Practical bipartite consensus for multi-agent systems:A barrier function-based adaptive sliding-mode control approach

This paper is concerned with bipartite consensus tracking for multi-agent systems with unknown disturbances.A barrier function-based adaptive sliding-mode control(SMC)approach is proposed such that the bipartite steady-state error is converged to a predefined region of zero in finite time.Specifically,based on an error auxiliary taking neighboring antagonistic interactions into account,an SMC law is designed with an adaptive gain.The gain can switch to a positive semi-definite barrier function to ensure that the error auxiliary is constrained to a predefined neighborhood of zero,which in turn guarantees practical bipartite consensus tracking.A distinguished feature of the proposed controller is its independence on the bound of disturbances,while the input chattering phenomenon is alleviated.Finally,a numerical example is provided to verify the effectiveness of the proposed controller.

A Survey on the Control Lyapunov Function and Control Barrier Function for Nonlinear-Affine Control Systems

This survey provides a brief overview on the control Lyapunov function(CLF)and control barrier function(CBF)for general nonlinear-affine control systems.The problem of control is formulated as an optimization problem where the optimal control policy is derived by solving a constrained quadratic programming(QP)problem.The CLF and CBF respectively characterize the stability objective and the safety objective for the nonlinear control systems.These objectives imply important properties including controllability,convergence,and robustness of control problems.Under this framework,optimal control corresponds to the minimal solution to a constrained QP problem.When uncertainties are explicitly considered,the setting of the CLF and CBF is proposed to study the input-to-state stability and input-to-state safety and to analyze the effect of disturbances.The recent theoretic progress and novel applications of CLF and CBF are systematically reviewed and discussed in this paper.Finally,we provide research directions that are significant for the advance of knowledge in this area.

Barrier-Certified Learning-Enabled Safe Control Design for Systems Operating in Uncertain Environments

This paper presents learning-enabled barriercertified safe controllers for systems that operate in a shared environment for which multiple systems with uncertain dynamics and behaviors interact.That is,safety constraints are imposed by not only the ego system’s own physical limitations but also other systems operating nearby.Since the model of the external agent is required to impose control barrier functions(CBFs)as safety constraints,a safety-aware loss function is defined and minimized to learn the uncertain and unknown behavior of external agents.More specifically,the loss function is defined based on barrier function error,instead of the system model error,and is minimized for both current samples as well as past samples stored in the memory to assure a fast and generalizable learning algorithm for approximating the safe set.The proposed model learning and CBF are then integrated together to form a learning-enabled zeroing CBF(L-ZCBF),which employs the approximated trajectory information of the external agents provided by the learned model but shrinks the safety boundary in case of an imminent safety violation using instantaneous sensory observations.It is shown that the proposed L-ZCBF assures the safety guarantees during learning and even in the face of inaccurate or simplified approximation of external agents,which is crucial in safety-critical applications in highly interactive environments.The efficacy of the proposed method is examined in a simulation of safe maneuver control of a vehicle in an urban area.

Novel method for random vibration analysis of single-degree-of-freedom vibroimpact systems with bilateral barriers

The vibroimpact systems with bilateral barriers are often encountered in practice.However,the dynamics of the vibroimpact system with bilateral barriers is full of challenges.Few closed-form solutions were obtained.In this paper,we propose a novel method for random vibration analysis of single-degree-of-freedom(SDOF)vibroim-pact systems with bilateral barriers under Gaussian white noise excitations.A periodic approximate transformation is employed to convert the equations of the motion to a con-tinuous form.The probabilistic description of the system is subsequently defined through the corresponding Fokker-Planck-Kolmogorov(FPK)equation.The closed-form station-ary probability density function(PDF)of the response is obtained by solving the reduced FPK equation and using the proposed iterative method of weighted residue together with the concepts of the circulatory probability flow and the potential probability flow.Finally,the versatility of the proposed approach is demonstrated by its application to two typical examples.Note that the solution obtained by using the proposed method can be used as the benchmark to examine the accuracy of approximate solutions obtained by other methods.

