Efficacy of Huangma Ding or autologous platelet-rich gel for the diabetic lower extremity arterial disease patients with foot ulcers

BACKGROUND Diabetes foot is one of the most serious complications of diabetes and an important cause of death and disability,traditional treatment has poor efficacy and there is an urgent need to develop a practical treatment method.AIM To investigate whether Huangma Ding or autologous platelet-rich gel(APG)treatment would benefit diabetic lower extremity arterial disease(LEAD)patients with foot ulcers.METHODS A total of 155 diabetic LEAD patients with foot ulcers were enrolled and divided into three groups:Group A(62 patients;basal treatment),Group B(38 patients;basal treatment and APG),and Group C(55 patients;basal treatment and Huangma Ding).All patients underwent routine follow-up visits for six months.After follow-up,we calculated the changes in all variables from baseline and determined the differences between groups and the relationships between parameters.RESULTS The infection status of the three groups before treatment was the same.Procalcitonin(PCT)improved after APG and Huangma Ding treatment more than after traditional treatment and was significantly greater in Group C than in Group B.Logistic regression analysis revealed that PCT was positively correlated with total amputation,primary amputation,and minor amputation rates.The ankle-brachial pressure and the transcutaneous oxygen pressure in Groups B and C were greater than those in Group A.The major amputation rate,minor amputation rate,and total amputation times in Groups B and C were lower than those in Group A.CONCLUSION Our research indicated that diabetic foot ulcers(DFUs)lead to major amputation,minor amputation,and total amputation through local infection and poor microcirculation and macrocirculation.Huangma Ding and APG were effective attreating DFUs.The clinical efficacy of Huangma Ding was better than that of autologous platelet gel,which may be related to the better control of local infection by Huangma Ding.This finding suggested that in patients with DFUs combined with coinfection,controlling infection is as important as improving circulation.

Evaluation of the treatment effect of rear slope cutting on hydrodynamic pressure landslides:A case study

After the impoundment of the Three Gorges Reservoir,some huge ancient landslides were reactivated and deformed,showing typical hydrodynamic pressure landslide characteristics.The Baishuihe landslide was a typical hydrodynamic pressure landslide.The management department conducted slope cutting treatments from 2018 to 2019.To evaluate the treatment effect of rear slope cutting,this study analyzed the data of the surface deformation survey and field monitoring over the past 20 years and the characteristics of the reservoir water-triggered Baishuihe landslide deformation,and calculated the seepage field,displacement field,and stability coefficient before and after landslide treatment.The results showed that the deformation of the Baishuihe landslide was primarily related to a decrease in the reservoir water level.Owing to the poor permeability of the landslide soil,the decrease in the reservoir water level produced a seepage force pointing to the outside of the landslide body,leading to the step deformation of the landslide displacement.The landslide was treated by rear slope cutting,and the“step”deformation of the landslide disappeared after treatment.The hydrodynamic pressure caused by the change in reservoir water after cutting the slope did not disappear.However,as the slope cutting greatly reduced the overall sliding force of the landslide,its stability was greatly improved.Notably,high stability can still be ensured under extreme rainfall after treatment.Slope cutting is effective for treating hydrodynamic pressure landslides.This study can provide effective technical support for the treatment of reservoir landslides.

Flume experiments to study fine-grain migration and its impact on slope stability

Fine grains migration is a primary cause of landslides and debris flows.This study investigates the effect of fine-grain migration on slope failure through flume experiments,focusing on the spatiotemporal characteristics and mechanisms of slope stability.A series of artificial rainfall flume experiments with varying rainfall intensities and slopes were conducted using soil samples collected from Wei Jia Gully.The experiments monitored pore-water pressure,grain migration,and failure sequences.Grain-size distribution parameters(μand Dc)were analyzed to understand the migration path and accumulation of fine grains.The experiments reveal that fine-grain migration significantly alters soil structure,leading to random blockage and interconnection of internal pore channels.These changes result in fluctuating pore-water pressure distributions and uneven fine-grain accumulation,critical factors in slope stability.Slope failures occur randomly and intermittently,influenced by fine-grain content in runoff and resulting pore-water pressure variations.This study highlights that fine-grain migration plays a vital role in slope stability,with significant implications for predicting and mitigating slope failures.The stochastic nature of fine-grain migration and its impact on soil properties should be incorporated into predictive models to enhance their accuracy and reliability.

