A coupled Navier-Stokes/free-wake method is developed to predict the rotor aerodynamics and wake.The widely-used Farassat 1 Aformulation is adopted to predict the rotor noise.In the coupled method,the Reynolds-average...A coupled Navier-Stokes/free-wake method is developed to predict the rotor aerodynamics and wake.The widely-used Farassat 1 Aformulation is adopted to predict the rotor noise.In the coupled method,the Reynolds-averaged Navier-Stokes(RANS)solver is established to simulate complex aerodynamic phenomena around blade and the tip-wake is captured by a free-wake model without numerical dissipation in the off-body wake zone.To overcome the time-consuming of the coupling strategy in previous studies,a more efficient coupling strategy is presented,by which only the induced velocity on the outer boundary grid need to be calculated.In order to obtain blade control settings,a delta trimming procedure is developed,which is more efficient than traditional trim method in the calculation of Jacobian matrix.Several flight conditions are simulated to demonstrate the validity of the coupled method.Then the rotor noise of operational load survey(OLS)is studied by the developed method as an application and the computational results are shown to be in good agreements with the available experimental data.展开更多
2006年10月9日证监公司字[2006]220号Globe Union lndustrial(BVl)Crop.欧阳明、欧阳磊、欧阳玄:你公司及其一致行动人报送的《深圳成霖洁具股份有限公司收购报告书》和《关于GOBO-BVI等收购人豁免要约收购的申请》及相关文件收悉。根...2006年10月9日证监公司字[2006]220号Globe Union lndustrial(BVl)Crop.欧阳明、欧阳磊、欧阳玄:你公司及其一致行动人报送的《深圳成霖洁具股份有限公司收购报告书》和《关于GOBO-BVI等收购人豁免要约收购的申请》及相关文件收悉。根据《证券法》、《上市公司收购管理办法》(证监会令第10号)的有关规定,经审核,现批复如下:展开更多
背景与目的最新的研究发现Ⅰ期非小细胞肺癌(NSCLC)术后辅助化疗可提高患者生存率,因此通过预后分层筛选高危患者给予辅助治疗,既可改善Ⅰ期NSCLC患者的整体预后,又可避免因过度治疗对低危患者造成损害,是目前临床急需解决的问题。本研...背景与目的最新的研究发现Ⅰ期非小细胞肺癌(NSCLC)术后辅助化疗可提高患者生存率,因此通过预后分层筛选高危患者给予辅助治疗,既可改善Ⅰ期NSCLC患者的整体预后,又可避免因过度治疗对低危患者造成损害,是目前临床急需解决的问题。本研究旨在探讨肿瘤血管生成和血管浸润(BVI)对Ⅰ期NSCLC预后的影响,建立Ⅰ期NSCLC预后模型。方法回顾性分析118例Ⅰ期NSCLC手术患者的临床病理资料,免疫组织化学检测血管内皮生长因子(VEGF)的表达水平,计算肿瘤内微血管密度(MVD)。以CD34标记的血管腔内瘤细胞的存在判定为BVI。结果肺癌组织VEGF低表达44例(37.3%),高表达74例(62.7%)。VEGF高表达组MVD显著高于低表达组(33.4±17.8vs24.7±14.8,P=0.010),VEGF与MVD间存在正相关(r=0.216,P=0.019)。VEGF高表达患者5年生存率显著低于低表达者(36.48% vs 72.20%,P=0.003)。无BVI者86例(72.9%),BVI者32例(27.1%),后者5年生存率显著低于前者(34.38% vs 60.47%,P=0.018)。多因素分析结果表明VEGF高表达(RR=2.96,P=0.001)和BVI(RR=1.95,P=0.020)为Ⅰ期NSCLC的独立预后因素。进一步根据VEGF表达及BVI情况,将患者分为低度危险组:VEGF低表达+BVI(-);中度危险组:VEGF高表达或BVI(+);高度危险组:VEGF高表达+BVI(+)。三组间5年生存率差异有统计学意义(72.28% vs 52.63% vs 28.00%,P=0.001)。结论VEGF表达与BVI的联合检测可能实现对Ⅰ期NSCLC进行预后分层,为术后患者的个性化治疗提供依据。展开更多
文摘A coupled Navier-Stokes/free-wake method is developed to predict the rotor aerodynamics and wake.The widely-used Farassat 1 Aformulation is adopted to predict the rotor noise.In the coupled method,the Reynolds-averaged Navier-Stokes(RANS)solver is established to simulate complex aerodynamic phenomena around blade and the tip-wake is captured by a free-wake model without numerical dissipation in the off-body wake zone.To overcome the time-consuming of the coupling strategy in previous studies,a more efficient coupling strategy is presented,by which only the induced velocity on the outer boundary grid need to be calculated.In order to obtain blade control settings,a delta trimming procedure is developed,which is more efficient than traditional trim method in the calculation of Jacobian matrix.Several flight conditions are simulated to demonstrate the validity of the coupled method.Then the rotor noise of operational load survey(OLS)is studied by the developed method as an application and the computational results are shown to be in good agreements with the available experimental data.
文摘2006年10月9日证监公司字[2006]220号Globe Union lndustrial(BVl)Crop.欧阳明、欧阳磊、欧阳玄:你公司及其一致行动人报送的《深圳成霖洁具股份有限公司收购报告书》和《关于GOBO-BVI等收购人豁免要约收购的申请》及相关文件收悉。根据《证券法》、《上市公司收购管理办法》(证监会令第10号)的有关规定,经审核,现批复如下:
文摘背景与目的最新的研究发现Ⅰ期非小细胞肺癌(NSCLC)术后辅助化疗可提高患者生存率,因此通过预后分层筛选高危患者给予辅助治疗,既可改善Ⅰ期NSCLC患者的整体预后,又可避免因过度治疗对低危患者造成损害,是目前临床急需解决的问题。本研究旨在探讨肿瘤血管生成和血管浸润(BVI)对Ⅰ期NSCLC预后的影响,建立Ⅰ期NSCLC预后模型。方法回顾性分析118例Ⅰ期NSCLC手术患者的临床病理资料,免疫组织化学检测血管内皮生长因子(VEGF)的表达水平,计算肿瘤内微血管密度(MVD)。以CD34标记的血管腔内瘤细胞的存在判定为BVI。结果肺癌组织VEGF低表达44例(37.3%),高表达74例(62.7%)。VEGF高表达组MVD显著高于低表达组(33.4±17.8vs24.7±14.8,P=0.010),VEGF与MVD间存在正相关(r=0.216,P=0.019)。VEGF高表达患者5年生存率显著低于低表达者(36.48% vs 72.20%,P=0.003)。无BVI者86例(72.9%),BVI者32例(27.1%),后者5年生存率显著低于前者(34.38% vs 60.47%,P=0.018)。多因素分析结果表明VEGF高表达(RR=2.96,P=0.001)和BVI(RR=1.95,P=0.020)为Ⅰ期NSCLC的独立预后因素。进一步根据VEGF表达及BVI情况,将患者分为低度危险组:VEGF低表达+BVI(-);中度危险组:VEGF高表达或BVI(+);高度危险组:VEGF高表达+BVI(+)。三组间5年生存率差异有统计学意义(72.28% vs 52.63% vs 28.00%,P=0.001)。结论VEGF表达与BVI的联合检测可能实现对Ⅰ期NSCLC进行预后分层,为术后患者的个性化治疗提供依据。