DETERMINATION OF CREEP PROPERTIES OF THERMAL BARRIER COATING(TBC)SYSTEMS FROM THE INDENTATION CREEP TESTING WITH ROUND FLAT INDENTERS

Indentation creep behavior with cylindrical flat indenters on the thermal barrier coating (TBC) was studied by finite element method (FEM). On ike constant applied indentation creep stress, there is a steady creep rate for each case studied for different creep properties of the TBC system. The steady creep depth rate depends on the applied indentation creep stress and size of the indenters as well as the creep properties of the bond coat of the TBC and the substrate. The possibilities to determine the creep properties of a thermal barrier system from indention creep testing were discussed. As an example, with two different size indenters, the creep properties of bond coat of the TBC system can be derived by an inverse FEM method. This study not only provides a numerical method to obtain the creep properties of the TBC system, but also extends the application of indentation creep method with cylindrical flat indenters.

Systems pharmacology approach reveals protective mechanisms of Jian-Pi Qing-Chang decoction on ulcerative colitis

BACKGROUND Given the complex pathogenesis of ulcerative colitis (UC), the conventional therapeutic methods are not fully curative. As a sort of systematic complementary and alternative medicine, traditional Chinese medicine (TCM) provides new options for the standard therapy. Nevertheless, there are still numerous problems with the promotion of TCM attributed to its complexity, and consequently, new research approaches are urgently needed. Thus, we explored the protective effects of Jian-Pi Qing-Chang (JPQC) decoction on UC based on systems pharmacology approach, which might fill the current innovation gap in drug discovery and clinical practice pertaining to TCM. AIM To investigate the protective mechanisms of JPQC decoction on UC based on systems pharmacology approach. METHODS We performed systems pharmacology to predict the active ingredients, the matched targets, and the potential pharmacological mechanism of JPQC on UC. In vivo, we explored the effects of JPQC in a colitis model induced by dextran sulfate sodium. In vitro, we adopted the bone marrow-derived macrophages (BMDMs) as well as BMDMs co-cultured with Caco2 cells to verify the underlying mechanisms and effects of JPQC on UC under TNF-α stimulation. RESULTS Systems pharmacology revealed 170 targets for the 107 active ingredients of JPQC and 112 candidate targets of UC. Protein-protein interaction networks were established to identify the underlying therapeutic targets of JPQC on UC. Based on enrichment analyses, we proposed our hypothesis that JPQC might have a protective effect on UC via the NF-κB/HIF-1α signalling pathway. Subsequent experimental validation revealed that treatment with TNFα activated the NF-κB/HIF-1α signalling pathway in BMDMs, thereby damaging the epithelial barrier permeability in co-cultured Caco2 cells, while JPQC rescued this situation. The findings were also confirmed in a dextran sulfate sodium-induced colitis model. CONCLUSION JPQC could improve the mucosal inflammatory response and intestinal epithelial barrier function via the NF-κB/HIF-1α signalling pathway, which provides new perspectives on the pharmaceutical development and clinical practice of TCM.

Adaptive Consensus Quantized Control for a Class of High-Order Nonlinear Multi-Agent Systems With Input Hysteresis and Full State Constraints

For a class of high-order nonlinear multi-agent systems with input hysteresis,an adaptive consensus output-feedback quantized control scheme with full state constraints is investigated.The major properties of the proposed control scheme are:1)According to the different hysteresis input characteristics of each agent in the multi-agent system,a hysteresis quantization inverse compensator is designed to eliminate the influence of hysteresis characteristics on the system while ensuring that the quantized signal maintains the desired value.2)A barrier Lyapunov function is introduced for the first time in the hysteretic multi-agent system.By constructing state constraint control strategy for the hysteretic multi-agent system,it ensures that all the states of the system are always maintained within a predetermined range.3)The designed adaptive consensus output-feedback quantization control scheme allows the hysteretic system to have unknown parameters and unknown disturbance,and ensures that the input signal transmitted between agents is the quantization value,and the introduced quantizer is implemented under the condition that only its sector bound property is required.The stability analysis has proved that all signals of the closed-loop are semi-globally uniformly bounded.The Star Sim hardware-in-the-loop simulation certificates the effectiveness of the proposed adaptive quantized control scheme.

