This work develops a heuristic method for the design of batch water-using networks of multiple contaminants with regeneration unit based on the concepts of concentration potential. A water-using network involving rege...This work develops a heuristic method for the design of batch water-using networks of multiple contaminants with regeneration unit based on the concepts of concentration potential. A water-using network involving regeneration unit can be formed by adding the regenerated stream(s) into the network involving reuse only. In the design procedure of the network operated in a single batch mode, time is take n as the primary factor a nd con centration potentials as the secondary one. For the networks operated in a repeated mode, the design procedure is similar to that for continuous processes, besides designing the storage tanks with the rules proposed. Continuous regeneration unit is selected in this work. With the proposed method, the network structure corresponding to the minimum freshwater consumption can be obtained. It is shown that the method proposed in this article is simple, effective and has clear engineering meaning.展开更多
The effects of equipment parameters of batch distillation column on the yield proportion are discussed and analyzed, the relations between maximal yield proportion and the column equipment parameters are correlated, w...The effects of equipment parameters of batch distillation column on the yield proportion are discussed and analyzed, the relations between maximal yield proportion and the column equipment parameters are correlated, which not only can be used to appraise rationality of the design parameters of the columns being employed and which but also can be used to new batch distillation column design. Under the assistance of the separation difficulty defined in this paper, the minimum number of theoretical plates is determined by the limit loss proportion method given, and further the actual number of theoretical plates and the height for the batch distillation are calculated by using the redundancy coefficient found to complete the whole design of the batch distillation as shown in the computational sample. Research showed that the actual number of theoretical plates and the height of batch distillation column with the column diameter 0.6 m are 17 and 5.1 m in alcohol mixture separation system of the sample proposed. Moreover, the approach can be extended to the design of batch distillation column with a separation system of multi-component liquid mixture after those adjacent components are treated as numerous binary component systems.展开更多
间歇生产过程具有弹性大、灵活等特点,其市场适应性较强。化工生产中间歇生产过程占相当比例,文章就间歇生产工艺的模拟与优化进行介绍,利用Aspen Batch Process Developer模拟间歇工艺过程,可以快速地得到工艺流程的物料衡算、热量衡...间歇生产过程具有弹性大、灵活等特点,其市场适应性较强。化工生产中间歇生产过程占相当比例,文章就间歇生产工艺的模拟与优化进行介绍,利用Aspen Batch Process Developer模拟间歇工艺过程,可以快速地得到工艺流程的物料衡算、热量衡算、操作时间、公用工程和成本估算等结果。同时,还可以对模拟结果进行分析,找出制约生产工艺的瓶颈,并对生产周期、生产规模、生产设备等进行优化,提高工艺设计效率,降低生产成本。展开更多
采取专利CN 102863437A的工艺,设计间歇工艺过程,将Aspen Batch Process Developer软件应用于盐酸鲁拉西酮原料药车间设计的全流程模拟和优化。间歇操作具有显著的优势:生产灵活,同一设备可生产不同产品,可根据市场需要调节生产能力及...采取专利CN 102863437A的工艺,设计间歇工艺过程,将Aspen Batch Process Developer软件应用于盐酸鲁拉西酮原料药车间设计的全流程模拟和优化。间歇操作具有显著的优势:生产灵活,同一设备可生产不同产品,可根据市场需要调节生产能力及变更产品。适合于小批量,高收益的精细化学品。过去的四十年里,使用计算机对化工连续化生产进行模拟和设计已经十分普及。制药工业与传统化工最大的区别是生产过程多采用间歇法操作。目前世界上应用于化工间歇生产的计算机软件有BATCHES、gPROMS和Aspen Batch Process Developer。本文所用版本为Aspen Tech V8.6,以年产25t盐酸鲁拉西酮原料药车间为例,对车间进行全流程模拟及优化。整个设计贯彻质量源于设计理念,运用元葱模型,将盐酸鲁拉西酮的生产工艺分为磺化、氨解、氢化、缩合、成盐、精烘包等6个模块。展开更多
An efficient culture medium producing a bacterial elastase with high yields was developed further following preliminary studies by means of response surface method. Central composite design (CCD) and response surface ...An efficient culture medium producing a bacterial elastase with high yields was developed further following preliminary studies by means of response surface method. Central composite design (CCD) and response surface methodology were applied to optimize the medium constituents. A central composite design was used to explain the combined effect of three medium constituents, viz, glucose, K2HPO4, MgSO4·7H2O. The strain produced more elastase in the completely optimized medium, as compared with the partially optimized medium. The fitted model of the second model, as per RSM, showed that glucose was 7.4 g/100 ml, casein 1.13 g/100 ml, corn steep flour 0.616 g/100 ml, KEHPO4 0.206 g/100 ml and MgSO4·7H2O 0.034 g/100 ml. The fermentation kinetics of these two culture media in the flask experiments were analyzed. It was found that the highest elastase productivity occurred at 54 hours. Higher glucose concentration had inhibitory effect on elastase production. At the same time, we observed that the glucose consumption rate was slow in the completely optimized medium, which can explain the lag period of the highest elastase production. Some metal ions and surfactant additives also affected elastase production and cell growth.展开更多
基金Supported by the Natural Science Foundation of Hebei Province(B2017202073)the Foundation of Educational Commission of Hebei Province(Z2017032)
文摘This work develops a heuristic method for the design of batch water-using networks of multiple contaminants with regeneration unit based on the concepts of concentration potential. A water-using network involving regeneration unit can be formed by adding the regenerated stream(s) into the network involving reuse only. In the design procedure of the network operated in a single batch mode, time is take n as the primary factor a nd con centration potentials as the secondary one. For the networks operated in a repeated mode, the design procedure is similar to that for continuous processes, besides designing the storage tanks with the rules proposed. Continuous regeneration unit is selected in this work. With the proposed method, the network structure corresponding to the minimum freshwater consumption can be obtained. It is shown that the method proposed in this article is simple, effective and has clear engineering meaning.
