This paper presents an attempt at assimilating clear-sky FY-4A Advanced Geosynchronous Radiation Imager(AGRI)radiances from two water vapor channels for the prediction of three landfalling typhoon events over the West...This paper presents an attempt at assimilating clear-sky FY-4A Advanced Geosynchronous Radiation Imager(AGRI)radiances from two water vapor channels for the prediction of three landfalling typhoon events over the West Pacific Ocean using the 3DVar data assimilation(DA)method along with the WRF model.A channel-sensitive cloud detection scheme based on the particle filter(PF)algorithm is developed and examined against a cloud detection scheme using the multivariate and minimum residual(MMR)algorithm and another traditional cloud mask–dependent cloud detection scheme.Results show that both channel-sensitive cloud detection schemes are effective,while the PF scheme is able to reserve more pixels than the MMR scheme for the same channel.In general,the added value of AGRI radiances is confirmed when comparing with the control experiment without AGRI radiances.Moreover,it is found that the analysis fields of the PF experiment are mostly improved in terms of better depicting the typhoon,including the temperature,moisture,and dynamical conditions.The typhoon track forecast skill is improved with AGRI radiance DA,which could be explained by better simulating the upper trough.The impact of assimilating AGRI radiances on typhoon intensity forecasts is small.On the other hand,improved rainfall forecasts from AGRI DA experiments are found along with reduced errors for both the thermodynamic and moisture fields,albeit the improvements are limited.展开更多
Infections with multidrug-resistant(MDR)Gram-negative bacteria,such as MDR Escherichia coli(E.coli),remain a challenge due to the lack of safe antibiotics and high fatality rates under anti-infection therapies.This wo...Infections with multidrug-resistant(MDR)Gram-negative bacteria,such as MDR Escherichia coli(E.coli),remain a challenge due to the lack of safe antibiotics and high fatality rates under anti-infection therapies.This work presents a form of biomimetic intelligent catalysis inspired by the selective biocatalytic property of macrophages(MΦs),consisting of an intelligent controlling center(a living MΦ)and a Fenton reaction catalyst(Fe_(3)O_(4)@poly(lactic-co-glycolic acid)(PLGA)nanoparticles)for killing MDR E.coli without harming normal cells.The MΦ-Fe_(3)O_(4)@PLGA particles(i.e.,the intelligent catalysis particles)exhibit selective biocatalysis activity toward MDR E.coli by producing H_(2)O_(2) and lipid droplets(LDs).This process activates the lipid metabolism and glycan biosynthesis and metabolism pathways based on the result of RNA sequencing data analysis.The H_(2)O_(2) further reacts with Fe_(3)O_(4)@PLGA to form highly toxic hydroxyl radicals(·OH),while the LDs contain antimicrobial peptides and can target MDR E.coli.The highly toxicOH and antimicrobial peptides are shown to combat with MDR E.coli,such that the antibacterial efficiency of the MΦ-Fe_(3)O_(4)@PLGA particles against MDR E.coli is 99.29%±0.31%in vitro.More importantly,after several passages,the intelligent catalysis function of the MΦ-Fe_(3)O_(4)@PLGA particles is well maintained.Hence,the concept of biomimetic intelligent catalysts displays potential for treating diseases other than infections.展开更多
Fe3O4 magnetic nanoparticles were prepared by the aqueous co-precipitation of FeCl3-6H2O and FeCl2-4H2O with addition of ammonium hydroxide. The conditions for the preparation of Fe3O4 magnetic nanoparticles were opti...Fe3O4 magnetic nanoparticles were prepared by the aqueous co-precipitation of FeCl3-6H2O and FeCl2-4H2O with addition of ammonium hydroxide. The conditions for the preparation of Fe3O4 magnetic nanoparticles were optimized, and Fe3O4 magnetic nanoparticles obtained were characterized systematically by means of transmission electron microscope （TEM）, dynamic laser scattering analyzer （DLS） and X-ray diffraction （XRD）. The results revealed that the magnetic nanoparticles were cubic shaped and