The deterministic condition for the ground reaction force acting point on the combined knee valgus and tibial internal rotation moments in early phase of cutting maneuvers in female athletes

Background:Combined knee valgus and tibial internal rotation(VL+IR)moments have been shown to stress the anterior cruciate ligament(ACL)in several in vitro cadaveric studies.To utilize this knowledge for non-contact ACL injury prevention in sports,it is necessary to elucidate how the ground reaction force(GRF)acting point(center of pressure(CoP))in the stance foot produces combined knee VL+IR moments in risky maneuvers,such as cuttings.However,the effects of the GRF acting point on the development of the combined knee VL+IR moment in cutting are still unknown.Methods:We first established the deterministic mechanical condition that the CoP position relative to the tibial rotational axis differentiates the GRF vector’s directional probability for developing the combined knee VL+IR moment,and theoretically predicted that when the CoP is posterior to the tibial rotational axis,the GRF vector is more likely to produce the combined knee VL+IR moment than when the CoP is anterior to the tibial rotational axis.Then,we tested a stochastic aspect of our theory in a lab-controlled in vivo experiment.Fourteen females performed 60˚cutting under forefoot/rearfoot strike conditions(10 trials each).The positions of lower limb markers and GRF data were measured,and the knee moment due to GRF vector was calculated.The trials were divided into anterior-and posterior-CoP groups depending on the CoP position relative to the tibial rotational axis at each 10 ms interval from 0 to 100 ms after foot strike,and the occurrence rate of the combined knee VL+IR moment was compared between trial groups.Results:The posterior-CoP group showed significantly higher occurrence rates of the combined knee VL+IR moment(maximum of 82.8%)at every time point than those of the anterior-CoP trials,as theoretically predicted by the deterministic mechanical condition.Conclusion:The rearfoot strikes inducing the posterior CoP should be avoided to reduce the risk of non-contact ACL injury associated with the combined knee VL+IR stress.

Management of negative pressure wound therapy in the treatment of diabetic foot ulcers

Diabetic foot(DF) is a common complication of diabetes and the first cause of hospital admission in diabetic patients. In recent years several guidelines have been proposed to reinforce the the management of DF with a notable increase in diabetes knowledge and an overall reduction of amputations. Significant improvements have been reached in the treatment of diabetic foot ulcers(DFUs) and nowadays clinicians have several advanced medications to apply for the best local therapy. Among these, negative pressure wound therapy(NPWT) is a useful adjunct in the management of chronic and complex wounds to promote healing and wound bed preparation for surgical procedures such as skin grafts and flap surgery. NPWT has shown remarkable results although its mechanisms of action are not completely understood. In this paper, we offer a complete overview of this medication and its implication in the clinical setting. We have examined literature related to NPWT concerning human, animal and in vitro studies, and we have summarized why, when and how we can use NPWT to treat DFUs. Further we have associated our clinical experience to scientific evidence in the field of diabetic foot to identify a defined strategy that could guide clinician in the use of NPWT approaching to DFUs.

Underground pressure characteristics analysis in back-gully mining of shallow coal seam under a bedrock gully slope

We studied underground pressure and its mechanism during back-gully mining in a shallow coal seam under a bedrock gully slope,by means of physical simulation,numerical modeling and field monitoring.The results show that the intensity of underground pressure is related to its relative position at the coalface.The underground pressure is intensive and the support resistance reaches a maximum when the coalface is at the bottom of the gully,whereas the underground pressure is moderate and decreases gradually when the coalface passes the gully.The mechanism of these changes is analyzed when the slope rotated in a reversed direction to the slope dip during back-gully mining and form an unstable,multilateral block hinged structure,due to slipping.The subsidence of multilateral blocks is considerable when the block fragmentation is small,resulting in enormous changes in the underground pressure.With an increase in the mass of the block body,the block displacement will be reduced in conjunction with an increased clamp effect by both the unbroken rocks and broken rocks in the goaf,resulting in a decrease of the underground pressure.

A Test Model of Water Pressures within a Fault in Rock Slope

This paper introduces model test results of water pressure in a fault, which is located in a slope and 16 different conditions. The results show that the water pressures in fault can be expressed by a linear function, which is similar to the theoretical model suggested by Hoek. Factors affecting water pressures are water level in tension crack, dip angle of fault, the height of filling materials and thickness of fault zone in sequence.

