We study the construction of mutually unbiased bases in Hilbert space for composite dimensions d which are not prime powers.We explore the results for composite dimensions which are true for prime power dimensions.We ...We study the construction of mutually unbiased bases in Hilbert space for composite dimensions d which are not prime powers.We explore the results for composite dimensions which are true for prime power dimensions.We then provide a method for selecting mutually unbiased vectors from the eigenvectors of generalized Pauli matrices to construct mutually unbiased bases.In particular,we present four mutually unbiased bases in C^(15).展开更多
In order to implement the national aesthetic education policy,it is essential to organically integrate relevant aesthetic education resources,promote interdisciplinary education,and carry out extracurricular practical...In order to implement the national aesthetic education policy,it is essential to organically integrate relevant aesthetic education resources,promote interdisciplinary education,and carry out extracurricular practical activities centered on aesthetic education.Strengthening the foundation of aesthetic education theory,addressing practical challenges in the teaching process,and closely linking research with teaching will create a feedback loop that benefits drama education.This article provides an in-depth analysis of the construction strategies,resource advantages and disadvantages,and development of aesthetic education bases,offering countermeasures and suggestions for their construction in universities.It aims to provide a solid research foundation for the growth and development of aesthetic education bases in higher education institutions.展开更多
With the continuous expansion of medical student enrollment,the number of clinical teaching bases is gradually increasing.However,there are significant differences in clinical teaching management models and teaching l...With the continuous expansion of medical student enrollment,the number of clinical teaching bases is gradually increasing.However,there are significant differences in clinical teaching management models and teaching levels among different bases.Most clinical teaching bases have incomplete teaching management systems,inadequate teaching management institutions,insufficient teaching personnel,and inadequate implementation of teaching rules and regulations.This article combines the construction practice of three-level clinical teaching base of the General Medicine College and the First Affiliated Hospital of Xi’an Medical University.We establish a standardized management system for the three-level clinical teaching base;implement a teaching supervision system and strengthen the monitoring of teaching quality;adopt multiple evaluations to test the effectiveness of clinical teaching implementation;explore the path of homogenization construction of teaching bases in terms of unified teacher training,promoting the development of teacher teaching abilities with equal quality and excellence,and providing a reference for improving the quality of medical talent training.展开更多
Boron is an essential microelement for plant growth.Tomato is one of the most cultivated fruits and vegetables in the world,and boron deficiency severely inhibits its yield and quality.However,the mechanism of tomato ...Boron is an essential microelement for plant growth.Tomato is one of the most cultivated fruits and vegetables in the world,and boron deficiency severely inhibits its yield and quality.However,the mechanism of tomato in response to boron deficiency remains largely unclear.Here,we investigated the physiological and molecular bases of the boron deficiency response in hydroponically grown tomato seedlings.Boron deficiency repressed the expression of genes associated with nitrogen metabolism,while it induced the expression of genes related to the pentose phosphate pathway,thereby altering carbon flow to provide energy for plants to cope with stress.Boron deficiency increased the accumulation of copper,manganese and iron,thereby maintaining chlorophyll content and photosynthetic efficiency at the early stage of stress.In addition,boron deficiency downregulated the expression of genes involved in cell wall organization and reduced the contents of pectin and cellulose in roots,ultimately retarding root growth.Furthermore,boron deficiency markedly altered phytohormone levels and signaling pathways in roots.The contents of jasmonic acid,jasmonoy1-L-isoleucine,trans-zeatin riboside,abscisic acid,salicylic acid,and SA glucoside were decreased;in contrast,the contents of isopentenyladenine riboside and ethylene precursor 1-aminocyclopropane-1-carboxylic acid were increased in the roots of boron-deficient tomato plants.These results collectively indicate that tomato roots reprogram carbon/nitrogen metabolism,alter cell wall components and modulate phytohormone pathways to survive boron deficiency.This study provides a theoretical basis for further elucidating the adaptive mechanism of tomato in response to boron deficiency.展开更多