dispersive, with narrow size distribution and average diameter of 11.4 nm. It was found that the homogeneous variation of pH value in the solution via the control on the dropping rate of aqueous ammonia played a critical role in size distribution. The magnetic response of the product in the magnetic field was also analyzed and evaluated carefully. A 32.6 mT magnetic field which is produced by four ferromagnets was found to be sufficient to excite the dipole moments of 0.05 g Fe3O4 powder 2 cm far away from the ferromagnets. In conclusion, the Fe3O4 magnetic nanoparticles with excellent properties were competent for the magnetic carders of targeted-drug in future application.展开更多
A novel liquid settling method was investigated and applied to fabricate TC4 spherical particle reinforced AZ91 alloy matrix composites.This method was called liquid state settling technique in which TC4 particles wou...A novel liquid settling method was investigated and applied to fabricate TC4 spherical particle reinforced AZ91 alloy matrix composites.This method was called liquid state settling technique in which TC4 particles would settle down under the force of gravity.High volume fraction(50%)particle reinforced AZ91 composites could be easily obtained via this novel method.This is difficult to achieve for other traditional liquid fabrication methods.In addition,there was a good dispersion of TC4 particles in the AZ91 matrix and no clusters were found,which indicate that this method was feasible.Interfacial reaction occurred and the reaction product was confirmed to be Al2Ti.Three kinds of pre-dispersion technologies were used before the settling process and different interfacial microstructures were found.Theoretical calculation and experimental results both indicated that the interfacial product which was embedded in the matrix strengthened the composites and improved the tensile strength.展开更多
Friction stir processing of AA6061-T4 alloy with SiC particles was successfully carried out.SiC particles were uniformly dispersed into an AA6061-T4 matrix.Also SiC particles promoted the grain refinement of the AA606...Friction stir processing of AA6061-T4 alloy with SiC particles was successfully carried out.SiC particles were uniformly dispersed into an AA6061-T4 matrix.Also SiC particles promoted the grain refinement of the AA6061-T4 matrix by FSP.The mean grain size of the stir zone (SZ) with the SiC particles was obviously smaller than that of the stir zone without the SiC particles.The microhardness of the SZ with the SiC particles reached about HV80 due to the grain refinement and the distribution of the SiC particles.展开更多
A facile and practical route was introduced to prepare LiFePO4/C cathode material with nano-sized primary particles and excellent electrochemical performance. LiH2PO4 was synthesized by using H3PO4 and LiOH as raw mat...A facile and practical route was introduced to prepare LiFePO4/C cathode material with nano-sized primary particles and excellent electrochemical performance. LiH2PO4 was synthesized by using H3PO4 and LiOH as raw materials. Then, as-prepared LiH2PO4, reduced iron powder andα-D-glucose were ball-milled, dried and sin-tered to prepare LiFePO4/C. X-ray diffractometry was used to characterize LiH2PO4, ball-milled product and LiFePO4/C. Differential scanning calorimeter-thermo gravimetric analysis was applied to investigate possible reac-tions in sintering and find suitable temperature for LiFePO4 formation. Scanning electron microscopy was em-ployed for the morphology of LiFePO4/C. As-prepared LiH2PO4 is characterized to be in P21cn（33） space group, which reacts with reduced iron powder to form Li3PO4, Fe3（PO4）2 and H2 in ball-milling and sintering. The appro-priate temperature for LiFePO4/C synthesis is 541.3-976.7 ℃. LiFePO4/C prepared at 700 ℃ presents nano-sized primary particles forming aggregates. Charge-discharge examination indicates that as-prepared LiFePO4/C displays appreciable discharge capacities of 145 and 131 mA·h·g^-1 at 0.1 and 1 C respectively and excellent discharge ca-pacity retention.展开更多