Negative pressure for diabetic foot:Evaluation based on calcitonin gene-related peptide in the limb skin of dogs

BACKGROUND:Very good therapeutic effect has been obtained for limb negative pressure in treating limb ischemic diseases.But its mechanism in treating diabetic foot needs further investigation.OBJECTIVE:To observe the changes of calcitonin gene related peptide(CGRP)in sensory nerve fiber of skin of dogs with diabetic foot before and after limb negative pressure treatment,and make a comparison with normal dogs,then analyze the mechanism of limb negative pressure in treating diabetic foot.DESIGN:A randomized controlled animal experiment.SETTING:Third Department of General Surgery,Xijing Hospital,Fourth Military Medical University of Chinese PLA.MATERIALS:Fifteen healthy hybrid dogs,of either gender,weighing 12-18 kg,were provided by Animal Room,Xijing Hospital of the Fourth Military Medical University of Chinese PLA.After being numbered,the involved dogs were randomly assigned into 3 groups:treatment group,model group and normal control group,5 dogs each.Limb negative pressure therapeutic machine(self-made);Anti-CGRP serum(primary antibody,Watpa Company,England);rabbit anti-BigG(second antibody),ABC compound solution,DAB reagent,glucose oxidase reagent,Trixon-X100 solution(Sigma company,USA),ammonium nickelous sulfate reagent(Xi'an Chemical Reagent Factory),neutral gum-solution(import,Shanghai Reagent Co.,Ltd.);Leitz1400 sliding freezing microtome(Leitz Company,Germany);Leica1800 cryostat microtome(Leica Company,Germany);Quantimet570 image analyzer(Leica Company,Germany).METHODS:This experiment was carried out in the Animal Room,Xijing Hospital,Fourth Military Medical University of Chinese PLA from October 2005 to June 2006.①After the dogs in the treatment and model groups were anesthetized,their pancreatic tissues were removed completely and animal models of typeⅠdiabetes mellitus were developed.All the femoral artery branches including deep femoral artery were ligated and cut off.A helical wire was inserted into the distal femoral artery cavity for narrowing femoral artery 1/2,then contributing to ischemic status of this limb,thus,dog models of diabetic foot of posterior limbs were developed.When the dogs in the treatment group were successfully modeled,negative pressure treatment was conducted on their affected limbs after 14 days.When the dogs were lightly anesthetized,depilation was performed on the base of left posterior limb in ring form.Then,their depilated limbs were placed in self-made negative pressure cabin for 15 minutes of-12 kPa negative pressure treatment every day within 10 days successively.Negative pressure treatment on affected limbs was omitted in the model group.The dogs in the normal control group were not modeled or given negative pressure treatment.②After 10 days of treatment,3 groups of animals all subjected to immunohistochemical staining of toe skin of affected limb for detecting CGRP-immunoreactive positive nerve fibers.Analysis of variance and LSD-t test were used for comparison of measurement data.MAIN OUTCOME MEASURES:Changes of CGRP in sensory nerve fibers of skin of 3 groups of animals.RESULTS:CGRP-immunoreactive positive nerve fibers in the skin of animals of model group were(53.24±5.6)μm/mm2,which were significantly more than those of control group[(11.73±2.3)μm/mm2,t=16.94,P<0.01].CGRP-immunoreactive positive nerve fibers in the skin of animals of treatment group were(32.49±2.9)μm/mm2,which were less than those of model group(t=8.47,P<0.01),but were still more than those of normal control group(t=8.47,P<0.01).CONCLUSION:①Following the onset of diabetic foot,CGRP-immunoreactive positive nerve fibers in the skin of distal limb are obviously increased,which may be a self-protective mechanism of body.②Limb negative pressure treatment can treat diabetic foot,which attributes to that the release of CGRP in the sensory nerve fibers can promote vasodilatation.

Evaluating the effects of open/closed eyes and age-related differences on center of foot pressure sway during stepping at a set tempo

This study aimed to examine the effects of open/ closed eyes and age difference on Center of Foot Pressure (COP) sway during stepping. The subjects were 87 healthy males aged 10 - 80 years. COP was measured 20 times when subjects stepped on two force plates (left and right) at a rate of 60 steps/min. The evaluation parameters selected were: total trace length, velocity, circumference, rectangular area,left-right width, and front-back width. The former four of these parameters were found to be significantly lower with eyes open than eyes closed in 80-year-old subjects, while the last parameter was significantly lower with eyes open in 10-year-old subjects. In 70- and 80-year-old subjects with eyes open, circumference was greater than that in 10- and 40 - 60-year-old subjects;their rectangular area was greater than that in 50- and 60-year-old subjects;and, their front-back width was greater than that in 10- and 30 - 60-year-old subjects. With eyes closed, circumference, rectangular area, left-right width, and front-back width in 80-year- old subjects, were greater than those in 10 - 70- year-old subjects. The front-back width during stepping with eyes closed was greater in 70- and 80-year-old subjects than in 30 - 50-year-old subjects. The Romberg quotient for all COP sway parameters revealed no significant age-related differences. From our findings, a difference in body sway was observed in 80-year-old subjects (with eyes open/closed) when compared with the other age groups. In addition, the extent of sway varied little among 80 year-old- subjects have greater body sway during stepping, particularly with eyes closed.