The aim of this paper is to given an algebraic computational method for finding maximal independent sets as well as the independent number of an arbitrary finite graph of n vertices G by strengthening the problem of f...The aim of this paper is to given an algebraic computational method for finding maximal independent sets as well as the independent number of an arbitrary finite graph of n vertices G by strengthening the problem of finding maximal independent sets of G to the problem of finding k-independent sets in G for. It is shown that the existence of k-independent sets in G is equivalent to the existence of solutions of a system of multivariate polynomial equations. It follows that the problem of finding k-independent sets can be realized by using Gröbner bases of polynomial ideals. Since the number of k-independent sets is finite, the triangular equations composed by Gröbner bases are easier to be solved. Consequently, the maximal independent sets and the independent number of G are obtained after solving at most n such equations. Finally, the numerical example is presented to illustrate the effectiveness of this algebraic computational method.展开更多
Under the background of emerging agricultural education,practice bases are an important place to train profession talented person that match social needs,so it is very important to build stable and long-term practice ...Under the background of emerging agricultural education,practice bases are an important place to train profession talented person that match social needs,so it is very important to build stable and long-term practice bases.At present,the main problems in the construction of practice bases for postgraduates in local colleges and universities are mainly focusing on construction and neglecting management,imperfect cooperation mechanism and lack of teaching management effectively.It is of great significance to build a long-term management mechanism to ensure the education quality of practice bases.Therefore,constructing the mode of"double integration and double promotion of production and education"with practice bases as the carrier and realizing the organic combination of industrial needs and postgraduate projects is an important idea for local colleges and universities to train professional degree postgraduates to"know agriculture,love agriculture,strengthen agriculture and promote agriculture",and it also provides a reference for the mechanism construction of postgraduate bases.展开更多
The compounds have been synthesized and characterized by routine MS, IR and NMR spectrometry methods. The compounds are all active on bacterial strains with the exception of Salmonella typhimirium, with a MIC value of...The compounds have been synthesized and characterized by routine MS, IR and NMR spectrometry methods. The compounds are all active on bacterial strains with the exception of Salmonella typhimirium, with a MIC value of 7.5 mg/mL. They show a percentage of anti-radical activity of 75.476 ± 5.070 for the compound DAN-S and of 68.142 ± 6.539 for the compound DAN-OV. The compounds are sensitive to the two champions used. DAN-S compound is then the most active.展开更多
A previous study was conducted on the synthesis and antibacterial evaluation of Mannich bases of 2-(thioalkyl)-1H-methylbenzimidazole derivatives. The results of this study showed that certain 2-(thioalkyl)-1H-methylb...A previous study was conducted on the synthesis and antibacterial evaluation of Mannich bases of 2-(thioalkyl)-1H-methylbenzimidazole derivatives. The results of this study showed that certain 2-(thioalkyl)-1H-methylbenzimidazole and 2-(thioalkyl)-methyl-1-(piperidin-1-ylmethyl)benzimidazole derivatives possess antibacterial activities against clinical strains, such as Escherichia coli, Klebsiella pneumonia (Gram-negative bacteria), Staphylococcus aureus and Pseudomonas aeruginosa (Gram-positive bacteria). Following these favorable results, we extended the antibacterial evaluation of this series of molecules to environmental strains. The aim of this study was to assess the impact of the methyl-piperidine group fixed at position-1 of this new series of benzimidazoles on the antibacterial activity of environmental strains. In addition, we first evaluated the antibacterial activity of four 2-(thioalkyl)methylbenzimidazole derivatives and then that of five 2-(thioalkyl)-methyl-1-(piperidin-1-ylmethyl) benzimidazole derivatives. This study allowed us to show that compounds 1d and 1e could inhibit bacterial growth in vitro of the Enterobacteria P1 strain with inhibition diameters of 17.3 ± 0.6 mm and 10 ± 0.0 mm, respectively. However, addition of methyl-piperidinyl in this series showed that five (5) of 2-(thioalkyl)-methyl-1-(piperidin-1-ylmethyl) benzimidazole derivatives had an inhibitory effect on the in vitro growth of bacterial strains used except on Enterobacteria P2 with inhibition diameters between 10.0 ± 0.8 mm and 27.9 ± 1.4 mm. The introduction of the methyl-piperidinyl group at the 1-position of 2-(thioalkyl)-1H-methylbenzimidazole derivatives greatly improved the antibacterial activity against environmental bacteria such as Escherichia coli A1, A2, A3, and A4 and two Enterobacteria P1.展开更多
To investigate the structural form of gossypol and gossypolone Schiff's bases, seven relevant Schiff's bases were synthesized and the electrospray ionization-tandem mass spectrometry (ESI-MS/MS) with low-energy co...To investigate the structural form of gossypol and gossypolone Schiff's bases, seven relevant Schiff's bases were synthesized and the electrospray ionization-tandem mass spectrometry (ESI-MS/MS) with low-energy collision-induced dissociation was used to analyze their fragmentations. A common fragmentation pathway with the loss of RNH2 from those schiff's bases quasi-molecular ions was observed and proposed on the basis of their MS/MS spectra data. This common pathway indicated that those Schiff's bases existed mainly as the enamine form not the imine form previously showed in most reports.展开更多