The application of GPR to barrier-lagoon sedimentation study in Boao of Hainan Island

Sedimentary successions and internal structure of the coastal barrier-lagoon system of Boao, eastern Hainan Island were studied through utilizing data from test holes and trenches and ground-penetrating-radar (GPR) profiles. During late Pleistocene, fluvial and delta plains developed over an unevenly eroded bedrock during low sea level stand, followed by the formation of littoral and lagoon facies and defined coastal barrier-lagoon-estuary system during the post-glacial uppermost Pleistocene-lower Holocene eustatic rise of the sea level, and the upper Holocene high stand. GPR results show that Yudaitan, a sandy coastal bar backed by a low-laying land (shoal) just east of the active lagoon, is a continuous, parallel and slightly-wavy reflectors indicating homogeneous sandy or sandy gravel sediments, and inclined reflectors partly caused by progradation and accumulation of beach sand and gravel. Quasi-continuous, hummocky and chaotic reflectors from the shoal of Nangang village correspond to mixed accumulation of sands and clay. This research indicates the GPR is a non-intrusive, rapid, and economical method for high-resolution profiling of subsurface sediments in sandy gravelly coast.

Clematichinenoside protects blood brain barrier against ischemic stroke superimposed on systemic inflammatory challenges through up-regulating A20

Suppression of excessive inflammation can ameliorate blood brain barrier （BBB） injury, which shows therapeutic potential for clinical treatment of brain injury induced by stroke superimposed on systemic inflammatory diseases. In this study, we investigated whether and how clematichinenoside （AR）, an anti-inflammatory triter- pene saponin, protects brain injury from stroke superimposed on systemic inflammation. Lipopolysaccharide （LPS） was intraperitoneally injected immediately after middle cerebral artery occlusion （MCAO） in rats. Rat microvessel endothelial cells （rBMECs） were exposed to hypoxia/reoxygenation （H/R） coexisting with LPS. The results re- vealed that AR suppressed the excessive inflammation, restored BBB dysfunction, alleviated brain edema, de- lessened neurological dysfunction, and decreased infarct rate. Further study demon- creased neutrophil infiltration, inducible nitric oxide synthase （iNOS） , strated that the expression of nucleus nuclear factor kappa B （NF-KB）, intercellular adhesion molecule-1 （ ICAM-1 ）, tumor necrosis factor-α （TNF-α） and interlukin-1β （ IL-1β） were suppressed by AR via zinc finger protein A20. Besides, AR increased in vitro BBB integrity through A20. In con- clusion, AR alleviated cerebral inflammatory injury through A20-NF-KB signal pathway, offering an alternative medication for stroke associated with systemic inflammatory diseases.

Treatment of Practical Dye Wastewater Using a Double Dielectric Barrier Discharge System Combined with a Sequencing Batch Reactor System

Synthetic dyes are substances that are relatively stable and difficult to degrade in wastewater treatment plants using normal physical,chemical or / and biological treatment. The present work explored the synergistic effect of non-thermal plasma( NTP) and biological wastewater treatment technologies on practical dye wastewater degradation by establishing a double dielectric barrier discharge( DDBD) system combined with a sequencing batch reactor( SBR) system. The biodegradation and degradation efficiency of the DDBD-SBR system was investigated. The investigation results indicated that the DDBD technology was effective in treating the practical dye wastewater as a pre-treatment process. After a 10-min treatment,although the total organic carbon( TOC) removal efficiency was not so significant, the decolouration and the biodegradation were improved greatly. The microbial toxicity test revealed that the sample after degradation became less toxic than the original dye,which demonstrated the treatment had a significant effect on the reduction of toxicity. In addition,the SBR technology remedied the defects of DDBD treatment and improved TOC removal efficiency noticeably. The hybrid DDBD-SBR system made full use of the advantages of the individual technologies and exhibited an efficient capability for practical dye wastewater treatment.

