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CDX2 Overexpression in Barrett’s Esophagus and Esophageal Adenocarcinoma 被引量:1
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作者 Leandro Almeida Streher Vinicius Campos +4 位作者 Guilherme da Silva Mazzini Marcelo Binato Luise Meurer Maria Isabel Edelweiss Richard Ricachenevsky Gurski 《Journal of Cancer Therapy》 2014年第7期657-663,共7页
Background: Patients with Barrett’s esophagus have an increased risk of developing esophageal adenocarcinoma. Our purpose was to determine CDX2 expression in esophageal mucosa and establish a correlation between this... Background: Patients with Barrett’s esophagus have an increased risk of developing esophageal adenocarcinoma. Our purpose was to determine CDX2 expression in esophageal mucosa and establish a correlation between this marker and the progression of disease. Methods: We analyzed biopsies and surgical specimens from 150 patients who were divided into five groups according to histopathological diagnosis: G1, normal mucosa (n = 29);G2, esophagitis (n = 19);G3, columnar epithelium without intestinal metaplasia (n = 26);G4, Barrett’s esophagus (n = 32), and G5, adenocarcinoma (n = 44). Immuno-histochemical determination of CDX2 expression was considered positive in the presence of nuclear staining. Results: No CDX2 expression was detected in the G1 or G3 groups;5% of G2, 62.5% of G4 and 70.5% of G5 patients were CDX2 positive. There was a statistically significant difference between the G4 and G5 groups compared to the G1, G2 and G3 (p < 0.05). Conclusions: CDX2 expression was observed among patients with Barrett’s esophagus and adenocarcinoma compared to other groups. CDX2 was not expressed in the phases preceding Barrett’s esophagus, but there was no linear correlation between CDX2 expression and metaplasia-adenocarcinoma progression. 展开更多
关键词 CDX2 barretts esophagus Intestinal METAPLAsIA EsOPHAGEAL adenocarcinoma immunohistochemistry
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bcl-2蛋白在Barrett食管和Barrett腺癌中的表达及其临床意义探讨 被引量:5
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作者 田辉 王善政 +2 位作者 陈明菊 曹丙振 刘文军 《中国肿瘤临床》 CAS CSCD 北大核心 1998年第3期187-188,共2页
应用免疫组化SABC法观察bcl-2蛋白在28例Barrett食管(BE)和6例Barrett腺癌(BA)中的表达情况。结果显示:恶性组bcl-2蛋白表达明显高于癌前病变组和良性组,其表达依次呈递减趋势,各组间比较均... 应用免疫组化SABC法观察bcl-2蛋白在28例Barrett食管(BE)和6例Barrett腺癌(BA)中的表达情况。结果显示:恶性组bcl-2蛋白表达明显高于癌前病变组和良性组,其表达依次呈递减趋势,各组间比较均有显著性差异(P<0.05)。提示bcl-2蛋白表达可有助于判断Barret食管的良、恶性,亦可用来监测Bar-rett食管的发展,以发现早期癌变。 展开更多
关键词 barrett食管 Barret腺癌 bcl-2蛋白 免疫组织化学
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细胞凋亡及凋亡相关蛋白bcl-2在Barrett食管及食管腺癌发病中的作用 被引量:3
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作者 赖圳宾 王雯 《临床消化病杂志》 2010年第2期88-90,101,共4页
目的探讨Barrett食管(BE)发生并进展到食管腺癌(EA)过程中细胞凋亡及凋亡相关蛋白bcl-2表达的变化规律及意义。方法采用细胞凋亡原位检测技术(TUNEL法)和免疫组化法检测正常食管黏膜、Barrett食管上皮和食管腺癌3组标本细胞凋亡及bcl-2... 目的探讨Barrett食管(BE)发生并进展到食管腺癌(EA)过程中细胞凋亡及凋亡相关蛋白bcl-2表达的变化规律及意义。方法采用细胞凋亡原位检测技术(TUNEL法)和免疫组化法检测正常食管黏膜、Barrett食管上皮和食管腺癌3组标本细胞凋亡及bcl-2的表达情况,并进行组间比较和相关分析。结果EA的凋亡指数(AI)低于BE和正常食管上皮(P<0.01);bcl-2蛋白在正常食管黏膜、BE及EA中的表达呈升高趋势(r=0.406,P<0.01);在BE与EA中,bcl-2蛋白表达与细胞凋亡呈负相关(r=-0.507,P<0.01)。结论BE发生并向EA发展过程中,凋亡抑制机制可能起重要作用,而bcl-2可能通过抑制细胞凋亡参与BE及EA的发生发展。 展开更多
关键词 barrett食管 食管腺癌 细胞凋亡 bcl-2
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