The economic transformation of the old industrial bases is a key research topic among geographers in China.In this paper,we propose that the concept of regional economic resilience(RER)has unique theoretical value in ...The economic transformation of the old industrial bases is a key research topic among geographers in China.In this paper,we propose that the concept of regional economic resilience(RER)has unique theoretical value in analyzing the economic transformation of the old industrial bases.We constructed an analytical framework and an index system and applied the conceptual tools to study the evolution of RER in the old industrial base of Liaoning Province in China,which is currently subjected to not only sudden shocks but‘slow burn’—longer term processes of change that may nevertheless affect the regional economy.There are four main findings:first,the evolution of RER in Liaoning can be divided into four stages from 2000 to 2015.Liaoning is currently in its conservation-release period,and the next stage will be a release-reorganization period.Second,the RER of the majority of the studied cities is lower than the average value for Liaoning,and this is mainly attributed to the relatively weak vulnerability-resistance and adaptability-transformation capacity of these cities.Third,the RER levels of the 14 cities in Liaoning differ significantly.At the first level is Shenyang and Dalian,at the second level is Dandong and Yingkou,and the third level comprises the remaining cities.Fourth,regional economic resilience is mainly determined by vulnerability-resistance,which indirectly reflects Liaoning’s lack of adaptability-transformation capacity,and the ability of the region to renew or create a new development path is weak.展开更多
Objective: A series of 2-benzylideneaminonaphthothiazoles were designed and synthesized incorporating the lipophilic naphthalene ring to render them more capable of penetrating various biomembranes. Methods: Schiff ...Objective: A series of 2-benzylideneaminonaphthothiazoles were designed and synthesized incorporating the lipophilic naphthalene ring to render them more capable of penetrating various biomembranes. Methods: Schiff bases were synthesized by the reaction of naphtha[1,2-d]thiazol-2-amine with various substituted aromatic aldehydes. 2-(2'-Hydroxy)ben- zylideneaminonaphthothiazole was converted to its Co(Ⅱ), Ni(Ⅱ) and Cu(Ⅱ) metal complexes upon treatment with metal salts in ethanol. All the compounds were evaluated for their antibacterial activities by paper disc diffusion method with Gram positive Staphylococcus aureus and Staphylococcus epidermidis and Gram negative Escherichia coli and Pseudomonas aeruginosa bacteria. The minimum inhibitory concentrations of all the Schiff bases and metal complexes were determined by agar streak dilution method. Results: All the compounds moderately inhibited the growth of Cram positive and Gram negative bacteria. In the present study among all Schiff bases 2-(2'-hydroxy)benzylideneaminonaphthothiazole showed maximum inhibitory activity and among metal complexes Cu(Ⅱ) metal complex was found to be most potent. Conclusion: The results obtained validate the hypothesis that Schiff bases having substitution with halogens, hydroxyl group and nitro group at phenyl ring are required for the antibacterial activity while methoxy group at different positions in the aromatic ring has minimal role in the inhibitory activity. The results also indicated that the metal complexes are better antibacterial agents as compared to the Schiff bases.展开更多
The reaction of nitrosonium (NO+) with Schiff bases produced diazonium salts and aldehydes in good yield. The reaction is assumed to be an electrophilic reaction of nitrosonium with imines via a four-member ring inter...The reaction of nitrosonium (NO+) with Schiff bases produced diazonium salts and aldehydes in good yield. The reaction is assumed to be an electrophilic reaction of nitrosonium with imines via a four-member ring intermediate.展开更多
The adsorption of DNA bases on a magnetic probe composed of Fe atoms and graphene is studied by using first- principles calculations. The stability of geometry, the electronic structure and magnetic property are inves...The adsorption of DNA bases on a magnetic probe composed of Fe atoms and graphene is studied by using first- principles calculations. The stability of geometry, the electronic structure and magnetic property are investigated. The results indicate that four DNA bases, i.e., adenine, thymine, cytosine and guanine, can all be adsorbed on the probe solidly. However, the magnetic moments of the composite structure can be observed only when adenine adsorbs on the probe. In the cases of the adsorption of the other three bases, the magnetic moments of the composite structure are zero. Based on the significant change of magnetic moment of the composite structure, adenine can be distinguished conveniently from thymine, cytosine and guanine. This work may provide a new way to detect DNA bases.展开更多