Effects of adjuvant raw rhubarb enema therapy on systemic inflammatory stress response and intestinal mucosal barrier function in patients with severe pancreatitis

Objective: To investigate the effects of adjuvant raw rhubarb enema therapy on systemic inflammatory stress response and intestinal mucosal barrier function in patients with severe pancreatitis. Methods: A total of 78 patients with severe pancreatitis treated in the Second People's Hospital of Neijiang, Sichuan, China between December 2016 and September 2018 were included in the study. The patients were divided into control group (n=39) and raw rhubarb group (n=39) by simple randomization. The control group of patients received conventional treatment of severe pancreatitis with western medicine, while the raw rhubarb group of patients received raw rhubarb enema on the basis of the treatment of control group, and the efficacy was evaluated after continuous treatment for 1 week. The differences in serum levels of inflammatory mediators (high mobility group protein B1, C-reactive protein, prostaglandin E2 and tumor necrosis factor α), stress hormones (cortisol and epinephrine) as well as intestinal mucosal barrier function indicators (D-lactate, endotoxin and diamine oxidase) were compared between the two groups of patients before and after treatment. Results: Before treatment, there was no statistically significant difference in serum levels of inflammatory mediators, stress hormones and intestinal mucosal barrier function indicators between the two groups (P>0.05). After treatment, serum high mobility group protein B1, C-reactive protein, prostaglandin E2 and tumor necrosis factor levels of the observation group were significantly lower than those of the control group;cortisol and epinephrine levels were significantly lower than those of the control group;D-lactate, endotoxin and diamine oxidase levels were significantly lower than those of the control group (P<0.05). Conclusions:Adjuvant raw rhubarb enema therapy on the basis of western medicine can help alleviate the inflammatory stress response and optimize the intestinal mucosal barrier function in patients with severe pancreatitis.

Stationary response of stochastic viscoelastic system with the right unilateral nonzero offset barrier impacts

The stationary response of viscoelastic dynamical system with the right unilateral nonzero offset barrier impacts subjected to stochastic excitations is investigated. First, the viscoelastic force is approximately treated as equivalent terms associated with effects. Then, the free vibro-impact(VI) system is absorbed to describe the periodic motion without impacts and quasi-periodic motion with impacts based upon the level of system energy. The stochastic averaging of energy envelope(SAEE) is adopted to seek the stationary probability density functions(PDFs). The detailed theoretical results for Van der Pol viscoelastic VI system with the right unilateral nonzero offset barrier are solved to demonstrate the important effects of the viscoelastic damping and nonzero rigid barrier impacts condition. Monte Carlo(MC) simulation is also performed to verify the reliability of the suggested approach. The stochastic P-bifurcation caused by certain system parameters is further explored. The variation of elastic modulus from negative to zero and then to positive witnesses the evolution process of stochastic P-bifurcation. From the vicinity of the common value to a wider range, the relaxation time induces the stochastic P-bifurcation in the two interval schemes.

考虑状态受限和一致性的微电网二次控制

为解决交流微电网下垂控制产生的偏差问题,本文采用二次控制对分布式电源输出电压和频率进行调节.将微电网看成分布式多智能体系统,智能体间通过稀疏网络进行通信,运用多智能体一致性协议,本文提出一种基于障碍Lyapunov函数和自适应模糊系统的二次电压和频率控制器.采用障碍Lyapunov函数设计控制器,不但能保持系统的稳定性,还可使输出的电压和频率限制在预设的范围内.采用自适应模糊系统可对系统中的一些参变量的变化进行估计,提高了控制器的鲁棒性.本文给出了严格的稳定性证明.通过对负载变化,以及拓扑结构改变等的仿真测试,验证了所提方案的有效性.

