数据作为输入变量,进行混凝土28 d抗压强度预测,将预测结果与实际试验结果进行比较,验证所提出BP神经网络模型的预测效果。结果表明:所提出的BP神经网络混凝土强度预测模型能较好地实时预测混凝土28 d抗压强度,且相对误差优于利用7 d抗压强度试验数据估算值;8项物料称重数据作为输入变量的BP神经网络预测模型预测精度更好,平均绝对百分比误差为0.82%,均方根误差为0.52 MPa;利用不同拌和站C20配比、C30配比混凝土拌和生产监控数据对8项输入变量BP神经网络混凝土抗压强度预测模型进行适应性验证可知,其预测平均绝对误差均在0.5 MPa之内,平均绝对百分比误差均小于2%,与C40配比预测误差一致;该预测模型充分挖掘了混凝土拌和站生产实时监控数据的价值,实现了传统混凝土抗压试验结果提前化,对提高工程建设质量水平具有重要意义。

基于CSSA-BPNN模型的胶结充填体动态抗压强度预测

充填采矿法二步骤回采时胶结充填体稳定性受爆破扰动而降低。为快速准确地获得充填体动态抗压强度,利用分离式霍普金森压杆(SHPB)进行了40组不同应变率的单轴冲击实验,以灰砂比、充填体密度、养护龄期和平均应变率作为输入参数,充填体动态抗压强度作为输出参数,建立了一种基于Logistic混沌麻雀搜索算法(CSSA)优化BP神经网络(BPNN)的预测模型,并与传统BPNN和麻雀搜索算法优化的BPNN进行了对比分析。结果表明:CSSA-BPNN模型的平均相对误差为4.11%,预测值与实测值之间拟合的相关系数均在0.96以上,模型预测精度高。CSSA-BPNN模型的均方根误差为0.395 0 MPa,平均绝对误差为0.359 2 MPa,决定系数为0.995 2,均优于另外两种预测模型。实现了对充填体动态抗压强度的准确预测,可大幅减小物理实验量,为矿山胶结充填体的强度设计提供了一种新方法。

采用改进BP-PID控制的机器人避障仿真研究

针对移动机器人避障过程中行驶路径长、寻路速度慢等问题,提出了一种改进反向传播-比例-积分-微分(BP-PID)控制器,并对移动机器人避障效果进行仿真验证。利用移动机器人在二维坐标系的避障简图,得出了移动机器人运动方程式。引用比例-积分-微分(PID)控制器和3层BP神经网络结构,利用BP神经网络的学习能力调整PID控制器参数。引用粒子群算法进行改进,通过改进粒子群算法在线优化BP-PID控制器,确保移动机器人BP-PID控制器收敛于全局最优值,从而使移动机器人避障效果更好。在不同环境中,采用Matlab软件对移动机器人避障效果进行仿真,比较改进前和改进后的移动机器人避障效果。结果显示:在不同环境中,改进前和改进后的BP-PID控制器均能使移动机器人安全地躲避障碍物;但是采用改进的粒子群算法优化BP-PID控制器,可以使移动机器人运动路径更短,迭代次数更少,搜索时间更短。采用改进BP-PID控制器,能够提高移动机器人避障过程中寻路速度,缩短行驶路径,效果更好。

双循环背景下石化企业供应链韧性评价研究——基于AHP-BP方法

随着环境不确定性的提高,中国石化企业供应链稳定性需求日渐攀升,供应链韧性评价已经成为判断石化企业风险应对能力的重要手段。基于双循环背景,通过构建石化企业供应链韧性评估指标体系,利用层次分析法和BP神经网络,对石化企业供应链韧性强度进行评估,确定了供应链韧性水平。结果表明,各石化企业的供应链韧性强度存在较大差异,供应链韧性整体水平偏低。在研究结果的基础上,对韧性供应链锻造提出了切实可行的建议。

基于泥水平衡盾构掘进参数的PSO-BP神经网络掘进地层识别模型研究

为解决泥水平衡盾构机在掘进时无法准确地实时识别掘进地层的问题,以珠三角水资源配置工程为例,研究泥水平衡盾构机的盾构推力、掘进速度、刀盘转速、刀盘扭矩在不同地层下的变化规律,提出基于掘进参数的PSO-BP神经网络掘进地层识别方法,建立盾构推力、掘进速度、刀盘转速、刀盘扭矩4种掘进参数为输入集,地层编码为输出集的地层识别模型。工程数据的验证结果表明,该模型在珠三角水资源配置工程数据集上的掘进地层的识别准确率达99.07%,PSO-BP神经网络算法的识别准确率明显高于BP、RF、RBF、CNN等机械学习算法。