On the basis of brief description of current situation of old industrial bases and primary industry of Liaoning Province, the paper introduces the general situation of agriculture-ecological zoning plan in Liaoning Pr...On the basis of brief description of current situation of old industrial bases and primary industry of Liaoning Province, the paper introduces the general situation of agriculture-ecological zoning plan in Liaoning Province. First, the ecological bases of agricultural zoning plan are introduced through various topographic and geomorphic types, regional climate differences and imbalanced distribution of natural resources; Second, in accordance with the theory of comparative advantage, distribution of production and resource economics, on the basis of comprehensive evaluation of agricultural natural resources, with the principle of fully excavating economic function of different natural resources, and in order to improve allocation efficiency of the two resources of market and government, the formation of ecological zoning plan of agriculture in Liaoning Province is analyzed; Third, according to Regional Layout Planning of Characteristic Agricultural Products of Liaoning Province (2006-2010), the paper describes basic layout of agriculture-ecological zoning plan in Liaoning Province. The policy support of agriculture-ecological zoning plan in Liaoning Province is analyzed from three aspects-support policy of functional zone major in producing grain, support policy of other characteristic agriculture-ecological zone and support measures of development of agriculture-ecological zone. The paper also analyzes experiences of agricultural development of old industrial bases in ecological zoning plan: First, agriculture-ecological zoning plan is a effective way of the revitalization of old industrial bases; Second, scientificity of plan is the basis of improving competitiveness of regional agriculture; Third, multi-input mechanism guiding by government is the key of agricultural packing effect; Fourth, integrated agricultural industrial chain is guarantee of realizing industrialization in ecological zone.展开更多
A novel method based on time-dependent stochastic orthogonal bases for stochastic response surface approximation is proposed to overcome the problem of significant errors in the utilization of the generalized polynomi...A novel method based on time-dependent stochastic orthogonal bases for stochastic response surface approximation is proposed to overcome the problem of significant errors in the utilization of the generalized polynomial chaos(GPC) method that approximates the stochastic response by orthogonal polynomials. The accuracy and effectiveness of the method are illustrated by different numerical examples including both linear and nonlinear problems. The results indicate that the proposed method modifies the stochastic bases adaptively, and has a better approximation for the probability density function in contrast to the GPC method.展开更多
Six lanthanide complexes with bis(phenylsulfinyl)ethane(bphse) and organic bases(phen: 1,10 phenanthroline and bipy: 2,2'-bipyridine) were synthesized and characterized by elemental analysis, conductance and spec...Six lanthanide complexes with bis(phenylsulfinyl)ethane(bphse) and organic bases(phen: 1,10 phenanthroline and bipy: 2,2'-bipyridine) were synthesized and characterized by elemental analysis, conductance and spectral (IR, UV Visible) data. The complexes were Ln(bphse) 2(bipy)(ClO 4) 3· n H 2O and Ln 2(bphse) 3(phen) 2(ClO 4) 6·H 2O(where Ln=Nd, Eu and Gd; n =0~2). IR spectral data confirmed that the lanthanide ions were coordinated by oxygen atoms from bphse and nitrogen atoms from phen or bipy. Exitation and emission spectra of Eu complexes were measured and discussed.展开更多
The factors affecting the developmcnt of Sinopec lubricating oil were analyzed in this paper, and an analytic hierarchy process (AHP) model for selecting lubricating-oil producing bases was developed. By using this ...The factors affecting the developmcnt of Sinopec lubricating oil were analyzed in this paper, and an analytic hierarchy process (AHP) model for selecting lubricating-oil producing bases was developed. By using this model, nine lubricating oil producing companies under Sinopec were comprehensively evaluated. The evaluation result showed that the Maoming Lubricating Oil Company (Guangdong province), Jingmen Lubricating Oil Company (Hubei province) and Changcheng Lube Oil Company (Beijing) are top three choices, and should be developed preferentially for the development of Sinopec producing bases of lubricating oil in the future. The conclusions provide the theoretical basis for selecting lubricating oil producing bases for decision makers.展开更多
Using ideas based on supersymmetric quantum mechanics, we design canonical transformations of the usual position and momentum to create generalized “Cartesian-like” positions, W, and momenta, Pw , with unit Poisson ...Using ideas based on supersymmetric quantum mechanics, we design canonical transformations of the usual position and momentum to create generalized “Cartesian-like” positions, W, and momenta, Pw , with unit Poisson brackets. These are quantized by the usual replacement of the classical , x Px by quantum operators, leading to an infinite family of potential “operator observables”. However, all but one of the resulting operators are not Hermitian (formally self-adjoint) in the original position representation. Using either the chain rule or Dirac quantization, we show that the resulting operators are “quasi-Hermitian” relative to the x-representation and that all are Hermitian in the W-representation. Depending on how one treats the Jacobian of the canonical transformation in the expression for the classical momentum, Pw , quantization yields a) continuous mutually unbiased bases (MUB), b) orthogonal bases (with Dirac delta normalization), c) biorthogonal bases (with Dirac delta normalization), d) new W-harmonic oscillators yielding standard orthonormal bases (as functions of W) and associated coherent states and Wigner distributions. The MUB lead to W-generalized Fourier transform kernels whose eigenvectors are the W-harmonic oscillator eigenstates, with the spectrum (±1,±i) , as well as “W-linear chirps”. As expected, W,?Pw satisfy the uncertainty product relation: ΔWΔPw ≥1/2 , h=1.展开更多