不确定电液伺服系统的时变输出约束自适应滤波控制

针对电液伺服系统位置跟踪控制中存在的输出约束和不确定性问题,提出一种基于正切型时变障碍Lyapunov函数的输出约束自适应滤波控制方法。构造具有时变约束边界的正切型时变障碍Lyapunov函数,通过时变边界函数的参数设置,使系统输出具有较好的瞬态和稳态性能;设计径向基函数(RBF)神经网络及权重自适应学习律,在线逼近由模型不确定性和未知干扰组成的复合干扰,并将逼近值用于反馈控制;采用二阶指令滤波反步法设计状态反馈控制律和误差补偿机制,避免反步设计中“计算爆炸”的问题,同时消除滤波误差,提高系统位置跟踪精度;依据Lyapunov稳定性理论证明闭环系统中所有误差信号的收敛性。仿真结果表明:系统的稳态误差在所提方法下约为3.48×10^(-8)m,相比于其他控制方法,跟踪误差始终约束在时变的约束边界内,跟踪精度和控制性能均得到提升。

采样控制下的Markov跳变系统稳定性与安全性分析

研究针对连续Markov跳变系统的稳定性和安全性问题通过状态采样控制器保证了其稳定性和安全性。首先,与通常只考虑Markov系统的稳定性不同的是,系统的安全性问题也被考虑了。其次,系统的安全性通过引入控制障碍函数的方法得到解决。因此,系统分析及计算变得极其复杂。最后,通过设计采样控制器保证了系统的稳定性和安全性,并提供了一个有效的数值例子验证了提出方法的有效性。

智能化视角下城市公园无障碍设计研究——以武汉市中山公园为例

为改善老年人的无障碍环境建设、分析其无障碍设计需求,从智能化的角度出发,研究新时期城市公园无障碍设计的发展需求与智能化融合实践应用,提出改善城市公园无障碍设计的智能化措施,进而构建城市公园无障碍设计智能化体系。文章以武汉市中山公园为例,结合行为注记法、实地调查和问卷调研法,发现其存在诸多无障碍环境建设问题,从智能化角度出发,为其提供改善无障碍环境的思路与策略。

城市群城市韧性水平测度及障碍因子识别

城市群是城市发展较高层次的空间组成形式,其城市韧性的提升对建设韧性城市、促进城市群持续健康发展具有重要意义。为全面测度城市群城市韧性水平并识别其障碍因子,构建了城市群城市韧性评价指标体系,采用熵值法和BP神经网络模型对关中平原城市群2011—2020年各城市分系统韧性和复合系统进行分析,进一步使用障碍度模型对影响关中平原城市群城市韧性的障碍因子进行识别。研究发现,关中平原城市群城市韧性位于中等韧性水平,但总体呈上升趋势,其空间分布格局呈现出“东西低,中间高”的倒V形。具体而言,经济系统韧性以较低韧性水平和中等韧性水平为主,社会系统韧性以中等韧性水平和较高韧性水平为主,生态系统韧性以较高韧性水平为主,而基础设施系统韧性则主要分布在较低至较高韧性水平之间;建成区绿化覆盖率和全社会用电量因子是影响关中平原城市群城市韧性提升的主要障碍因子;从分系统来看,社会系统始终是影响关中平原城市群城市韧性提升的关键系统。研究表明,城市群应进一步加强城市之间的合作,共享信息资源,提高人们生活水平,加大城市基础设施建设力度,不断促进城市群协调发展。

