Prion diseases are infectious and fatal neurodegenerative diseases.The pathogenic agent is an abnormal prion protein aggregate.Microglial activation in the centre nervous system is a characteristic feature of prion di...Prion diseases are infectious and fatal neurodegenerative diseases.The pathogenic agent is an abnormal prion protein aggregate.Microglial activation in the centre nervous system is a characteristic feature of prion disease.In this study,we examined the effect of PrP 106-126 on PrP mRNA gene expression in Mouse microglia cells BV-2 by real-time quantitative PCR.PrP mRNA expression level was found to be significantly increased after 18 h exposure of BV-2 cells to PrP 106-126,with 3-fold increase after 18 h and 4.5-fold increase after 24 h and BV-2 cells proliferating occurred correspondingly.Our results provide the first in vitro evidence of the increase of PrP mRNA levels in microglial cells exposed to PrP 106-126,and indicate that microglial cells might play a critical role in prion pathogenesis.展开更多
2004年7月6~15日,我们应邀赴俄罗斯圣彼得堡市参加了第11届国际振动与噪声学术会议(ICSV11)。国际振动与噪声会议ICSV(International Congress on Sound and Vibration)始创于1994年,每年召开一次,是声学与振动领域最重要的学...2004年7月6~15日,我们应邀赴俄罗斯圣彼得堡市参加了第11届国际振动与噪声学术会议(ICSV11)。国际振动与噪声会议ICSV(International Congress on Sound and Vibration)始创于1994年,每年召开一次,是声学与振动领域最重要的学术会议之一。ICSV11由俄罗斯噪声与振动控制学会和波罗的海州立技术大学主办,俄罗斯声学学会、俄罗斯教育部东欧声学学会、美国机械工程学会和圣彼得鲣市政府协办,有55个国家和地区共500余人参会。会议共收到学术论文700余篇,结集出版了会议论文全文集、摘要集和有关CD光盘。大会除安排论文宣读、专家讲座、会议代表交流等活动外,还邀请丹麦B&K公司、Microflown Technologies BV公司等世界著名厂商展示了其最新研制开发的振动噪声测量、分析、监测诊断仪器设备及其软件系统,并组织与会代表参观了俄罗斯历史博物馆、沙俄时期古建筑和圣彼得堡市建市300周年庆祝活动。展开更多
Amorphous Ni-Ru-B/ZrO_2 catalyst was prepared by the means of chemical reduction,and selective CO methanation as a strategy for CO removal in fuel processing applications was investigated over the amorphous Ni-Ru-B/Zr...Amorphous Ni-Ru-B/ZrO_2 catalyst was prepared by the means of chemical reduction,and selective CO methanation as a strategy for CO removal in fuel processing applications was investigated over the amorphous Ni-Ru-B/ZrO_2 catalyst.The result showed that,at the temperature of 210-230℃,the catalyst was shown to be capable of reducing CO in a hydrogen-rich reformate to less than 10 ppm,while keeping the CO_2 conversion below 1.55%and the hydrogen consumption below 6.50%.展开更多
基金National Natural Science Foundations ofChina (30871854)National Science and Technology Supporting Program of China (2006BAD06A13)
文摘Prion diseases are infectious and fatal neurodegenerative diseases.The pathogenic agent is an abnormal prion protein aggregate.Microglial activation in the centre nervous system is a characteristic feature of prion disease.In this study,we examined the effect of PrP 106-126 on PrP mRNA gene expression in Mouse microglia cells BV-2 by real-time quantitative PCR.PrP mRNA expression level was found to be significantly increased after 18 h exposure of BV-2 cells to PrP 106-126,with 3-fold increase after 18 h and 4.5-fold increase after 24 h and BV-2 cells proliferating occurred correspondingly.Our results provide the first in vitro evidence of the increase of PrP mRNA levels in microglial cells exposed to PrP 106-126,and indicate that microglial cells might play a critical role in prion pathogenesis.
文摘2004年7月6~15日,我们应邀赴俄罗斯圣彼得堡市参加了第11届国际振动与噪声学术会议(ICSV11)。国际振动与噪声会议ICSV(International Congress on Sound and Vibration)始创于1994年,每年召开一次,是声学与振动领域最重要的学术会议之一。ICSV11由俄罗斯噪声与振动控制学会和波罗的海州立技术大学主办,俄罗斯声学学会、俄罗斯教育部东欧声学学会、美国机械工程学会和圣彼得鲣市政府协办,有55个国家和地区共500余人参会。会议共收到学术论文700余篇,结集出版了会议论文全文集、摘要集和有关CD光盘。大会除安排论文宣读、专家讲座、会议代表交流等活动外,还邀请丹麦B&K公司、Microflown Technologies BV公司等世界著名厂商展示了其最新研制开发的振动噪声测量、分析、监测诊断仪器设备及其软件系统,并组织与会代表参观了俄罗斯历史博物馆、沙俄时期古建筑和圣彼得堡市建市300周年庆祝活动。
基金supported by the grant from The National Natural Science Foundation of China(No.30725048)National Basic Research Program of China(No.2009CB522303)the Foundation of Chinese Academy of Sciences(West Light Program).
基金supported by the National Natural Science Foundation of China(No.20576023)the Guangdong Province Natural Science Foundation(No.06025660).
文摘Amorphous Ni-Ru-B/ZrO_2 catalyst was prepared by the means of chemical reduction,and selective CO methanation as a strategy for CO removal in fuel processing applications was investigated over the amorphous Ni-Ru-B/ZrO_2 catalyst.The result showed that,at the temperature of 210-230℃,the catalyst was shown to be capable of reducing CO in a hydrogen-rich reformate to less than 10 ppm,while keeping the CO_2 conversion below 1.55%and the hydrogen consumption below 6.50%.
基金supported by the Scientific Research Fund of Fujian Provincial Department of Science &Technology(No.2008Y0086)the Traditional Chinese Medicine Research Fund of Fujian Provincial Public Health Bureau(No.wzy0606),China