Failure of levees induced by toe uplift:Investigation of post-failure behavior using material point method

Levees are essential structures in flood defense systems,and their failures can lead to devastating consequences on the surrounding territories.One of the failure mechanisms mostly controlled by the foundation soil stratigraphy is the instability of the land side slope,triggered by the development of high uplift pressures in the foundation.This complex phenomenon has been investigated experimentally with centrifuge tests or large-scale tests and numerically with the limit equilibrium method(LEM)and the finite element method(FEM).In this work,we applied a multiphase formulation of the material point method(MPM)to analyze the development of toe uplift instability mechanism,from the onset of failure to large displacements.The numerical model is inspired by an experiment carried out in a geotechnical centrifuge test by Allersma and Rohe(2003).The comparison with the experiment allows for understanding critical pore pressure triggering large displacements in the foundation soils.Moreover,we numerically evaluated the impact of different values of foundation soils’hydraulic conductivity on the failure mechanism.The results show that hydraulic conductivity mainly influences the time of failure onset and the extension of shear localization at depth.Finally,the advantages of using large displacement approaches in the safety assessment of earth structures are discussed.Unlike FEM,there are no issues with element distortions generating difficulties with numerical convergence,allowing for full postfailure reproduction.This capability permits precise quantification of earth structure damages and post-failure displacements.The ensuing reinforcement systems’design is no longer over-conservative,with a significant reduction in associated costs.

Experimental Study of the Pressure Fluctuations in a Pump Turbine at Large Partial Flow Conditions

Frequent shifts of output and operating mode require a pump turbine with excellent stability. Current researches show that large partial flow conditions in pump mode experience positive-slope phenomena with a large head drop. The pressure fluctuation at the positive slope is crucial to the pump turbine unit safety. The operating instabilities at large partial flow conditions for a pump turbine are analyzed. The hydraulic performance of a model pump turbine is tested with the pressure fluctuations measured at unstable operating points near a positive slope in the performance curve. The hydraulic performance tests show that there are two separated positive-slope regions for the pump turbine, with the flow discharge for the first positive slope from 0.85 to 0.91 times that at the maximum efficiency point. The amplitudes of the pressure fluctuations at these unstable large partial flow conditions near the first positive slope are much larger than those at stable operating condtions. A dominant frequency is measured at 0.2 times the impeller rotational frequency in the flow passage near the impeller exit, which is believed to be induced by the rotating stall in the flow passage of the wicket gates. The test results also show hysteresis with pressure fluctuations when the pump turbine is operated near the first positive slope. The hysteresis creates different pressure fluctuations for those operation points even though their flow rates and heads are similar respectively. The pressure fluctuation characteristics at large partial flow conditions obtained by the present study will be helpful for the safe operation of pumped storage units.

Stability analysis of unsaturated soil slope during rainfall infiltration using coupled liquid-gas-solid three-phase model

Generally, most soil slope failures are induced by rainfall infiltration, a process that involves interactions between the liquid phase, gas phase,and solid skeleton in an unsaturated soil slope. In this study, a loosely coupled liquid-gas-solid three-phase model, linking two numerical codes,TOUGH2/EOS3, which is used for water-air two-phase flow analysis, and FLAC^(3D), which is used for mechanical analysis, was established. The model was validated through a documented water drainage experiment over a sandy column and a comparison of the results with measured data and simulated results from other researchers. The proposed model was used to investigate the features of water-air two-phase flow and stress fields in an unsaturated soil slope during rainfall infiltration. The slope stability analysis was then performed based on the simulated water-air two-phase seepage and stress fields on a given slip surface. The results show that the safety factor for the given slip surface decreases first, then increases, and later decreases until the rainfall stops. Subsequently, a sudden rise occurs. After that, the safety factor decreases continually and reaches its lowest value, and then increases slowly to a steady value. The lowest value does not occur when the rainfall stops, indicating a delayed effect of the safety factor. The variations of the safety factor for the given slip surface are therefore caused by a combination of pore-air pressure, matric suction, normal stress, and net normal stress.