肾素血管紧张素系统在溃疡性结肠炎小鼠肠-血屏障损伤中的调控作用

本研究旨在探讨肾素血管紧张素系统(renin-angiotensin system, RAS)在溃疡性结肠炎小鼠肠-血屏障损伤中发挥的作用。选取16只ICR小鼠,随机分为正常对照组(Control组)和葡聚糖硫酸钠盐处理组(DSS组),等体积灌胃生理盐水。试验至第4天,DSS组小鼠在饮用水中添加DSS(终浓度为4%)制造小鼠溃疡性结肠炎模型。期间每天记录小鼠体重、粪便性状和粪便隐血情况,并计算疾病活跃指数(disease activity index, DAI)。DSS饮用至第8天,所有小鼠采血后剖检,量取结肠长度,取结肠组织等样品。进行如下试验:1)HE染色观察结肠组织病理变化;2)ELISA法检测血液中血管内皮生长因子(vascular endothelial growth factor, VEGFA)及结肠组织中Ang1-7和AngⅡ的含量;3)Western blot检测结肠组织中血管紧张素转化酶2(angiotensin-coverting enzyme 2, ACE2)、血管紧张素转化酶(ACE)和质膜膜泡关联蛋白(plasmalemma vesicle associated protein, PLVAP)的表达;4)斯皮尔曼相关性分析ACE2、ACE与PLVAP表达变化的相关性以及Ang1-7、AngⅡ和VEGFA含量变化的相关性。结果显示:1)成功建立了DSS诱导小鼠溃疡性结肠炎模型,小鼠表现为体重下降、DAI极显著升高(P<0.01)、结肠极显著缩短(P<0.01)和结肠组织出现明显的病理变化;2)与对照组相比,DSS组小鼠表现肛门明显出血,结肠组织中PLVAP和VEGFA蛋白表达均极显著升高(P<0.01);3)与对照组相比,DSS组小鼠结肠组织中ACE2和ACE表达均极显著上调(P<0.01),Ang1-7和AngⅡ含量分别显著(P<0.05)和极显著(P<0.01)升高;4)相关性分析显示,ACE2、ACE的表达变化和PLVAP表达变化呈正相关,Ang1-7、AngⅡ含量变化与VEGFA含量变化也呈正相关。以上结果表明,DSS致小鼠结肠炎症过程中小鼠结肠血管屏障受损,结肠局部RAS均处于激活状态,ACE/AngⅡ通路的激活占优势,提示:AngⅡ参与了结肠炎小鼠肠-血屏障的损伤过程。通过激活ACE2或过表达ACE2,增强其对AngⅡ的降解作用以缓解肠-血屏障的损伤,可能是治疗或缓解溃疡性结肠炎的一个新的思路或途径。

基于障碍函数内点法的防御武器配系部署建模与智能优化

针对防空任务中我方多平台、多武器、多区域部署带来的防御武器配系难以建模和实时优化难的问题,在考虑敌我双方攻防武器对抗博弈的条件下,提出了一种基于障碍函数内点法的我方防御武器部署优化模型,并综合武器防御效能、防御成本、保卫目标的资产价值等指标对模型进行智能优化解算与分析.首先,建立我方部阵地、防御武器与保卫目标的参数化模型,并建立我方武器对于敌方武器拦截的概率函数与约束条件;然后,将防御武器优化部署问题转化为性能指标函数为凸函数的无约束优化问题;最后,引入障碍函数内点法对其进行快速求解,给出了防御阵地武器部署的最优配置方案.所提方法充分考虑了来袭目标的不同类型、异构特性以及大气层内外防御的多元化火力运用方式;能够在具有混合整数非线性、约束强耦合、变量规模大等特征的防御武器配系场景下快速给出最优配置结果.并且,通过数值仿真验证了在对抗博弈条件下所提部署建模与智能优化方法的有效性与优越性.