基金primarily supported by the Chinese National Natural Science Foundation of China(Grant No. G42192553)Open Fund of Fujian Key Laboratory ofSevere Weather and Key Laboratory of Straits Severe Weather(Grant No. 2023KFKT03)+6 种基金the Open Project Fund of China Meteorological Administration Basin Heavy Rainfall Key Laboratory(Grant No. 2023BHR-Y20)the Open Fund of the State Key Laboratory of Remote Sensing Science (Grant No. OFSLRSS202321)the Program of Shanghai Academic/Technology Research Leader(Grant No. 21XD1404500)the Shanghai Typhoon Research Foundation (Grant No. TFJJ202107)the Chinese National Natural Science Foundation of China (Grant No. G41805016)the National Meteorological Center Foundation (Grant No. FY-APP-2021.0207)the High Performance Computing Center of Nanjing University of Information Science&Technology for their support of this work
文摘This paper presents an attempt at assimilating clear-sky FY-4A Advanced Geosynchronous Radiation Imager(AGRI)radiances from two water vapor channels for the prediction of three landfalling typhoon events over the West Pacific Ocean using the 3DVar data assimilation(DA)method along with the WRF model.A channel-sensitive cloud detection scheme based on the particle filter(PF)algorithm is developed and examined against a cloud detection scheme using the multivariate and minimum residual(MMR)algorithm and another traditional cloud mask–dependent cloud detection scheme.Results show that both channel-sensitive cloud detection schemes are effective,while the PF scheme is able to reserve more pixels than the MMR scheme for the same channel.In general,the added value of AGRI radiances is confirmed when comparing with the control experiment without AGRI radiances.Moreover,it is found that the analysis fields of the PF experiment are mostly improved in terms of better depicting the typhoon,including the temperature,moisture,and dynamical conditions.The typhoon track forecast skill is improved with AGRI radiance DA,which could be explained by better simulating the upper trough.The impact of assimilating AGRI radiances on typhoon intensity forecasts is small.On the other hand,improved rainfall forecasts from AGRI DA experiments are found along with reduced errors for both the thermodynamic and moisture fields,albeit the improvements are limited.
基金supported by the China National Funds for Distinguished Young Scientists (51925104)the National Natural Science Foundation of China (NSFC) (51871162 and 52173251)+1 种基金NSFC-Guangdong Province Joint Program (U21A2084)the Central Guidance on Local Science and Technology Development Fund of Hebei Province (226Z1303G).
文摘Infections with multidrug-resistant(MDR)Gram-negative bacteria,such as MDR Escherichia coli(E.coli),remain a challenge due to the lack of safe antibiotics and high fatality rates under anti-infection therapies.This work presents a form of biomimetic intelligent catalysis inspired by the selective biocatalytic property of macrophages(MΦs),consisting of an intelligent controlling center(a living MΦ)and a Fenton reaction catalyst(Fe_(3)O_(4)@poly(lactic-co-glycolic acid)(PLGA)nanoparticles)for killing MDR E.coli without harming normal cells.The MΦ-Fe_(3)O_(4)@PLGA particles(i.e.,the intelligent catalysis particles)exhibit selective biocatalysis activity toward MDR E.coli by producing H_(2)O_(2) and lipid droplets(LDs).This process activates the lipid metabolism and glycan biosynthesis and metabolism pathways based on the result of RNA sequencing data analysis.The H_(2)O_(2) further reacts with Fe_(3)O_(4)@PLGA to form highly toxic hydroxyl radicals(·OH),while the LDs contain antimicrobial peptides and can target MDR E.coli.The highly toxicOH and antimicrobial peptides are shown to combat with MDR E.coli,such that the antibacterial efficiency of the MΦ-Fe_(3)O_(4)@PLGA particles against MDR E.coli is 99.29%±0.31%in vitro.More importantly,after several passages,the intelligent catalysis function of the MΦ-Fe_(3)O_(4)@PLGA particles is well maintained.Hence,the concept of biomimetic intelligent catalysts displays potential for treating diseases other than infections.
