Objective:To investigate the therapeutic effect of Bai Hu Ren Shen Soup(BHRSS)on type 2 diabetes mellitus(T2DM)rats and explore whether its therapeutic effect is achieved by promoting autophagy in the pancreas tissue ...Objective:To investigate the therapeutic effect of Bai Hu Ren Shen Soup(BHRSS)on type 2 diabetes mellitus(T2DM)rats and explore whether its therapeutic effect is achieved by promoting autophagy in the pancreas tissue of T2DM rats.Methods:Thirty male standard deviation rats were equally divided into normal control group,T2DM group and BHRSS group.Firstly,the therapeutic effect of BHRSS on T2DM was evaluated by biochemical indices in serum and pathological changes in the pancreas tissue of rats in each group after modeling and medication.Then,the levels of microtubule-associated protein 1 light chain 3(LC3)protein and p62 protein in the pancreas tissue of rats in each group after BHRSS intervention were detected by Western blot.Results:BHRSS intervention significantly reduced the levels of blood sugar,liver and kidney function,and other related biochemical indices in the serum of T2DM rats,and effectively improved the pathological changes in the pancreas tissue of T2DM rats.In addition,Western blot results showed that the expression levels of autophagy-related protein LC3 protein in the pancreas tissue of rats were increased,and the expression level of p62 protein was decreased after BHRSS intervention.Conclusion:BHRSS has a clear therapeutic effect on T2DM model rats,which may be related to that increase of autophagy protein LC3 and the decrease of p62 protein level in the pancreas tissue.展开更多
对杭州湾北岸3处现代潮滩沉积物进行高精度粒度分析,查找研究区潮滩不同微相的粒度特征和差异,提取基于粒度分析的潮滩微相识别敏感指标,并将其应用到该区域的全新世钻孔潮滩沉积物中,识别钻孔潮滩沉积微相,据此建立研究区全新世早期的...对杭州湾北岸3处现代潮滩沉积物进行高精度粒度分析,查找研究区潮滩不同微相的粒度特征和差异,提取基于粒度分析的潮滩微相识别敏感指标,并将其应用到该区域的全新世钻孔潮滩沉积物中,识别钻孔潮滩沉积微相,据此建立研究区全新世早期的海平面曲线。研究表明:杭州湾北岸现代高潮滩盐沼沉积物粘土含量明显高于高潮滩下部和中潮滩,而砂含量与之相反;高潮滩盐沼平均粒径等粒度参数明显小于中、高潮滩的粒度参数;盐沼沉积物粒度频率曲线峰态宽缓,明显区别于高潮滩下部和中潮滩。上述现代潮滩微相粒度敏感指标可成功应用到钻孔潮滩沉积微相划分中,并建立了该区域全新世早期海平面曲线。曲线显示,9700~8700 cal a BP期间海平面上升约11.6 m,海平面上升速率可达1.2 cm/a。现代潮滩不同位置沉积物粒度参数的规律性差异可作为潮滩微相识别的有效指标,为古潮滩沉积微相识别和古海平面重建提供参考依据。展开更多
文摘Objective:To investigate the therapeutic effect of Bai Hu Ren Shen Soup(BHRSS)on type 2 diabetes mellitus(T2DM)rats and explore whether its therapeutic effect is achieved by promoting autophagy in the pancreas tissue of T2DM rats.Methods:Thirty male standard deviation rats were equally divided into normal control group,T2DM group and BHRSS group.Firstly,the therapeutic effect of BHRSS on T2DM was evaluated by biochemical indices in serum and pathological changes in the pancreas tissue of rats in each group after modeling and medication.Then,the levels of microtubule-associated protein 1 light chain 3(LC3)protein and p62 protein in the pancreas tissue of rats in each group after BHRSS intervention were detected by Western blot.Results:BHRSS intervention significantly reduced the levels of blood sugar,liver and kidney function,and other related biochemical indices in the serum of T2DM rats,and effectively improved the pathological changes in the pancreas tissue of T2DM rats.In addition,Western blot results showed that the expression levels of autophagy-related protein LC3 protein in the pancreas tissue of rats were increased,and the expression level of p62 protein was decreased after BHRSS intervention.Conclusion:BHRSS has a clear therapeutic effect on T2DM model rats,which may be related to that increase of autophagy protein LC3 and the decrease of p62 protein level in the pancreas tissue.
基金国家自然科学基金项目《杭州湾北岸全新世早期(10-9 cal ka BP)高精度海平面重建及沉积环境响应》(批准号:41706098)《基于微体化石识别全新世高海面阶段长江口外水团相互作用及调控机制》(批准号:42076081)。
文摘对杭州湾北岸3处现代潮滩沉积物进行高精度粒度分析,查找研究区潮滩不同微相的粒度特征和差异,提取基于粒度分析的潮滩微相识别敏感指标,并将其应用到该区域的全新世钻孔潮滩沉积物中,识别钻孔潮滩沉积微相,据此建立研究区全新世早期的海平面曲线。研究表明:杭州湾北岸现代高潮滩盐沼沉积物粘土含量明显高于高潮滩下部和中潮滩,而砂含量与之相反;高潮滩盐沼平均粒径等粒度参数明显小于中、高潮滩的粒度参数;盐沼沉积物粒度频率曲线峰态宽缓,明显区别于高潮滩下部和中潮滩。上述现代潮滩微相粒度敏感指标可成功应用到钻孔潮滩沉积微相划分中,并建立了该区域全新世早期海平面曲线。曲线显示,9700~8700 cal a BP期间海平面上升约11.6 m,海平面上升速率可达1.2 cm/a。现代潮滩不同位置沉积物粒度参数的规律性差异可作为潮滩微相识别的有效指标,为古潮滩沉积微相识别和古海平面重建提供参考依据。