Assessment of bearing capacity of interfering strip footings located near sloping surface considering artificial neural network technique

The bearing capacity of interfering footings located near the slope face suffers from reduced bearing capacity due to the formation of the curtailed passive zone. Depending upon the position of the footing, their spacing and steepness of the slope different extents of bearing capacity reduction can be exhibited. A series of finite element investigation has been done with the aid of Plaxis 3 D v AE.01 to elucidate the influence of various geotechnical and geometrical parameters on the ultimate bearing capacity of interfering surface strip footings located at the crest of the natural soil slope. Based on the large database obtained from the numerical simulation, a6-8-1 Artificial Neural Network architecture has been considered for the assessment of the ultimate bearing capacity of interfering strip footings placed on the crest of natural soil slope. Sensitivity analyses have been conducted to establish the relative significance of the contributory parameters, which exhibited that for the stated problem, apart from shear strength parameters, the setback ratio and spacing of footing are the prime contributory parameters.

Machine learning for pore-water pressure time-series prediction:Application of recurrent neural networks

Knowledge of pore-water pressure(PWP)variation is fundamental for slope stability.A precise prediction of PWP is difficult due to complex physical mechanisms and in situ natural variability.To explore the applicability and advantages of recurrent neural networks(RNNs)on PWP prediction,three variants of RNNs,i.e.,standard RNN,long short-term memory(LSTM)and gated recurrent unit(GRU)are adopted and compared with a traditional static artificial neural network(ANN),i.e.,multi-layer perceptron(MLP).Measurements of rainfall and PWP of representative piezometers from a fully instrumented natural slope in Hong Kong are used to establish the prediction models.The coefficient of determination(R^2)and root mean square error(RMSE)are used for model evaluations.The influence of input time series length on the model performance is investigated.The results reveal that MLP can provide acceptable performance but is not robust.The uncertainty bounds of RMSE of the MLP model range from 0.24 kPa to 1.12 k Pa for the selected two piezometers.The standard RNN can perform better but the robustness is slightly affected when there are significant time lags between PWP changes and rainfall.The GRU and LSTM models can provide more precise and robust predictions than the standard RNN.The effects of the hidden layer structure and the dropout technique are investigated.The single-layer GRU is accurate enough for PWP prediction,whereas a double-layer GRU brings extra time cost with little accuracy improvement.The dropout technique is essential to overfitting prevention and improvement of accuracy.

Bearing capacity and settlement of strip footing on geosynthetic reinforced clayey slopes

The effect of geosynthetic reinforcing on bearing capacity of a strip footing resting on georeinforced clayey slopes was investigated.The results of a series of numerical study using finite element analyses on strip footing upon both reinforced and unreinforced clayey slopes were presented.The objectives of this work are to:1) determine the influence of reinforcement on the bearing-capacity of the strip footings adjacent slopes,2) suggest an optimum number of reinforcement and 3) survey the effect of friction angle in clayey soils reinforced by geogrids.The investigations were carried out by varying the edge distance of the footing from slope.Also different numbers of geosynthetic layers were applied to obtaining the maximum bearing capacity and minimum settlement.To achieve the third objective,two different friction angles were used.The results show that the load?settlement behavior and ultimate bearing capacity of footing can be considerably improved by the inclusion of reinforcing layer.But using more than one layer reinforcement,the ultimate bearing capacity does not change considerably.It is also shown that for both reinforced and unreinforced slopes,the bearing capacity increases with an increase in edge distance.In addition,as the soil friction angle is increased,the efficiency of reinforcing reduces.

An In Vivo Experimental Validation of a Computational Model of Human Foot

Reliable computational foot models offer an alternative means to enhance knowledge on the biomechanics of human foot. Model validation is one of the most critical aspects of the entire foot modeling and analysis process.This paper presents an in vivo experiment combining motion capture system and plantar pressure measure platform to validate a three-dimensional finite element model of human foot.The Magnetic Resonance Imaging(MRI)slices for the foot modeling and the experimental data for validation were both collected from the same volunteer subject.The validated components included the comparison of static model predictions of plantar force,plantar pressure and foot surface deformation during six loading conditions,to equivalent measured data.During the whole experiment,foot surface deformation,plantar force and plantar pressure were recorded simultaneously during six different loaded standing conditions.The predictions of the current FE model were in good agreement with these experimental results.