大黄素和子苷配伍对全身炎症反应综合征大鼠肠黏膜屏障损伤及炎症反应的影响

目的观察大黄素和子苷配伍对全身炎症反应综合征(SIRS)大鼠肠黏膜屏障功能损伤的保护和炎症反应的抑制作用。方法选择6~8周龄雄性SD大鼠,按随机数字表法分为正常对照组、模型组、大黄素组、子苷组、大黄素与子苷配伍组(配伍组)乌司他丁组。通过腹腔注射酵母多糖的方法构建大鼠SIRS模型,大黄素组、子苷组、乌司他丁组、配伍组于大鼠注射酵母多糖后即刻和12h后各给药1次。制模后24h,测定各组大鼠血清D-乳酸(D-LA)、二胺氧化酶(DAO)、内毒素(ET)、肿瘤坏死因子-α(TNF-α)、白细胞介素(IL-1β、IL-6、IL-10)含量;取小肠组织观察病理学改变;采用免疫组化法测定小肠组织核转录因子-kBp65(NF-kBp65)及Toll样受体4(TLR-4)的蛋白阳性表达水平。结果与正常对照组比较,模型组大鼠血清D-LA、DAO、ET、TNF-α、IL-1β、IL-6、IL-10均明显升高[D-LA(μmol/L):99.11±11.93比36.94±1.92,DAO(U/L):5018.80±759.00比2253.23±372.40,ET(μg/L):0.36±0.04比0.15±0.02,TNF-α(ng/L):66.61±20.88比9.47±0.78,IL-1β(ng/L):63.73±7.64比25.86±5.90,IL-6(ng/L):392.00±56.47比111.17±36.22,IL-10(ng/L):41.90±8.12比19.75±1.54,均P<0.05],组织病理学观察可见小肠黏膜水肿明显,黏膜上皮细胞排列紊乱并伴有细胞脱落,肠黏膜内炎症细胞浸润增多,杯状细胞减少,固有层松散、充血;小肠组织中TLR-4及NF-kB蛋白阳性表达明显增强[TLR-4蛋白阳性表达(A值):0.59±0.08比0.27±0.04,NF-kB蛋白阳性表达(A值):0.65土0.07比0.30土0.06,均P<0.05]。与模型组比较,大黄素组、子苷组、乌司他丁组、配伍组血清D-LA、DAO和ET水平均明显降低[D-LA(μmol/L):67.49±8.32、69.08±6.76、69.17±5.63、58.16±7.12比99.11±11.93,DAO(U/L):3659.38±563.90、3713.29±354.70、3575.30±444.40、3087.01±227.50比5018.80±759.00,ET(μg/L):0.27±0.04、0.24±0.03、0.23±0.03、0.20±0.02比0.36±0.04,均P<0.05],促炎因子TNF-α、IL-1β、IL-6含量亦均明显著降低[TNF-α(ng/L):44.34±10.63、39.23±11.74、35.80±11.49、28.74±9.56比66.61±20.88,IL-1β(ng/L):50.30±8.22、46.74±5.10、48.25±5.16、40.84±5.02比63.73±7.64,IL-6(ng/L):299.27±50.65、263.98±37.62、281.84±63.24、216.72±38.90比392.00土56.47,均P<0.05]。大黄素、子苷、大黄素与子苷配伍、乌司他丁均可升高血清抗炎因子IL-10水平(ng/L:92.63±32.83、87.34±30.79、71.66±16.82、133.70±39.40比41.90±8.12,均P<0.05)。大黄素组、子苷组、配伍组、乌司他丁组肠组织病理改变减轻,小肠组织中NF-kBp65和TLR-4蛋白阳性表达均显著降低[TLR-4蛋白阳性表达(A值):0.49±0.03、0.47±0.08、0.36±0.08、0.42±0.06比0.59±0.08,NF-kBp65蛋白阳性表达(A值):0.50±0.06、0.49±0.07、0.42±0.06、0.46±0.09比0.65±0.07,均P<0.05]。与大黄素组、子苷组比较,配伍组血清D-LA、DAO、ET、TNF-α、IL-1β、IL-6均显著降低,IL-10水平显著升高,肠组织病理改变减轻,小肠组织NF-kBp65和TLR-4蛋白阳性表达水平均明显降低(均P<0.05)。结论大黄素和子苷有助于缓解酵母多糖引发的SIRS,其作用与保护小肠黏膜屏障、抑制炎症反应有关,二者配伍有增效作用。