基金Project supported by Zhoukou Normal University,ChinaHigh Level Talents Research Start Funding Project (Grant No.ZKNUC2022010)+2 种基金Key Scientific Research Project of Henan Province (Grant No.22B110022)Key Research and Development Project of Guangdong Province (Grant No.2020B0303300001)the Guangdong Basic and Applied Basic Research Foundation (Grant No.2020B1515310016)。
文摘We study the construction of mutually unbiased bases in Hilbert space for composite dimensions d which are not prime powers.We explore the results for composite dimensions which are true for prime power dimensions.We then provide a method for selecting mutually unbiased vectors from the eigenvectors of generalized Pauli matrices to construct mutually unbiased bases.In particular,we present four mutually unbiased bases in C^(15).
文摘In order to implement the national aesthetic education policy,it is essential to organically integrate relevant aesthetic education resources,promote interdisciplinary education,and carry out extracurricular practical activities centered on aesthetic education.Strengthening the foundation of aesthetic education theory,addressing practical challenges in the teaching process,and closely linking research with teaching will create a feedback loop that benefits drama education.This article provides an in-depth analysis of the construction strategies,resource advantages and disadvantages,and development of aesthetic education bases,offering countermeasures and suggestions for their construction in universities.It aims to provide a solid research foundation for the growth and development of aesthetic education bases in higher education institutions.
基金2022 Education and Teaching Reform Research Project of Xi’an Medical University“Construction and Practice of the Teaching Quality Assurance System in the Three-Level Teaching Base of General Practice Medicine Under the Internet+Model”(Project number:2022JG-05)。
文摘With the continuous expansion of medical student enrollment,the number of clinical teaching bases is gradually increasing.However,there are significant differences in clinical teaching management models and teaching levels among different bases.Most clinical teaching bases have incomplete teaching management systems,inadequate teaching management institutions,insufficient teaching personnel,and inadequate implementation of teaching rules and regulations.This article combines the construction practice of three-level clinical teaching base of the General Medicine College and the First Affiliated Hospital of Xi’an Medical University.We establish a standardized management system for the three-level clinical teaching base;implement a teaching supervision system and strengthen the monitoring of teaching quality;adopt multiple evaluations to test the effectiveness of clinical teaching implementation;explore the path of homogenization construction of teaching bases in terms of unified teacher training,promoting the development of teacher teaching abilities with equal quality and excellence,and providing a reference for improving the quality of medical talent training.
基金This research was supported by the China National Natural Sciences Foundation(32070314)to J.X.the Science and Technology Innovation Fund project of Shanxi Agricultural University(2020BQ24)to P.Z.the Basic Research Program of Shanxi Province(Free Exploration)(20210302124369)to L.S.
文摘Boron is an essential microelement for plant growth.Tomato is one of the most cultivated fruits and vegetables in the world,and boron deficiency severely inhibits its yield and quality.However,the mechanism of tomato in response to boron deficiency remains largely unclear.Here,we investigated the physiological and molecular bases of the boron deficiency response in hydroponically grown tomato seedlings.Boron deficiency repressed the expression of genes associated with nitrogen metabolism,while it induced the expression of genes related to the pentose phosphate pathway,thereby altering carbon flow to provide energy for plants to cope with stress.Boron deficiency increased the accumulation of copper,manganese and iron,thereby maintaining chlorophyll content and photosynthetic efficiency at the early stage of stress.In addition,boron deficiency downregulated the expression of genes involved in cell wall organization and reduced the contents of pectin and cellulose in roots,ultimately retarding root growth.Furthermore,boron deficiency markedly altered phytohormone levels and signaling pathways in roots.The contents of jasmonic acid,jasmonoy1-L-isoleucine,trans-zeatin riboside,abscisic acid,salicylic acid,and SA glucoside were decreased;in contrast,the contents of isopentenyladenine riboside and ethylene precursor 1-aminocyclopropane-1-carboxylic acid were increased in the roots of boron-deficient tomato plants.These results collectively indicate that tomato roots reprogram carbon/nitrogen metabolism,alter cell wall components and modulate phytohormone pathways to survive boron deficiency.This study provides a theoretical basis for further elucidating the adaptive mechanism of tomato in response to boron deficiency.