Experimental Study of Pore Water Pressure and Bed Profile Change Under Regular Breaking Waves

There lies a close relationship between the seabed destruction and the distribution of pore water pressure under the action of breaking wave. The experiments were carried out in a wave flume with a 1：30 sloping sandy seabed to study regular breaking wave induced pore water pressure. A wide range of measurements from the regular wave runs were reported, including time series of wave heights, pore pressures. The video records were analysed to measure the time development of the seabed form and the characteristics of the orbital motion of the sand in the wave breaking region. The pore water pressure in the breaker zone showed the time variation depending on the wave phases including wave breaking and bore propagation. The time-averaged pore water pressure was higher near the seabed surface. The peak values of pore water pressure increase significantly at the breaking point. The direction of pore water pressure difference forces in the breaker zone is of fundamental importance for a correct description of the sediment dynamics. The upwards- directed pressure differences may increase sand transport by reducing the effective weight of the sediment, thereby increasing the bed form evolution. The seabed configuration changed greatly at the wave breaking zone and a sand bar was generated remarkably. The amplitude of the pore water pressure changed with the seabed surface. The results are to improve the understanding of sand transport mechanisms and seabed responses due to breaking regular waves over a sloping sandy bed.

Fiber Bragg Grating Based Sensing'Platform for Foot Plantar Pressure Measurement

presented an application of using 3 D printing technique for the design and fabrication of a novel fiber Bragg grating( FBG)based sensing platform for foot planar pressure measurement.Pressure sensing unit was fabricated using 3 D printing technique by layering of extruded polylactic acid( PLA) material and mounting FBG sensor at the center of each sensing unit for pressure measurement. Performance of the sensing system was validated by applying load step by step as well as cyclic load on FBG pressure sensors. A simulation study was carried out using the sensing platform to assess foot plantar pressure distribution arises from weight gaining and losing processes of pregnant woman. The monitored four different foot positions such as first metatarsus,second metatarsus,mid-foot and heel exhibited obvious differences during testing process. Foot plantar pressure of heel was 1. 7 times of the pressure occurred at the first and second metatarsus( fore-foot),while there was limited pressure occurred at the mid-foot position during weight gaining process of a female subject. The occurred pressures at the two metatarsus areas were around 90%( pressure ratio) of heel and decreased continuously as the increase of subject weight,but weight losing process had very limited influence on this pressure ratio. Center of gravity of pregnant woman was found to shift backward substantially during the weighting gaining process,leading to a significant rise of the heel pressure. Hence, the protection of the heel position for female is highly important during both pregnancy and after baby delivery.

Characteristics of pressure gradient force errors in a terrain-following coordinate

A terrain-following coordinate （a-coordinate） in which the computational form of pressure gradient force （PGF） is two-term （the so-called classic method） has significant PGF errors near steep terrain. Using the covariant equations of the a-coordinate to create a one-term PGF （the covariant method） can reduce the PGF errors. This study investigates the factors inducing the PGF errors of these two methods, through geometric analysis and idealized experiments. The geometric analysis first demonstrates that the terrain slope and the vertical pressure gradient can induce the PGF errors of the classic method, and then generalize the effect of the terrain slope to the effect of the slope of each vertical layer （φ）. More importantly, a new factor, the direction of PGF （a）, is proposed by the geometric analysis, and the effects of φ and a are quantified by tan φ.tan a. When tan φ.tan a is greater than 1/9 or smaller than -10/9, the two terms of PGF of the classic method are of the same order but opposite in sign, and then the PGF errors of the classic method are large. Finally, the effects of three factors on inducing the PGF errors of the classic method are validated by a series of idealized experiments using various terrain types and pressure fields. The experimental results also demonstrate that the PGF errors of the covariant method are affected little by the three factors.

Simulation study of the void space gas effect on slope instability triggered by an earthquake

This study aims at exploring the void space gas effect of earthquake-triggered slope instability and providing a new method for studying the formation mechanism of earthquake-triggered landslides. We analysed the basic characteristics, kinematic characteristics, initiation mechanisms and physical mechanical parameters of the Daguangbao landslide, generalized a landslide prototype, and established a geological model and performed simulation tests. Based on the seismic wave propagation theory of rock-soil mass, rock fracture mechanics and the effective stress principle, we found that the void space gas effect is due to the occurrence of excess void space gas pressure when the dynamic response of seismic loads impacts the void space gas in weak intercalated layers of the slope. The excess void space gas pressure generated by the vibration(earthquake) damages the rock mass around the void space with a certain regularity. The model test results show that the effective shear strength of the rock mass can be reduced by 4.4% to 21.6% due to the void space gas effect.