文摘The effects of equipment parameters of batch distillation column on the yield proportion are discussed and analyzed, the relations between maximal yield proportion and the column equipment parameters are correlated, which not only can be used to appraise rationality of the design parameters of the columns being employed and which but also can be used to new batch distillation column design. Under the assistance of the separation difficulty defined in this paper, the minimum number of theoretical plates is determined by the limit loss proportion method given, and further the actual number of theoretical plates and the height for the batch distillation are calculated by using the redundancy coefficient found to complete the whole design of the batch distillation as shown in the computational sample. Research showed that the actual number of theoretical plates and the height of batch distillation column with the column diameter 0.6 m are 17 and 5.1 m in alcohol mixture separation system of the sample proposed. Moreover, the approach can be extended to the design of batch distillation column with a separation system of multi-component liquid mixture after those adjacent components are treated as numerous binary component systems.
文摘间歇生产过程具有弹性大、灵活等特点,其市场适应性较强。化工生产中间歇生产过程占相当比例,文章就间歇生产工艺的模拟与优化进行介绍,利用Aspen Batch Process Developer模拟间歇工艺过程,可以快速地得到工艺流程的物料衡算、热量衡算、操作时间、公用工程和成本估算等结果。同时,还可以对模拟结果进行分析,找出制约生产工艺的瓶颈,并对生产周期、生产规模、生产设备等进行优化,提高工艺设计效率,降低生产成本。
文摘采取专利CN 102863437A的工艺,设计间歇工艺过程,将Aspen Batch Process Developer软件应用于盐酸鲁拉西酮原料药车间设计的全流程模拟和优化。间歇操作具有显著的优势:生产灵活,同一设备可生产不同产品,可根据市场需要调节生产能力及变更产品。适合于小批量,高收益的精细化学品。过去的四十年里,使用计算机对化工连续化生产进行模拟和设计已经十分普及。制药工业与传统化工最大的区别是生产过程多采用间歇法操作。目前世界上应用于化工间歇生产的计算机软件有BATCHES、gPROMS和Aspen Batch Process Developer。本文所用版本为Aspen Tech V8.6,以年产25t盐酸鲁拉西酮原料药车间为例,对车间进行全流程模拟及优化。整个设计贯彻质量源于设计理念,运用元葱模型,将盐酸鲁拉西酮的生产工艺分为磺化、氨解、氢化、缩合、成盐、精烘包等6个模块。
文摘An efficient culture medium producing a bacterial elastase with high yields was developed further following preliminary studies by means of response surface method. Central composite design (CCD) and response surface methodology were applied to optimize the medium constituents. A central composite design was used to explain the combined effect of three medium constituents, viz, glucose, K2HPO4, MgSO4·7H2O. The strain produced more elastase in the completely optimized medium, as compared with the partially optimized medium. The fitted model of the second model, as per RSM, showed that glucose was 7.4 g/100 ml, casein 1.13 g/100 ml, corn steep flour 0.616 g/100 ml, KEHPO4 0.206 g/100 ml and MgSO4·7H2O 0.034 g/100 ml. The fermentation kinetics of these two culture media in the flask experiments were analyzed. It was found that the highest elastase productivity occurred at 54 hours. Higher glucose concentration had inhibitory effect on elastase production. At the same time, we observed that the glucose consumption rate was slow in the completely optimized medium, which can explain the lag period of the highest elastase production. Some metal ions and surfactant additives also affected elastase production and cell growth.