文摘The aim of this paper is to given an algebraic computational method for finding maximal independent sets as well as the independent number of an arbitrary finite graph of n vertices G by strengthening the problem of finding maximal independent sets of G to the problem of finding k-independent sets in G for. It is shown that the existence of k-independent sets in G is equivalent to the existence of solutions of a system of multivariate polynomial equations. It follows that the problem of finding k-independent sets can be realized by using Gröbner bases of polynomial ideals. Since the number of k-independent sets is finite, the triangular equations composed by Gröbner bases are easier to be solved. Consequently, the maximal independent sets and the independent number of G are obtained after solving at most n such equations. Finally, the numerical example is presented to illustrate the effectiveness of this algebraic computational method.
基金Supported by 2021-2023 Postgraduate Talent Training Quality and Teaching Reform Project of Chengdu University (cdjgy2022035)2021-2023 Higher Education Talent Training Quality and Teaching Reform Project of Sichuan Province (JG2021-1109JG2021-130).
文摘Under the background of emerging agricultural education,practice bases are an important place to train profession talented person that match social needs,so it is very important to build stable and long-term practice bases.At present,the main problems in the construction of practice bases for postgraduates in local colleges and universities are mainly focusing on construction and neglecting management,imperfect cooperation mechanism and lack of teaching management effectively.It is of great significance to build a long-term management mechanism to ensure the education quality of practice bases.Therefore,constructing the mode of"double integration and double promotion of production and education"with practice bases as the carrier and realizing the organic combination of industrial needs and postgraduate projects is an important idea for local colleges and universities to train professional degree postgraduates to"know agriculture,love agriculture,strengthen agriculture and promote agriculture",and it also provides a reference for the mechanism construction of postgraduate bases.
文摘The compounds have been synthesized and characterized by routine MS, IR and NMR spectrometry methods. The compounds are all active on bacterial strains with the exception of Salmonella typhimirium, with a MIC value of 7.5 mg/mL. They show a percentage of anti-radical activity of 75.476 ± 5.070 for the compound DAN-S and of 68.142 ± 6.539 for the compound DAN-OV. The compounds are sensitive to the two champions used. DAN-S compound is then the most active.
文摘A previous study was conducted on the synthesis and antibacterial evaluation of Mannich bases of 2-(thioalkyl)-1H-methylbenzimidazole derivatives. The results of this study showed that certain 2-(thioalkyl)-1H-methylbenzimidazole and 2-(thioalkyl)-methyl-1-(piperidin-1-ylmethyl)benzimidazole derivatives possess antibacterial activities against clinical strains, such as Escherichia coli, Klebsiella pneumonia (Gram-negative bacteria), Staphylococcus aureus and Pseudomonas aeruginosa (Gram-positive bacteria). Following these favorable results, we extended the antibacterial evaluation of this series of molecules to environmental strains. The aim of this study was to assess the impact of the methyl-piperidine group fixed at position-1 of this new series of benzimidazoles on the antibacterial activity of environmental strains. In addition, we first evaluated the antibacterial activity of four 2-(thioalkyl)methylbenzimidazole derivatives and then that of five 2-(thioalkyl)-methyl-1-(piperidin-1-ylmethyl) benzimidazole derivatives. This study allowed us to show that compounds 1d and 1e could inhibit bacterial growth in vitro of the Enterobacteria P1 strain with inhibition diameters of 17.3 ± 0.6 mm and 10 ± 0.0 mm, respectively. However, addition of methyl-piperidinyl in this series showed that five (5) of 2-(thioalkyl)-methyl-1-(piperidin-1-ylmethyl) benzimidazole derivatives had an inhibitory effect on the in vitro growth of bacterial strains used except on Enterobacteria P2 with inhibition diameters between 10.0 ± 0.8 mm and 27.9 ± 1.4 mm. The introduction of the methyl-piperidinyl group at the 1-position of 2-(thioalkyl)-1H-methylbenzimidazole derivatives greatly improved the antibacterial activity against environmental bacteria such as Escherichia coli A1, A2, A3, and A4 and two Enterobacteria P1.