基金the Technology Project of Jiangxi Provincial Education DepartmentJiangxi Provincial Science Department
文摘Fe3O4 magnetic nanoparticles were prepared by the aqueous co-precipitation of FeCl3-6H2O and FeCl2-4H2O with addition of ammonium hydroxide. The conditions for the preparation of Fe3O4 magnetic nanoparticles were optimized, and Fe3O4 magnetic nanoparticles obtained were characterized systematically by means of transmission electron microscope （TEM）, dynamic laser scattering analyzer （DLS） and X-ray diffraction （XRD）. The results revealed that the magnetic nanoparticles were cubic shaped and dispersive, with narrow size distribution and average diameter of 11.4 nm. It was found that the homogeneous variation of pH value in the solution via the control on the dropping rate of aqueous ammonia played a critical role in size distribution. The magnetic response of the product in the magnetic field was also analyzed and evaluated carefully. A 32.6 mT magnetic field which is produced by four ferromagnets was found to be sufficient to excite the dipole moments of 0.05 g Fe3O4 powder 2 cm far away from the ferromagnets. In conclusion, the Fe3O4 magnetic nanoparticles with excellent properties were competent for the magnetic carders of targeted-drug in future application.
基金the National Natural Science Foundation of China(Grant No.51471059).
文摘A novel liquid settling method was investigated and applied to fabricate TC4 spherical particle reinforced AZ91 alloy matrix composites.This method was called liquid state settling technique in which TC4 particles would settle down under the force of gravity.High volume fraction(50%)particle reinforced AZ91 composites could be easily obtained via this novel method.This is difficult to achieve for other traditional liquid fabrication methods.In addition,there was a good dispersion of TC4 particles in the AZ91 matrix and no clusters were found,which indicate that this method was feasible.Interfacial reaction occurred and the reaction product was confirmed to be Al2Ti.Three kinds of pre-dispersion technologies were used before the settling process and different interfacial microstructures were found.Theoretical calculation and experimental results both indicated that the interfacial product which was embedded in the matrix strengthened the composites and improved the tensile strength.
基金Project(10038688)supported by the Fundamental R&D Program for Core Technology of Materials Funded by the Ministry of Knowledge Economy,Republic of Korea
文摘Friction stir processing of AA6061-T4 alloy with SiC particles was successfully carried out.SiC particles were uniformly dispersed into an AA6061-T4 matrix.Also SiC particles promoted the grain refinement of the AA6061-T4 matrix by FSP.The mean grain size of the stir zone (SZ) with the SiC particles was obviously smaller than that of the stir zone without the SiC particles.The microhardness of the SZ with the SiC particles reached about HV80 due to the grain refinement and the distribution of the SiC particles.
基金Supported partially by the Natural Science Foundation of Yunnan Province(2010ZC051)Analysis and Testing Foundation(2009-041)Starting Research Fund(14118245) from Kunming University of Science and Technology
文摘A facile and practical route was introduced to prepare LiFePO4/C cathode material with nano-sized primary particles and excellent electrochemical performance. LiH2PO4 was synthesized by using H3PO4 and LiOH as raw materials. Then, as-prepared LiH2PO4, reduced iron powder andα-D-glucose were ball-milled, dried and sin-tered to prepare LiFePO4/C. X-ray diffractometry was used to characterize LiH2PO4, ball-milled product and LiFePO4/C. Differential scanning calorimeter-thermo gravimetric analysis was applied to investigate possible reac-tions in sintering and find suitable temperature for LiFePO4 formation. Scanning electron microscopy was em-ployed for the morphology of LiFePO4/C. As-prepared LiH2PO4 is characterized to be in P21cn（33） space group, which reacts with reduced iron powder to form Li3PO4, Fe3（PO4）2 and H2 in ball-milling and sintering. The appro-priate temperature for LiFePO4/C synthesis is 541.3-976.7 ℃. LiFePO4/C prepared at 700 ℃ presents nano-sized primary particles forming aggregates. Charge-discharge examination indicates that as-prepared LiFePO4/C displays appreciable discharge capacities of 145 and 131 mA·h·g^-1 at 0.1 and 1 C respectively and excellent discharge ca-pacity retention.