文摘To investigate the structural form of gossypol and gossypolone Schiff's bases, seven relevant Schiff's bases were synthesized and the electrospray ionization-tandem mass spectrometry (ESI-MS/MS) with low-energy collision-induced dissociation was used to analyze their fragmentations. A common fragmentation pathway with the loss of RNH2 from those schiff's bases quasi-molecular ions was observed and proposed on the basis of their MS/MS spectra data. This common pathway indicated that those Schiff's bases existed mainly as the enamine form not the imine form previously showed in most reports.
基金Under the auspices of National Natural Science Foundation of China(No.41571152,41771179).
文摘The economic transformation of the old industrial bases is a key research topic among geographers in China.In this paper,we propose that the concept of regional economic resilience(RER)has unique theoretical value in analyzing the economic transformation of the old industrial bases.We constructed an analytical framework and an index system and applied the conceptual tools to study the evolution of RER in the old industrial base of Liaoning Province in China,which is currently subjected to not only sudden shocks but‘slow burn’—longer term processes of change that may nevertheless affect the regional economy.There are four main findings:first,the evolution of RER in Liaoning can be divided into four stages from 2000 to 2015.Liaoning is currently in its conservation-release period,and the next stage will be a release-reorganization period.Second,the RER of the majority of the studied cities is lower than the average value for Liaoning,and this is mainly attributed to the relatively weak vulnerability-resistance and adaptability-transformation capacity of these cities.Third,the RER levels of the 14 cities in Liaoning differ significantly.At the first level is Shenyang and Dalian,at the second level is Dandong and Yingkou,and the third level comprises the remaining cities.Fourth,regional economic resilience is mainly determined by vulnerability-resistance,which indirectly reflects Liaoning’s lack of adaptability-transformation capacity,and the ability of the region to renew or create a new development path is weak.
文摘Objective: A series of 2-benzylideneaminonaphthothiazoles were designed and synthesized incorporating the lipophilic naphthalene ring to render them more capable of penetrating various biomembranes. Methods: Schiff bases were synthesized by the reaction of naphtha[1,2-d]thiazol-2-amine with various substituted aromatic aldehydes. 2-(2'-Hydroxy)ben- zylideneaminonaphthothiazole was converted to its Co(Ⅱ), Ni(Ⅱ) and Cu(Ⅱ) metal complexes upon treatment with metal salts in ethanol. All the compounds were evaluated for their antibacterial activities by paper disc diffusion method with Gram positive Staphylococcus aureus and Staphylococcus epidermidis and Gram negative Escherichia coli and Pseudomonas aeruginosa bacteria. The minimum inhibitory concentrations of all the Schiff bases and metal complexes were determined by agar streak dilution method. Results: All the compounds moderately inhibited the growth of Cram positive and Gram negative bacteria. In the present study among all Schiff bases 2-(2'-hydroxy)benzylideneaminonaphthothiazole showed maximum inhibitory activity and among metal complexes Cu(Ⅱ) metal complex was found to be most potent. Conclusion: The results obtained validate the hypothesis that Schiff bases having substitution with halogens, hydroxyl group and nitro group at phenyl ring are required for the antibacterial activity while methoxy group at different positions in the aromatic ring has minimal role in the inhibitory activity. The results also indicated that the metal complexes are better antibacterial agents as compared to the Schiff bases.
文摘The reaction of nitrosonium (NO+) with Schiff bases produced diazonium salts and aldehydes in good yield. The reaction is assumed to be an electrophilic reaction of nitrosonium with imines via a four-member ring intermediate.
基金Supported by the National Natural Science Foundation of China under Grant Nos 51301119 and 11204201the Natural Science Foundation for Young Scientists of Shanxi Province under Grant No 2013021010-1
文摘The adsorption of DNA bases on a magnetic probe composed of Fe atoms and graphene is studied by using first- principles calculations. The stability of geometry, the electronic structure and magnetic property are investigated. The results indicate that four DNA bases, i.e., adenine, thymine, cytosine and guanine, can all be adsorbed on the probe solidly. However, the magnetic moments of the composite structure can be observed only when adenine adsorbs on the probe. In the cases of the adsorption of the other three bases, the magnetic moments of the composite structure are zero. Based on the significant change of magnetic moment of the composite structure, adenine can be distinguished conveniently from thymine, cytosine and guanine. This work may provide a new way to detect DNA bases.
文摘On the basis of brief description of current situation of old industrial bases and primary industry of Liaoning Province, the paper introduces the general situation of agriculture-ecological zoning plan in Liaoning Province. First, the ecological bases of agricultural zoning plan are introduced through various topographic and geomorphic types, regional climate differences and imbalanced distribution of natural resources; Second, in accordance with the theory of comparative advantage, distribution of production and resource economics, on the basis of comprehensive evaluation of agricultural natural resources, with the principle of fully excavating economic function of different natural resources, and in order to improve allocation efficiency of the two resources of market and government, the formation of ecological zoning plan of agriculture in Liaoning Province is analyzed; Third, according to Regional Layout Planning of Characteristic Agricultural Products of Liaoning Province (2006-2010), the paper describes basic layout of agriculture-ecological zoning plan in Liaoning Province. The policy support of agriculture-ecological zoning plan in Liaoning Province is analyzed from three aspects-support policy of functional zone major in producing grain, support policy of other characteristic agriculture-ecological zone and support measures of development of agriculture-ecological zone. The paper also analyzes experiences of agricultural development of old industrial bases in ecological zoning plan: First, agriculture-ecological zoning plan is a effective way of the revitalization of old industrial bases; Second, scientificity of plan is the basis of improving competitiveness of regional agriculture; Third, multi-input mechanism guiding by government is the key of agricultural packing effect; Fourth, integrated agricultural industrial chain is guarantee of realizing industrialization in ecological zone.
基金Project supported by the National Natural Science Foundation of China(Nos.11632011,11572189,and 51421092)the China Postdoctoral Science Foundation(No.2016M601585)
文摘A novel method based on time-dependent stochastic orthogonal bases for stochastic response surface approximation is proposed to overcome the problem of significant errors in the utilization of the generalized polynomial chaos(GPC) method that approximates the stochastic response by orthogonal polynomials. The accuracy and effectiveness of the method are illustrated by different numerical examples including both linear and nonlinear problems. The results indicate that the proposed method modifies the stochastic bases adaptively, and has a better approximation for the probability density function in contrast to the GPC method.
文摘Six lanthanide complexes with bis(phenylsulfinyl)ethane(bphse) and organic bases(phen: 1,10 phenanthroline and bipy: 2,2'-bipyridine) were synthesized and characterized by elemental analysis, conductance and spectral (IR, UV Visible) data. The complexes were Ln(bphse) 2(bipy)(ClO 4) 3· n H 2O and Ln 2(bphse) 3(phen) 2(ClO 4) 6·H 2O(where Ln=Nd, Eu and Gd; n =0~2). IR spectral data confirmed that the lanthanide ions were coordinated by oxygen atoms from bphse and nitrogen atoms from phen or bipy. Exitation and emission spectra of Eu complexes were measured and discussed.
文摘The factors affecting the developmcnt of Sinopec lubricating oil were analyzed in this paper, and an analytic hierarchy process (AHP) model for selecting lubricating-oil producing bases was developed. By using this model, nine lubricating oil producing companies under Sinopec were comprehensively evaluated. The evaluation result showed that the Maoming Lubricating Oil Company (Guangdong province), Jingmen Lubricating Oil Company (Hubei province) and Changcheng Lube Oil Company (Beijing) are top three choices, and should be developed preferentially for the development of Sinopec producing bases of lubricating oil in the future. The conclusions provide the theoretical basis for selecting lubricating oil producing bases for decision makers.
文摘Using ideas based on supersymmetric quantum mechanics, we design canonical transformations of the usual position and momentum to create generalized “Cartesian-like” positions, W, and momenta, Pw , with unit Poisson brackets. These are quantized by the usual replacement of the classical , x Px by quantum operators, leading to an infinite family of potential “operator observables”. However, all but one of the resulting operators are not Hermitian (formally self-adjoint) in the original position representation. Using either the chain rule or Dirac quantization, we show that the resulting operators are “quasi-Hermitian” relative to the x-representation and that all are Hermitian in the W-representation. Depending on how one treats the Jacobian of the canonical transformation in the expression for the classical momentum, Pw , quantization yields a) continuous mutually unbiased bases (MUB), b) orthogonal bases (with Dirac delta normalization), c) biorthogonal bases (with Dirac delta normalization), d) new W-harmonic oscillators yielding standard orthonormal bases (as functions of W) and associated coherent states and Wigner distributions. The MUB lead to W-generalized Fourier transform kernels whose eigenvectors are the W-harmonic oscillator eigenstates, with the spectrum (±1,±i) , as well as “W-linear chirps”. As expected, W,?Pw satisfy the uncertainty product relation: ΔWΔPw ≥1/2 , h=1.